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P83780 (G6PI_CANAL) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glucose-6-phosphate isomerase

Short name=GPI
EC=5.3.1.9
Alternative name(s):
Phosphoglucose isomerase
Short name=PGI
Phosphohexose isomerase
Short name=PHI
Gene names
Name:PGI1
ORF Names:CaO19.11369, CaO19.3888
OrganismCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]
Taxonomic identifier237561 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

Protein attributes

Sequence length550 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP-Rule MF_00473

Pathway

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP-Rule MF_00473

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00473

Subcellular location

Cytoplasm Ref.2.

Miscellaneous

Has antigenic properties. Elicits a specific immune response in systemic candidiasis human patients undergoing malignant hematological disorders.

Sequence similarities

Belongs to the GPI family.

Ontologies

Keywords
   Biological processGluconeogenesis
Glycolysis
   Cellular componentCytoplasm
   Molecular functionIsomerase
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processgluconeogenesis

Inferred from electronic annotation. Source: UniProtKB-KW

glycolytic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionglucose-6-phosphate isomerase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 550550Glucose-6-phosphate isomerase HAMAP-Rule MF_00473
PRO_0000180572

Sites

Active site3931 By similarity
Active site5151 By similarity

Sequences

Sequence LengthMass (Da)Tools
P83780 [UniParc].

Last modified March 3, 2009. Version 2.
Checksum: 6E3C83DF9189887E

FASTA55061,186
        10         20         30         40         50         60 
MASFKLATDL PEWKKLEETY KSVGEKFSVR DAFAKDPKRF EEFSWIYKNY DDSKILFDFS 

        70         80         90        100        110        120 
KNLVNKEILD QLVTLAKEAG VEKLRDAMFA GDHINTTEDR AVYHVALRNR ALRKMPVDGK 

       130        140        150        160        170        180 
DTAQEVDDVL KHMKEFSDSI RDGSWTGYTG KSITDVVNIG IGGSDLGPVM VTEALKAYSK 

       190        200        210        220        230        240 
PGLNVHFISN IDGTHTAETL KNLNPETTLF LIASKTFTTA ETITNATSAK NWFLATAKDS 

       250        260        270        280        290        300 
KHIAKHFAAL STNEKEVVAF GIDAKNMFGF ESWVGGRYSV WSAIGLSVAI YIGFENFNDF 

       310        320        330        340        350        360 
LKGAEAMDQH FLTTPLENNI PVIGGLLSVW YNNFFGAQTH LVVPFDQYLH RFPAYLQQLS 

       370        380        390        400        410        420 
MESNGKSVTR ANVFTNYQTG TILFGEPATN AQHSFFQLVH QGTKLIPADF ILAAQSHNPI 

       430        440        450        460        470        480 
EKNLHQRMLA SNFFAQSEAL MVGKDEAKVK AEGATGGLVP HKEFSGNRPT TSILAQKITP 

       490        500        510        520        530        540 
ATLGSLIAYY EHLTFTEGAI WNINSFDQWG VELGKVLAKV IGKELDDKKA VATHDASTNG 

       550 
LINQFKEWEE 

« Hide

References

« Hide 'large scale' references
[1]"The diploid genome sequence of Candida albicans."
Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S.
Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SC5314 / ATCC MYA-2876.
[2]"Proteomics-based identification of novel Candida albicans antigens for diagnosis of systemic candidiasis in patients with underlying hematological malignancies."
Pitarch A., Abian J., Carrascal M., Sanchez M., Nombela C., Gil C.
Proteomics 4:3084-3106(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 89-100 AND 121-131, SUBCELLULAR LOCATION, ANTIGENICITY.
Strain: SC5314 / ATCC MYA-2876.
Tissue: Protoplast.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AACQ01000125 Genomic DNA. Translation: EAK94404.1.
AACQ01000124 Genomic DNA. Translation: EAK94449.1.
RefSeqXP_713513.1. XM_708420.1.
XP_713554.1. XM_708461.1.

3D structure databases

ProteinModelPortalP83780.
SMRP83780. Positions 7-550.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5476.CAL0002184.

2D gel databases

COMPLUYEAST-2DPAGEP83780.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3644831.
3644847.
KEGGcal:CaO19.11369.
cal:CaO19.3888.

Organism-specific databases

CGDCAL0002184. PGI1.

Phylogenomic databases

eggNOGCOG0166.
KOK01810.
OrthoDBEOG7N0CDV.

Enzyme and pathway databases

UniPathwayUPA00109; UER00181.

Family and domain databases

Gene3D1.10.1390.10. 1 hit.
HAMAPMF_00473. G6P_isomerase.
InterProIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERPTHR11469. PTHR11469. 1 hit.
PfamPF00342. PGI. 1 hit.
[Graphical view]
PRINTSPR00662. G6PISOMERASE.
PROSITEPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameG6PI_CANAL
AccessionPrimary (citable) accession number: P83780
Secondary accession number(s): Q59V64
Entry history
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: March 3, 2009
Last modified: June 11, 2014
This is version 55 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Candida albicans

Candida albicans: entries and gene names