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Protein

Glucose-6-phosphate isomerase

Gene

PGI1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.

Pathway: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase (PGI1), Glucose-6-phosphate isomerase (I503_06048)
  3. ATP-dependent 6-phosphofructokinase (PFK2), ATP-dependent 6-phosphofructokinase (PFK1)
  4. Fructose-bisphosphate aldolase (FBA1)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei393 – 3931By similarity
Active sitei515 – 5151By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Gluconeogenesis, Glycolysis

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomerase (EC:5.3.1.9)
Short name:
GPI
Alternative name(s):
Phosphoglucose isomerase
Short name:
PGI
Phosphohexose isomerase
Short name:
PHI
Gene namesi
Name:PGI1
ORF Names:CaO19.11369, CaO19.3888
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
ProteomesiUP000000559 Componenti: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0002184. PGI1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 550550Glucose-6-phosphate isomerasePRO_0000180572Add
BLAST

2D gel databases

COMPLUYEAST-2DPAGEP83780.

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP83780.
SMRiP83780. Positions 7-550.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.Curated

Phylogenomic databases

eggNOGiCOG0166.
InParanoidiP83780.
KOiK01810.
OrthoDBiEOG7N0CDV.

Family and domain databases

Gene3Di1.10.1390.10. 1 hit.
HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P83780-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASFKLATDL PEWKKLEETY KSVGEKFSVR DAFAKDPKRF EEFSWIYKNY
60 70 80 90 100
DDSKILFDFS KNLVNKEILD QLVTLAKEAG VEKLRDAMFA GDHINTTEDR
110 120 130 140 150
AVYHVALRNR ALRKMPVDGK DTAQEVDDVL KHMKEFSDSI RDGSWTGYTG
160 170 180 190 200
KSITDVVNIG IGGSDLGPVM VTEALKAYSK PGLNVHFISN IDGTHTAETL
210 220 230 240 250
KNLNPETTLF LIASKTFTTA ETITNATSAK NWFLATAKDS KHIAKHFAAL
260 270 280 290 300
STNEKEVVAF GIDAKNMFGF ESWVGGRYSV WSAIGLSVAI YIGFENFNDF
310 320 330 340 350
LKGAEAMDQH FLTTPLENNI PVIGGLLSVW YNNFFGAQTH LVVPFDQYLH
360 370 380 390 400
RFPAYLQQLS MESNGKSVTR ANVFTNYQTG TILFGEPATN AQHSFFQLVH
410 420 430 440 450
QGTKLIPADF ILAAQSHNPI EKNLHQRMLA SNFFAQSEAL MVGKDEAKVK
460 470 480 490 500
AEGATGGLVP HKEFSGNRPT TSILAQKITP ATLGSLIAYY EHLTFTEGAI
510 520 530 540 550
WNINSFDQWG VELGKVLAKV IGKELDDKKA VATHDASTNG LINQFKEWEE
Length:550
Mass (Da):61,186
Last modified:March 3, 2009 - v2
Checksum:i6E3C83DF9189887E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACQ01000125 Genomic DNA. Translation: EAK94404.1.
AACQ01000124 Genomic DNA. Translation: EAK94449.1.
RefSeqiXP_713513.1. XM_708420.1.
XP_713554.1. XM_708461.1.

Genome annotation databases

GeneIDi3644831.
3644847.
KEGGical:CaO19.11369.
cal:CaO19.3888.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACQ01000125 Genomic DNA. Translation: EAK94404.1.
AACQ01000124 Genomic DNA. Translation: EAK94449.1.
RefSeqiXP_713513.1. XM_708420.1.
XP_713554.1. XM_708461.1.

3D structure databases

ProteinModelPortaliP83780.
SMRiP83780. Positions 7-550.
ModBaseiSearch...
MobiDBiSearch...

2D gel databases

COMPLUYEAST-2DPAGEP83780.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3644831.
3644847.
KEGGical:CaO19.11369.
cal:CaO19.3888.

Organism-specific databases

CGDiCAL0002184. PGI1.

Phylogenomic databases

eggNOGiCOG0166.
InParanoidiP83780.
KOiK01810.
OrthoDBiEOG7N0CDV.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181.

Family and domain databases

Gene3Di1.10.1390.10. 1 hit.
HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.
  2. "Proteomics-based identification of novel Candida albicans antigens for diagnosis of systemic candidiasis in patients with underlying hematological malignancies."
    Pitarch A., Abian J., Carrascal M., Sanchez M., Nombela C., Gil C.
    Proteomics 4:3084-3106(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 89-100 AND 121-131, SUBCELLULAR LOCATION, ANTIGENICITY.
    Strain: SC5314 / ATCC MYA-2876.
    Tissue: Protoplast.

Entry informationi

Entry nameiG6PI_CANAL
AccessioniPrimary (citable) accession number: P83780
Secondary accession number(s): Q59V64
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: March 3, 2009
Last modified: June 24, 2015
This is version 59 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Has antigenic properties. Elicits a specific immune response in systemic candidiasis human patients undergoing malignant hematological disorders.

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.