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Protein

Heat shock protein SSC1, mitochondrial

Gene

SSC1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Constitutes the ATP-driven core of the motor and binds the precursor preprotein (By similarity).By similarity

Miscellaneous

Has antigenic properties. Elicits a specific immune response in systemic candidiasis human patients undergoing malignant hematological disorders.

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • unfolded protein binding Source: CGD

GO - Biological processi

Keywordsi

Molecular functionChaperone
Biological processStress response
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock protein SSC1, mitochondrial
Alternative name(s):
Cytoplasmic antigenic protein 6
mtHSP70
Gene namesi
Name:SSC1
Ordered Locus Names:CAALFM_C207380WA
ORF Names:CaO19.1896, CaO19.9452
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
Proteomesi

Organism-specific databases

CGDiCAL0000178007 SSC1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 23MitochondrionSequence analysisAdd BLAST23
ChainiPRO_000008930624 – 648Heat shock protein SSC1, mitochondrialAdd BLAST625

Proteomic databases

PRIDEiP83784

2D gel databases

COMPLUYEAST-2DPAGEiP83784

Interactioni

GO - Molecular functioni

  • unfolded protein binding Source: CGD

Structurei

3D structure databases

ProteinModelPortaliP83784
SMRiP83784
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili560 – 633Sequence analysisAdd BLAST74

Sequence similaritiesi

Belongs to the heat shock protein 70 family.Curated

Keywords - Domaini

Coiled coil, Transit peptide

Phylogenomic databases

InParanoidiP83784
KOiK04043
OMAiISIKRHM
OrthoDBiEOG092C1VPN

Family and domain databases

Gene3Di1.20.1270.10, 1 hit
2.60.34.10, 1 hit
HAMAPiMF_00332 DnaK, 1 hit
InterProiView protein in InterPro
IPR012725 Chaperone_DnaK
IPR018181 Heat_shock_70_CS
IPR029048 HSP70_C_sf
IPR029047 HSP70_peptide-bd_sf
IPR013126 Hsp_70_fam
PANTHERiPTHR19375 PTHR19375, 1 hit
PfamiView protein in Pfam
PF00012 HSP70, 1 hit
PRINTSiPR00301 HEATSHOCK70
SUPFAMiSSF100920 SSF100920, 1 hit
TIGRFAMsiTIGR02350 prok_dnaK, 1 hit
PROSITEiView protein in PROSITE
PS00297 HSP70_1, 1 hit
PS00329 HSP70_2, 1 hit
PS01036 HSP70_3, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P83784-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSARNSLKN ISRQFPKALT RAQSTAAAPT GPVIGIDLGT TNSAVAVMEG
60 70 80 90 100
KTPKILENSE GGRTTPSIVA FTKDGERLVG IPAKRQAVVN PSDTLFATKR
110 120 130 140 150
LIGRRYEDPE VQRDINQVPY KIVKHGNGDA WLEARGEQYS PQQIGGFILN
160 170 180 190 200
KMKETAEAAL SKKVNSAVVT CPAYFNDAQR QATKDAGKIV GLNVLRVINE
210 220 230 240 250
PTAAALAYGL EKKDGEVVAV FDLGGGTFDV SILDIGAGVF EVKSTNGDTH
260 270 280 290 300
LGGEDFDIAL VRYIVDAFKK ESGIDLEKDK MAIQRIREAA EKAKIELSST
310 320 330 340 350
VSTEINLPFI TADASGPKHI NQKISRAQFE QLVEPLIKKT IEPCKKALKD
360 370 380 390 400
AGLSTSDVSE VILVGGMSRM PKVVETVKSI FGKEPSKGIN PDEAVAMGAA
410 420 430 440 450
IQGGILAGEV KDVVLLDVTP LSLGIETMGG VFARLISRNT TIPAKKSQIF
460 470 480 490 500
STAAAGQTSV EIRVFQGERE LTRDNKLIGN FTLSGIPPAP KGVPQIEVTF
510 520 530 540 550
DIDTDGIIKV SARDKATNKD ASITVAGSSG LSDAEIEKMV NDAEKFAESD
560 570 580 590 600
KARREAIEFA NRADQLCNDT ENSLNEHKEK LSSESVQKVQ DQIQQLREIV
610 620 630 640
LKAQAGEEVS PEELKQKTEE LQNEAINLFK DLYKDGGESS GSSEQPKN
Length:648
Mass (Da):69,748
Last modified:October 19, 2011 - v2
Checksum:iFDE4AAEBEF3D1DA3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP017624 Genomic DNA Translation: AOW27736.1
RefSeqiXP_713153.1, XM_708060.2

Genome annotation databases

EnsemblFungiiAOW27736; AOW27736; CAALFM_C207380WA
GeneIDi3645232
KEGGical:CAALFM_C207380WA

Entry informationi

Entry nameiHSP77_CANAL
AccessioniPrimary (citable) accession number: P83784
Secondary accession number(s): A0A1D8PHW3, Q59U57
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: October 19, 2011
Last modified: March 28, 2018
This is version 51 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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