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Protein

Hexokinase-2

Gene

HXK2

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Main glucose phosphorylating enzyme. May play a regulatory role in both induction and repression of gene expression by glucose (By similarity).By similarity

Catalytic activityi

ATP + D-hexose = ADP + D-hexose 6-phosphate.

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. hexokinase activity Source: UniProtKB-EC
  3. N-acetylglucosamine kinase activity Source: CGD

GO - Biological processi

  1. adhesion of symbiont to host Source: CGD
  2. carbohydrate phosphorylation Source: GOC
  3. development of symbiont in host Source: CGD
  4. filamentous growth Source: CGD
  5. filamentous growth of a population of unicellular organisms Source: CGD
  6. glucosamine catabolic process Source: CGD
  7. glycolytic process Source: UniProtKB-KW
  8. growth of symbiont in host Source: CGD
  9. hexose metabolic process Source: UniProtKB-UniPathway
  10. hyphal growth Source: CGD
  11. N-acetylglucosamine catabolic process Source: CGD
  12. pathogenesis Source: CGD
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00242.

Names & Taxonomyi

Protein namesi
Recommended name:
Hexokinase-2 (EC:2.7.1.1)
Alternative name(s):
Cytoplasmic antigenic protein 3
Hexokinase PII
Hexokinase-B
Gene namesi
Name:HXK2
ORF Names:CaO19.542, CaO19.8176
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
ProteomesiUP000000559: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0000198. HXK2.
CAL0078705. HXK2.

Subcellular locationi

Cytoplasm 1 Publication

GO - Cellular componenti

  1. cytosol Source: CGD
  2. mitochondrion Source: CGD
  3. nucleus Source: CGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 484484Hexokinase-2PRO_0000089303Add
BLAST

2D gel databases

COMPLUYEAST-2DPAGEP83776.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi5476.CAL0000198.

Structurei

3D structure databases

ProteinModelPortaliP83776.
SMRiP83776. Positions 18-484.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the hexokinase family.Curated

Phylogenomic databases

eggNOGiCOG5026.
InParanoidiP83776.
KOiK00844.
OrthoDBiEOG79SF68.

Family and domain databases

InterProiIPR001312. Hexokinase.
IPR022673. Hexokinase_C.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiPF00349. Hexokinase_1. 1 hit.
PF03727. Hexokinase_2. 1 hit.
[Graphical view]
PRINTSiPR00475. HEXOKINASE.

Sequencei

Sequence statusi: Complete.

P83776-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVHLGPKPAQ KRKGTFTDVS PQLLEALKPI QEQFTISADK LRAIVKHFIS
60 70 80 90 100
ELDRGLSKAG GNIPMIPGWV MDFPTGKETG SYLAIDLGGT NLRVVLVKLG
110 120 130 140 150
GNRDFDTTQS KFALPAHMRT ATSDELWDFI AKCLKEFVDE IYPDGCSEPL
160 170 180 190 200
PLGFTFSYPA SQNRINEGIL QRWTKGWSID GIEGKDVVPM LQKAIKKVGV
210 220 230 240 250
PIDVVALIND TTGTLVASMY TDPEAKMGLI FGTGVNGAYF DVVKDIPKLE
260 270 280 290 300
GKCPSDIPPE SPMAINCEYG SFDNEKYILP RTKYDVQIDE ESPRPGQQTF
310 320 330 340 350
EKMISGYYLG EVLRLILLEF AEEKKLIFKG QNLDKLKVPY VMDASYPSKI
360 370 380 390 400
EEDPFENLSD VADLFREKLG IETTEPERKI IRCLAELIGE RSARFSVCGI
410 420 430 440 450
AAICQKRGYK TAHCAADGSV YNKYPGFKER TAQALRDIYE WPADVKDPII
460 470 480
IVPAEDGSGV GAAVIAALTE KRLKEGKSVG LLGA
Length:484
Mass (Da):53,416
Last modified:October 19, 2011 - v2
Checksum:i7248469B1536C23A
GO

Sequence cautioni

The sequence EAK98532.1 differs from that shown. Reason: Frameshift at positions 62 and 67. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti64 – 652PM → LK in allele CaO19.8176.
Natural varianti72 – 721D → I in allele CaO19.8176.
Natural varianti100 – 1001G → A in allele CaO19.8176.
Natural varianti383 – 3831C → R in allele CaO19.8176.
Natural varianti410 – 4101K → E in allele CaO19.8176.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACQ01000054 Genomic DNA. Translation: EAK98532.1. Frameshift.
AACQ01000055 Genomic DNA. Translation: EAK98436.1.
RefSeqiXP_717405.1. XM_712312.1.
XP_717498.1. XM_712405.1.

Genome annotation databases

GeneIDi3640936.
3641015.
KEGGical:CaO19.542.
cal:CaO19.8176.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACQ01000054 Genomic DNA. Translation: EAK98532.1. Frameshift.
AACQ01000055 Genomic DNA. Translation: EAK98436.1.
RefSeqiXP_717405.1. XM_712312.1.
XP_717498.1. XM_712405.1.

3D structure databases

ProteinModelPortaliP83776.
SMRiP83776. Positions 18-484.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi5476.CAL0000198.

2D gel databases

COMPLUYEAST-2DPAGEP83776.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3640936.
3641015.
KEGGical:CaO19.542.
cal:CaO19.8176.

Organism-specific databases

CGDiCAL0000198. HXK2.
CAL0078705. HXK2.

Phylogenomic databases

eggNOGiCOG5026.
InParanoidiP83776.
KOiK00844.
OrthoDBiEOG79SF68.

Enzyme and pathway databases

UniPathwayiUPA00242.

Family and domain databases

InterProiIPR001312. Hexokinase.
IPR022673. Hexokinase_C.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiPF00349. Hexokinase_1. 1 hit.
PF03727. Hexokinase_2. 1 hit.
[Graphical view]
PRINTSiPR00475. HEXOKINASE.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.
  2. "Proteomics-based identification of novel Candida albicans antigens for diagnosis of systemic candidiasis in patients with underlying hematological malignancies."
    Pitarch A., Abian J., Carrascal M., Sanchez M., Nombela C., Gil C.
    Proteomics 4:3084-3106(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 176-185 AND 317-325, SUBCELLULAR LOCATION, ANTIGENICITY.
    Strain: SC5314 / ATCC MYA-2876.
    Tissue: Protoplast.

Entry informationi

Entry nameiHXKB_CANAL
AccessioniPrimary (citable) accession number: P83776
Secondary accession number(s): Q5A6L2, Q5A6V6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: October 19, 2011
Last modified: January 7, 2015
This is version 36 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Has antigenic properties. Elicits a specific immune response in systemic candidiasis human patients undergoing malignant hematological disorders.

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.