Reviewed,
UniProtKB/Swiss-Prot P83778 (MDHC_CANAL)
Last modified
November 24, 2009.
Version 22.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Malate dehydrogenase, cytoplasmic EC=1.1.1.37 | ||
| Gene names |
| ||
| Organism | Candida albicans (Yeast) | ||
| Taxonomic identifier | 5476 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida |
Protein attributes
| Sequence length | 51 AA. |
| Sequence status | Fragments. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Catalytic activity | (S)-malate + NAD+ = oxaloacetate + NADH. |
| Subunit structure | Homodimer By similarity. |
| Subcellular location | |
| Miscellaneous | Has antigenic properties. Elicits a specific immune response in systemic candidiasis human patients undergoing malignant hematological disorders. |
| Sequence similarities | Belongs to the LDH/MDH superfamily. MDH type 1 family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Tricarboxylic acid cycle |
| Cellular component | Cytoplasm |
| Ligand | NAD |
| Molecular function | Oxidoreductase |
| Technical term | Direct protein sequencing |
| Gene Ontology (GO) | |
| Biological process | malate metabolic process Inferred from electronic annotation. Source: InterPro oxidation reductionInferred from electronic annotation. Source: UniProtKB-KW tricarboxylic acid cycleInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | L-malate dehydrogenase activity Inferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | ‹1 – ›51 | ›51 | Malate dehydrogenase, cytoplasmic | PRO_0000113337 | |||||
Experimental info | |||||||||
| Non-adjacent residues | 10 – 11 | 2 | |||||||
| Non-adjacent residues | 27 – 28 | 2 | |||||||
| Non-adjacent residues | 37 – 38 | 2 | |||||||
| Non-terminal residue | 1 | 1 | |||||||
| Non-terminal residue | 51 | 1 | |||||||
Sequences
References
| [1] | "Proteomics-based identification of novel Candida albicans antigens for diagnosis of systemic candidiasis in patients with underlying hematological malignancies." Pitarch A., Abian J., Carrascal M., Sanchez M., Nombela C., Gil C. Proteomics 4:3084-3106(2004) [PubMed: 15378761] [Abstract] Cited for: PROTEIN SEQUENCE, SUBCELLULAR LOCATION, ANTIGENICITY. Strain: SC5314. Tissue: Protoplast. |
Cross-references
3D structure databases | |
|---|---|
| ModBase | Search... |
Enzyme and pathway databases | |
| BRENDA | 1.1.1.37. 1124. |
Family and domain databases | |
| InterPro | IPR010097. Malate_DH_NAD-dep_euk/g-bac. [Graphical view] |
| PANTHER | PTHR11540:SF1. MDH_euk_g_bac. 1 hit. |
| PROSITE | PS00068. MDH. Partial match. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | MDHC_CANAL | ||||||||
| Accession | Primary (citable) accession number: P83778 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | FPAP (Fungal Proteome Annotation Project) | ||||||||
Relevant documents
| Candida albicans Candida albicans: entries and gene names |
| SIMILARITY comments Index of protein domains and families |

Clusters with


