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P83859

- OX26_HUMAN

UniProt

P83859 - OX26_HUMAN

Protein

Orexigenic neuropeptide QRFP

Gene

QRFP

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Stimulates feeding behavior, metabolic rate and locomotor activity and increases blood pressure. May have orexigenic activity. May promote aldosterone secretion by the adrenal gland By similarity.By similarity

    GO - Molecular functioni

    1. neuropeptide hormone activity Source: UniProtKB
    2. orexigenic neuropeptide QRFP receptor binding Source: UniProtKB

    GO - Biological processi

    1. grooming behavior Source: Ensembl
    2. locomotory behavior Source: UniProtKB
    3. neuropeptide signaling pathway Source: UniProtKB
    4. positive regulation of blood pressure Source: UniProtKB
    5. regulation of feeding behavior Source: UniProtKB

    Keywords - Molecular functioni

    Neuropeptide

    Enzyme and pathway databases

    ReactomeiREACT_16973. Orexin and neuropeptides FF and QRFP bind to their respective receptors.
    REACT_18283. G alpha (q) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Orexigenic neuropeptide QRFP
    Alternative name(s):
    P518
    Cleaved into the following chain:
    Alternative name(s):
    Neuropeptide RF-amide
    Pyroglutamylated arginine-phenylalanine-amide peptide
    Gene namesi
    Name:QRFPImported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:29982. QRFP.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: Reactome

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162400554.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818Sequence AnalysisAdd
    BLAST
    Propeptidei19 – 9072CuratedSequence AnalysisPRO_0000010086Add
    BLAST
    Peptidei91 – 13343QRF-amideCuratedPRO_0000010087Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei91 – 911Pyrrolidone carboxylic acidCurated
    Modified residuei133 – 1331Phenylalanine amideBy similarity

    Keywords - PTMi

    Amidation, Pyrrolidone carboxylic acid

    Proteomic databases

    PaxDbiP83859.
    PRIDEiP83859.

    Expressioni

    Tissue specificityi

    Expressed widely in the brain with highest expression levels in the cerebellum, medulla, pituitary, retina, vestibular nucleus, and white matter. Also expressed in the bladder, colon, coronary artery, parathyroid gland, prostate, testis, and thyroid.1 Publication

    Gene expression databases

    BgeeiP83859.
    CleanExiHS_QRFP.
    GenevestigatoriP83859.

    Organism-specific databases

    HPAiHPA043377.

    Interactioni

    Subunit structurei

    Ligand for the G-protein coupled receptor QRFPR/GPR103.By similarity

    Protein-protein interaction databases

    STRINGi9606.ENSP00000345487.

    Structurei

    3D structure databases

    ProteinModelPortaliP83859.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the RFamide neuropeptide family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG47837.
    HOGENOMiHOG000231990.
    HOVERGENiHBG053386.
    InParanoidiP83859.
    OMAiGREHAGC.
    OrthoDBiEOG7J182M.
    PhylomeDBiP83859.
    TreeFamiTF336317.

    Family and domain databases

    InterProiIPR024565. P518.
    [Graphical view]
    PfamiPF11109. RFamide_26RFa. 1 hit.
    [Graphical view]
    ProDomiPD786889. PD786889. 1 hit.
    [Graphical view] [Entries sharing at least one domain]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P83859-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVRPYPLIYF LFLPLGACFP LLDRREPTDA MGGLGAGERW ADLAMGPRPH    50
    SVWGSSRWLR ASQPQALLVI ARGLQTSGRE HAGCRFRFGR QDEGSEATGF 100
    LPAAGEKTSG PLGNLAEELN GYSRKKGGFS FRFGRR 136
    Length:136
    Mass (Da):14,941
    Last modified:May 10, 2004 - v1
    Checksum:i4FC036F7ADF4551F
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti68 – 681L → H.
    Corresponds to variant rs12340616 [ dbSNP | Ensembl ].
    VAR_049184

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB109625 mRNA. Translation: BAC98934.1.
    AY438326 Genomic DNA. Translation: AAR24354.1.
    AL161733 Genomic DNA. Translation: CAM45757.1.
    BC101127 mRNA. Translation: AAI01128.1.
    CCDSiCCDS6936.1.
    RefSeqiNP_937823.1. NM_198180.1.
    UniGeneiHs.660704.

    Genome annotation databases

    EnsembliENST00000343079; ENSP00000345487; ENSG00000188710.
    GeneIDi347148.
    KEGGihsa:347148.
    UCSCiuc011mcb.2. human.

    Polymorphism databases

    DMDMi50400831.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB109625 mRNA. Translation: BAC98934.1 .
    AY438326 Genomic DNA. Translation: AAR24354.1 .
    AL161733 Genomic DNA. Translation: CAM45757.1 .
    BC101127 mRNA. Translation: AAI01128.1 .
    CCDSi CCDS6936.1.
    RefSeqi NP_937823.1. NM_198180.1.
    UniGenei Hs.660704.

    3D structure databases

    ProteinModelPortali P83859.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000345487.

    Polymorphism databases

    DMDMi 50400831.

    Proteomic databases

    PaxDbi P83859.
    PRIDEi P83859.

    Protocols and materials databases

    DNASUi 347148.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000343079 ; ENSP00000345487 ; ENSG00000188710 .
    GeneIDi 347148.
    KEGGi hsa:347148.
    UCSCi uc011mcb.2. human.

    Organism-specific databases

    CTDi 347148.
    GeneCardsi GC09M133768.
    HGNCi HGNC:29982. QRFP.
    HPAi HPA043377.
    MIMi 609795. gene.
    neXtProti NX_P83859.
    PharmGKBi PA162400554.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG47837.
    HOGENOMi HOG000231990.
    HOVERGENi HBG053386.
    InParanoidi P83859.
    OMAi GREHAGC.
    OrthoDBi EOG7J182M.
    PhylomeDBi P83859.
    TreeFami TF336317.

    Enzyme and pathway databases

    Reactomei REACT_16973. Orexin and neuropeptides FF and QRFP bind to their respective receptors.
    REACT_18283. G alpha (q) signalling events.

    Miscellaneous databases

    GeneWikii QRFP.
    GenomeRNAii 347148.
    NextBioi 99051.
    PROi P83859.
    SOURCEi Search...

    Gene expression databases

    Bgeei P83859.
    CleanExi HS_QRFP.
    Genevestigatori P83859.

    Family and domain databases

    InterProi IPR024565. P518.
    [Graphical view ]
    Pfami PF11109. RFamide_26RFa. 1 hit.
    [Graphical view ]
    ProDomi PD786889. PD786889. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification and characterization of a novel RF-amide peptide ligand for orphan G-protein-coupled receptor SP9155."
      Jiang Y., Luo L., Gustafson E.L., Yadav D., Laverty M., Murgolo N., Vassileva G., Zeng M., Laz T.M., Behan J., Qiu P., Wang L., Wang S., Bayne M., Greene J., Monsma F.J. Jr., Zhang F.L.
      J. Biol. Chem. 278:27652-27657(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    2. "A new peptidic ligand and its receptor regulating adrenal function in rats."
      Fukusumi S., Yoshida H., Fujii R., Maruyama M., Komatsu H., Habata Y., Shintani Y., Hinuma S., Fujino M.
      J. Biol. Chem. 278:46387-46395(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
      Tissue: Brain1 Publication.
    3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
      Tissue: HypothalamusImported.
    4. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiOX26_HUMAN
    AccessioniPrimary (citable) accession number: P83859
    Secondary accession number(s): A3KFJ6, Q495K6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2004
    Last sequence update: May 10, 2004
    Last modified: October 1, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3