P83780 (G6PI_CANAL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glucose-6-phosphate isomerase
Short name=GPI
EC=5.3.1.9

Alternative name(s):
Phosphoglucose isomerase
Short name=PGI
Phosphohexose isomerase
Short name=PHI

Gene names

Name:	PGI1
ORF Names:	CaO19.3888, CaO19.11369

Organism

Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)

Taxonomic identifier

237561 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida

Protein attributes

Sequence length	550 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Catalytic activity	D-glucose 6-phosphate = D-fructose 6-phosphate.
Pathway	Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4.
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm Ref.2.
Miscellaneous	Has antigenic properties. Elicits a specific immune response in systemic candidiasis human patients undergoing malignant hematological disorders.
Sequence similarities	Belongs to the GPI family.

Ontologies

Keywords
Biological process	Gluconeogenesis Glycolysis
Cellular component	Cytoplasm
Molecular function	Isomerase
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	gluconeogenesis Inferred from electronic annotation. Source: UniProtKB-KW glycolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell soluble fraction Inferred from direct assay. Source: CGD
Molecular function	glucose-6-phosphate isomerase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 550	550	Glucose-6-phosphate isomerase		PRO_0000180572
Sites
	Active site	393	1	By similarity
	Active site	515	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	P83780 [UniParc]. Last modified March 3, 2009. Version 2. Checksum: 6E3C83DF9189887E	FASTA	550	61,186
	10 20 30 40 50 60 MASFKLATDL PEWKKLEETY KSVGEKFSVR DAFAKDPKRF EEFSWIYKNY DDSKILFDFS 70 80 90 100 110 120 KNLVNKEILD QLVTLAKEAG VEKLRDAMFA GDHINTTEDR AVYHVALRNR ALRKMPVDGK 130 140 150 160 170 180 DTAQEVDDVL KHMKEFSDSI RDGSWTGYTG KSITDVVNIG IGGSDLGPVM VTEALKAYSK 190 200 210 220 230 240 PGLNVHFISN IDGTHTAETL KNLNPETTLF LIASKTFTTA ETITNATSAK NWFLATAKDS 250 260 270 280 290 300 KHIAKHFAAL STNEKEVVAF GIDAKNMFGF ESWVGGRYSV WSAIGLSVAI YIGFENFNDF 310 320 330 340 350 360 LKGAEAMDQH FLTTPLENNI PVIGGLLSVW YNNFFGAQTH LVVPFDQYLH RFPAYLQQLS 370 380 390 400 410 420 MESNGKSVTR ANVFTNYQTG TILFGEPATN AQHSFFQLVH QGTKLIPADF ILAAQSHNPI 430 440 450 460 470 480 EKNLHQRMLA SNFFAQSEAL MVGKDEAKVK AEGATGGLVP HKEFSGNRPT TSILAQKITP 490 500 510 520 530 540 ATLGSLIAYY EHLTFTEGAI WNINSFDQWG VELGKVLAKV IGKELDDKKA VATHDASTNG 550 LINQFKEWEE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The diploid genome sequence of Candida albicans." Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S. Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed: 15123810] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314 / ATCC MYA-2876.
[2]	"Proteomics-based identification of novel Candida albicans antigens for diagnosis of systemic candidiasis in patients with underlying hematological malignancies." Pitarch A., Abian J., Carrascal M., Sanchez M., Nombela C., Gil C. Proteomics 4:3084-3106(2004) [PubMed: 15378761] [Abstract] Cited for: PROTEIN SEQUENCE OF 89-100 AND 121-131, SUBCELLULAR LOCATION, ANTIGENICITY. Strain: SC5314 / ATCC MYA-2876. Tissue: Protoplast.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AACQ01000125 Genomic DNA. Translation: EAK94404.1. AACQ01000124 Genomic DNA. Translation: EAK94449.1.
RefSeq	XP_713513.1. XM_708420.1. XP_713554.1. XM_708461.1.
3D structure databases
ProteinModelPortal	P83780.
SMR	P83780. Positions 7-550.
ModBase	Search...
Protein-protein interaction databases
STRING	P83780.
2D gel databases
COMPLUYEAST-2DPAGE	P83780.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3644831. 3644847.
KEGG	cal:CaO19.11369. cal:CaO19.3888.
Organism-specific databases
CGD	CAL0002184. PGI1.
Phylogenomic databases
OMA	NDFLKGA.
PhylomeDB	P83780.
Family and domain databases
InterPro	IPR001672. G6P_Isomerase. IPR023096. G6P_Isomerase_C. IPR018189. Phosphoglucose_isomerase_CS. [Graphical view]
Gene3D	G3DSA:1.10.1390.10. G6P_Isomerase_C. 1 hit.
KO	K01810.
PANTHER	PTHR11469. G6P_Isomerase. 1 hit.
Pfam	PF00342. PGI. 1 hit. [Graphical view]
PRINTS	PR00662. G6PISOMERASE.
PROSITE	PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit. PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit. PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

G6PI_CANAL

Accession

Primary (citable) accession number: P83780
Secondary accession number(s): Q59V64

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 4, 2005
Last sequence update:	March 3, 2009
Last modified:	January 25, 2012
This is version 38 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program