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P83784

- HSP77_CANAL

UniProt

P83784 - HSP77_CANAL

Protein

Heat shock protein SSC1, mitochondrial

Gene

SSC1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 33 (01 Oct 2014)
      Sequence version 2 (19 Oct 2011)
      Previous versions | rss
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    Functioni

    Required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Constitutes the ATP-driven core of the motor and binds the precursor preprotein By similarity.By similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. unfolded protein binding Source: CGD

    GO - Biological processi

    1. protein folding Source: InterPro
    2. response to stress Source: UniProtKB-KW

    Keywords - Molecular functioni

    Chaperone

    Keywords - Biological processi

    Stress response

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Heat shock protein SSC1, mitochondrial
    Alternative name(s):
    Cytoplasmic antigenic protein 6
    mtHSP70
    Gene namesi
    Name:SSC1
    ORF Names:CaO19.1896, CaO19.9452
    OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
    Taxonomic identifieri237561 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
    ProteomesiUP000000559: Unassembled WGS sequence

    Organism-specific databases

    CGDiCAL0001828. SSC1.

    Subcellular locationi

    Mitochondrion matrix By similarity

    GO - Cellular componenti

    1. cell surface Source: CGD
    2. mitochondrial matrix Source: UniProtKB-SubCell
    3. plasma membrane Source: CGD
    4. yeast-form cell wall Source: CGD

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 2323MitochondrionSequence AnalysisAdd
    BLAST
    Chaini24 – 648625Heat shock protein SSC1, mitochondrialPRO_0000089306Add
    BLAST

    2D gel databases

    COMPLUYEAST-2DPAGEP83784.

    Interactioni

    Protein-protein interaction databases

    STRINGi5476.CAL0001828.

    Structurei

    3D structure databases

    ProteinModelPortaliP83784.
    SMRiP83784. Positions 31-559.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili560 – 63374Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the heat shock protein 70 family.Curated

    Keywords - Domaini

    Coiled coil, Transit peptide

    Phylogenomic databases

    eggNOGiCOG0443.
    KOiK04043.
    OrthoDBiEOG728916.

    Family and domain databases

    Gene3Di1.20.1270.10. 1 hit.
    2.60.34.10. 1 hit.
    HAMAPiMF_00332. DnaK.
    InterProiIPR012725. Chaperone_DnaK.
    IPR018181. Heat_shock_70_CS.
    IPR029048. HSP70_C.
    IPR029047. HSP70_peptide-bd.
    IPR013126. Hsp_70_fam.
    [Graphical view]
    PfamiPF00012. HSP70. 1 hit.
    [Graphical view]
    PRINTSiPR00301. HEATSHOCK70.
    SUPFAMiSSF100920. SSF100920. 1 hit.
    TIGRFAMsiTIGR02350. prok_dnaK. 1 hit.
    PROSITEiPS00297. HSP70_1. 1 hit.
    PS00329. HSP70_2. 1 hit.
    PS01036. HSP70_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P83784-1 [UniParc]FASTAAdd to Basket

