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Protein

Pyroglutamylated RFamide peptide receptor

Gene

Qrfpr

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for the orexigenic neuropeptide QRFP. The activity of this receptor is mediated by G proteins that modulate adenylate cyclase activity and intracellular calcium levels.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-RNO-389397 Orexin and neuropeptides FF and QRFP bind to their respective receptors
R-RNO-416476 G alpha (q) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Pyroglutamylated RFamide peptide receptor
Alternative name(s):
AQ27
G-protein coupled receptor 103
Orexigenic neuropeptide QRFP receptor
SP9155
Gene namesi
Name:Qrfpr
Synonyms:Gpr103
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi728380 Qrfpr

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 46ExtracellularSequence analysisAdd BLAST46
Transmembranei47 – 67Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini68 – 81CytoplasmicSequence analysisAdd BLAST14
Transmembranei82 – 102Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini103 – 120ExtracellularSequence analysisAdd BLAST18
Transmembranei121 – 141Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini142 – 162CytoplasmicSequence analysisAdd BLAST21
Transmembranei163 – 183Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini184 – 212ExtracellularSequence analysisAdd BLAST29
Transmembranei213 – 233Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini234 – 271CytoplasmicSequence analysisAdd BLAST38
Transmembranei272 – 292Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini293 – 313ExtracellularSequence analysisAdd BLAST21
Transmembranei314 – 334Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini335 – 433CytoplasmicSequence analysisAdd BLAST99

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL1949484
GuidetoPHARMACOLOGYi333

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000700991 – 433Pyroglutamylated RFamide peptide receptorAdd BLAST433

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi19N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP83858
PRIDEiP83858

PTM databases

PhosphoSitePlusiP83858

Expressioni

Tissue specificityi

Highly expressed in the adrenal gland and at moderate levels in the eye and testis. Expressed widely in the brain with high levels in the hypothalamus and moderate levels in the amygdala, basal forebrain, cortex, medulla oblongata, midbrain and thalamus.1 Publication

Gene expression databases

BgeeiENSRNOG00000014414

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000035152

Structurei

3D structure databases

ProteinModelPortaliP83858
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00900000140797
HOGENOMiHOG000136537
HOVERGENiHBG067831
InParanoidiP83858
KOiK08378
OMAiGNALVFY
OrthoDBiEOG091G0976
PhylomeDBiP83858
TreeFamiTF315303

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000611 NPY_rcpt
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR01012 NRPEPTIDEYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

P83858-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQALNITAEQ FSRLLSAHNL TREQFIHRYG LRPLVYTPEL PARAKVAFAL
60 70 80 90 100
AGALIFALAL FGNSLVIYVV TRSKAMRTVT NIFICSLALS DLLIAFFCIP
110 120 130 140 150
VTMLQNISDK WLGGAFICKM VPFVQSTAVV TEILTMTCIA VERHQGLVHP
160 170 180 190 200
FKMKWQYTTR RAFTILGVVW LAAIIVGSPM WHVQRLEIKY DFLYEKEHIC
210 220 230 240 250
CLEEWASPVH QRIYSTFILV ILFLLPLVVM LVLYSKIGYE LWIKKRVGDS
260 270 280 290 300
SALQTIHGKE MSKIARKKKR AVIMMVTVVA LFAACWAPFH VVHMMVEYSN
310 320 330 340 350
FEKEYDDVTI KMVFAVAQTI GFFNSICNPF VYAFMNENFK KNFLSAVCYC
360 370 380 390 400
IVKESSSPAR KPGNSGISMM QKRAKLSRPQ RPVEETKGDT FSDASIDVKL
410 420 430
CEQPREKRQL KRQLAFFSSE LSENSTFGSG HEL
Length:433
Mass (Da):49,311
Last modified:May 10, 2004 - v1
Checksum:i284A1589D38F93AD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB109630 mRNA Translation: BAC98939.1
RefSeqiNP_937842.1, NM_198199.1
UniGeneiRn.162584

Genome annotation databases

EnsembliENSRNOT00000039615; ENSRNOP00000035152; ENSRNOG00000014414
GeneIDi310327
KEGGirno:310327
UCSCiRGD:728380 rat

Similar proteinsi

Entry informationi

Entry nameiQRFPR_RAT
AccessioniPrimary (citable) accession number: P83858
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: May 10, 2004
Last modified: May 23, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

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