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Protein

Orexigenic neuropeptide QRFP

Gene

QRFP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Stimulates feeding behavior, metabolic rate and locomotor activity and increases blood pressure. May have orexigenic activity. May promote aldosterone secretion by the adrenal gland (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Neuropeptide

Enzyme and pathway databases

ReactomeiREACT_16973. Orexin and neuropeptides FF and QRFP bind to their respective receptors.
REACT_18283. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Orexigenic neuropeptide QRFP
Alternative name(s):
P518
Cleaved into the following chain:
Alternative name(s):
Neuropeptide RF-amide
Pyroglutamylated arginine-phenylalanine-amide peptide
Gene namesi
Name:QRFPImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:29982. QRFP.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162400554.

Polymorphism and mutation databases

BioMutaiQRFP.
DMDMi50400831.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence AnalysisAdd
BLAST
Propeptidei19 – 9072Sequence AnalysisCuratedPRO_0000010086Add
BLAST
Peptidei91 – 13343QRF-amideCuratedPRO_0000010087Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei91 – 911Pyrrolidone carboxylic acidCurated
Modified residuei133 – 1331Phenylalanine amideBy similarity

Keywords - PTMi

Amidation, Pyrrolidone carboxylic acid

Proteomic databases

PaxDbiP83859.
PRIDEiP83859.

Expressioni

Tissue specificityi

Expressed widely in the brain with highest expression levels in the cerebellum, medulla, pituitary, retina, vestibular nucleus, and white matter. Also expressed in the bladder, colon, coronary artery, parathyroid gland, prostate, testis, and thyroid.1 Publication

Gene expression databases

BgeeiP83859.
CleanExiHS_QRFP.

Organism-specific databases

HPAiHPA043377.

Interactioni

Subunit structurei

Ligand for the G-protein coupled receptor QRFPR/GPR103.By similarity

Protein-protein interaction databases

STRINGi9606.ENSP00000345487.

Structurei

3D structure databases

ProteinModelPortaliP83859.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RFamide neuropeptide family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG47837.
GeneTreeiENSGT00390000015756.
HOGENOMiHOG000231990.
HOVERGENiHBG053386.
InParanoidiP83859.
OMAiFPLLDRR.
OrthoDBiEOG7J182M.
PhylomeDBiP83859.
TreeFamiTF336317.

Family and domain databases

InterProiIPR024565. P518.
[Graphical view]
PfamiPF11109. RFamide_26RFa. 1 hit.
[Graphical view]
ProDomiPD786889. PD786889. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P83859-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVRPYPLIYF LFLPLGACFP LLDRREPTDA MGGLGAGERW ADLAMGPRPH
60 70 80 90 100
SVWGSSRWLR ASQPQALLVI ARGLQTSGRE HAGCRFRFGR QDEGSEATGF
110 120 130
LPAAGEKTSG PLGNLAEELN GYSRKKGGFS FRFGRR
Length:136
Mass (Da):14,941
Last modified:May 10, 2004 - v1
Checksum:i4FC036F7ADF4551F
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti68 – 681L → H.
Corresponds to variant rs12340616 [ dbSNP | Ensembl ].
VAR_049184

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB109625 mRNA. Translation: BAC98934.1.
AY438326 Genomic DNA. Translation: AAR24354.1.
AL161733 Genomic DNA. Translation: CAM45757.1.
BC101127 mRNA. Translation: AAI01128.1.
CCDSiCCDS6936.1.
RefSeqiNP_937823.1. NM_198180.1.
UniGeneiHs.660704.

Genome annotation databases

EnsembliENST00000343079; ENSP00000345487; ENSG00000188710.
ENST00000623824; ENSP00000485512; ENSG00000188710.
GeneIDi347148.
KEGGihsa:347148.
UCSCiuc011mcb.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB109625 mRNA. Translation: BAC98934.1.
AY438326 Genomic DNA. Translation: AAR24354.1.
AL161733 Genomic DNA. Translation: CAM45757.1.
BC101127 mRNA. Translation: AAI01128.1.
CCDSiCCDS6936.1.
RefSeqiNP_937823.1. NM_198180.1.
UniGeneiHs.660704.

3D structure databases

ProteinModelPortaliP83859.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000345487.

Polymorphism and mutation databases

BioMutaiQRFP.
DMDMi50400831.

Proteomic databases

PaxDbiP83859.
PRIDEiP83859.

Protocols and materials databases

DNASUi347148.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000343079; ENSP00000345487; ENSG00000188710.
ENST00000623824; ENSP00000485512; ENSG00000188710.
GeneIDi347148.
KEGGihsa:347148.
UCSCiuc011mcb.2. human.

Organism-specific databases

CTDi347148.
GeneCardsiGC09M133768.
HGNCiHGNC:29982. QRFP.
HPAiHPA043377.
MIMi609795. gene.
neXtProtiNX_P83859.
PharmGKBiPA162400554.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG47837.
GeneTreeiENSGT00390000015756.
HOGENOMiHOG000231990.
HOVERGENiHBG053386.
InParanoidiP83859.
OMAiFPLLDRR.
OrthoDBiEOG7J182M.
PhylomeDBiP83859.
TreeFamiTF336317.

Enzyme and pathway databases

ReactomeiREACT_16973. Orexin and neuropeptides FF and QRFP bind to their respective receptors.
REACT_18283. G alpha (q) signalling events.

Miscellaneous databases

GeneWikiiQRFP.
GenomeRNAii347148.
NextBioi99051.
PROiP83859.
SOURCEiSearch...

Gene expression databases

BgeeiP83859.
CleanExiHS_QRFP.

Family and domain databases

InterProiIPR024565. P518.
[Graphical view]
PfamiPF11109. RFamide_26RFa. 1 hit.
[Graphical view]
ProDomiPD786889. PD786889. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of a novel RF-amide peptide ligand for orphan G-protein-coupled receptor SP9155."
    Jiang Y., Luo L., Gustafson E.L., Yadav D., Laverty M., Murgolo N., Vassileva G., Zeng M., Laz T.M., Behan J., Qiu P., Wang L., Wang S., Bayne M., Greene J., Monsma F.J. Jr., Zhang F.L.
    J. Biol. Chem. 278:27652-27657(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. "A new peptidic ligand and its receptor regulating adrenal function in rats."
    Fukusumi S., Yoshida H., Fujii R., Maruyama M., Komatsu H., Habata Y., Shintani Y., Hinuma S., Fujino M.
    J. Biol. Chem. 278:46387-46395(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
    Tissue: Brain1 Publication.
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
    Tissue: HypothalamusImported.
  4. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiOX26_HUMAN
AccessioniPrimary (citable) accession number: P83859
Secondary accession number(s): A3KFJ6, Q495K6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: May 10, 2004
Last modified: June 24, 2015
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.