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P83773

- ACH1_CANAL

UniProt

P83773 - ACH1_CANAL

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Protein

Acetyl-CoA hydrolase

Gene

ACH1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Presumably involved in regulating the intracellular acetyl-CoA pool for fatty acid and cholesterol synthesis and fatty acid oxidation.By similarity

Catalytic activityi

Acetyl-CoA + H2O = CoA + acetate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei300 – 30015-glutamyl coenzyme A thioester intermediateBy similarity
Binding sitei390 – 3901Coenzyme ABy similarity
Binding sitei394 – 3941Coenzyme A; via amide nitrogenBy similarity

GO - Molecular functioni

  1. acetyl-CoA hydrolase activity Source: CGD

GO - Biological processi

  1. acetate metabolic process Source: CGD
  2. acetyl-CoA metabolic process Source: InterPro
  3. cellular response to alkaline pH Source: CGD
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyl-CoA hydrolase (EC:3.1.2.1)
Alternative name(s):
Acetyl-CoA deacylase
Short name:
Acetyl-CoA acylase
Gene namesi
Name:ACH1
ORF Names:CaO19.10681, CaO19.3171
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
ProteomesiUP000000559: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0002388. ACH1.

Subcellular locationi

Cytoplasm 1 Publication

GO - Cellular componenti

  1. cytosol Source: CGD
  2. mitochondrion Source: CGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 524524Acetyl-CoA hydrolasePRO_0000215517Add
BLAST

2D gel databases

COMPLUYEAST-2DPAGEP83773.

Interactioni

Protein-protein interaction databases

STRINGi5476.CAL0002388.

Structurei

3D structure databases

ProteinModelPortaliP83773.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni275 – 2795Coenzyme A bindingBy similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0427.
InParanoidiP83773.
KOiK01067.
OrthoDBiEOG7TQV8M.

Family and domain databases

InterProiIPR026888. AcetylCoA_hyd_C.
IPR003702. ActCoA_hydro.
[Graphical view]
PfamiPF13336. AcetylCoA_hyd_C. 1 hit.
PF02550. AcetylCoA_hydro. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P83773-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSAILKQRVK YAPYLKKLRT GEQCIDLFKH GQYLGWSGFT GVGAPKVIPT
60 70 80 90 100
TLVDHVEKNN LQGKLGFHLF VGASAGPEES RWAENNMILT RAPHQVGKPI
110 120 130 140 150
AAAINDGRTQ FFDKHLSMFP QDLTYGFYTK DKPNGSNLDY TIIEATAITE
160 170 180 190 200
DGSIVPGPAV GASPEMISVS DKIIIEVNTK TPSFEGIHDI DMPVNPPFRQ
210 220 230 240 250
PYPHTSADFK IGKTAIPVDP EKVVAIVEST SGDKVPPNTP SDEQSRGIAN
260 270 280 290 300
HLIEFLEHEV KQGRLPANLH PLQSGIGNIA NAVVEGLASS NFKNLTVWTE
310 320 330 340 350
VLQDSFLDFF ESGSLDYATA TSIRLTNDGF KKFYDNWDTY SKKLCLRSQV
360 370 380 390 400
VSNSPEIIRR LGVIAMNTPV EVDIYGHANS TNVMGSRMLN GLGGSADFLR
410 420 430 440 450
NAKLSIMHTP SARPSKVDPT GLSCIVPMAS HVDQTEHDLD VVVTEQGLAD
460 470 480 490 500
LRGLAPKARA KVIIDKCSHP DYKPQLQEYY DRSVFYATKK KTLHEPHILR
510 520
DVFKMHLNFQ ENGTMKLDSW DQKF
Length:524
Mass (Da):57,977
Last modified:May 5, 2009 - v2
Checksum:i199E534C8FA0CB7A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACQ01000100 Genomic DNA. Translation: EAK95537.1.
AACQ01000097 Genomic DNA. Translation: EAK95674.1.
RefSeqiXP_714589.1. XM_709496.1.
XP_714720.1. XM_709627.1.

Genome annotation databases

GeneIDi3643603.
3643773.
KEGGical:CaO19.10681.
cal:CaO19.3171.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACQ01000100 Genomic DNA. Translation: EAK95537.1 .
AACQ01000097 Genomic DNA. Translation: EAK95674.1 .
RefSeqi XP_714589.1. XM_709496.1.
XP_714720.1. XM_709627.1.

3D structure databases

ProteinModelPortali P83773.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5476.CAL0002388.

2D gel databases

COMPLUYEAST-2DPAGE P83773.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3643603.
3643773.
KEGGi cal:CaO19.10681.
cal:CaO19.3171.

Organism-specific databases

CGDi CAL0002388. ACH1.

Phylogenomic databases

eggNOGi COG0427.
InParanoidi P83773.
KOi K01067.
OrthoDBi EOG7TQV8M.

Family and domain databases

InterProi IPR026888. AcetylCoA_hyd_C.
IPR003702. ActCoA_hydro.
[Graphical view ]
Pfami PF13336. AcetylCoA_hyd_C. 1 hit.
PF02550. AcetylCoA_hydro. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.
  2. "Proteomics-based identification of novel Candida albicans antigens for diagnosis of systemic candidiasis in patients with underlying hematological malignancies."
    Pitarch A., Abian J., Carrascal M., Sanchez M., Nombela C., Gil C.
    Proteomics 4:3084-3106(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 82-91 AND 350-359, SUBCELLULAR LOCATION, ANTIGENICITY.
    Strain: SC5314 / ATCC MYA-2876.
    Tissue: Protoplast.

Entry informationi

Entry nameiACH1_CANAL
AccessioniPrimary (citable) accession number: P83773
Secondary accession number(s): Q59YK9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: May 5, 2009
Last modified: October 29, 2014
This is version 54 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Has antigenic properties. Elicits a specific immune response in systemic candidiasis human patients undergoing malignant hematological disorders.

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3