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Protein

Malate dehydrogenase, cytoplasmic

Gene

MDH1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

Has antigenic properties. Elicits a specific immune response in systemic candidiasis human patients undergoing malignant hematological disorders.

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei34NADBy similarity1
Binding sitei86SubstratePROSITE-ProRule annotation1
Binding sitei92SubstratePROSITE-ProRule annotation1
Binding sitei99NADBy similarity1
Binding sitei124SubstratePROSITE-ProRule annotation1
Binding sitei158SubstratePROSITE-ProRule annotation1
Active sitei184Proton acceptorBy similarity1
Binding sitei238NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi8 – 14NADBy similarity7
Nucleotide bindingi122 – 124NADBy similarity3

GO - Molecular functioni

  • L-malate dehydrogenase activity Source: UniProtKB-EC
  • malate dehydrogenase activity Source: CGD

GO - Biological processi

  • carbohydrate metabolic process Source: InterPro
  • malate metabolic process Source: InterPro
  • tricarboxylic acid cycle Source: CGD

Keywordsi

Molecular functionOxidoreductase
Biological processTricarboxylic acid cycle
LigandNAD

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenase, cytoplasmic (EC:1.1.1.37)
Gene namesi
Name:MDH1
Synonyms:MDH2
Ordered Locus Names:CAALFM_CR00540CA
ORF Names:CaO19.7481
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
Proteomesi
  • UP000000559 Componenti: Chromosome R

Organism-specific databases

CGDiCAL0000181993 MDH1
EuPathDBiFungiDB:CR_00540C_A

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001133371 – 337Malate dehydrogenase, cytoplasmicAdd BLAST337

Proteomic databases

PRIDEiP83778

2D gel databases

COMPLUYEAST-2DPAGEiP83778

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP83778
SMRiP83778
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 1 family.Curated

Phylogenomic databases

InParanoidiP83778
KOiK00026
OMAiCTFLNLD
OrthoDBiEOG092C34N7

Family and domain databases

Gene3Di3.90.110.101 hit
InterProiView protein in InterPro
IPR001557 L-lactate/malate_DH
IPR022383 Lactate/malate_DH_C
IPR001236 Lactate/malate_DH_N
IPR015955 Lactate_DH/Glyco_Ohase_4_C
IPR001252 Malate_DH_AS
IPR010097 Malate_DH_type1
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF02866 Ldh_1_C, 1 hit
PF00056 Ldh_1_N, 1 hit
PIRSFiPIRSF000102 Lac_mal_DH, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
SSF56327 SSF56327, 1 hit
TIGRFAMsiTIGR01772 MDH_euk_gproteo, 1 hit
PROSITEiView protein in PROSITE
PS00068 MDH, 1 hit

Sequencei

Sequence statusi: Complete.

P83778-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVKVAILGAA GGIGQPLSLL TKLNPNVDEL ALFDVVNVPG VGADLSHINS
60 70 80 90 100
DSKTQSYLPK DKEDKTALAA ALKGSDLVII PAGVPRKPGM TRDDLFNINA
110 120 130 140 150
SIVQGLAEGI AANSPKAFVL VISNPVNSTV PIVAETLQAK GVYDPARLFG
160 170 180 190 200
VTTLDIVRAN TFISQLFLDQ TKPSDFNINV VGGHSGETIV PLYSLGNSKQ
210 220 230 240 250
YYDILSEEQK KELIKRVQFG GDEVVQAKNG AGSATLSMAY AGYRLAESIL
260 270 280 290 300
AAVNGKTDIV ECTFLNLDSS IKGASEARKL VKDLDFFSLP VQLGKNGITE
310 320 330
VKYDILNQIS DDEKKLLEVA IEQLQKNIEK GVSFAKK
Length:337
Mass (Da):36,004
Last modified:October 19, 2011 - v2
Checksum:i0BB466CAA0010CE4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti28 – 29DE → TD AA sequence (PubMed:15378761).Curated2
Sequence conflicti33 – 36FDVV → YDIR AA sequence (PubMed:15378761).Curated4
Sequence conflicti42G → A AA sequence (PubMed:15378761).Curated1
Sequence conflicti45L → V AA sequence (PubMed:15378761).Curated1
Sequence conflicti48 – 55INSDSKTQ → VPTNSTVK AA sequence (PubMed:15378761).Curated8
Sequence conflicti98I → T AA sequence (PubMed:15378761).Curated1
Sequence conflicti104Q → R AA sequence (PubMed:15378761).Curated1
Sequence conflicti240Y → Q AA sequence (PubMed:15378761).Curated1
Sequence conflicti243Y → A AA sequence (PubMed:15378761).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP017630 Genomic DNA Translation: AOW30823.1
RefSeqiXP_718638.1, XM_713545.1

Genome annotation databases

EnsemblFungiiAOW30823; AOW30823; CAALFM_CR00540CA
GeneIDi3639667
KEGGical:CAALFM_CR00540CA

Similar proteinsi

Entry informationi

Entry nameiMDHC_CANAL
AccessioniPrimary (citable) accession number: P83778
Secondary accession number(s): A0A1D8PRT1, Q5AAK8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: October 19, 2011
Last modified: March 28, 2018
This is version 67 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome