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P83776 (HXKB_CANAL) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 33. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hexokinase-2

EC=2.7.1.1
Alternative name(s):
Cytoplasmic antigenic protein 3
Hexokinase PII
Hexokinase-B
Gene names
Name:HXK2
ORF Names:CaO19.542, CaO19.8176
OrganismCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]
Taxonomic identifier237561 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

Protein attributes

Sequence length484 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Main glucose phosphorylating enzyme. May play a regulatory role in both induction and repression of gene expression by glucose By similarity.

Catalytic activity

ATP + D-hexose = ADP + D-hexose 6-phosphate.

Pathway

Carbohydrate metabolism; hexose metabolism.

Subunit structure

Homodimer By similarity.

Subcellular location

Cytoplasm Ref.2.

Miscellaneous

Has antigenic properties. Elicits a specific immune response in systemic candidiasis human patients undergoing malignant hematological disorders.

Sequence similarities

Belongs to the hexokinase family.

Sequence caution

The sequence EAK98532.1 differs from that shown. Reason: Frameshift at positions 62 and 67.

Ontologies

Keywords
   Biological processGlycolysis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processN-acetylglucosamine catabolic process

Inferred from mutant phenotype PubMed 11298769PubMed 11705974. Source: CGD

adhesion of symbiont to host

Inferred from direct assay PubMed 17139615. Source: CGD

carbohydrate phosphorylation

Inferred from direct assay PubMed 11298769. Source: GOC

development of symbiont in host

Inferred from mutant phenotype PubMed 17139615. Source: CGD

filamentous growth

Inferred from mutant phenotype PubMed 17139615. Source: CGD

filamentous growth of a population of unicellular organisms

Inferred from mutant phenotype PubMed 17139615PubMed 23341961. Source: CGD

glucosamine catabolic process

Inferred from mutant phenotype PubMed 11705974. Source: CGD

glycolytic process

Inferred from electronic annotation. Source: UniProtKB-KW

growth of symbiont in host

Inferred from mutant phenotype PubMed 11298769. Source: CGD

hexose metabolic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

hyphal growth

Inferred from genetic interaction PubMed 11705974. Source: CGD

pathogenesis

Inferred from mutant phenotype PubMed 11298769. Source: CGD

   Cellular_componentcytosol

Inferred from direct assay PubMed 23341961. Source: CGD

mitochondrion

Inferred from direct assay PubMed 23341961. Source: CGD

nucleus

Inferred from direct assay PubMed 23341961. Source: CGD

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

N-acetylglucosamine kinase activity

Inferred from direct assay PubMed 11298769. Source: CGD

hexokinase activity

Inferred from sequence or structural similarity PubMed 11114181. Source: CGD

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 484484Hexokinase-2
PRO_0000089303

Natural variations

Natural variant64 – 652PM → LK in allele CaO19.8176.
Natural variant721D → I in allele CaO19.8176.
Natural variant1001G → A in allele CaO19.8176.
Natural variant3831C → R in allele CaO19.8176.
Natural variant4101K → E in allele CaO19.8176.

Sequences

Sequence LengthMass (Da)Tools
P83776 [UniParc].

Last modified October 19, 2011. Version 2.
Checksum: 7248469B1536C23A

FASTA48453,416
        10         20         30         40         50         60 
MVHLGPKPAQ KRKGTFTDVS PQLLEALKPI QEQFTISADK LRAIVKHFIS ELDRGLSKAG 

        70         80         90        100        110        120 
GNIPMIPGWV MDFPTGKETG SYLAIDLGGT NLRVVLVKLG GNRDFDTTQS KFALPAHMRT 

       130        140        150        160        170        180 
ATSDELWDFI AKCLKEFVDE IYPDGCSEPL PLGFTFSYPA SQNRINEGIL QRWTKGWSID 

       190        200        210        220        230        240 
GIEGKDVVPM LQKAIKKVGV PIDVVALIND TTGTLVASMY TDPEAKMGLI FGTGVNGAYF 

       250        260        270        280        290        300 
DVVKDIPKLE GKCPSDIPPE SPMAINCEYG SFDNEKYILP RTKYDVQIDE ESPRPGQQTF 

       310        320        330        340        350        360 
EKMISGYYLG EVLRLILLEF AEEKKLIFKG QNLDKLKVPY VMDASYPSKI EEDPFENLSD 

       370        380        390        400        410        420 
VADLFREKLG IETTEPERKI IRCLAELIGE RSARFSVCGI AAICQKRGYK TAHCAADGSV 

       430        440        450        460        470        480 
YNKYPGFKER TAQALRDIYE WPADVKDPII IVPAEDGSGV GAAVIAALTE KRLKEGKSVG 


LLGA 

« Hide

References

« Hide 'large scale' references
[1]"The diploid genome sequence of Candida albicans."
Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S.
Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SC5314 / ATCC MYA-2876.
[2]"Proteomics-based identification of novel Candida albicans antigens for diagnosis of systemic candidiasis in patients with underlying hematological malignancies."
Pitarch A., Abian J., Carrascal M., Sanchez M., Nombela C., Gil C.
Proteomics 4:3084-3106(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 176-185 AND 317-325, SUBCELLULAR LOCATION, ANTIGENICITY.
Strain: SC5314 / ATCC MYA-2876.
Tissue: Protoplast.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AACQ01000054 Genomic DNA. Translation: EAK98532.1. Frameshift.
AACQ01000055 Genomic DNA. Translation: EAK98436.1.
RefSeqXP_717405.1. XM_712312.1.
XP_717498.1. XM_712405.1.

3D structure databases

ProteinModelPortalP83776.
SMRP83776. Positions 18-484.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5476.CAL0000198.

2D gel databases

COMPLUYEAST-2DPAGEP83776.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3640936.
3641015.
KEGGcal:CaO19.542.
cal:CaO19.8176.

Organism-specific databases

CGDCAL0000198. HXK2.
CAL0078705. HXK2.

Phylogenomic databases

eggNOGCOG5026.
KOK00844.
OrthoDBEOG79SF68.

Enzyme and pathway databases

UniPathwayUPA00242.

Family and domain databases

InterProIPR001312. Hexokinase.
IPR022673. Hexokinase_C.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERPTHR19443. PTHR19443. 1 hit.
PfamPF00349. Hexokinase_1. 1 hit.
PF03727. Hexokinase_2. 1 hit.
[Graphical view]
PRINTSPR00475. HEXOKINASE.
ProtoNetSearch...

Entry information

Entry nameHXKB_CANAL
AccessionPrimary (citable) accession number: P83776
Secondary accession number(s): Q5A6L2, Q5A6V6
Entry history
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: October 19, 2011
Last modified: July 9, 2014
This is version 33 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Candida albicans

Candida albicans: entries and gene names