Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Signal recognition particle receptor FtsY

Gene

ftsY

Organism
Thermus aquaticus
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi109 – 116GTPUniRule annotation8
Nucleotide bindingi191 – 195GTPUniRule annotation5
Nucleotide bindingi255 – 258GTPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Signal recognition particle receptor FtsYUniRule annotation
Short name:
SRP receptorUniRule annotation
Gene namesi
Name:ftsYUniRule annotation
OrganismiThermus aquaticusImported
Taxonomic identifieri271 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi17R → Q: No effect on proteolysis; when associated with M-18. 1 Publication1
Mutagenesisi18L → M: No effect on proteolysis; when associated with Q-17. 1 Publication1
Mutagenesisi86R → Q: No effect proteolysis; when associated with Q-87 and I-88. 1 Publication1
Mutagenesisi87K → Q: No effect proteolysis; when associated with Q-86 and I-88. 1 Publication1
Mutagenesisi88L → I: No effect proteolysis; when associated with Q-86 and Q-87. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001011472 – 304Signal recognition particle receptor FtsYAdd BLAST303

Post-translational modificationi

Sensitive to endogenous proteolytic cleavage between residues 18 and 19 and between residues 86 and 87.

Interactioni

Subunit structurei

Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.UniRule annotation

Binary interactionsi

WithEntry#Exp.IntActNotes
ffhO073472EBI-1037899,EBI-1037906

Protein-protein interaction databases

IntActiP83749. 1 interactor.
STRINGi498848.TaqDRAFT_3813.

Structurei

Secondary structure

1304
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi3 – 10Combined sources8
Helixi12 – 15Combined sources4
Turni16 – 18Combined sources3
Helixi19 – 21Combined sources3
Helixi28 – 41Combined sources14
Helixi46 – 58Combined sources13
Helixi66 – 72Combined sources7
Turni73 – 76Combined sources4
Helixi81 – 87Combined sources7
Beta strandi101 – 108Combined sources8
Helixi115 – 127Combined sources13
Turni128 – 130Combined sources3
Beta strandi133 – 136Combined sources4
Turni143 – 146Combined sources4
Helixi147 – 156Combined sources10
Beta strandi164 – 166Combined sources3
Helixi169 – 183Combined sources15
Beta strandi186 – 190Combined sources5
Helixi200 – 216Combined sources17
Beta strandi222 – 229Combined sources8
Helixi230 – 234Combined sources5
Helixi235 – 247Combined sources13
Beta strandi250 – 255Combined sources6
Beta strandi259 – 261Combined sources3
Helixi263 – 265Combined sources3
Helixi266 – 273Combined sources8
Beta strandi277 – 281Combined sources5
Beta strandi283 – 285Combined sources3
Helixi286 – 288Combined sources3
Beta strandi289 – 291Combined sources3
Helixi294 – 301Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OKKX-ray2.05D2-304[»]
1RJ9X-ray1.90A1-304[»]
2CNWX-ray2.39D/E/F21-304[»]
2IYLX-ray2.10D21-304[»]
2J7PX-ray1.97D/E22-304[»]
2Q9AX-ray2.24A/B1-304[»]
2Q9BX-ray2.30A/B1-304[»]
2Q9CX-ray2.20A/B1-304[»]
2XKVelectron microscopy13.50D2-304[»]
ProteinModelPortaliP83749.
SMRiP83749.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP83749.

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP-binding SRP family. FtsY subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CCP. Bacteria.
COG0552. LUCA.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00920. FtsY. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR027417. P-loop_NTPase.
IPR013822. Signal_recog_particl_SRP54_hlx.
IPR004390. SR_rcpt_FtsY.
IPR000897. SRP54_GTPase_dom.
[Graphical view]
PfamiPF00448. SRP54. 1 hit.
PF02881. SRP54_N. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
SM00962. SRP54. 1 hit.
SM00963. SRP54_N. 1 hit.
[Graphical view]
SUPFAMiSSF47364. SSF47364. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00064. ftsY. 1 hit.
PROSITEiPS00300. SRP54. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P83749-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGFFDRLKAG LAKTRERLLK AIPWGGNLEE VLEELEMALL AADVGLSATE
60 70 80 90 100
EILQEVRASG RKDLKEAVKE KLVGMLEPDE RRATLRKLGF NPQKPKPVEP
110 120 130 140 150
KGRVVLVVGV NGVGKTTTIA KLGRYYQNLG KKVMFCAGDT FRAAGGTQLS
160 170 180 190 200
EWGKRLSIPV IQGPEGTDPA ALAYDAVQAM KARGYDLLFV DTAGRLHTKH
210 220 230 240 250
NLMEELKKVK RAIAKADPEE PKEVWLVLDA VTGQNGLEQA KKFHEAVGLT
260 270 280 290 300
GVIVTKLDGT AKGGVLIPIV RTLKVPIKFV GVGEGPDDLQ PFDPEAFVEA

LLED
Length:304
Mass (Da):33,055
Last modified:January 23, 2007 - v2
Checksum:i51881F90B4780536
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY484668 Genomic DNA. Translation: AAR28967.1.
RefSeqiWP_053767748.1. NZ_LHCI01000106.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY484668 Genomic DNA. Translation: AAR28967.1.
RefSeqiWP_053767748.1. NZ_LHCI01000106.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OKKX-ray2.05D2-304[»]
1RJ9X-ray1.90A1-304[»]
2CNWX-ray2.39D/E/F21-304[»]
2IYLX-ray2.10D21-304[»]
2J7PX-ray1.97D/E22-304[»]
2Q9AX-ray2.24A/B1-304[»]
2Q9BX-ray2.30A/B1-304[»]
2Q9CX-ray2.20A/B1-304[»]
2XKVelectron microscopy13.50D2-304[»]
ProteinModelPortaliP83749.
SMRiP83749.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP83749. 1 interactor.
STRINGi498848.TaqDRAFT_3813.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG4105CCP. Bacteria.
COG0552. LUCA.

Miscellaneous databases

EvolutionaryTraceiP83749.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00920. FtsY. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR027417. P-loop_NTPase.
IPR013822. Signal_recog_particl_SRP54_hlx.
IPR004390. SR_rcpt_FtsY.
IPR000897. SRP54_GTPase_dom.
[Graphical view]
PfamiPF00448. SRP54. 1 hit.
PF02881. SRP54_N. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
SM00962. SRP54. 1 hit.
SM00963. SRP54_N. 1 hit.
[Graphical view]
SUPFAMiSSF47364. SSF47364. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00064. ftsY. 1 hit.
PROSITEiPS00300. SRP54. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFTSY_THEAQ
AccessioniPrimary (citable) accession number: P83749
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.