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P83782

- QCR2_CANAL

UniProt

P83782 - QCR2_CANAL

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Protein

Cytochrome b-c1 complex subunit 2, mitochondrial

Gene

QCR2

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. The core protein 2 is required for the assembly of the complex (By similarity).By similarity

GO - Molecular functioni

  1. catalytic activity Source: InterPro
  2. metal ion binding Source: InterPro

GO - Biological processi

  1. oxidation-reduction process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome b-c1 complex subunit 2, mitochondrial
Alternative name(s):
Complex III subunit 2
Core protein II
Cytoplasmic antigenic protein 5
Ubiquinol-cytochrome-c reductase complex core protein 2
Gene namesi
Name:QCR2
ORF Names:CaO19.10167, CaO19.2644
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
ProteomesiUP000000559: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0003458. QCR2.

Subcellular locationi

GO - Cellular componenti

  1. membrane Source: CGD
  2. mitochondrial inner membrane Source: UniProtKB-KW
  3. plasma membrane Source: CGD
  4. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 1111MitochondrionSequence AnalysisAdd
BLAST
Chaini12 – 374363Cytochrome b-c1 complex subunit 2, mitochondrialPRO_0000089305Add
BLAST

2D gel databases

COMPLUYEAST-2DPAGEP83782.

Interactioni

Subunit structurei

Fungi bc1 complex contains 10 subunits; 3 respiratory subunits, 2 core proteins and 5 low-molecular weight proteins.By similarity

Protein-protein interaction databases

STRINGi5476.CAL0003458.

Structurei

3D structure databases

ProteinModelPortaliP83782.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0612.
InParanoidiP83782.
KOiK00415.
OrthoDBiEOG7F51BJ.

Family and domain databases

Gene3Di3.30.830.10. 2 hits.
InterProiIPR011249. Metalloenz_LuxS/M16.
IPR011237. Pept_M16_dom.
IPR011765. Pept_M16_N.
IPR007863. Peptidase_M16_C.
[Graphical view]
PfamiPF00675. Peptidase_M16. 1 hit.
PF05193. Peptidase_M16_C. 1 hit.
[Graphical view]
SUPFAMiSSF63411. SSF63411. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P83782-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLSRASIRAY SSIPNSVKIA AKESATDLTK LSVIINNAGS KTGKSGVSHL
60 70 80 90 100
LSKFTFLNNG AKSALRFTRE SELLGGTFES KVTRDALILN TTFLKQDLPY
110 120 130 140 150
YVEALGNVVS NTQFAPHEFN EIVLPTANAE TKLANANPAF KGVEKLHEIT
160 170 180 190 200
FRRGLGNPLF YNESTPIKLE EVAQFSKEQF SGENISIVAE GANEEDLTKF
210 220 230 240 250
VSESAFCYLP SSSSNGAKAL PTNTFTGQEA RVPSSGASSA LIGIPVKPAD
260 270 280 290 300
FGKYEVLSAA IGTSTLPSTS TPLAQIPGAT SHLYKYQDAG LFVISVSGEA
310 320 330 340 350
SQVAQGIKQA KSVAESVSSS ALSEAVKAAE LSVALQSTVD SPLNVKVVAE
360 370
EAPISKFNYV AVGDLDVLPY ADEL
Length:374
Mass (Da):39,558
Last modified:October 19, 2011 - v2
Checksum:i47018DF7D1968EC1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACQ01000171 Genomic DNA. Translation: EAK92828.1.
AACQ01000170 Genomic DNA. Translation: EAK92850.1.
RefSeqiXP_712027.1. XM_706934.1.
XP_712048.1. XM_706955.1.

Genome annotation databases

GeneIDi3646331.
3646352.
KEGGical:CaO19.10167.
cal:CaO19.2644.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACQ01000171 Genomic DNA. Translation: EAK92828.1 .
AACQ01000170 Genomic DNA. Translation: EAK92850.1 .
RefSeqi XP_712027.1. XM_706934.1.
XP_712048.1. XM_706955.1.

3D structure databases

ProteinModelPortali P83782.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5476.CAL0003458.

2D gel databases

COMPLUYEAST-2DPAGE P83782.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3646331.
3646352.
KEGGi cal:CaO19.10167.
cal:CaO19.2644.

Organism-specific databases

CGDi CAL0003458. QCR2.

Phylogenomic databases

eggNOGi COG0612.
InParanoidi P83782.
KOi K00415.
OrthoDBi EOG7F51BJ.

Family and domain databases

Gene3Di 3.30.830.10. 2 hits.
InterProi IPR011249. Metalloenz_LuxS/M16.
IPR011237. Pept_M16_dom.
IPR011765. Pept_M16_N.
IPR007863. Peptidase_M16_C.
[Graphical view ]
Pfami PF00675. Peptidase_M16. 1 hit.
PF05193. Peptidase_M16_C. 1 hit.
[Graphical view ]
SUPFAMi SSF63411. SSF63411. 2 hits.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.
  2. "Proteomics-based identification of novel Candida albicans antigens for diagnosis of systemic candidiasis in patients with underlying hematological malignancies."
    Pitarch A., Abian J., Carrascal M., Sanchez M., Nombela C., Gil C.
    Proteomics 4:3084-3106(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 221-231, ANTIGENICITY.
    Strain: SC5314 / ATCC MYA-2876.
    Tissue: Protoplast.

Entry informationi

Entry nameiQCR2_CANAL
AccessioniPrimary (citable) accession number: P83782
Secondary accession number(s): Q59QS9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: October 19, 2011
Last modified: October 29, 2014
This is version 36 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Has antigenic properties. Elicits a specific immune response in systemic candidiasis human patients undergoing malignant hematological disorders.

Caution

Does not seem to have a protease activity as it lack the zinc-binding site.Curated

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3