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P83773

- ACH1_CANAL

UniProt

P83773 - ACH1_CANAL

Protein

Acetyl-CoA hydrolase

Gene

ACH1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 53 (01 Oct 2014)
      Sequence version 2 (05 May 2009)
      Previous versions | rss
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    Functioni

    Presumably involved in regulating the intracellular acetyl-CoA pool for fatty acid and cholesterol synthesis and fatty acid oxidation.By similarity

    Catalytic activityi

    Acetyl-CoA + H2O = CoA + acetate.

    GO - Molecular functioni

    1. acetyl-CoA hydrolase activity Source: CGD

    GO - Biological processi

    1. acetate metabolic process Source: CGD
    2. acetyl-CoA metabolic process Source: InterPro
    3. cellular response to alkaline pH Source: CGD

    Keywords - Molecular functioni

    Hydrolase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acetyl-CoA hydrolase (EC:3.1.2.1)
    Alternative name(s):
    Acetyl-CoA deacylase
    Short name:
    Acetyl-CoA acylase
    Gene namesi
    Name:ACH1
    ORF Names:CaO19.10681, CaO19.3171
    OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
    Taxonomic identifieri237561 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
    ProteomesiUP000000559: Unassembled WGS sequence

    Organism-specific databases

    CGDiCAL0002388. ACH1.

    Subcellular locationi

    Cytoplasm 1 Publication

    GO - Cellular componenti

    1. cytosol Source: CGD
    2. mitochondrion Source: CGD

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 524524Acetyl-CoA hydrolasePRO_0000215517Add
    BLAST

    2D gel databases

    COMPLUYEAST-2DPAGEP83773.

    Interactioni

    Protein-protein interaction databases

    STRINGi5476.CAL0002388.

    Structurei

    3D structure databases

    ProteinModelPortaliP83773.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0427.
    KOiK01067.
    OrthoDBiEOG7TQV8M.

    Family and domain databases

    InterProiIPR026888. AcetylCoA_hyd_C.
    IPR003702. ActCoA_hydro.
    [Graphical view]
    PfamiPF13336. AcetylCoA_hyd_C. 1 hit.
    PF02550. AcetylCoA_hydro. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P83773-1 [UniParc]FASTAAdd to Basket

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    MSAILKQRVK YAPYLKKLRT GEQCIDLFKH GQYLGWSGFT GVGAPKVIPT    50
    TLVDHVEKNN LQGKLGFHLF VGASAGPEES RWAENNMILT RAPHQVGKPI 100
    AAAINDGRTQ FFDKHLSMFP QDLTYGFYTK DKPNGSNLDY TIIEATAITE 150
    DGSIVPGPAV GASPEMISVS DKIIIEVNTK TPSFEGIHDI DMPVNPPFRQ 200
    PYPHTSADFK IGKTAIPVDP EKVVAIVEST SGDKVPPNTP SDEQSRGIAN 250
    HLIEFLEHEV KQGRLPANLH PLQSGIGNIA NAVVEGLASS NFKNLTVWTE 300
    VLQDSFLDFF ESGSLDYATA TSIRLTNDGF KKFYDNWDTY SKKLCLRSQV 350
    VSNSPEIIRR LGVIAMNTPV EVDIYGHANS TNVMGSRMLN GLGGSADFLR 400
    NAKLSIMHTP SARPSKVDPT GLSCIVPMAS HVDQTEHDLD VVVTEQGLAD 450
    LRGLAPKARA KVIIDKCSHP DYKPQLQEYY DRSVFYATKK KTLHEPHILR 500
    DVFKMHLNFQ ENGTMKLDSW DQKF 524
    Length:524
    Mass (Da):57,977
    Last modified:May 5, 2009 - v2
    Checksum:i199E534C8FA0CB7A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACQ01000100 Genomic DNA. Translation: EAK95537.1.
    AACQ01000097 Genomic DNA. Translation: EAK95674.1.
    RefSeqiXP_714589.1. XM_709496.1.
    XP_714720.1. XM_709627.1.

    Genome annotation databases

    GeneIDi3643603.
    3643773.
    KEGGical:CaO19.10681.
    cal:CaO19.3171.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACQ01000100 Genomic DNA. Translation: EAK95537.1 .
    AACQ01000097 Genomic DNA. Translation: EAK95674.1 .
    RefSeqi XP_714589.1. XM_709496.1.
    XP_714720.1. XM_709627.1.

    3D structure databases

    ProteinModelPortali P83773.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5476.CAL0002388.

    2D gel databases

    COMPLUYEAST-2DPAGE P83773.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 3643603.
    3643773.
    KEGGi cal:CaO19.10681.
    cal:CaO19.3171.

    Organism-specific databases

    CGDi CAL0002388. ACH1.

    Phylogenomic databases

    eggNOGi COG0427.
    KOi K01067.
    OrthoDBi EOG7TQV8M.

    Family and domain databases

    InterProi IPR026888. AcetylCoA_hyd_C.
    IPR003702. ActCoA_hydro.
    [Graphical view ]
    Pfami PF13336. AcetylCoA_hyd_C. 1 hit.
    PF02550. AcetylCoA_hydro. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SC5314 / ATCC MYA-2876.
    2. "Proteomics-based identification of novel Candida albicans antigens for diagnosis of systemic candidiasis in patients with underlying hematological malignancies."
      Pitarch A., Abian J., Carrascal M., Sanchez M., Nombela C., Gil C.
      Proteomics 4:3084-3106(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 82-91 AND 350-359, SUBCELLULAR LOCATION, ANTIGENICITY.
      Strain: SC5314 / ATCC MYA-2876.
      Tissue: Protoplast.

    Entry informationi

    Entry nameiACH1_CANAL
    AccessioniPrimary (citable) accession number: P83773
    Secondary accession number(s): Q59YK9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 4, 2005
    Last sequence update: May 5, 2009
    Last modified: October 1, 2014
    This is version 53 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Has antigenic properties. Elicits a specific immune response in systemic candidiasis human patients undergoing malignant hematological disorders.

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Candida albicans
      Candida albicans: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3