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P83778 (MDHC_CANAL) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Malate dehydrogenase, cytoplasmic

EC=1.1.1.37
Gene names
Name:MDH1
Synonyms:MDH2
ORF Names:CaO19.7481
OrganismCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]
Taxonomic identifier237561 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

Protein attributes

Sequence length337 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

(S)-malate + NAD+ = oxaloacetate + NADH.

Subunit structure

Homodimer By similarity.

Subcellular location

Cytoplasm Ref.2.

Miscellaneous

Has antigenic properties. Elicits a specific immune response in systemic candidiasis human patients undergoing malignant hematological disorders.

Sequence similarities

Belongs to the LDH/MDH superfamily. MDH type 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 337337Malate dehydrogenase, cytoplasmic
PRO_0000113337

Regions

Nucleotide binding8 – 147NAD By similarity
Nucleotide binding122 – 1243NAD By similarity

Sites

Active site1841Proton acceptor By similarity
Binding site341NAD By similarity
Binding site861Substrate By similarity
Binding site921Substrate By similarity
Binding site991NAD By similarity
Binding site1241Substrate By similarity
Binding site1581Substrate By similarity
Binding site2381NAD By similarity

Experimental info

Sequence conflict28 – 292DE → TD AA sequence Ref.2
Sequence conflict33 – 364FDVV → YDIR AA sequence Ref.2
Sequence conflict421G → A AA sequence Ref.2
Sequence conflict451L → V AA sequence Ref.2
Sequence conflict48 – 558INSDSKTQ → VPTNSTVK AA sequence Ref.2
Sequence conflict981I → T AA sequence Ref.2
Sequence conflict1041Q → R AA sequence Ref.2
Sequence conflict2401Y → Q AA sequence Ref.2
Sequence conflict2431Y → A AA sequence Ref.2

Sequences

Sequence LengthMass (Da)Tools
P83778 [UniParc].

Last modified October 19, 2011. Version 2.
Checksum: 0BB466CAA0010CE4

FASTA33736,004
        10         20         30         40         50         60 
MVKVAILGAA GGIGQPLSLL TKLNPNVDEL ALFDVVNVPG VGADLSHINS DSKTQSYLPK 

        70         80         90        100        110        120 
DKEDKTALAA ALKGSDLVII PAGVPRKPGM TRDDLFNINA SIVQGLAEGI AANSPKAFVL 

       130        140        150        160        170        180 
VISNPVNSTV PIVAETLQAK GVYDPARLFG VTTLDIVRAN TFISQLFLDQ TKPSDFNINV 

       190        200        210        220        230        240 
VGGHSGETIV PLYSLGNSKQ YYDILSEEQK KELIKRVQFG GDEVVQAKNG AGSATLSMAY 

       250        260        270        280        290        300 
AGYRLAESIL AAVNGKTDIV ECTFLNLDSS IKGASEARKL VKDLDFFSLP VQLGKNGITE 

       310        320        330 
VKYDILNQIS DDEKKLLEVA IEQLQKNIEK GVSFAKK 

« Hide

References

« Hide 'large scale' references
[1]"The diploid genome sequence of Candida albicans."
Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S.
Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SC5314 / ATCC MYA-2876.
[2]"Proteomics-based identification of novel Candida albicans antigens for diagnosis of systemic candidiasis in patients with underlying hematological malignancies."
Pitarch A., Abian J., Carrascal M., Sanchez M., Nombela C., Gil C.
Proteomics 4:3084-3106(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 27-36; 39-55; 95-104 AND 231-244, SUBCELLULAR LOCATION, ANTIGENICITY.
Strain: SC5314 / ATCC MYA-2876.
Tissue: Protoplast.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AACQ01000039 Genomic DNA. Translation: EAK99723.1.
RefSeqXP_718638.1. XM_713545.1.

3D structure databases

ProteinModelPortalP83778.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5476.CAL0005697.

2D gel databases

COMPLUYEAST-2DPAGEP83778.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3639667.
KEGGcal:CaO19.7481.

Organism-specific databases

CGDCAL0005697. MDH1.

Phylogenomic databases

eggNOGCOG0039.
KOK00026.
OrthoDBEOG7GJ6Q7.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
InterProIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR001252. Malate_DH_AS.
IPR010097. Malate_DH_type1.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERPTHR11540. PTHR11540. 1 hit.
PTHR11540:SF1. PTHR11540:SF1. 1 hit.
PfamPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFPIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMSSF56327. SSF56327. 1 hit.
TIGRFAMsTIGR01772. MDH_euk_gproteo. 1 hit.
PROSITEPS00068. MDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMDHC_CANAL
AccessionPrimary (citable) accession number: P83778
Secondary accession number(s): Q5AAK8
Entry history
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: October 19, 2011
Last modified: November 13, 2013
This is version 45 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Candida albicans

Candida albicans: entries and gene names