ID   OX26_HUMAN              Reviewed;         136 AA.
AC   P83859; A3KFJ6; Q495K6;
DT   19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT   10-MAY-2004, sequence version 1.
DT   27-MAR-2024, entry version 134.
DE   RecName: Full=Orexigenic neuropeptide QRFP;
DE   AltName: Full=P518;
DE   Contains:
DE     RecName: Full=QRF-amide;
DE     AltName: Full=Neuropeptide RF-amide;
DE     AltName: Full=Pyroglutamylated arginine-phenylalanine-amide peptide;
DE   Flags: Precursor;
GN   Name=QRFP {ECO:0000312|EMBL:BAC98934.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000312|EMBL:AAR24354.1};
RN   [1] {ECO:0000305}
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX   PubMed=12714592; DOI=10.1074/jbc.m302945200;
RA   Jiang Y., Luo L., Gustafson E.L., Yadav D., Laverty M., Murgolo N.,
RA   Vassileva G., Zeng M., Laz T.M., Behan J., Qiu P., Wang L., Wang S.,
RA   Bayne M., Greene J., Monsma F.J. Jr., Zhang F.L.;
RT   "Identification and characterization of a novel RF-amide peptide ligand for
RT   orphan G-protein-coupled receptor SP9155.";
RL   J. Biol. Chem. 278:27652-27657(2003).
RN   [2] {ECO:0000305}
RP   NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
RC   TISSUE=Brain {ECO:0000269|PubMed:12714592};
RX   PubMed=12960173; DOI=10.1074/jbc.m305270200;
RA   Fukusumi S., Yoshida H., Fujii R., Maruyama M., Komatsu H., Habata Y.,
RA   Shintani Y., Hinuma S., Fujino M.;
RT   "A new peptidic ligand and its receptor regulating adrenal function in
RT   rats.";
RL   J. Biol. Chem. 278:46387-46395(2003).
RN   [3] {ECO:0000305}
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RC   TISSUE=Hypothalamus {ECO:0000312|EMBL:AAR24354.1};
RX   PubMed=14657341; DOI=10.1073/pnas.2434676100;
RA   Chartrel N., Dujardin C., Anouar Y., Leprince J., Decker A., Clerens S.,
RA   Do-Rego J.-C., Vandesande F., Llorens-Cortes C., Costentin J.,
RA   Beauvillain J.-C., Vaudry H.;
RT   "Identification of 26RFa, a hypothalamic neuropeptide of the RFamide
RT   peptide family with orexigenic activity.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:15247-15252(2003).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=14574404; DOI=10.1038/nature02055;
RA   Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA   Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA   Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA   Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA   Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA   Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA   Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA   Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA   Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA   Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA   French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA   Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA   Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA   Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA   Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA   Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA   Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA   Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA   Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA   Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA   Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA   Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA   Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA   Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA   Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA   Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA   West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA   Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA   Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA   Rogers J., Beck S.;
RT   "The DNA sequence and analysis of human chromosome 6.";
RL   Nature 425:805-811(2003).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Stimulates feeding behavior, metabolic rate and locomotor
CC       activity and increases blood pressure. May have orexigenic activity.
CC       May promote aldosterone secretion by the adrenal gland (By similarity).
CC       {ECO:0000250, ECO:0000269|PubMed:12960173,
CC       ECO:0000269|PubMed:14657341}.
CC   -!- SUBUNIT: Ligand for the G-protein coupled receptor QRFPR/GPR103.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed widely in the brain with highest
CC       expression levels in the cerebellum, medulla, pituitary, retina,
CC       vestibular nucleus, and white matter. Also expressed in the bladder,
CC       colon, coronary artery, parathyroid gland, prostate, testis, and
CC       thyroid. {ECO:0000269|PubMed:12714592}.
CC   -!- SIMILARITY: Belongs to the RFamide neuropeptide family. {ECO:0000305}.
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DR   EMBL; AB109625; BAC98934.1; -; mRNA.
DR   EMBL; AY438326; AAR24354.1; -; Genomic_DNA.
DR   EMBL; AL161733; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC101127; AAI01128.1; -; mRNA.
DR   CCDS; CCDS6936.1; -.
DR   RefSeq; NP_937823.1; NM_198180.2.
DR   AlphaFoldDB; P83859; -.
DR   STRING; 9606.ENSP00000485512; -.
DR   BioMuta; QRFP; -.
DR   DMDM; 50400831; -.
DR   PaxDb; 9606-ENSP00000485512; -.
DR   PeptideAtlas; P83859; -.
