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Protein

Carboxypeptidase D

Gene

CPD

Organism
Lophonetta specularioides (Crested duck) (Anas specularioides)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Releases C-terminal Arg and Lys from polypeptides.By similarity

Cofactori

Zn2+1 PublicationNote: Binds 2 Zn2+ ions per subunit.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi71 – 711Zinc; catalytic1 Publication
Metal bindingi74 – 741Zinc; catalytic1 Publication
Metal bindingi178 – 1781Zinc; catalytic1 Publication
Active sitei269 – 2691Proton donor/acceptorBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Carboxypeptidase D (EC:3.4.17.22)
Alternative name(s):
CPD-2
Metallocarboxypeptidase D
Gene namesi
Name:CPD
OrganismiLophonetta specularioides (Crested duck) (Anas specularioides)
Taxonomic identifieri75873 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeAnseriformesAnatidaeLophonetta

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – ›380›380Carboxypeptidase DPRO_0000212786Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi133 – 1331N-linked (GlcNAc...)1 Publication
Disulfide bondi227 ↔ 2721 Publication
Glycosylationi318 – 3181N-linked (GlcNAc...)1 Publication
Glycosylationi374 – 3741N-linked (GlcNAc...)1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP83852.

Structurei

Secondary structure

1
380
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi13 – 2614Combined sources
Turni28 – 303Combined sources
Beta strandi31 – 388Combined sources
Beta strandi44 – 5310Combined sources
Beta strandi63 – 675Combined sources
Helixi76 – 9116Combined sources
Turni92 – 943Combined sources
Helixi96 – 1049Combined sources
Beta strandi106 – 1116Combined sources
Helixi115 – 1195Combined sources
Turni130 – 1323Combined sources
Helixi140 – 1423Combined sources
Beta strandi147 – 1493Combined sources
Helixi157 – 16812Combined sources
Beta strandi171 – 1788Combined sources
Beta strandi180 – 1878Combined sources
Beta strandi195 – 1973Combined sources
Helixi204 – 21512Combined sources
Helixi219 – 2224Combined sources
Turni228 – 2303Combined sources
Helixi237 – 2393Combined sources
Beta strandi240 – 2423Combined sources
Helixi243 – 2464Combined sources
Helixi253 – 2608Combined sources
Beta strandi264 – 2729Combined sources
Helixi278 – 2803Combined sources
Helixi281 – 29717Combined sources
Helixi298 – 3003Combined sources
Beta strandi302 – 3098Combined sources
Turni310 – 3123Combined sources
Beta strandi320 – 3234Combined sources
Beta strandi326 – 3316Combined sources
Beta strandi336 – 3405Combined sources
Beta strandi344 – 3529Combined sources
Beta strandi359 – 3657Combined sources
Beta strandi370 – 3723Combined sources
Beta strandi375 – 3773Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1H8LX-ray2.60A1-380[»]
1QMUX-ray2.70A1-380[»]
ProteinModelPortaliP83852.
SMRiP83852. Positions 1-380.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP83852.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – ›380›380Carboxypeptidase 2Add
BLAST

Sequence similaritiesi

Belongs to the peptidase M14 family.Sequence analysis

Phylogenomic databases

HOVERGENiHBG003410.

Family and domain databases

Gene3Di2.60.40.1120. 1 hit.
InterProiIPR008969. CarboxyPept-like_regulatory.
IPR014766. CarboxyPept_regulatory_dom.
IPR015567. Pept_M14B_carboxypept_D2.
IPR000834. Peptidase_M14.
[Graphical view]
PANTHERiPTHR11532:SF50. PTHR11532:SF50. 1 hit.
PfamiPF00246. Peptidase_M14. 1 hit.
[Graphical view]
PRINTSiPR00765. CRBOXYPTASEA.
SMARTiSM00631. Zn_pept. 1 hit.
[Graphical view]
SUPFAMiSSF49464. SSF49464. 1 hit.
PROSITEiPS00132. CARBOXYPEPT_ZN_1. 1 hit.
PS00133. CARBOXYPEPT_ZN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

P83852-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
QAVQPVDFRH HHFSDMEIFL RRYANEYPSI TRLYSVGKSV ELRELYVMEI
60 70 80 90 100
SDNPGIHEAG EPEFKYIGNM HGNEVVGREL LLNLIEYLCK NFGTDPEVTD
110 120 130 140 150
LVQSTRIHIM PSMNPDGYEK SQEGDRGGTV GRNNSNNYDL NRNFPDQFFQ
160 170 180 190 200
VTDPPQPETL AVMSWLKTYP FVLSANLHGG SLVVNYPFDD DEQGIAIYSK
210 220 230 240 250
SPDDAVFQQL ALSYSKENKK MYQGSPCKDL YPTEYFPHGI TNGAQWYNVP
260 270 280 290 300
GGMQDWNYLN TNCFEVTIEL GCVKYPKAEE LPKYWEQNRR SLLQFIKQVH
310 320 330 340 350
RGIWGFVLDA TDGRGILNAT ISVADINHPV TTYKDGDYWR LLVQGTYKVT
360 370 380
ASARGYDPVT KTVEVDSKGG VQVNFTLSRT
Length:380
Mass (Da):43,292
Last modified:April 13, 2004 - v1
Checksum:i536498919536E949
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 111 Publication
Non-terminal residuei380 – 38011 Publication

Cross-referencesi

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1H8LX-ray2.60A1-380[»]
1QMUX-ray2.70A1-380[»]
ProteinModelPortaliP83852.
SMRiP83852. Positions 1-380.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP83852.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG003410.

Miscellaneous databases

EvolutionaryTraceiP83852.

Family and domain databases

Gene3Di2.60.40.1120. 1 hit.
InterProiIPR008969. CarboxyPept-like_regulatory.
IPR014766. CarboxyPept_regulatory_dom.
IPR015567. Pept_M14B_carboxypept_D2.
IPR000834. Peptidase_M14.
[Graphical view]
PANTHERiPTHR11532:SF50. PTHR11532:SF50. 1 hit.
PfamiPF00246. Peptidase_M14. 1 hit.
[Graphical view]
PRINTSiPR00765. CRBOXYPTASEA.
SMARTiSM00631. Zn_pept. 1 hit.
[Graphical view]
SUPFAMiSSF49464. SSF49464. 1 hit.
PROSITEiPS00132. CARBOXYPEPT_ZN_1. 1 hit.
PS00133. CARBOXYPEPT_ZN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCBPD_LOPSP
AccessioniPrimary (citable) accession number: P83852
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: April 13, 2004
Last modified: January 20, 2016
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.