Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P83782 (QCR2_CANAL) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 34. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome b-c1 complex subunit 2, mitochondrial
Alternative name(s):
Complex III subunit 2
Core protein II
Cytoplasmic antigenic protein 5
Ubiquinol-cytochrome-c reductase complex core protein 2
Gene names
Name:QCR2
ORF Names:CaO19.10167, CaO19.2644
OrganismCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]
Taxonomic identifier237561 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

Protein attributes

Sequence length374 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. The core protein 2 is required for the assembly of the complex By similarity.

Subunit structure

Fungi bc1 complex contains 10 subunits; 3 respiratory subunits, 2 core proteins and 5 low-molecular weight proteins By similarity.

Subcellular location

Mitochondrion inner membrane By similarity.

Miscellaneous

Has antigenic properties. Elicits a specific immune response in systemic candidiasis human patients undergoing malignant hematological disorders.

Sequence similarities

Belongs to the peptidase M16 family. UQCRC2/QCR2 subfamily.

Caution

Does not seem to have a protease activity as it lack the zinc-binding site.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 1111Mitochondrion Potential
Chain12 – 374363Cytochrome b-c1 complex subunit 2, mitochondrial
PRO_0000089305

Sequences

Sequence LengthMass (Da)Tools
P83782 [UniParc].

Last modified October 19, 2011. Version 2.
Checksum: 47018DF7D1968EC1

FASTA37439,558
        10         20         30         40         50         60 
MLSRASIRAY SSIPNSVKIA AKESATDLTK LSVIINNAGS KTGKSGVSHL LSKFTFLNNG 

        70         80         90        100        110        120 
AKSALRFTRE SELLGGTFES KVTRDALILN TTFLKQDLPY YVEALGNVVS NTQFAPHEFN 

       130        140        150        160        170        180 
EIVLPTANAE TKLANANPAF KGVEKLHEIT FRRGLGNPLF YNESTPIKLE EVAQFSKEQF 

       190        200        210        220        230        240 
SGENISIVAE GANEEDLTKF VSESAFCYLP SSSSNGAKAL PTNTFTGQEA RVPSSGASSA 

       250        260        270        280        290        300 
LIGIPVKPAD FGKYEVLSAA IGTSTLPSTS TPLAQIPGAT SHLYKYQDAG LFVISVSGEA 

       310        320        330        340        350        360 
SQVAQGIKQA KSVAESVSSS ALSEAVKAAE LSVALQSTVD SPLNVKVVAE EAPISKFNYV 

       370 
AVGDLDVLPY ADEL 

« Hide

References

« Hide 'large scale' references
[1]"The diploid genome sequence of Candida albicans."
Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S.
Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SC5314 / ATCC MYA-2876.
[2]"Proteomics-based identification of novel Candida albicans antigens for diagnosis of systemic candidiasis in patients with underlying hematological malignancies."
Pitarch A., Abian J., Carrascal M., Sanchez M., Nombela C., Gil C.
Proteomics 4:3084-3106(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 221-231, ANTIGENICITY.
Strain: SC5314 / ATCC MYA-2876.
Tissue: Protoplast.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AACQ01000171 Genomic DNA. Translation: EAK92828.1.
AACQ01000170 Genomic DNA. Translation: EAK92850.1.
RefSeqXP_712027.1. XM_706934.1.
XP_712048.1. XM_706955.1.

3D structure databases

ProteinModelPortalP83782.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5476.CAL0003458.

2D gel databases

COMPLUYEAST-2DPAGEP83782.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3646331.
3646352.
KEGGcal:CaO19.10167.
cal:CaO19.2644.

Organism-specific databases

CGDCAL0003458. QCR2.

Phylogenomic databases

eggNOGCOG0612.
KOK00415.
OrthoDBEOG7F51BJ.

Family and domain databases

Gene3D3.30.830.10. 2 hits.
InterProIPR011249. Metalloenz_LuxS/M16.
IPR011237. Pept_M16_dom.
IPR011765. Pept_M16_N.
IPR007863. Peptidase_M16_C.
[Graphical view]
PfamPF00675. Peptidase_M16. 1 hit.
PF05193. Peptidase_M16_C. 1 hit.
[Graphical view]
SUPFAMSSF63411. SSF63411. 2 hits.
ProtoNetSearch...

Entry information

Entry nameQCR2_CANAL
AccessionPrimary (citable) accession number: P83782
Secondary accession number(s): Q59QS9
Entry history
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: October 19, 2011
Last modified: April 16, 2014
This is version 34 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries

Candida albicans

Candida albicans: entries and gene names