DR   Antibodypedia; 48446; 41 antibodies from 7 providers.
DR   DNASU; 347148; -.
DR   Ensembl; ENST00000343079.1; ENSP00000345487.1; ENSG00000188710.3.
DR   Ensembl; ENST00000623824.2; ENSP00000485512.1; ENSG00000188710.3.
DR   GeneID; 347148; -.
DR   KEGG; hsa:347148; -.
DR   MANE-Select; ENST00000623824.2; ENSP00000485512.1; NM_198180.3; NP_937823.1.
DR   UCSC; uc011mcb.2; human.
DR   AGR; HGNC:29982; -.
DR   CTD; 347148; -.
DR   DisGeNET; 347148; -.
DR   GeneCards; QRFP; -.
DR   HGNC; HGNC:29982; QRFP.
DR   HPA; ENSG00000188710; Low tissue specificity.
DR   MIM; 609795; gene.
DR   neXtProt; NX_P83859; -.
DR   OpenTargets; ENSG00000188710; -.
DR   PharmGKB; PA162400554; -.
DR   VEuPathDB; HostDB:ENSG00000188710; -.
DR   eggNOG; ENOG502S84J; Eukaryota.
DR   GeneTree; ENSGT00390000015756; -.
DR   HOGENOM; CLU_155319_0_0_1; -.
DR   InParanoid; P83859; -.
DR   OMA; PLGTCFP; -.
DR   OrthoDB; 5315787at2759; -.
DR   PhylomeDB; P83859; -.
DR   TreeFam; TF336317; -.
DR   PathwayCommons; P83859; -.
DR   Reactome; R-HSA-389397; Orexin and neuropeptides FF and QRFP bind to their respective receptors.
DR   Reactome; R-HSA-416476; G alpha (q) signalling events.
DR   BioGRID-ORCS; 347148; 21 hits in 1135 CRISPR screens.
DR   GeneWiki; QRFP; -.
DR   GenomeRNAi; 347148; -.
DR   Pharos; P83859; Tbio.
DR   PRO; PR:P83859; -.
DR   Proteomes; UP000005640; Chromosome 9.
DR   RNAct; P83859; Protein.
DR   Bgee; ENSG00000188710; Expressed in male germ line stem cell (sensu Vertebrata) in testis and 88 other cell types or tissues.
DR   GO; GO:0005576; C:extracellular region; TAS:Reactome.
DR   GO; GO:0005184; F:neuropeptide hormone activity; IDA:UniProtKB.
DR   GO; GO:0031854; F:orexigenic neuropeptide QRFP receptor binding; ISS:UniProtKB.
DR   GO; GO:0007625; P:grooming behavior; IEA:Ensembl.
DR   GO; GO:0007626; P:locomotory behavior; ISS:UniProtKB.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IDA:UniProtKB.
DR   GO; GO:0045777; P:positive regulation of blood pressure; ISS:UniProtKB.
DR   GO; GO:0060259; P:regulation of feeding behavior; ISS:UniProtKB.
DR   InterPro; IPR024565; P518.
DR   PANTHER; PTHR36476; OREXIGENIC NEUROPEPTIDE QRFP; 1.
DR   PANTHER; PTHR36476:SF1; OREXIGENIC NEUROPEPTIDE QRFP; 1.
DR   Pfam; PF11109; RFamide_26RFa; 1.
PE   2: Evidence at transcript level;
KW   Amidation; Neuropeptide; Pyrrolidone carboxylic acid; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   PROPEP          19..90
FT                   /evidence="ECO:0000255, ECO:0000305"
FT                   /id="PRO_0000010086"
FT   PEPTIDE         91..133
FT                   /note="QRF-amide"
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_0000010087"
FT   MOD_RES         91
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000250|UniProtKB:P83860, ECO:0000305"
FT   MOD_RES         133
FT                   /note="Phenylalanine amide"
FT                   /evidence="ECO:0000250"
FT   VARIANT         68
FT                   /note="L -> H (in dbSNP:rs12340616)"
FT                   /id="VAR_049184"
SQ   SEQUENCE   136 AA;  14941 MW;  4FC036F7ADF4551F CRC64;
     MVRPYPLIYF LFLPLGACFP LLDRREPTDA MGGLGAGERW ADLAMGPRPH SVWGSSRWLR
     ASQPQALLVI ARGLQTSGRE HAGCRFRFGR QDEGSEATGF LPAAGEKTSG PLGNLAEELN
     GYSRKKGGFS FRFGRR
//