P83773 (ACH1_CANAL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acetyl-CoA hydrolase
EC=3.1.2.1

Alternative name(s):
Acetyl-CoA deacylase
Short name=Acetyl-CoA acylase

Gene names

Name:	ACH1
ORF Names:	CaO19.10681, CaO19.3171

Organism

Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]

Taxonomic identifier

237561 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida › Candida albicans

Protein attributes

Sequence length	524 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Presumably involved in regulating the intracellular acetyl-CoA pool for fatty acid and cholesterol synthesis and fatty acid oxidation By similarity.
Catalytic activity	Acetyl-CoA + H2O = CoA + acetate.
Subcellular location	Cytoplasm Ref.2.
Miscellaneous	Has antigenic properties. Elicits a specific immune response in systemic candidiasis human patients undergoing malignant hematological disorders.
Sequence similarities	Belongs to the acetyl-CoA hydrolase/transferase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Hydrolase
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	acetate metabolic process Inferred from sequence alignment PubMed 18689527. Source: CGD acetyl-CoA metabolic process Inferred from electronic annotation. Source: InterPro cellular response to alkalinity Inferred from mutant phenotype PubMed 21586647. Source: CGD
Cellular_component	cytosol Inferred from genetic interaction PubMed 18689527. Source: CGD mitochondrion Inferred from sequence alignment PubMed 18689527. Source: CGD
Molecular_function	acetyl-CoA hydrolase activity Inferred from sequence alignment PubMed 18689527. Source: CGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 524	524	Acetyl-CoA hydrolase		PRO_0000215517

Sequences

	Sequence		Length	Mass (Da)
	P83773 [UniParc]. Last modified May 5, 2009. Version 2. Checksum: 199E534C8FA0CB7A	FASTA	524	57,977
	10 20 30 40 50 60 MSAILKQRVK YAPYLKKLRT GEQCIDLFKH GQYLGWSGFT GVGAPKVIPT TLVDHVEKNN 70 80 90 100 110 120 LQGKLGFHLF VGASAGPEES RWAENNMILT RAPHQVGKPI AAAINDGRTQ FFDKHLSMFP 130 140 150 160 170 180 QDLTYGFYTK DKPNGSNLDY TIIEATAITE DGSIVPGPAV GASPEMISVS DKIIIEVNTK 190 200 210 220 230 240 TPSFEGIHDI DMPVNPPFRQ PYPHTSADFK IGKTAIPVDP EKVVAIVEST SGDKVPPNTP 250 260 270 280 290 300 SDEQSRGIAN HLIEFLEHEV KQGRLPANLH PLQSGIGNIA NAVVEGLASS NFKNLTVWTE 310 320 330 340 350 360 VLQDSFLDFF ESGSLDYATA TSIRLTNDGF KKFYDNWDTY SKKLCLRSQV VSNSPEIIRR 370 380 390 400 410 420 LGVIAMNTPV EVDIYGHANS TNVMGSRMLN GLGGSADFLR NAKLSIMHTP SARPSKVDPT 430 440 450 460 470 480 GLSCIVPMAS HVDQTEHDLD VVVTEQGLAD LRGLAPKARA KVIIDKCSHP DYKPQLQEYY 490 500 510 520 DRSVFYATKK KTLHEPHILR DVFKMHLNFQ ENGTMKLDSW DQKF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The diploid genome sequence of Candida albicans." Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S. Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314 / ATCC MYA-2876.
[2]	"Proteomics-based identification of novel Candida albicans antigens for diagnosis of systemic candidiasis in patients with underlying hematological malignancies." Pitarch A., Abian J., Carrascal M., Sanchez M., Nombela C., Gil C. Proteomics 4:3084-3106(2004) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 82-91 AND 350-359, SUBCELLULAR LOCATION, ANTIGENICITY. Strain: SC5314 / ATCC MYA-2876. Tissue: Protoplast.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AACQ01000100 Genomic DNA. Translation: EAK95537.1. AACQ01000097 Genomic DNA. Translation: EAK95674.1.
RefSeq	XP_714589.1. XM_709496.1. XP_714720.1. XM_709627.1.
3D structure databases
ProteinModelPortal	P83773.
ModBase	Search...
Protein-protein interaction databases
STRING	5476.CAL0002388.
2D gel databases
COMPLUYEAST-2DPAGE	P83773.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3643603. 3643773.
KEGG	cal:CaO19.10681. cal:CaO19.3171.
Organism-specific databases
CGD	CAL0002388. ACH1.
Phylogenomic databases
eggNOG	COG0427.
KO	K01067.
Family and domain databases
InterPro	IPR026888. AcetylCoA_hyd_C. IPR003702. ActCoA_hydro. IPR017821. Succinate_CoA_transferase. [Graphical view]
PANTHER	PTHR21432. PTHR21432. 1 hit. PTHR21432:SF10. PTHR21432:SF10. 1 hit.
Pfam	PF13336. AcetylCoA_hyd_C. 1 hit. PF02550. AcetylCoA_hydro. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ACH1_CANAL

Accession

Primary (citable) accession number: P83773
Secondary accession number(s): Q59YK9

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 4, 2005
Last sequence update:	May 5, 2009
Last modified:	May 1, 2013
This is version 45 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program