P83782 (QCR2_CANAL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytochrome b-c1 complex subunit 2, mitochondrial

Alternative name(s):
Complex III subunit 2
Core protein II
Cytoplasmic antigenic protein 5
Ubiquinol-cytochrome-c reductase complex core protein 2

Gene names

Name:	QCR2
ORF Names:	CaO19.10167, CaO19.2644

Organism

Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]

Taxonomic identifier

237561 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida › Candida albicans

Protein attributes

Sequence length	374 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. The core protein 2 is required for the assembly of the complex By similarity.
Subunit structure	Fungi bc1 complex contains 10 subunits; 3 respiratory subunits, 2 core proteins and 5 low-molecular weight proteins By similarity.
Subcellular location	Mitochondrion inner membrane By similarity.
Miscellaneous	Has antigenic properties. Elicits a specific immune response in systemic candidiasis human patients undergoing malignant hematological disorders.
Sequence similarities	Belongs to the peptidase M16 family. UQCRC2/QCR2 subfamily.
Caution	Does not seem to have a protease activity as it lack the zinc-binding site.

Ontologies

Keywords
Biological process	Electron transport Respiratory chain Transport
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Domain	Transit peptide
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	mitochondrial inner membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from direct assay PubMed 19824013. Source: CGD respiratory chain Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	catalytic activity Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 11	11	Mitochondrion Potential
	Chain	12 – 374	363	Cytochrome b-c1 complex subunit 2, mitochondrial		PRO_0000089305

Sequences

	Sequence		Length	Mass (Da)
	P83782 [UniParc]. Last modified October 19, 2011. Version 2. Checksum: 47018DF7D1968EC1	FASTA	374	39,558
	10 20 30 40 50 60 MLSRASIRAY SSIPNSVKIA AKESATDLTK LSVIINNAGS KTGKSGVSHL LSKFTFLNNG 70 80 90 100 110 120 AKSALRFTRE SELLGGTFES KVTRDALILN TTFLKQDLPY YVEALGNVVS NTQFAPHEFN 130 140 150 160 170 180 EIVLPTANAE TKLANANPAF KGVEKLHEIT FRRGLGNPLF YNESTPIKLE EVAQFSKEQF 190 200 210 220 230 240 SGENISIVAE GANEEDLTKF VSESAFCYLP SSSSNGAKAL PTNTFTGQEA RVPSSGASSA 250 260 270 280 290 300 LIGIPVKPAD FGKYEVLSAA IGTSTLPSTS TPLAQIPGAT SHLYKYQDAG LFVISVSGEA 310 320 330 340 350 360 SQVAQGIKQA KSVAESVSSS ALSEAVKAAE LSVALQSTVD SPLNVKVVAE EAPISKFNYV 370 AVGDLDVLPY ADEL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The diploid genome sequence of Candida albicans." Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S. Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314 / ATCC MYA-2876.
[2]	"Proteomics-based identification of novel Candida albicans antigens for diagnosis of systemic candidiasis in patients with underlying hematological malignancies." Pitarch A., Abian J., Carrascal M., Sanchez M., Nombela C., Gil C. Proteomics 4:3084-3106(2004) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 221-231, ANTIGENICITY. Strain: SC5314 / ATCC MYA-2876. Tissue: Protoplast.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AACQ01000171 Genomic DNA. Translation: EAK92828.1. AACQ01000170 Genomic DNA. Translation: EAK92850.1.
RefSeq	XP_712027.1. XM_706934.1. XP_712048.1. XM_706955.1.
3D structure databases
ProteinModelPortal	P83782.
ModBase	Search...
Protein-protein interaction databases
STRING	5476.CAL0003458.
2D gel databases
COMPLUYEAST-2DPAGE	P83782.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3646331. 3646352.
KEGG	cal:CaO19.10167. cal:CaO19.2644.
Organism-specific databases
CGD	CAL0003458. QCR2.
Phylogenomic databases
eggNOG	COG0612.
KO	K00415.
Family and domain databases
Gene3D	3.30.830.10. 2 hits.
InterPro	IPR011249. Metalloenz_LuxS/M16. IPR011237. Pept_M16_dom. IPR011765. Pept_M16_N. IPR007863. Peptidase_M16_C. [Graphical view]
Pfam	PF00675. Peptidase_M16. 1 hit. PF05193. Peptidase_M16_C. 1 hit. [Graphical view]
SUPFAM	SSF63411. Metalloenz_metal-bd. 2 hits.
ProtoNet	Search...

Entry information

Entry name

QCR2_CANAL

Accession

Primary (citable) accession number: P83782
Secondary accession number(s): Q59QS9

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 4, 2005
Last sequence update:	October 19, 2011
Last modified:	May 1, 2013
This is version 31 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program