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Protein

Threonine synthase

Gene
N/A
Organism
Thermus thermophilus
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.UniRule annotation

Catalytic activityi

O-phospho-L-homoserine + H2O = L-threonine + phosphate.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi: L-threonine biosynthesis

This protein is involved in step 5 of the subpathway that synthesizes L-threonine from L-aspartate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Aspartokinase (ask), Aspartokinase (TTMY_0900)
  2. Aspartate-semialdehyde dehydrogenase (asd)
  3. Homoserine dehydrogenase (TTMY_0955)
  4. Homoserine kinase (thrB)
  5. Threonine synthase (thrC), Threonine synthase
This subpathway is part of the pathway L-threonine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-threonine from L-aspartate, the pathway L-threonine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei87Pyridoxal phosphateUniRule annotation1
Binding sitei317Pyridoxal phosphateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyaseUniRule annotation
Biological processAmino-acid biosynthesis, Threonine biosynthesisUniRule annotation
LigandPyridoxal phosphateUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00050; UER00065.

Names & Taxonomyi

Protein namesi
Recommended name:
Threonine synthaseUniRule annotation (EC:4.2.3.1UniRule annotation)
OrganismiThermus thermophilusImported
Taxonomic identifieri274 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei61N6-(pyridoxal phosphate)lysineUniRule annotationCombined sources1

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1UIMX-ray2.15A/B1-351[»]
1UINX-ray2.25A/B1-351[»]
1V7CX-ray2.00A/B/C/D1-351[»]
ProteinModelPortaliP83823.
SMRiP83823.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP83823.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 318PALPInterPro annotationAdd BLAST296

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni187 – 191Pyridoxal phosphate bindingUniRule annotation5

Sequence similaritiesi

Belongs to the threonine synthase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107R5I. Bacteria.
COG0498. LUCA.

Family and domain databases

InterProiView protein in InterPro
IPR001926. PLP-dep.
IPR000634. Ser/Thr_deHydtase_PyrdxlP-BS.
IPR004450. Thr_synthase-like.
IPR026260. Thr_Synthase_bac/arc.
IPR036052. Trypto_synt_PLP_dependent.
PfamiView protein in Pfam
PF00291. PALP. 1 hit.
PIRSFiPIRSF038945. Thr_synthase. 1 hit.
SUPFAMiSSF53686. SSF53686. 1 hit.
TIGRFAMsiTIGR00260. thrC. 1 hit.
PROSITEiView protein in PROSITE
PS00165. DEHYDRATASE_SER_THR. 1 hit.

Sequencei

Sequence statusi: Complete.

P83823-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRPPLIERYR NLLPVSEKTP VISLLEGSTP LIPLKGPEEA RKKGIRLYAK
60 70 80 90 100
YEGLNPTGSF KDRGMTLAVS KAVEGGAQAV ACASTGNTAA SAAAYAARAG
110 120 130 140 150
ILAIVVLPAG YVALGKVAQS LVHGARIVQV EGNFDDALRL TQKLTEAFPV
160 170 180 190 200
ALVNSVNPHR LEGQKTLAFE VVDELGDAPH YHALPVGNAG NITAHWMGYK
210 220 230 240 250
AYHALGKAKR LPRMLGFQAA GAAPLVLGRP VERPETLATA IRIGNPASWQ
260 270 280 290 300
GAVRAKEESG GVIEAVTDEE ILFAYRYLAR EEGIFCEPAS AAAMAGVFKL
310 320 330 340 350
LREGRLEPES TVVLTLTGHG LKDPATAERV AELPPPVPAR LEAVAAAAGL

L
Length:351
Mass (Da):37,010
Last modified:March 15, 2004 - v1
Checksum:iC9F0752976C46CDF
GO

Similar proteinsi

Entry informationi

Entry nameiP83823_THETH
AccessioniPrimary (citable) accession number: P83823
Entry historyiIntegrated into UniProtKB/TrEMBL: March 15, 2004
Last sequence update: March 15, 2004
Last modified: October 25, 2017
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sourcesImported