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P83859

- OX26_HUMAN

UniProt

P83859 - OX26_HUMAN

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Protein

Orexigenic neuropeptide QRFP

Gene

QRFP

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Stimulates feeding behavior, metabolic rate and locomotor activity and increases blood pressure. May have orexigenic activity. May promote aldosterone secretion by the adrenal gland By similarity.By similarity

GO - Molecular functioni

  1. neuropeptide hormone activity Source: UniProtKB
  2. orexigenic neuropeptide QRFP receptor binding Source: UniProtKB

GO - Biological processi

  1. grooming behavior Source: Ensembl
  2. locomotory behavior Source: UniProtKB
  3. neuropeptide signaling pathway Source: UniProtKB
  4. positive regulation of blood pressure Source: UniProtKB
  5. regulation of feeding behavior Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Neuropeptide

Enzyme and pathway databases

ReactomeiREACT_16973. Orexin and neuropeptides FF and QRFP bind to their respective receptors.
REACT_18283. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Orexigenic neuropeptide QRFP
Alternative name(s):
P518
Cleaved into the following chain:
Alternative name(s):
Neuropeptide RF-amide
Pyroglutamylated arginine-phenylalanine-amide peptide
Gene namesi
Name:QRFPImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:29982. QRFP.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162400554.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence AnalysisAdd
BLAST
Propeptidei19 – 9072CuratedSequence AnalysisPRO_0000010086Add
BLAST
Peptidei91 – 13343QRF-amideCuratedPRO_0000010087Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei91 – 911Pyrrolidone carboxylic acidCurated
Modified residuei133 – 1331Phenylalanine amideBy similarity

Keywords - PTMi

Amidation, Pyrrolidone carboxylic acid

Proteomic databases

PaxDbiP83859.
PRIDEiP83859.

Expressioni

Tissue specificityi

Expressed widely in the brain with highest expression levels in the cerebellum, medulla, pituitary, retina, vestibular nucleus, and white matter. Also expressed in the bladder, colon, coronary artery, parathyroid gland, prostate, testis, and thyroid.1 Publication

Gene expression databases

BgeeiP83859.
CleanExiHS_QRFP.
GenevestigatoriP83859.

Organism-specific databases

HPAiHPA043377.

Interactioni

Subunit structurei

Ligand for the G-protein coupled receptor QRFPR/GPR103.By similarity

Protein-protein interaction databases

STRINGi9606.ENSP00000345487.

Structurei

3D structure databases

ProteinModelPortaliP83859.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RFamide neuropeptide family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG47837.
GeneTreeiENSGT00390000015756.
HOGENOMiHOG000231990.
HOVERGENiHBG053386.
InParanoidiP83859.
OMAiGREHAGC.
OrthoDBiEOG7J182M.
PhylomeDBiP83859.
TreeFamiTF336317.

Family and domain databases

InterProiIPR024565. P518.
[Graphical view]
PfamiPF11109. RFamide_26RFa. 1 hit.
[Graphical view]
ProDomiPD786889. PD786889. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P83859-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVRPYPLIYF LFLPLGACFP LLDRREPTDA MGGLGAGERW ADLAMGPRPH
60 70 80 90 100
SVWGSSRWLR ASQPQALLVI ARGLQTSGRE HAGCRFRFGR QDEGSEATGF
110 120 130
LPAAGEKTSG PLGNLAEELN GYSRKKGGFS FRFGRR
Length:136
Mass (Da):14,941
Last modified:May 10, 2004 - v1
Checksum:i4FC036F7ADF4551F
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti68 – 681L → H.
Corresponds to variant rs12340616 [ dbSNP | Ensembl ].
VAR_049184

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB109625 mRNA. Translation: BAC98934.1.
AY438326 Genomic DNA. Translation: AAR24354.1.
AL161733 Genomic DNA. Translation: CAM45757.1.
BC101127 mRNA. Translation: AAI01128.1.
CCDSiCCDS6936.1.
RefSeqiNP_937823.1. NM_198180.1.
UniGeneiHs.660704.

Genome annotation databases

GeneIDi347148.
KEGGihsa:347148.
UCSCiuc011mcb.2. human.

Polymorphism databases

DMDMi50400831.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB109625 mRNA. Translation: BAC98934.1 .
AY438326 Genomic DNA. Translation: AAR24354.1 .
AL161733 Genomic DNA. Translation: CAM45757.1 .
BC101127 mRNA. Translation: AAI01128.1 .
CCDSi CCDS6936.1.
RefSeqi NP_937823.1. NM_198180.1.
UniGenei Hs.660704.

3D structure databases

ProteinModelPortali P83859.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000345487.

Polymorphism databases

DMDMi 50400831.

Proteomic databases

PaxDbi P83859.
PRIDEi P83859.

Protocols and materials databases

DNASUi 347148.
Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 347148.
KEGGi hsa:347148.
UCSCi uc011mcb.2. human.

Organism-specific databases

CTDi 347148.
GeneCardsi GC09M133768.
HGNCi HGNC:29982. QRFP.
HPAi HPA043377.
MIMi 609795. gene.
neXtProti NX_P83859.
PharmGKBi PA162400554.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG47837.
GeneTreei ENSGT00390000015756.
HOGENOMi HOG000231990.
HOVERGENi HBG053386.
InParanoidi P83859.
OMAi GREHAGC.
OrthoDBi EOG7J182M.
PhylomeDBi P83859.
TreeFami TF336317.

Enzyme and pathway databases

Reactomei REACT_16973. Orexin and neuropeptides FF and QRFP bind to their respective receptors.
REACT_18283. G alpha (q) signalling events.

Miscellaneous databases

GeneWikii QRFP.
GenomeRNAii 347148.
NextBioi 99051.
PROi P83859.
SOURCEi Search...

Gene expression databases

Bgeei P83859.
CleanExi HS_QRFP.
Genevestigatori P83859.

Family and domain databases

InterProi IPR024565. P518.
[Graphical view ]
Pfami PF11109. RFamide_26RFa. 1 hit.
[Graphical view ]
ProDomi PD786889. PD786889. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of a novel RF-amide peptide ligand for orphan G-protein-coupled receptor SP9155."
    Jiang Y., Luo L., Gustafson E.L., Yadav D., Laverty M., Murgolo N., Vassileva G., Zeng M., Laz T.M., Behan J., Qiu P., Wang L., Wang S., Bayne M., Greene J., Monsma F.J. Jr., Zhang F.L.
    J. Biol. Chem. 278:27652-27657(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. "A new peptidic ligand and its receptor regulating adrenal function in rats."
    Fukusumi S., Yoshida H., Fujii R., Maruyama M., Komatsu H., Habata Y., Shintani Y., Hinuma S., Fujino M.
    J. Biol. Chem. 278:46387-46395(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
    Tissue: Brain1 Publication.
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
    Tissue: HypothalamusImported.
  4. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiOX26_HUMAN
AccessioniPrimary (citable) accession number: P83859
Secondary accession number(s): A3KFJ6, Q495K6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: May 10, 2004
Last modified: October 29, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3