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P83773 (ACH1_CANAL) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Acetyl-CoA hydrolase

EC=3.1.2.1
Alternative name(s):
Acetyl-CoA deacylase
Short name=Acetyl-CoA acylase
Gene names
Name:ACH1
ORF Names:CaO19.10681, CaO19.3171
OrganismCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]
Taxonomic identifier237561 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

Protein attributes

Sequence length524 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Presumably involved in regulating the intracellular acetyl-CoA pool for fatty acid and cholesterol synthesis and fatty acid oxidation By similarity.

Catalytic activity

Acetyl-CoA + H2O = CoA + acetate.

Subcellular location

Cytoplasm Ref.2.

Miscellaneous

Has antigenic properties. Elicits a specific immune response in systemic candidiasis human patients undergoing malignant hematological disorders.

Sequence similarities

Belongs to the acetyl-CoA hydrolase/transferase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 524524Acetyl-CoA hydrolase
PRO_0000215517

Sequences

Sequence LengthMass (Da)Tools
P83773 [UniParc].

Last modified May 5, 2009. Version 2.
Checksum: 199E534C8FA0CB7A

FASTA52457,977
        10         20         30         40         50         60 
MSAILKQRVK YAPYLKKLRT GEQCIDLFKH GQYLGWSGFT GVGAPKVIPT TLVDHVEKNN 

        70         80         90        100        110        120 
LQGKLGFHLF VGASAGPEES RWAENNMILT RAPHQVGKPI AAAINDGRTQ FFDKHLSMFP 

       130        140        150        160        170        180 
QDLTYGFYTK DKPNGSNLDY TIIEATAITE DGSIVPGPAV GASPEMISVS DKIIIEVNTK 

       190        200        210        220        230        240 
TPSFEGIHDI DMPVNPPFRQ PYPHTSADFK IGKTAIPVDP EKVVAIVEST SGDKVPPNTP 

       250        260        270        280        290        300 
SDEQSRGIAN HLIEFLEHEV KQGRLPANLH PLQSGIGNIA NAVVEGLASS NFKNLTVWTE 

       310        320        330        340        350        360 
VLQDSFLDFF ESGSLDYATA TSIRLTNDGF KKFYDNWDTY SKKLCLRSQV VSNSPEIIRR 

       370        380        390        400        410        420 
LGVIAMNTPV EVDIYGHANS TNVMGSRMLN GLGGSADFLR NAKLSIMHTP SARPSKVDPT 

       430        440        450        460        470        480 
GLSCIVPMAS HVDQTEHDLD VVVTEQGLAD LRGLAPKARA KVIIDKCSHP DYKPQLQEYY 

       490        500        510        520 
DRSVFYATKK KTLHEPHILR DVFKMHLNFQ ENGTMKLDSW DQKF 

« Hide

References

« Hide 'large scale' references
[1]"The diploid genome sequence of Candida albicans."
Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S.
Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SC5314 / ATCC MYA-2876.
[2]"Proteomics-based identification of novel Candida albicans antigens for diagnosis of systemic candidiasis in patients with underlying hematological malignancies."
Pitarch A., Abian J., Carrascal M., Sanchez M., Nombela C., Gil C.
Proteomics 4:3084-3106(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 82-91 AND 350-359, SUBCELLULAR LOCATION, ANTIGENICITY.
Strain: SC5314 / ATCC MYA-2876.
Tissue: Protoplast.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AACQ01000100 Genomic DNA. Translation: EAK95537.1.
AACQ01000097 Genomic DNA. Translation: EAK95674.1.
RefSeqXP_714589.1. XM_709496.1.
XP_714720.1. XM_709627.1.

3D structure databases

ProteinModelPortalP83773.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5476.CAL0002388.

2D gel databases

COMPLUYEAST-2DPAGEP83773.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3643603.
3643773.
KEGGcal:CaO19.10681.
cal:CaO19.3171.

Organism-specific databases

CGDCAL0002388. ACH1.

Phylogenomic databases

eggNOGCOG0427.
KOK01067.
OrthoDBEOG7TQV8M.

Family and domain databases

InterProIPR026888. AcetylCoA_hyd_C.
IPR003702. ActCoA_hydro.
[Graphical view]
PANTHERPTHR21432:SF10. PTHR21432:SF10. 1 hit.
PfamPF13336. AcetylCoA_hyd_C. 1 hit.
PF02550. AcetylCoA_hydro. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameACH1_CANAL
AccessionPrimary (citable) accession number: P83773
Secondary accession number(s): Q59YK9
Entry history
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: May 5, 2009
Last modified: November 13, 2013
This is version 51 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Candida albicans

Candida albicans: entries and gene names