Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P83776

- HXKB_CANAL

UniProt

P83776 - HXKB_CANAL

Protein

Hexokinase-2

Gene

HXK2

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 34 (01 Oct 2014)
      Sequence version 2 (19 Oct 2011)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Main glucose phosphorylating enzyme. May play a regulatory role in both induction and repression of gene expression by glucose By similarity.By similarity

    Catalytic activityi

    ATP + D-hexose = ADP + D-hexose 6-phosphate.

    Pathwayi

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. hexokinase activity Source: CGD
    3. N-acetylglucosamine kinase activity Source: CGD

    GO - Biological processi

    1. adhesion of symbiont to host Source: CGD
    2. carbohydrate phosphorylation Source: GOC
    3. development of symbiont in host Source: CGD
    4. filamentous growth Source: CGD
    5. filamentous growth of a population of unicellular organisms Source: CGD
    6. glucosamine catabolic process Source: CGD
    7. glycolytic process Source: UniProtKB-KW
    8. growth of symbiont in host Source: CGD
    9. hexose metabolic process Source: UniProtKB-UniPathway
    10. hyphal growth Source: CGD
    11. N-acetylglucosamine catabolic process Source: CGD
    12. pathogenesis Source: CGD

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00242.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hexokinase-2 (EC:2.7.1.1)
    Alternative name(s):
    Cytoplasmic antigenic protein 3
    Hexokinase PII
    Hexokinase-B
    Gene namesi
    Name:HXK2
    ORF Names:CaO19.542, CaO19.8176
    OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
    Taxonomic identifieri237561 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
    ProteomesiUP000000559: Unassembled WGS sequence

    Organism-specific databases

    CGDiCAL0000198. HXK2.
    CAL0078705. HXK2.

    Subcellular locationi

    Cytoplasm 1 Publication

    GO - Cellular componenti

    1. cytosol Source: CGD
    2. mitochondrion Source: CGD
    3. nucleus Source: CGD

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 484484Hexokinase-2PRO_0000089303Add
    BLAST

    2D gel databases

    COMPLUYEAST-2DPAGEP83776.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi5476.CAL0000198.

    Structurei

    3D structure databases

    ProteinModelPortaliP83776.
    SMRiP83776. Positions 18-484.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the hexokinase family.Curated

    Phylogenomic databases

    eggNOGiCOG5026.
    KOiK00844.
    OrthoDBiEOG79SF68.

    Family and domain databases

    InterProiIPR001312. Hexokinase.
    IPR022673. Hexokinase_C.
    IPR022672. Hexokinase_N.
    [Graphical view]
    PANTHERiPTHR19443. PTHR19443. 1 hit.
    PfamiPF00349. Hexokinase_1. 1 hit.
    PF03727. Hexokinase_2. 1 hit.
    [Graphical view]
    PRINTSiPR00475. HEXOKINASE.

    Sequencei

    Sequence statusi: Complete.

    P83776-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVHLGPKPAQ KRKGTFTDVS PQLLEALKPI QEQFTISADK LRAIVKHFIS    50
    ELDRGLSKAG GNIPMIPGWV MDFPTGKETG SYLAIDLGGT NLRVVLVKLG 100
    GNRDFDTTQS KFALPAHMRT ATSDELWDFI AKCLKEFVDE IYPDGCSEPL 150
    PLGFTFSYPA SQNRINEGIL QRWTKGWSID GIEGKDVVPM LQKAIKKVGV 200
    PIDVVALIND TTGTLVASMY TDPEAKMGLI FGTGVNGAYF DVVKDIPKLE 250
    GKCPSDIPPE SPMAINCEYG SFDNEKYILP RTKYDVQIDE ESPRPGQQTF 300
    EKMISGYYLG EVLRLILLEF AEEKKLIFKG QNLDKLKVPY VMDASYPSKI 350
    EEDPFENLSD VADLFREKLG IETTEPERKI IRCLAELIGE RSARFSVCGI 400
    AAICQKRGYK TAHCAADGSV YNKYPGFKER TAQALRDIYE WPADVKDPII 450
    IVPAEDGSGV GAAVIAALTE KRLKEGKSVG LLGA 484
    Length:484
    Mass (Da):53,416
    Last modified:October 19, 2011 - v2
    Checksum:i7248469B1536C23A
    GO

    Sequence cautioni

    The sequence EAK98532.1 differs from that shown. Reason: Frameshift at positions 62 and 67.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti64 – 652PM → LK in allele CaO19.8176.
    Natural varianti72 – 721D → I in allele CaO19.8176.
    Natural varianti100 – 1001G → A in allele CaO19.8176.
    Natural varianti383 – 3831C → R in allele CaO19.8176.
    Natural varianti410 – 4101K → E in allele CaO19.8176.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACQ01000054 Genomic DNA. Translation: EAK98532.1. Frameshift.
    AACQ01000055 Genomic DNA. Translation: EAK98436.1.
    RefSeqiXP_717405.1. XM_712312.1.
    XP_717498.1. XM_712405.1.

    Genome annotation databases

    GeneIDi3640936.
    3641015.
    KEGGical:CaO19.542.
    cal:CaO19.8176.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACQ01000054 Genomic DNA. Translation: EAK98532.1 . Frameshift.
    AACQ01000055 Genomic DNA. Translation: EAK98436.1 .
    RefSeqi XP_717405.1. XM_712312.1.
    XP_717498.1. XM_712405.1.

    3D structure databases

    ProteinModelPortali P83776.
    SMRi P83776. Positions 18-484.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5476.CAL0000198.

    2D gel databases

    COMPLUYEAST-2DPAGE P83776.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 3640936.
    3641015.
    KEGGi cal:CaO19.542.
    cal:CaO19.8176.

    Organism-specific databases

    CGDi CAL0000198. HXK2.
    CAL0078705. HXK2.

    Phylogenomic databases

    eggNOGi COG5026.
    KOi K00844.
    OrthoDBi EOG79SF68.

    Enzyme and pathway databases

    UniPathwayi UPA00242 .

    Family and domain databases

    InterProi IPR001312. Hexokinase.
    IPR022673. Hexokinase_C.
    IPR022672. Hexokinase_N.
    [Graphical view ]
    PANTHERi PTHR19443. PTHR19443. 1 hit.
    Pfami PF00349. Hexokinase_1. 1 hit.
    PF03727. Hexokinase_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00475. HEXOKINASE.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SC5314 / ATCC MYA-2876.
    2. "Proteomics-based identification of novel Candida albicans antigens for diagnosis of systemic candidiasis in patients with underlying hematological malignancies."
      Pitarch A., Abian J., Carrascal M., Sanchez M., Nombela C., Gil C.
      Proteomics 4:3084-3106(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 176-185 AND 317-325, SUBCELLULAR LOCATION, ANTIGENICITY.
      Strain: SC5314 / ATCC MYA-2876.
      Tissue: Protoplast.

    Entry informationi

    Entry nameiHXKB_CANAL
    AccessioniPrimary (citable) accession number: P83776
    Secondary accession number(s): Q5A6L2, Q5A6V6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 4, 2005
    Last sequence update: October 19, 2011
    Last modified: October 1, 2014
    This is version 34 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Has antigenic properties. Elicits a specific immune response in systemic candidiasis human patients undergoing malignant hematological disorders.

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Candida albicans
      Candida albicans: entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3