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    MLSARNSLKN ISRQFPKALT RAQSTAAAPT GPVIGIDLGT TNSAVAVMEG    50
    KTPKILENSE GGRTTPSIVA FTKDGERLVG IPAKRQAVVN PSDTLFATKR 100
    LIGRRYEDPE VQRDINQVPY KIVKHGNGDA WLEARGEQYS PQQIGGFILN 150
    KMKETAEAAL SKKVNSAVVT CPAYFNDAQR QATKDAGKIV GLNVLRVINE 200
    PTAAALAYGL EKKDGEVVAV FDLGGGTFDV SILDIGAGVF EVKSTNGDTH 250
    LGGEDFDIAL VRYIVDAFKK ESGIDLEKDK MAIQRIREAA EKAKIELSST 300
    VSTEINLPFI TADASGPKHI NQKISRAQFE QLVEPLIKKT IEPCKKALKD 350
    AGLSTSDVSE VILVGGMSRM PKVVETVKSI FGKEPSKGIN PDEAVAMGAA 400
    IQGGILAGEV KDVVLLDVTP LSLGIETMGG VFARLISRNT TIPAKKSQIF 450
    STAAAGQTSV EIRVFQGERE LTRDNKLIGN FTLSGIPPAP KGVPQIEVTF 500
    DIDTDGIIKV SARDKATNKD ASITVAGSSG LSDAEIEKMV NDAEKFAESD 550
    KARREAIEFA NRADQLCNDT ENSLNEHKEK LSSESVQKVQ DQIQQLREIV 600
    LKAQAGEEVS PEELKQKTEE LQNEAINLFK DLYKDGGESS GSSEQPKN 648
    Length:648
    Mass (Da):69,748
    Last modified:October 19, 2011 - v2
    Checksum:iFDE4AAEBEF3D1DA3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACQ01000133 Genomic DNA. Translation: EAK94036.1.
    AACQ01000132 Genomic DNA. Translation: EAK94082.1.
    RefSeqiXP_713153.1. XM_708060.1.
    XP_713199.1. XM_708106.1.

    Genome annotation databases

    GeneIDi3645186.
    3645232.
    KEGGical:CaO19.1896.
    cal:CaO19.9452.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACQ01000133 Genomic DNA. Translation: EAK94036.1 .
    AACQ01000132 Genomic DNA. Translation: EAK94082.1 .
    RefSeqi XP_713153.1. XM_708060.1.
    XP_713199.1. XM_708106.1.

    3D structure databases

    ProteinModelPortali P83784.
    SMRi P83784. Positions 31-559.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5476.CAL0001828.

    2D gel databases

    COMPLUYEAST-2DPAGE P83784.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 3645186.
    3645232.
    KEGGi cal:CaO19.1896.
    cal:CaO19.9452.

    Organism-specific databases

    CGDi CAL0001828. SSC1.

    Phylogenomic databases

    eggNOGi COG0443.
    KOi K04043.
    OrthoDBi EOG728916.

    Family and domain databases

    Gene3Di 1.20.1270.10. 1 hit.
    2.60.34.10. 1 hit.
    HAMAPi MF_00332. DnaK.
    InterProi IPR012725. Chaperone_DnaK.
    IPR018181. Heat_shock_70_CS.
    IPR029048. HSP70_C.
    IPR029047. HSP70_peptide-bd.
    IPR013126. Hsp_70_fam.
    [Graphical view ]
    Pfami PF00012. HSP70. 1 hit.
    [Graphical view ]
    PRINTSi PR00301. HEATSHOCK70.
    SUPFAMi SSF100920. SSF100920. 1 hit.
    TIGRFAMsi TIGR02350. prok_dnaK. 1 hit.
    PROSITEi PS00297. HSP70_1. 1 hit.
    PS00329. HSP70_2. 1 hit.
    PS01036. HSP70_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SC5314 / ATCC MYA-2876.
    2. "Proteomics-based identification of novel Candida albicans antigens for diagnosis of systemic candidiasis in patients with underlying hematological malignancies."
      Pitarch A., Abian J., Carrascal M., Sanchez M., Nombela C., Gil C.
      Proteomics 4:3084-3106(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 591-597, ANTIGENICITY.
      Strain: SC5314 / ATCC MYA-2876.
      Tissue: Protoplast.

    Entry informationi

    Entry nameiHSP77_CANAL
    AccessioniPrimary (citable) accession number: P83784
    Secondary accession number(s): Q59U57
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 4, 2005
    Last sequence update: October 19, 2011
    Last modified: October 1, 2014
    This is version 33 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Has antigenic properties. Elicits a specific immune response in systemic candidiasis human patients undergoing malignant hematological disorders.

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Candida albicans
      Candida albicans: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3