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P83778

- MDHC_CANAL

UniProt

P83778 - MDHC_CANAL

Protein

Malate dehydrogenase, cytoplasmic

Gene

MDH1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 2 (19 Oct 2011)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    (S)-malate + NAD+ = oxaloacetate + NADH.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei34 – 341NADBy similarity
    Binding sitei86 – 861SubstratePROSITE-ProRule annotation
    Binding sitei92 – 921SubstratePROSITE-ProRule annotation
    Binding sitei99 – 991NADBy similarity
    Binding sitei124 – 1241SubstratePROSITE-ProRule annotation
    Binding sitei158 – 1581SubstratePROSITE-ProRule annotation
    Active sitei184 – 1841Proton acceptorBy similarity
    Binding sitei238 – 2381NADBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi8 – 147NADBy similarity
    Nucleotide bindingi122 – 1243NADBy similarity

    GO - Molecular functioni

    1. L-malate dehydrogenase activity Source: UniProtKB-EC
    2. malate dehydrogenase activity Source: CGD

    GO - Biological processi

    1. cellular carbohydrate metabolic process Source: InterPro
    2. malate metabolic process Source: InterPro
    3. tricarboxylic acid cycle Source: CGD

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Tricarboxylic acid cycle

    Keywords - Ligandi

    NAD

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Malate dehydrogenase, cytoplasmic (EC:1.1.1.37)
    Gene namesi
    Name:MDH1
    Synonyms:MDH2
    ORF Names:CaO19.7481
    OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
    Taxonomic identifieri237561 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
    ProteomesiUP000000559: Unassembled WGS sequence

    Organism-specific databases

    CGDiCAL0005697. MDH1.

    Subcellular locationi

    Cytoplasm 1 Publication

    GO - Cellular componenti

    1. mitochondrion Source: CGD

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 337337Malate dehydrogenase, cytoplasmicPRO_0000113337Add
    BLAST

    2D gel databases

    COMPLUYEAST-2DPAGEP83778.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi5476.CAL0005697.

    Structurei

    3D structure databases

    ProteinModelPortaliP83778.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LDH/MDH superfamily. MDH type 1 family.Curated

    Phylogenomic databases

    eggNOGiCOG0039.
    KOiK00026.
    OrthoDBiEOG7GJ6Q7.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    3.90.110.10. 1 hit.
    InterProiIPR001557. L-lactate/malate_DH.
    IPR022383. Lactate/malate_DH_C.
    IPR001236. Lactate/malate_DH_N.
    IPR015955. Lactate_DH/Glyco_Ohase_4_C.
    IPR001252. Malate_DH_AS.
    IPR010097. Malate_DH_type1.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR11540. PTHR11540. 1 hit.
    PfamiPF02866. Ldh_1_C. 1 hit.
    PF00056. Ldh_1_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
    SUPFAMiSSF56327. SSF56327. 1 hit.
    TIGRFAMsiTIGR01772. MDH_euk_gproteo. 1 hit.
    PROSITEiPS00068. MDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P83778-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVKVAILGAA GGIGQPLSLL TKLNPNVDEL ALFDVVNVPG VGADLSHINS    50
    DSKTQSYLPK DKEDKTALAA ALKGSDLVII PAGVPRKPGM TRDDLFNINA 100
    SIVQGLAEGI AANSPKAFVL VISNPVNSTV PIVAETLQAK GVYDPARLFG 150
    VTTLDIVRAN TFISQLFLDQ TKPSDFNINV VGGHSGETIV PLYSLGNSKQ 200
    YYDILSEEQK KELIKRVQFG GDEVVQAKNG AGSATLSMAY AGYRLAESIL 250
    AAVNGKTDIV ECTFLNLDSS IKGASEARKL VKDLDFFSLP VQLGKNGITE 300
    VKYDILNQIS DDEKKLLEVA IEQLQKNIEK GVSFAKK 337
    Length:337
    Mass (Da):36,004
    Last modified:October 19, 2011 - v2
    Checksum:i0BB466CAA0010CE4
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti28 – 292DE → TD AA sequence (PubMed:15378761)Curated
    Sequence conflicti33 – 364FDVV → YDIR AA sequence (PubMed:15378761)Curated
    Sequence conflicti42 – 421G → A AA sequence (PubMed:15378761)Curated
    Sequence conflicti45 – 451L → V AA sequence (PubMed:15378761)Curated
    Sequence conflicti48 – 558INSDSKTQ → VPTNSTVK AA sequence (PubMed:15378761)Curated
    Sequence conflicti98 – 981I → T AA sequence (PubMed:15378761)Curated
    Sequence conflicti104 – 1041Q → R AA sequence (PubMed:15378761)Curated
    Sequence conflicti240 – 2401Y → Q AA sequence (PubMed:15378761)Curated
    Sequence conflicti243 – 2431Y → A AA sequence (PubMed:15378761)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACQ01000039 Genomic DNA. Translation: EAK99723.1.
    RefSeqiXP_718638.1. XM_713545.1.

    Genome annotation databases

    GeneIDi3639667.
    KEGGical:CaO19.7481.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACQ01000039 Genomic DNA. Translation: EAK99723.1 .
    RefSeqi XP_718638.1. XM_713545.1.

    3D structure databases

    ProteinModelPortali P83778.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5476.CAL0005697.

    2D gel databases

    COMPLUYEAST-2DPAGE P83778.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 3639667.
    KEGGi cal:CaO19.7481.

    Organism-specific databases

    CGDi CAL0005697. MDH1.

    Phylogenomic databases

    eggNOGi COG0039.
    KOi K00026.
    OrthoDBi EOG7GJ6Q7.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    3.90.110.10. 1 hit.
    InterProi IPR001557. L-lactate/malate_DH.
    IPR022383. Lactate/malate_DH_C.
    IPR001236. Lactate/malate_DH_N.
    IPR015955. Lactate_DH/Glyco_Ohase_4_C.
    IPR001252. Malate_DH_AS.
    IPR010097. Malate_DH_type1.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR11540. PTHR11540. 1 hit.
    Pfami PF02866. Ldh_1_C. 1 hit.
    PF00056. Ldh_1_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
    SUPFAMi SSF56327. SSF56327. 1 hit.
    TIGRFAMsi TIGR01772. MDH_euk_gproteo. 1 hit.
    PROSITEi PS00068. MDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SC5314 / ATCC MYA-2876.
    2. "Proteomics-based identification of novel Candida albicans antigens for diagnosis of systemic candidiasis in patients with underlying hematological malignancies."
      Pitarch A., Abian J., Carrascal M., Sanchez M., Nombela C., Gil C.
      Proteomics 4:3084-3106(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 27-36; 39-55; 95-104 AND 231-244, SUBCELLULAR LOCATION, ANTIGENICITY.
      Strain: SC5314 / ATCC MYA-2876.
      Tissue: Protoplast.

    Entry informationi

    Entry nameiMDHC_CANAL
    AccessioniPrimary (citable) accession number: P83778
    Secondary accession number(s): Q5AAK8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 4, 2005
    Last sequence update: October 19, 2011
    Last modified: October 1, 2014
    This is version 47 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Has antigenic properties. Elicits a specific immune response in systemic candidiasis human patients undergoing malignant hematological disorders.

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Candida albicans
      Candida albicans: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3