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P83782

- QCR2_CANAL

UniProt

P83782 - QCR2_CANAL

Protein

Cytochrome b-c1 complex subunit 2, mitochondrial

Gene

QCR2

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 35 (01 Oct 2014)
      Sequence version 2 (19 Oct 2011)
      Previous versions | rss
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    Functioni

    This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. The core protein 2 is required for the assembly of the complex By similarity.By similarity

    GO - Molecular functioni

    1. catalytic activity Source: InterPro
    2. metal ion binding Source: InterPro

    GO - Biological processi

    1. oxidation-reduction process Source: UniProtKB-KW

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome b-c1 complex subunit 2, mitochondrial
    Alternative name(s):
    Complex III subunit 2
    Core protein II
    Cytoplasmic antigenic protein 5
    Ubiquinol-cytochrome-c reductase complex core protein 2
    Gene namesi
    Name:QCR2
    ORF Names:CaO19.10167, CaO19.2644
    OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
    Taxonomic identifieri237561 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
    ProteomesiUP000000559: Unassembled WGS sequence

    Organism-specific databases

    CGDiCAL0003458. QCR2.

    Subcellular locationi

    GO - Cellular componenti

    1. membrane Source: CGD
    2. mitochondrial inner membrane Source: UniProtKB-SubCell
    3. plasma membrane Source: CGD
    4. respiratory chain Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 1111MitochondrionSequence AnalysisAdd
    BLAST
    Chaini12 – 374363Cytochrome b-c1 complex subunit 2, mitochondrialPRO_0000089305Add
    BLAST

    2D gel databases

    COMPLUYEAST-2DPAGEP83782.

    Interactioni

    Subunit structurei

    Fungi bc1 complex contains 10 subunits; 3 respiratory subunits, 2 core proteins and 5 low-molecular weight proteins.By similarity

    Protein-protein interaction databases

    STRINGi5476.CAL0003458.

    Structurei

    3D structure databases

    ProteinModelPortaliP83782.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0612.
    KOiK00415.
    OrthoDBiEOG7F51BJ.

    Family and domain databases

    Gene3Di3.30.830.10. 2 hits.
    InterProiIPR011249. Metalloenz_LuxS/M16.
    IPR011237. Pept_M16_dom.
    IPR011765. Pept_M16_N.
    IPR007863. Peptidase_M16_C.
    [Graphical view]
    PfamiPF00675. Peptidase_M16. 1 hit.
    PF05193. Peptidase_M16_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF63411. SSF63411. 2 hits.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P83782-1 [UniParc]FASTAAdd to Basket

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    MLSRASIRAY SSIPNSVKIA AKESATDLTK LSVIINNAGS KTGKSGVSHL    50
    LSKFTFLNNG AKSALRFTRE SELLGGTFES KVTRDALILN TTFLKQDLPY 100
    YVEALGNVVS NTQFAPHEFN EIVLPTANAE TKLANANPAF KGVEKLHEIT 150
    FRRGLGNPLF YNESTPIKLE EVAQFSKEQF SGENISIVAE GANEEDLTKF 200
    VSESAFCYLP SSSSNGAKAL PTNTFTGQEA RVPSSGASSA LIGIPVKPAD 250
    FGKYEVLSAA IGTSTLPSTS TPLAQIPGAT SHLYKYQDAG LFVISVSGEA 300
    SQVAQGIKQA KSVAESVSSS ALSEAVKAAE LSVALQSTVD SPLNVKVVAE 350
    EAPISKFNYV AVGDLDVLPY ADEL 374
    Length:374
    Mass (Da):39,558
    Last modified:October 19, 2011 - v2
    Checksum:i47018DF7D1968EC1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACQ01000171 Genomic DNA. Translation: EAK92828.1.
    AACQ01000170 Genomic DNA. Translation: EAK92850.1.
    RefSeqiXP_712027.1. XM_706934.1.
    XP_712048.1. XM_706955.1.

    Genome annotation databases

    GeneIDi3646331.
    3646352.
    KEGGical:CaO19.10167.
    cal:CaO19.2644.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACQ01000171 Genomic DNA. Translation: EAK92828.1 .
    AACQ01000170 Genomic DNA. Translation: EAK92850.1 .
    RefSeqi XP_712027.1. XM_706934.1.
    XP_712048.1. XM_706955.1.

    3D structure databases

    ProteinModelPortali P83782.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5476.CAL0003458.

    2D gel databases

    COMPLUYEAST-2DPAGE P83782.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 3646331.
    3646352.
    KEGGi cal:CaO19.10167.
    cal:CaO19.2644.

    Organism-specific databases

    CGDi CAL0003458. QCR2.

    Phylogenomic databases

    eggNOGi COG0612.
    KOi K00415.
    OrthoDBi EOG7F51BJ.

    Family and domain databases

    Gene3Di 3.30.830.10. 2 hits.
    InterProi IPR011249. Metalloenz_LuxS/M16.
    IPR011237. Pept_M16_dom.
    IPR011765. Pept_M16_N.
    IPR007863. Peptidase_M16_C.
    [Graphical view ]
    Pfami PF00675. Peptidase_M16. 1 hit.
    PF05193. Peptidase_M16_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF63411. SSF63411. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SC5314 / ATCC MYA-2876.
    2. "Proteomics-based identification of novel Candida albicans antigens for diagnosis of systemic candidiasis in patients with underlying hematological malignancies."
      Pitarch A., Abian J., Carrascal M., Sanchez M., Nombela C., Gil C.
      Proteomics 4:3084-3106(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 221-231, ANTIGENICITY.
      Strain: SC5314 / ATCC MYA-2876.
      Tissue: Protoplast.

    Entry informationi

    Entry nameiQCR2_CANAL
    AccessioniPrimary (citable) accession number: P83782
    Secondary accession number(s): Q59QS9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 4, 2005
    Last sequence update: October 19, 2011
    Last modified: October 1, 2014
    This is version 35 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Has antigenic properties. Elicits a specific immune response in systemic candidiasis human patients undergoing malignant hematological disorders.

    Caution

    Does not seem to have a protease activity as it lack the zinc-binding site.Curated

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Candida albicans
      Candida albicans: entries and gene names
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3