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Protein

Hexokinase-2

Gene

HXK2

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Main glucose phosphorylating enzyme. May play a regulatory role in both induction and repression of gene expression by glucose (By similarity).By similarity

Catalytic activityi

ATP + D-hexose = ADP + D-hexose 6-phosphate.

Pathwayi: hexose metabolism

This protein is involved in the pathway hexose metabolism, which is part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the pathway hexose metabolism and in Carbohydrate metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processGlycolysis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00242.

Names & Taxonomyi

Protein namesi
Recommended name:
Hexokinase-2 (EC:2.7.1.1)
Alternative name(s):
Cytoplasmic antigenic protein 3
Hexokinase PII
Hexokinase-B
Gene namesi
Name:HXK2
Ordered Locus Names:CAALFM_CR04510WA
ORF Names:CaO19.542, CaO19.8176
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
Proteomesi
  • UP000000559 Componenti: Chromosome R

Organism-specific databases

CGDiCAL0000189097. HXK2.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000893031 – 484Hexokinase-2Add BLAST484

Proteomic databases

PRIDEiP83776.

2D gel databases

COMPLUYEAST-2DPAGEP83776.

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP83776.
SMRiP83776.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini21 – 467HexokinasePROSITE-ProRule annotationAdd BLAST447

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni75 – 208Hexokinase small subdomainPROSITE-ProRule annotationAdd BLAST134
Regioni209 – 456Hexokinase large subdomainPROSITE-ProRule annotationAdd BLAST248

Sequence similaritiesi

Belongs to the hexokinase family.PROSITE-ProRule annotationCurated

Phylogenomic databases

InParanoidiP83776.
KOiK00844.
OrthoDBiEOG092C2JW4.

Family and domain databases

InterProiView protein in InterPro
IPR001312. Hexokinase.
IPR022673. Hexokinase_C.
IPR022672. Hexokinase_N.
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiView protein in Pfam
PF00349. Hexokinase_1. 1 hit.
PF03727. Hexokinase_2. 1 hit.
PROSITEiView protein in PROSITE
PS51748. HEXOKINASE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P83776-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVHLGPKPAQ KRKGTFTDVS PQLLEALKPI QEQFTISADK LRAIVKHFIS
60 70 80 90 100
ELDRGLSKAG GNIPMIPGWV MDFPTGKETG SYLAIDLGGT NLRVVLVKLG
110 120 130 140 150
GNRDFDTTQS KFALPAHMRT ATSDELWDFI AKCLKEFVDE IYPDGCSEPL
160 170 180 190 200
PLGFTFSYPA SQNRINEGIL QRWTKGWSID GIEGKDVVPM LQKAIKKVGV
210 220 230 240 250
PIDVVALIND TTGTLVASMY TDPEAKMGLI FGTGVNGAYF DVVKDIPKLE
260 270 280 290 300
GKCPSDIPPE SPMAINCEYG SFDNEKYILP RTKYDVQIDE ESPRPGQQTF
310 320 330 340 350
EKMISGYYLG EVLRLILLEF AEEKKLIFKG QNLDKLKVPY VMDASYPSKI
360 370 380 390 400
EEDPFENLSD VADLFREKLG IETTEPERKI IRCLAELIGE RSARFSVCGI
410 420 430 440 450
AAICQKRGYK TAHCAADGSV YNKYPGFKER TAQALRDIYE WPADVKDPII
460 470 480
IVPAEDGSGV GAAVIAALTE KRLKEGKSVG LLGA
Length:484
Mass (Da):53,416
Last modified:October 19, 2011 - v2
Checksum:i7248469B1536C23A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP017630 Genomic DNA. Translation: AOW31187.1.
RefSeqiXP_717405.1. XM_712312.1.

Genome annotation databases

EnsemblFungiiEAK98436; EAK98436; CaO19.542.
EAK98532; EAK98532; CaO19.8176.
GeneIDi3641015.
KEGGical:CaO19.542.
cal:CaO19.8176.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP017630 Genomic DNA. Translation: AOW31187.1.
RefSeqiXP_717405.1. XM_712312.1.

3D structure databases

ProteinModelPortaliP83776.
SMRiP83776.
ModBaseiSearch...
MobiDBiSearch...

2D gel databases

COMPLUYEAST-2DPAGEP83776.

Proteomic databases

PRIDEiP83776.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEAK98436; EAK98436; CaO19.542.
EAK98532; EAK98532; CaO19.8176.
GeneIDi3641015.
KEGGical:CaO19.542.
cal:CaO19.8176.

Organism-specific databases

CGDiCAL0000189097. HXK2.

Phylogenomic databases

InParanoidiP83776.
KOiK00844.
OrthoDBiEOG092C2JW4.

Enzyme and pathway databases

UniPathwayiUPA00242.

Family and domain databases

InterProiView protein in InterPro
IPR001312. Hexokinase.
IPR022673. Hexokinase_C.
IPR022672. Hexokinase_N.
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiView protein in Pfam
PF00349. Hexokinase_1. 1 hit.
PF03727. Hexokinase_2. 1 hit.
PROSITEiView protein in PROSITE
PS51748. HEXOKINASE_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiHXKB_CANAL
AccessioniPrimary (citable) accession number: P83776
Secondary accession number(s): A0A1D8PSR8, Q5A6L2, Q5A6V6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: October 19, 2011
Last modified: March 15, 2017
This is version 48 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Has antigenic properties. Elicits a specific immune response in systemic candidiasis human patients undergoing malignant hematological disorders.

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.