Reviewed, UniProtKB/Swiss-Prot P83778 (MDHC_CANAL)

Names and origin

Protein names

Recommended name:
    Malate dehydrogenase, cytoplasmic
    EC=1.1.1.37

Gene names

Name:

MDH2

Organism

Candida albicans (Yeast)

Taxonomic identifier

5476 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida

Protein attributes

Sequence length	51 AA.
Sequence status	Fragments.
Protein existence	Evidence at protein level.

General annotation (Comments)

Catalytic activity	(S)-malate + NAD+ = oxaloacetate + NADH.
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm Ref.1.
Miscellaneous	Has antigenic properties. Elicits a specific immune response in systemic candidiasis human patients undergoing malignant hematological disorders.
Sequence similarities	Belongs to the LDH/MDH superfamily. MDH type 1 family.

Ontologies

Keywords
Biological process	Tricarboxylic acid cycle
Cellular component	Cytoplasm
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	malate metabolic process Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW tricarboxylic acid cycle Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	L-malate dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – ›51	›51	Malate dehydrogenase, cytoplasmic		PRO_0000113337
Experimental info
	Non-adjacent residues	10 – 11	2
	Non-adjacent residues	27 – 28	2
	Non-adjacent residues	37 – 38	2
	Non-terminal residue	1	1
	Non-terminal residue	51	1

Sequences

	Sequence		Length	Mass (Da)
	P83778-1 [UniParc]. Last modified January 4, 2005. Version 1. Checksum: 0617C24C3C61ACAD	FASTA	51	5,229
	10 20 30 40 50 VTDLALYDIR PGVAADVSHV PTNSTVKLFN TNASIVRAGS ATLSMAQAGA R

References

[1]

"Proteomics-based identification of novel Candida albicans antigens for diagnosis of systemic candidiasis in patients with underlying hematological malignancies." Pitarch A., Abian J., Carrascal M., Sanchez M., Nombela C., Gil C. Proteomics 4:3084-3106(2004) [PubMed: 15378761] [Abstract] Cited for: PROTEIN SEQUENCE, SUBCELLULAR LOCATION, ANTIGENICITY. Strain: SC5314. Tissue: Protoplast.

Cross-references

3D structure databases
ModBase	Search...
Enzyme and pathway databases
BRENDA	1.1.1.37. 1124.
Family and domain databases
InterPro	IPR010097. Malate_DH_NAD-dep_euk/g-bac. [Graphical view]
PANTHER	PTHR11540:SF1. MDH_euk_g_bac. 1 hit.
PROSITE	PS00068. MDH. Partial match. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MDHC_CANAL

Accession

Primary (citable) accession number: P83778

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 4, 2005
Last sequence update:	January 4, 2005
Last modified:	November 24, 2009
This is version 22 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)