P83784 (HSP77_CANAL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Heat shock protein SSC1, mitochondrial

Alternative name(s):
Cytoplasmic antigenic protein 6
mtHSP70

Gene names

Name:	SSC1
ORF Names:	CaO19.1896, CaO19.9452

Organism

Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]

Taxonomic identifier

237561 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida › Candida albicans

Protein attributes

Sequence length	648 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Constitutes the ATP-driven core of the motor and binds the precursor preprotein By similarity.
Subcellular location	Mitochondrion matrix By similarity.
Miscellaneous	Has antigenic properties. Elicits a specific immune response in systemic candidiasis human patients undergoing malignant hematological disorders.
Sequence similarities	Belongs to the heat shock protein 70 family.

Ontologies

Keywords
Biological process	Stress response
Cellular component	Mitochondrion
Domain	Coiled coil Transit peptide
Ligand	ATP-binding Nucleotide-binding
Molecular function	Chaperone
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	protein folding Inferred from electronic annotation. Source: InterPro response to stress Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cell surface Inferred from direct assay PubMed 12782322. Source: CGD mitochondrial matrix Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from direct assay PubMed 19824013. Source: CGD yeast-form cell wall Inferred from direct assay PubMed 12782322. Source: CGD
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW unfolded protein binding Non-traceable author statement PubMed 12782322. Source: CGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 23	23	Mitochondrion Potential
	Chain	24 – 648	625	Heat shock protein SSC1, mitochondrial		PRO_0000089306
Regions
	Coiled coil	560 – 633	74	Potential

Sequences

	Sequence		Length	Mass (Da)
	P83784 [UniParc]. Last modified October 19, 2011. Version 2. Checksum: FDE4AAEBEF3D1DA3	FASTA	648	69,748
	10 20 30 40 50 60 MLSARNSLKN ISRQFPKALT RAQSTAAAPT GPVIGIDLGT TNSAVAVMEG KTPKILENSE 70 80 90 100 110 120 GGRTTPSIVA FTKDGERLVG IPAKRQAVVN PSDTLFATKR LIGRRYEDPE VQRDINQVPY 130 140 150 160 170 180 KIVKHGNGDA WLEARGEQYS PQQIGGFILN KMKETAEAAL SKKVNSAVVT CPAYFNDAQR 190 200 210 220 230 240 QATKDAGKIV GLNVLRVINE PTAAALAYGL EKKDGEVVAV FDLGGGTFDV SILDIGAGVF 250 260 270 280 290 300 EVKSTNGDTH LGGEDFDIAL VRYIVDAFKK ESGIDLEKDK MAIQRIREAA EKAKIELSST 310 320 330 340 350 360 VSTEINLPFI TADASGPKHI NQKISRAQFE QLVEPLIKKT IEPCKKALKD AGLSTSDVSE 370 380 390 400 410 420 VILVGGMSRM PKVVETVKSI FGKEPSKGIN PDEAVAMGAA IQGGILAGEV KDVVLLDVTP 430 440 450 460 470 480 LSLGIETMGG VFARLISRNT TIPAKKSQIF STAAAGQTSV EIRVFQGERE LTRDNKLIGN 490 500 510 520 530 540 FTLSGIPPAP KGVPQIEVTF DIDTDGIIKV SARDKATNKD ASITVAGSSG LSDAEIEKMV 550 560 570 580 590 600 NDAEKFAESD KARREAIEFA NRADQLCNDT ENSLNEHKEK LSSESVQKVQ DQIQQLREIV 610 620 630 640 LKAQAGEEVS PEELKQKTEE LQNEAINLFK DLYKDGGESS GSSEQPKN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The diploid genome sequence of Candida albicans." Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S. Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314 / ATCC MYA-2876.
[2]	"Proteomics-based identification of novel Candida albicans antigens for diagnosis of systemic candidiasis in patients with underlying hematological malignancies." Pitarch A., Abian J., Carrascal M., Sanchez M., Nombela C., Gil C. Proteomics 4:3084-3106(2004) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 591-597, ANTIGENICITY. Strain: SC5314 / ATCC MYA-2876. Tissue: Protoplast.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AACQ01000133 Genomic DNA. Translation: EAK94036.1. AACQ01000132 Genomic DNA. Translation: EAK94082.1.
RefSeq	XP_713153.1. XM_708060.1. XP_713199.1. XM_708106.1.
3D structure databases
ProteinModelPortal	P83784.
SMR	P83784. Positions 31-559.
ModBase	Search...
Protein-protein interaction databases
STRING	5476.CAL0001828.
2D gel databases
COMPLUYEAST-2DPAGE	P83784.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3645186. 3645232.
KEGG	cal:CaO19.1896. cal:CaO19.9452.
Organism-specific databases
CGD	CAL0001828. SSC1.
Phylogenomic databases
eggNOG	COG0443.
KO	K04043.
Family and domain databases
InterPro	IPR012725. Chaperone_DnaK. IPR018181. Heat_shock_70_CS. IPR013126. Hsp_70_fam. [Graphical view]
Pfam	PF00012. HSP70. 1 hit. [Graphical view]
PRINTS	PR00301. HEATSHOCK70.
TIGRFAMs	TIGR02350. prok_dnaK. 1 hit.
PROSITE	PS00297. HSP70_1. 1 hit. PS00329. HSP70_2. 1 hit. PS01036. HSP70_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HSP77_CANAL

Accession

Primary (citable) accession number: P83784
Secondary accession number(s): Q59U57

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 4, 2005
Last sequence update:	October 19, 2011
Last modified:	April 3, 2013
This is version 29 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program