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P83780

- G6PI_CANAL

UniProt

P83780 - G6PI_CANAL

Protein

Glucose-6-phosphate isomerase

Gene

PGI1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 56 (01 Oct 2014)
      Sequence version 2 (03 Mar 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    D-glucose 6-phosphate = D-fructose 6-phosphate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei393 – 3931By similarity
    Active sitei515 – 5151By similarity

    GO - Molecular functioni

    1. glucose-6-phosphate isomerase activity Source: UniProtKB-EC

    GO - Biological processi

    1. gluconeogenesis Source: UniProtKB-KW
    2. glycolytic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Gluconeogenesis, Glycolysis

    Enzyme and pathway databases

    UniPathwayiUPA00109; UER00181.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glucose-6-phosphate isomerase (EC:5.3.1.9)
    Short name:
    GPI
    Alternative name(s):
    Phosphoglucose isomerase
    Short name:
    PGI
    Phosphohexose isomerase
    Short name:
    PHI
    Gene namesi
    Name:PGI1
    ORF Names:CaO19.11369, CaO19.3888
    OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
    Taxonomic identifieri237561 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
    ProteomesiUP000000559: Unassembled WGS sequence

    Organism-specific databases

    CGDiCAL0002184. PGI1.

    Subcellular locationi

    Cytoplasm 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 550550Glucose-6-phosphate isomerasePRO_0000180572Add
    BLAST

    2D gel databases

    COMPLUYEAST-2DPAGEP83780.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi5476.CAL0002184.

    Structurei

    3D structure databases

    ProteinModelPortaliP83780.
    SMRiP83780. Positions 7-550.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GPI family.Curated

    Phylogenomic databases

    eggNOGiCOG0166.
    KOiK01810.
    OrthoDBiEOG7N0CDV.

    Family and domain databases

    Gene3Di1.10.1390.10. 1 hit.
    HAMAPiMF_00473. G6P_isomerase.
    InterProiIPR001672. G6P_Isomerase.
    IPR023096. G6P_Isomerase_C.
    IPR018189. Phosphoglucose_isomerase_CS.
    [Graphical view]
    PANTHERiPTHR11469. PTHR11469. 1 hit.
    PfamiPF00342. PGI. 1 hit.
    [Graphical view]
    PRINTSiPR00662. G6PISOMERASE.
    PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
    PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
    PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P83780-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASFKLATDL PEWKKLEETY KSVGEKFSVR DAFAKDPKRF EEFSWIYKNY    50
    DDSKILFDFS KNLVNKEILD QLVTLAKEAG VEKLRDAMFA GDHINTTEDR 100
    AVYHVALRNR ALRKMPVDGK DTAQEVDDVL KHMKEFSDSI RDGSWTGYTG 150
    KSITDVVNIG IGGSDLGPVM VTEALKAYSK PGLNVHFISN IDGTHTAETL 200
    KNLNPETTLF LIASKTFTTA ETITNATSAK NWFLATAKDS KHIAKHFAAL 250
    STNEKEVVAF GIDAKNMFGF ESWVGGRYSV WSAIGLSVAI YIGFENFNDF 300
    LKGAEAMDQH FLTTPLENNI PVIGGLLSVW YNNFFGAQTH LVVPFDQYLH 350
    RFPAYLQQLS MESNGKSVTR ANVFTNYQTG TILFGEPATN AQHSFFQLVH 400
    QGTKLIPADF ILAAQSHNPI EKNLHQRMLA SNFFAQSEAL MVGKDEAKVK 450
    AEGATGGLVP HKEFSGNRPT TSILAQKITP ATLGSLIAYY EHLTFTEGAI 500
    WNINSFDQWG VELGKVLAKV IGKELDDKKA VATHDASTNG LINQFKEWEE 550
    Length:550
    Mass (Da):61,186
    Last modified:March 3, 2009 - v2
    Checksum:i6E3C83DF9189887E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACQ01000125 Genomic DNA. Translation: EAK94404.1.
    AACQ01000124 Genomic DNA. Translation: EAK94449.1.
    RefSeqiXP_713513.1. XM_708420.1.
    XP_713554.1. XM_708461.1.

    Genome annotation databases

    GeneIDi3644831.
    3644847.
    KEGGical:CaO19.11369.
    cal:CaO19.3888.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACQ01000125 Genomic DNA. Translation: EAK94404.1 .
    AACQ01000124 Genomic DNA. Translation: EAK94449.1 .
    RefSeqi XP_713513.1. XM_708420.1.
    XP_713554.1. XM_708461.1.

    3D structure databases

    ProteinModelPortali P83780.
    SMRi P83780. Positions 7-550.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5476.CAL0002184.

    2D gel databases

    COMPLUYEAST-2DPAGE P83780.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 3644831.
    3644847.
    KEGGi cal:CaO19.11369.
    cal:CaO19.3888.

    Organism-specific databases

    CGDi CAL0002184. PGI1.

    Phylogenomic databases

    eggNOGi COG0166.
    KOi K01810.
    OrthoDBi EOG7N0CDV.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00181 .

    Family and domain databases

    Gene3Di 1.10.1390.10. 1 hit.
    HAMAPi MF_00473. G6P_isomerase.
    InterProi IPR001672. G6P_Isomerase.
    IPR023096. G6P_Isomerase_C.
    IPR018189. Phosphoglucose_isomerase_CS.
    [Graphical view ]
    PANTHERi PTHR11469. PTHR11469. 1 hit.
    Pfami PF00342. PGI. 1 hit.
    [Graphical view ]
    PRINTSi PR00662. G6PISOMERASE.
    PROSITEi PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
    PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
    PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SC5314 / ATCC MYA-2876.
    2. "Proteomics-based identification of novel Candida albicans antigens for diagnosis of systemic candidiasis in patients with underlying hematological malignancies."
      Pitarch A., Abian J., Carrascal M., Sanchez M., Nombela C., Gil C.
      Proteomics 4:3084-3106(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 89-100 AND 121-131, SUBCELLULAR LOCATION, ANTIGENICITY.
      Strain: SC5314 / ATCC MYA-2876.
      Tissue: Protoplast.

    Entry informationi

    Entry nameiG6PI_CANAL
    AccessioniPrimary (citable) accession number: P83780
    Secondary accession number(s): Q59V64
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 4, 2005
    Last sequence update: March 3, 2009
    Last modified: October 1, 2014
    This is version 56 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Has antigenic properties. Elicits a specific immune response in systemic candidiasis human patients undergoing malignant hematological disorders.

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Candida albicans
      Candida albicans: entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3