P83859 (OX26_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Orexigenic neuropeptide QRFP

Alternative name(s):
P518

Cleaved into the following chain:

1. QRF-amide
   Alternative name(s):
   Neuropeptide RF-amide
   Pyroglutamylated arginine-phenylalanine-amide peptide

Gene names

Name:

QRFP

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	136 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Stimulates feeding behavior, metabolic rate and locomotor activity and increases blood pressure. May have orexigenic activity. May promote aldosterone secretion by the adrenal gland By similarity. Ref.2 Ref.3
Subunit structure	Ligand for the G-protein coupled receptor QRFPR/GPR103 By similarity.
Subcellular location	Secreted.
Tissue specificity	Expressed widely in the brain with highest expression levels in the cerebellum, medulla, pituitary, retina, vestibular nucleus, and white matter. Also expressed in the bladder, colon, coronary artery, parathyroid gland, prostate, testis, and thyroid. Ref.1
Sequence similarities	Belongs to the RFamide neuropeptide family.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Polymorphism
Domain	Signal
Molecular function	Neuropeptide
PTM	Amidation Pyrrolidone carboxylic acid
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	grooming behavior Inferred from electronic annotation. Source: Compara locomotory behavior Inferred from sequence or structural similarity. Source: UniProtKB neuropeptide signaling pathway Inferred from direct assay Ref.3. Source: UniProtKB positive regulation of blood pressure Inferred from sequence or structural similarity. Source: UniProtKB regulation of feeding behavior Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	extracellular region Traceable author statement. Source: Reactome
Molecular_function	neuropeptide hormone activity Inferred from direct assay Ref.3. Source: UniProtKB orexigenic neuropeptide QRFP receptor binding Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 18	18	Potential
	Propeptide	19 – 90	72			PRO_0000010086
	Peptide	91 – 133	43	QRF-amide		PRO_0000010087
Amino acid modifications
	Modified residue	91	1	Pyrrolidone carboxylic acid Probable
	Modified residue	133	1	Phenylalanine amide By similarity UniProtKB P83683
Natural variations
	Natural variant	68	1	L → H. Corresponds to variant rs12340616 [ dbSNP | Ensembl ].		VAR_049184

Sequences

	Sequence		Length	Mass (Da)
	P83859 [UniParc]. Last modified May 10, 2004. Version 1. Checksum: 4FC036F7ADF4551F	FASTA	136	14,941
	10 20 30 40 50 60 MVRPYPLIYF LFLPLGACFP LLDRREPTDA MGGLGAGERW ADLAMGPRPH SVWGSSRWLR 70 80 90 100 110 120 ASQPQALLVI ARGLQTSGRE HAGCRFRFGR QDEGSEATGF LPAAGEKTSG PLGNLAEELN 130 GYSRKKGGFS FRFGRR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification and characterization of a novel RF-amide peptide ligand for orphan G-protein-coupled receptor SP9155." Jiang Y., Luo L., Gustafson E.L., Yadav D., Laverty M., Murgolo N., Vassileva G., Zeng M., Laz T.M., Behan J., Qiu P., Wang L., Wang S., Bayne M., Greene J., Monsma F.J. Jr., Zhang F.L. J. Biol. Chem. 278:27652-27657(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
[2]	"A new peptidic ligand and its receptor regulating adrenal function in rats." Fukusumi S., Yoshida H., Fujii R., Maruyama M., Komatsu H., Habata Y., Shintani Y., Hinuma S., Fujino M. J. Biol. Chem. 278:46387-46395(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION. Tissue: Brain.
[3]	"Identification of 26RFa, a hypothalamic neuropeptide of the RFamide peptide family with orexigenic activity." Chartrel N., Dujardin C., Anouar Y., Leprince J., Decker A., Clerens S., Do-Rego J.-C., Vandesande F., Llorens-Cortes C., Costentin J., Beauvillain J.-C., Vaudry H. Proc. Natl. Acad. Sci. U.S.A. 100:15247-15252(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION. Tissue: Hypothalamus.
[4]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB109625 mRNA. Translation: BAC98934.1. AY438326 Genomic DNA. Translation: AAR24354.1. AL161733 Genomic DNA. Translation: CAM45757.1. BC101127 mRNA. Translation: AAI01128.1.
IPI	IPI00377074.
RefSeq	NP_937823.1. NM_198180.1.
UniGene	Hs.660704.
3D structure databases
ProteinModelPortal	P83859.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000345487.
Polymorphism databases
DMDM	50400831.
Proteomic databases
PaxDb	P83859.
PRIDE	P83859.
Protocols and materials databases
DNASU	347148.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000343079; ENSP00000345487; ENSG00000188710.
GeneID	347148.
KEGG	hsa:347148.
UCSC	uc011mcb.2. human.
Organism-specific databases
CTD	347148.
GeneCards	GC09M133768.
HGNC	HGNC:29982. QRFP.
HPA	HPA043377.
MIM	609795. gene.
neXtProt	NX_P83859.
PharmGKB	PA162400554.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG47837.
HOGENOM	HOG000231990.
HOVERGEN	HBG053386.
InParanoid	P83859.
OMA	LPLGACF.
OrthoDB	EOG43XV54.
PhylomeDB	P83859.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
Bgee	P83859.
CleanEx	HS_QRFP.
Genevestigator	P83859.
Family and domain databases
InterPro	IPR024565. P518. [Graphical view]
Pfam	PF11109. RFamide_26RFa. 1 hit. [Graphical view]
ProDom	PD786889. PD786889. 1 hit. [Graphical view] [Entries sharing at least one domain]
ProtoNet	Search...
Other
GenomeRNAi	347148.
NextBio	99051.
SOURCE	Search...

Entry information

Entry name

OX26_HUMAN

Accession

Primary (citable) accession number: P83859
Secondary accession number(s): A3KFJ6, Q495K6

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2004
Last sequence update:	May 10, 2004
Last modified:	April 3, 2013
This is version 71 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.