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Protein

Acetyl-CoA hydrolase

Gene

ACH1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Presumably involved in regulating the intracellular acetyl-CoA pool for fatty acid and cholesterol synthesis and fatty acid oxidation.By similarity

Catalytic activityi

Acetyl-CoA + H2O = CoA + acetate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei3005-glutamyl coenzyme A thioester intermediateBy similarity1
Binding sitei390Coenzyme ABy similarity1
Binding sitei394Coenzyme A; via amide nitrogenBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyl-CoA hydrolase (EC:3.1.2.1)
Alternative name(s):
Acetyl-CoA deacylase
Short name:
Acetyl-CoA acylase
Gene namesi
Name:ACH1
ORF Names:CaO19.10681, CaO19.3171
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
Proteomesi
  • UP000000559 Componenti: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002155171 – 524Acetyl-CoA hydrolaseAdd BLAST524

Proteomic databases

PRIDEiP83773.

2D gel databases

COMPLUYEAST-2DPAGEP83773.

Structurei

3D structure databases

ProteinModelPortaliP83773.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni275 – 279Coenzyme A bindingBy similarity5

Sequence similaritiesi

Phylogenomic databases

InParanoidiP83773.
KOiK01067.
OrthoDBiEOG093706YA.

Family and domain databases

InterProiView protein in InterPro
IPR026888. AcetylCoA_hyd_C.
IPR003702. ActCoA_hydro.
PfamiView protein in Pfam
PF13336. AcetylCoA_hyd_C. 1 hit.
PF02550. AcetylCoA_hydro. 1 hit.

Sequencei

Sequence statusi: Complete.

P83773-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAILKQRVK YAPYLKKLRT GEQCIDLFKH GQYLGWSGFT GVGAPKVIPT
60 70 80 90 100
TLVDHVEKNN LQGKLGFHLF VGASAGPEES RWAENNMILT RAPHQVGKPI
110 120 130 140 150
AAAINDGRTQ FFDKHLSMFP QDLTYGFYTK DKPNGSNLDY TIIEATAITE
160 170 180 190 200
DGSIVPGPAV GASPEMISVS DKIIIEVNTK TPSFEGIHDI DMPVNPPFRQ
210 220 230 240 250
PYPHTSADFK IGKTAIPVDP EKVVAIVEST SGDKVPPNTP SDEQSRGIAN
260 270 280 290 300
HLIEFLEHEV KQGRLPANLH PLQSGIGNIA NAVVEGLASS NFKNLTVWTE
310 320 330 340 350
VLQDSFLDFF ESGSLDYATA TSIRLTNDGF KKFYDNWDTY SKKLCLRSQV
360 370 380 390 400
VSNSPEIIRR LGVIAMNTPV EVDIYGHANS TNVMGSRMLN GLGGSADFLR
410 420 430 440 450
NAKLSIMHTP SARPSKVDPT GLSCIVPMAS HVDQTEHDLD VVVTEQGLAD
460 470 480 490 500
LRGLAPKARA KVIIDKCSHP DYKPQLQEYY DRSVFYATKK KTLHEPHILR
510 520
DVFKMHLNFQ ENGTMKLDSW DQKF
Length:524
Mass (Da):57,977
Last modified:May 5, 2009 - v2
Checksum:i199E534C8FA0CB7A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACQ01000100 Genomic DNA. Translation: EAK95537.1.
AACQ01000097 Genomic DNA. Translation: EAK95674.1.
RefSeqiXP_714589.1. XM_709496.1.
XP_714720.1. XM_709627.1.

Genome annotation databases

EnsemblFungiiEAK95537; EAK95537; CaO19.3171.
EAK95674; EAK95674; CaO19.10681.
GeneIDi3643603.
3643773.
KEGGical:CaO19.10681.
cal:CaO19.3171.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACQ01000100 Genomic DNA. Translation: EAK95537.1.
AACQ01000097 Genomic DNA. Translation: EAK95674.1.
RefSeqiXP_714589.1. XM_709496.1.
XP_714720.1. XM_709627.1.

3D structure databases

ProteinModelPortaliP83773.
ModBaseiSearch...
MobiDBiSearch...

2D gel databases

COMPLUYEAST-2DPAGEP83773.

Proteomic databases

PRIDEiP83773.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEAK95537; EAK95537; CaO19.3171.
EAK95674; EAK95674; CaO19.10681.
GeneIDi3643603.
3643773.
KEGGical:CaO19.10681.
cal:CaO19.3171.

Phylogenomic databases

InParanoidiP83773.
KOiK01067.
OrthoDBiEOG093706YA.

Family and domain databases

InterProiView protein in InterPro
IPR026888. AcetylCoA_hyd_C.
IPR003702. ActCoA_hydro.
PfamiView protein in Pfam
PF13336. AcetylCoA_hyd_C. 1 hit.
PF02550. AcetylCoA_hydro. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiACH1_CANAL
AccessioniPrimary (citable) accession number: P83773
Secondary accession number(s): Q59YK9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: May 5, 2009
Last modified: February 15, 2017
This is version 63 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Has antigenic properties. Elicits a specific immune response in systemic candidiasis human patients undergoing malignant hematological disorders.

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.