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P83784

- HSP77_CANAL

UniProt

P83784 - HSP77_CANAL

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Protein

Heat shock protein SSC1, mitochondrial

Gene
SSC1, CaO19.1896, CaO19.9452
Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Constitutes the ATP-driven core of the motor and binds the precursor preprotein By similarity.UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. unfolded protein binding Source: CGD

GO - Biological processi

  1. protein folding Source: InterPro
  2. response to stress Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Stress response

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock protein SSC1, mitochondrial
Alternative name(s):
Cytoplasmic antigenic protein 6
mtHSP70
Gene namesi
Name:SSC1
ORF Names:CaO19.1896, CaO19.9452
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
ProteomesiUP000000559: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0001828. SSC1.

Subcellular locationi

Mitochondrion matrix By similarity UniRule annotation

GO - Cellular componenti

  1. cell surface Source: CGD
  2. mitochondrial matrix Source: UniProtKB-SubCell
  3. plasma membrane Source: CGD
  4. yeast-form cell wall Source: CGD
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2323Mitochondrion Reviewed predictionAdd
BLAST
Chaini24 – 648625Heat shock protein SSC1, mitochondrialUniRule annotationPRO_0000089306Add
BLAST

2D gel databases

COMPLUYEAST-2DPAGEP83784.

Interactioni

Protein-protein interaction databases

STRINGi5476.CAL0001828.

Structurei

3D structure databases

ProteinModelPortaliP83784.
SMRiP83784. Positions 31-559.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili560 – 63374 Reviewed predictionAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Coiled coil, Transit peptide

Phylogenomic databases

eggNOGiCOG0443.
KOiK04043.
OrthoDBiEOG728916.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
HAMAPiMF_00332. DnaK.
InterProiIPR012725. Chaperone_DnaK.
IPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
TIGRFAMsiTIGR02350. prok_dnaK. 1 hit.
PROSITEiPS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P83784-1 [UniParc]FASTAAdd to Basket

« Hide

MLSARNSLKN ISRQFPKALT RAQSTAAAPT GPVIGIDLGT TNSAVAVMEG    50
KTPKILENSE GGRTTPSIVA FTKDGERLVG IPAKRQAVVN PSDTLFATKR 100
LIGRRYEDPE VQRDINQVPY KIVKHGNGDA WLEARGEQYS PQQIGGFILN 150
KMKETAEAAL SKKVNSAVVT CPAYFNDAQR QATKDAGKIV GLNVLRVINE 200
PTAAALAYGL EKKDGEVVAV FDLGGGTFDV SILDIGAGVF EVKSTNGDTH 250
LGGEDFDIAL VRYIVDAFKK ESGIDLEKDK MAIQRIREAA EKAKIELSST 300
VSTEINLPFI TADASGPKHI NQKISRAQFE QLVEPLIKKT IEPCKKALKD 350
AGLSTSDVSE VILVGGMSRM PKVVETVKSI FGKEPSKGIN PDEAVAMGAA 400
IQGGILAGEV KDVVLLDVTP LSLGIETMGG VFARLISRNT TIPAKKSQIF 450
STAAAGQTSV EIRVFQGERE LTRDNKLIGN FTLSGIPPAP KGVPQIEVTF 500
DIDTDGIIKV SARDKATNKD ASITVAGSSG LSDAEIEKMV NDAEKFAESD 550
KARREAIEFA NRADQLCNDT ENSLNEHKEK LSSESVQKVQ DQIQQLREIV 600
LKAQAGEEVS PEELKQKTEE LQNEAINLFK DLYKDGGESS GSSEQPKN 648
Length:648
Mass (Da):69,748
Last modified:October 19, 2011 - v2
Checksum:iFDE4AAEBEF3D1DA3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACQ01000133 Genomic DNA. Translation: EAK94036.1.
AACQ01000132 Genomic DNA. Translation: EAK94082.1.
RefSeqiXP_713153.1. XM_708060.1.
XP_713199.1. XM_708106.1.

Genome annotation databases

GeneIDi3645186.
3645232.
KEGGical:CaO19.1896.
cal:CaO19.9452.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACQ01000133 Genomic DNA. Translation: EAK94036.1 .
AACQ01000132 Genomic DNA. Translation: EAK94082.1 .
RefSeqi XP_713153.1. XM_708060.1.
XP_713199.1. XM_708106.1.

3D structure databases

ProteinModelPortali P83784.
SMRi P83784. Positions 31-559.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5476.CAL0001828.

2D gel databases

COMPLUYEAST-2DPAGE P83784.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3645186.
3645232.
KEGGi cal:CaO19.1896.
cal:CaO19.9452.

Organism-specific databases

CGDi CAL0001828. SSC1.

Phylogenomic databases

eggNOGi COG0443.
KOi K04043.
OrthoDBi EOG728916.

Family and domain databases

Gene3Di 1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
HAMAPi MF_00332. DnaK.
InterProi IPR012725. Chaperone_DnaK.
IPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view ]
Pfami PF00012. HSP70. 1 hit.
[Graphical view ]
PRINTSi PR00301. HEATSHOCK70.
SUPFAMi SSF100920. SSF100920. 1 hit.
TIGRFAMsi TIGR02350. prok_dnaK. 1 hit.
PROSITEi PS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.
  2. "Proteomics-based identification of novel Candida albicans antigens for diagnosis of systemic candidiasis in patients with underlying hematological malignancies."
    Pitarch A., Abian J., Carrascal M., Sanchez M., Nombela C., Gil C.
    Proteomics 4:3084-3106(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 591-597, ANTIGENICITY.
    Strain: SC5314 / ATCC MYA-2876.
    Tissue: Protoplast.

Entry informationi

Entry nameiHSP77_CANAL
AccessioniPrimary (citable) accession number: P83784
Secondary accession number(s): Q59U57
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: October 19, 2011
Last modified: June 11, 2014
This is version 32 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Has antigenic properties. Elicits a specific immune response in systemic candidiasis human patients undergoing malignant hematological disorders.

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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