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Protein

Heat shock protein SSC1, mitochondrial

Gene

SSC1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Constitutes the ATP-driven core of the motor and binds the precursor preprotein (By similarity).By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. unfolded protein binding Source: CGD

GO - Biological processi

  1. protein folding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Stress response

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock protein SSC1, mitochondrial
Alternative name(s):
Cytoplasmic antigenic protein 6
mtHSP70
Gene namesi
Name:SSC1
ORF Names:CaO19.1896, CaO19.9452
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
ProteomesiUP000000559 Componenti: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0001828. SSC1.

Subcellular locationi

  1. Mitochondrion matrix By similarity

GO - Cellular componenti

  1. cell surface Source: CGD
  2. mitochondrial matrix Source: UniProtKB-SubCell
  3. plasma membrane Source: CGD
  4. yeast-form cell wall Source: CGD
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2323MitochondrionSequence AnalysisAdd
BLAST
Chaini24 – 648625Heat shock protein SSC1, mitochondrialPRO_0000089306Add
BLAST

2D gel databases

COMPLUYEAST-2DPAGEP83784.

Interactioni

Protein-protein interaction databases

STRINGi5476.CAL0001828.

Structurei

3D structure databases

ProteinModelPortaliP83784.
SMRiP83784. Positions 31-559.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili560 – 63374Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the heat shock protein 70 family.Curated

Keywords - Domaini

Coiled coil, Transit peptide

Phylogenomic databases

eggNOGiCOG0443.
InParanoidiP83784.
KOiK04043.
OrthoDBiEOG728916.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
HAMAPiMF_00332. DnaK.
InterProiIPR012725. Chaperone_DnaK.
IPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
TIGRFAMsiTIGR02350. prok_dnaK. 1 hit.
PROSITEiPS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P83784-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSARNSLKN ISRQFPKALT RAQSTAAAPT GPVIGIDLGT TNSAVAVMEG
60 70 80 90 100
KTPKILENSE GGRTTPSIVA FTKDGERLVG IPAKRQAVVN PSDTLFATKR
110 120 130 140 150
LIGRRYEDPE VQRDINQVPY KIVKHGNGDA WLEARGEQYS PQQIGGFILN
160 170 180 190 200
KMKETAEAAL SKKVNSAVVT CPAYFNDAQR QATKDAGKIV GLNVLRVINE
210 220 230 240 250
PTAAALAYGL EKKDGEVVAV FDLGGGTFDV SILDIGAGVF EVKSTNGDTH
260 270 280 290 300
LGGEDFDIAL VRYIVDAFKK ESGIDLEKDK MAIQRIREAA EKAKIELSST
310 320 330 340 350
VSTEINLPFI TADASGPKHI NQKISRAQFE QLVEPLIKKT IEPCKKALKD
360 370 380 390 400
AGLSTSDVSE VILVGGMSRM PKVVETVKSI FGKEPSKGIN PDEAVAMGAA
410 420 430 440 450
IQGGILAGEV KDVVLLDVTP LSLGIETMGG VFARLISRNT TIPAKKSQIF
460 470 480 490 500
STAAAGQTSV EIRVFQGERE LTRDNKLIGN FTLSGIPPAP KGVPQIEVTF
510 520 530 540 550
DIDTDGIIKV SARDKATNKD ASITVAGSSG LSDAEIEKMV NDAEKFAESD
560 570 580 590 600
KARREAIEFA NRADQLCNDT ENSLNEHKEK LSSESVQKVQ DQIQQLREIV
610 620 630 640
LKAQAGEEVS PEELKQKTEE LQNEAINLFK DLYKDGGESS GSSEQPKN
Length:648
Mass (Da):69,748
Last modified:October 19, 2011 - v2
Checksum:iFDE4AAEBEF3D1DA3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACQ01000133 Genomic DNA. Translation: EAK94036.1.
AACQ01000132 Genomic DNA. Translation: EAK94082.1.
RefSeqiXP_713153.1. XM_708060.1.
XP_713199.1. XM_708106.1.

Genome annotation databases

GeneIDi3645186.
3645232.
KEGGical:CaO19.1896.
cal:CaO19.9452.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACQ01000133 Genomic DNA. Translation: EAK94036.1.
AACQ01000132 Genomic DNA. Translation: EAK94082.1.
RefSeqiXP_713153.1. XM_708060.1.
XP_713199.1. XM_708106.1.

3D structure databases

ProteinModelPortaliP83784.
SMRiP83784. Positions 31-559.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi5476.CAL0001828.

2D gel databases

COMPLUYEAST-2DPAGEP83784.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3645186.
3645232.
KEGGical:CaO19.1896.
cal:CaO19.9452.

Organism-specific databases

CGDiCAL0001828. SSC1.

Phylogenomic databases

eggNOGiCOG0443.
InParanoidiP83784.
KOiK04043.
OrthoDBiEOG728916.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
HAMAPiMF_00332. DnaK.
InterProiIPR012725. Chaperone_DnaK.
IPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
TIGRFAMsiTIGR02350. prok_dnaK. 1 hit.
PROSITEiPS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.
  2. "Proteomics-based identification of novel Candida albicans antigens for diagnosis of systemic candidiasis in patients with underlying hematological malignancies."
    Pitarch A., Abian J., Carrascal M., Sanchez M., Nombela C., Gil C.
    Proteomics 4:3084-3106(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 591-597, ANTIGENICITY.
    Strain: SC5314 / ATCC MYA-2876.
    Tissue: Protoplast.

Entry informationi

Entry nameiHSP77_CANAL
AccessioniPrimary (citable) accession number: P83784
Secondary accession number(s): Q59U57
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: October 19, 2011
Last modified: January 7, 2015
This is version 35 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Has antigenic properties. Elicits a specific immune response in systemic candidiasis human patients undergoing malignant hematological disorders.

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.