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Protein

Malate dehydrogenase, cytoplasmic

Gene

MDH1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei34NADBy similarity1
Binding sitei86SubstratePROSITE-ProRule annotation1
Binding sitei92SubstratePROSITE-ProRule annotation1
Binding sitei99NADBy similarity1
Binding sitei124SubstratePROSITE-ProRule annotation1
Binding sitei158SubstratePROSITE-ProRule annotation1
Active sitei184Proton acceptorBy similarity1
Binding sitei238NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi8 – 14NADBy similarity7
Nucleotide bindingi122 – 124NADBy similarity3

GO - Molecular functioni

  • L-malate dehydrogenase activity Source: UniProtKB-EC
  • malate dehydrogenase activity Source: CGD

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenase, cytoplasmic (EC:1.1.1.37)
Gene namesi
Name:MDH1
Synonyms:MDH2
ORF Names:CaO19.7481
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
Proteomesi
  • UP000000559 Componenti: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0000181993. MDH1.
EuPathDBiFungiDB:CR_00540C_A.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: EnsemblFungi
  • mitochondrion Source: CGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001133371 – 337Malate dehydrogenase, cytoplasmicAdd BLAST337

Proteomic databases

PRIDEiP83778.

2D gel databases

COMPLUYEAST-2DPAGEP83778.

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP83778.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 1 family.Curated

Phylogenomic databases

InParanoidiP83778.
KOiK00026.
OrthoDBiEOG092C34N7.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR001252. Malate_DH_AS.
IPR010097. Malate_DH_type1.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01772. MDH_euk_gproteo. 1 hit.
PROSITEiPS00068. MDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P83778-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVKVAILGAA GGIGQPLSLL TKLNPNVDEL ALFDVVNVPG VGADLSHINS
60 70 80 90 100
DSKTQSYLPK DKEDKTALAA ALKGSDLVII PAGVPRKPGM TRDDLFNINA
110 120 130 140 150
SIVQGLAEGI AANSPKAFVL VISNPVNSTV PIVAETLQAK GVYDPARLFG
160 170 180 190 200
VTTLDIVRAN TFISQLFLDQ TKPSDFNINV VGGHSGETIV PLYSLGNSKQ
210 220 230 240 250
YYDILSEEQK KELIKRVQFG GDEVVQAKNG AGSATLSMAY AGYRLAESIL
260 270 280 290 300
AAVNGKTDIV ECTFLNLDSS IKGASEARKL VKDLDFFSLP VQLGKNGITE
310 320 330
VKYDILNQIS DDEKKLLEVA IEQLQKNIEK GVSFAKK
Length:337
Mass (Da):36,004
Last modified:October 19, 2011 - v2
Checksum:i0BB466CAA0010CE4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti28 – 29DE → TD AA sequence (PubMed:15378761).Curated2
Sequence conflicti33 – 36FDVV → YDIR AA sequence (PubMed:15378761).Curated4
Sequence conflicti42G → A AA sequence (PubMed:15378761).Curated1
Sequence conflicti45L → V AA sequence (PubMed:15378761).Curated1
Sequence conflicti48 – 55INSDSKTQ → VPTNSTVK AA sequence (PubMed:15378761).Curated8
Sequence conflicti98I → T AA sequence (PubMed:15378761).Curated1
Sequence conflicti104Q → R AA sequence (PubMed:15378761).Curated1
Sequence conflicti240Y → Q AA sequence (PubMed:15378761).Curated1
Sequence conflicti243Y → A AA sequence (PubMed:15378761).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACQ01000039 Genomic DNA. Translation: EAK99723.1.
RefSeqiXP_718638.1. XM_713545.1.

Genome annotation databases

EnsemblFungiiEAK99723; EAK99723; CaO19.7481.
GeneIDi3639667.
KEGGical:CaO19.7481.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACQ01000039 Genomic DNA. Translation: EAK99723.1.
RefSeqiXP_718638.1. XM_713545.1.

3D structure databases

ProteinModelPortaliP83778.
ModBaseiSearch...
MobiDBiSearch...

2D gel databases

COMPLUYEAST-2DPAGEP83778.

Proteomic databases

PRIDEiP83778.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEAK99723; EAK99723; CaO19.7481.
GeneIDi3639667.
KEGGical:CaO19.7481.

Organism-specific databases

CGDiCAL0000181993. MDH1.
EuPathDBiFungiDB:CR_00540C_A.

Phylogenomic databases

InParanoidiP83778.
KOiK00026.
OrthoDBiEOG092C34N7.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR001252. Malate_DH_AS.
IPR010097. Malate_DH_type1.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01772. MDH_euk_gproteo. 1 hit.
PROSITEiPS00068. MDH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMDHC_CANAL
AccessioniPrimary (citable) accession number: P83778
Secondary accession number(s): Q5AAK8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: October 19, 2011
Last modified: November 30, 2016
This is version 59 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Has antigenic properties. Elicits a specific immune response in systemic candidiasis human patients undergoing malignant hematological disorders.

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.