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P83784 (HSP77_CANAL) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 32. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Heat shock protein SSC1, mitochondrial
Alternative name(s):
Cytoplasmic antigenic protein 6
mtHSP70
Gene names
Name:SSC1
ORF Names:CaO19.1896, CaO19.9452
OrganismCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]
Taxonomic identifier237561 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

Protein attributes

Sequence length648 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Constitutes the ATP-driven core of the motor and binds the precursor preprotein By similarity. HAMAP-Rule MF_00332

Subcellular location

Mitochondrion matrix By similarity HAMAP-Rule MF_00332.

Miscellaneous

Has antigenic properties. Elicits a specific immune response in systemic candidiasis human patients undergoing malignant hematological disorders.

Sequence similarities

Belongs to the heat shock protein 70 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 2323Mitochondrion Potential
Chain24 – 648625Heat shock protein SSC1, mitochondrial HAMAP-Rule MF_00332
PRO_0000089306

Regions

Coiled coil560 – 63374 Potential

Sequences

Sequence LengthMass (Da)Tools
P83784 [UniParc].

Last modified October 19, 2011. Version 2.
Checksum: FDE4AAEBEF3D1DA3

FASTA64869,748
        10         20         30         40         50         60 
MLSARNSLKN ISRQFPKALT RAQSTAAAPT GPVIGIDLGT TNSAVAVMEG KTPKILENSE 

        70         80         90        100        110        120 
GGRTTPSIVA FTKDGERLVG IPAKRQAVVN PSDTLFATKR LIGRRYEDPE VQRDINQVPY 

       130        140        150        160        170        180 
KIVKHGNGDA WLEARGEQYS PQQIGGFILN KMKETAEAAL SKKVNSAVVT CPAYFNDAQR 

       190        200        210        220        230        240 
QATKDAGKIV GLNVLRVINE PTAAALAYGL EKKDGEVVAV FDLGGGTFDV SILDIGAGVF 

       250        260        270        280        290        300 
EVKSTNGDTH LGGEDFDIAL VRYIVDAFKK ESGIDLEKDK MAIQRIREAA EKAKIELSST 

       310        320        330        340        350        360 
VSTEINLPFI TADASGPKHI NQKISRAQFE QLVEPLIKKT IEPCKKALKD AGLSTSDVSE 

       370        380        390        400        410        420 
VILVGGMSRM PKVVETVKSI FGKEPSKGIN PDEAVAMGAA IQGGILAGEV KDVVLLDVTP 

       430        440        450        460        470        480 
LSLGIETMGG VFARLISRNT TIPAKKSQIF STAAAGQTSV EIRVFQGERE LTRDNKLIGN 

       490        500        510        520        530        540 
FTLSGIPPAP KGVPQIEVTF DIDTDGIIKV SARDKATNKD ASITVAGSSG LSDAEIEKMV 

       550        560        570        580        590        600 
NDAEKFAESD KARREAIEFA NRADQLCNDT ENSLNEHKEK LSSESVQKVQ DQIQQLREIV 

       610        620        630        640 
LKAQAGEEVS PEELKQKTEE LQNEAINLFK DLYKDGGESS GSSEQPKN 

« Hide

References

« Hide 'large scale' references
[1]"The diploid genome sequence of Candida albicans."
Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S.
Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SC5314 / ATCC MYA-2876.
[2]"Proteomics-based identification of novel Candida albicans antigens for diagnosis of systemic candidiasis in patients with underlying hematological malignancies."
Pitarch A., Abian J., Carrascal M., Sanchez M., Nombela C., Gil C.
Proteomics 4:3084-3106(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 591-597, ANTIGENICITY.
Strain: SC5314 / ATCC MYA-2876.
Tissue: Protoplast.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AACQ01000133 Genomic DNA. Translation: EAK94036.1.
AACQ01000132 Genomic DNA. Translation: EAK94082.1.
RefSeqXP_713153.1. XM_708060.1.
XP_713199.1. XM_708106.1.

3D structure databases

ProteinModelPortalP83784.
SMRP83784. Positions 31-559.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5476.CAL0001828.

2D gel databases

COMPLUYEAST-2DPAGEP83784.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3645186.
3645232.
KEGGcal:CaO19.1896.
cal:CaO19.9452.

Organism-specific databases

CGDCAL0001828. SSC1.

Phylogenomic databases

eggNOGCOG0443.
KOK04043.
OrthoDBEOG728916.

Family and domain databases

Gene3D1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
HAMAPMF_00332. DnaK.
InterProIPR012725. Chaperone_DnaK.
IPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSPR00301. HEATSHOCK70.
SUPFAMSSF100920. SSF100920. 1 hit.
TIGRFAMsTIGR02350. prok_dnaK. 1 hit.
PROSITEPS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHSP77_CANAL
AccessionPrimary (citable) accession number: P83784
Secondary accession number(s): Q59U57
Entry history
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: October 19, 2011
Last modified: June 11, 2014
This is version 32 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Candida albicans

Candida albicans: entries and gene names