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Reviewed, UniProtKB/Swiss-Prot P83773 (ACH1_CANAL)

Last modified January 19, 2010. Version 20. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Acetyl-CoA hydrolase
    EC=3.1.2.1
Alternative name(s):
    Acetyl-CoA deacylase
      Short name=Acetyl-CoA acylase
Gene names
Name: ACH1
ORF Names: CaO19.3171, CaO19.10681
OrganismCandida albicans (Yeast)
Taxonomic identifier5476 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

Protein attributes

Sequence length524 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Presumably involved in regulating the intracellular acetyl-CoA pool for fatty acid and cholesterol synthesis and fatty acid oxidation By similarity.

Catalytic activity

Acetyl-CoA + H2O = CoA + acetate.

Subcellular location

Cytoplasm Ref.2.

Miscellaneous

Has antigenic properties. Elicits a specific immune response in systemic candidiasis human patients undergoing malignant hematological disorders.

Sequence similarities

Belongs to the acetyl-CoA hydrolase/transferase family.

Ontologies

Keywords
   Cellular componentCytoplasm
   Molecular functionHydrolase
   Technical termDirect protein sequencing
Gene Ontology (GO)
   Biological processacetyl-CoA metabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionacetyl-CoA hydrolase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 524524Acetyl-CoA hydrolase
PRO_0000215517

Sequences

Sequence LengthMass (Da)Tools
P83773-1 [UniParc].

Last modified May 5, 2009. Version 2.
Checksum: 199E534C8FA0CB7A

FASTA52457,977
        10         20         30         40         50         60 
MSAILKQRVK YAPYLKKLRT GEQCIDLFKH GQYLGWSGFT GVGAPKVIPT TLVDHVEKNN 

        70         80         90        100        110        120 
LQGKLGFHLF VGASAGPEES RWAENNMILT RAPHQVGKPI AAAINDGRTQ FFDKHLSMFP 

       130        140        150        160        170        180 
QDLTYGFYTK DKPNGSNLDY TIIEATAITE DGSIVPGPAV GASPEMISVS DKIIIEVNTK 

       190        200        210        220        230        240 
TPSFEGIHDI DMPVNPPFRQ PYPHTSADFK IGKTAIPVDP EKVVAIVEST SGDKVPPNTP 

       250        260        270        280        290        300 
SDEQSRGIAN HLIEFLEHEV KQGRLPANLH PLQSGIGNIA NAVVEGLASS NFKNLTVWTE 

       310        320        330        340        350        360 
VLQDSFLDFF ESGSLDYATA TSIRLTNDGF KKFYDNWDTY SKKLCLRSQV VSNSPEIIRR 

       370        380        390        400        410        420 
LGVIAMNTPV EVDIYGHANS TNVMGSRMLN GLGGSADFLR NAKLSIMHTP SARPSKVDPT 

       430        440        450        460        470        480 
GLSCIVPMAS HVDQTEHDLD VVVTEQGLAD LRGLAPKARA KVIIDKCSHP DYKPQLQEYY 

       490        500        510        520 
DRSVFYATKK KTLHEPHILR DVFKMHLNFQ ENGTMKLDSW DQKF 

« Hide

References

« Hide 'large scale' references
[1]"The diploid genome sequence of Candida albicans."
Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S.
Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed: 15123810] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SC5314.
[2]"Proteomics-based identification of novel Candida albicans antigens for diagnosis of systemic candidiasis in patients with underlying hematological malignancies."
Pitarch A., Abian J., Carrascal M., Sanchez M., Nombela C., Gil C.
Proteomics 4:3084-3106(2004) [PubMed: 15378761] [Abstract]
Cited for: PROTEIN SEQUENCE OF 82-91 AND 350-359, SUBCELLULAR LOCATION, ANTIGENICITY.
Strain: SC5314.
Tissue: Protoplast.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AACQ01000100 Genomic DNA. Translation: EAK95537.1.
AACQ01000097 Genomic DNA. Translation: EAK95674.1.
RefSeqXP_714589.1.
XP_714720.1.

3D structure databases

SMRP83773. Positions 6-517.
ModBaseSearch...

Genome annotation databases

GeneID3643603.
3643773.
KEGGcal:CaO19.10681.
cal:CaO19.3171.

Organism-specific databases

CGDCAL0002388. ACH1.

Phylogenomic databases

OrthoDBEOG951G6X.
PhylomeDBP83773.

Enzyme and pathway databases

BRENDA3.1.2.1. 1124.

Family and domain databases

InterProIPR003702. ActCoA_hydro.
[Graphical view]
PANTHERPTHR21432. ActCoA_hydro. 1 hit.
PfamPF02550. AcetylCoA_hydro. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameACH1_CANAL
AccessionPrimary (citable) accession number: P83773
Secondary accession number(s): Q59YK9
Entry history
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: May 5, 2009
Last modified: January 19, 2010
This is version 20 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectFPAP (Fungal Proteome Annotation Project)

Relevant documents

Candida albicans

Candida albicans: entries and gene names

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents