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P83734 (ADOK_MYCTU) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Adenosine kinase
Short name=AK
EC=2.7.1.20
Gene names
Name:adoK
Synonyms:cbhK
Ordered Locus Names:Rv2202c, MT2258
ORF Names:MTCY190.13c
OrganismMycobacterium tuberculosis
Taxonomic identifier1773 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length324 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

ATP dependent phosphorylation of adenosine to monophosphate derivatives By similarity.

Catalytic activity

ATP + adenosine = ADP + AMP.

Cofactor

Magnesium By similarity.

Enzyme regulation

Activity is stimulated in the presence of potassium, resulting in a 13-fold increase in the catalytic efficiency for adenosine By similarity.

Pathway

Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenosine: step 1/1.

Subunit structure

Homodimer Probable.

Miscellaneous

Was identified as a high-confidence drug target.

Sequence similarities

Belongs to the carbohydrate kinase pfkB family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 324323Adenosine kinase
PRO_0000080064

Sites

Active site2571 By similarity

Secondary structure

1 ............................................................... 324
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P83734 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: 0C072206A3210A1D

FASTA32434,472
        10         20         30         40         50         60 
MTIAVTGSIA TDHLMRFPGR FSEQLLPEHL HKVSLSFLVD DLVMHRGGVA GNMAFAIGVL 

        70         80         90        100        110        120 
GGEVALVGAA GADFADYRDW LKARGVNCDH VLISETAHTA RFTCTTDVDM AQIASFYPGA 

       130        140        150        160        170        180 
MSEARNIKLA DVVSAIGKPE LVIIGANDPE AMFLHTEECR KLGLAFAADP SQQLARLSGE 

       190        200        210        220        230        240 
EIRRLVNGAA YLFTNDYEWD LLLSKTGWSE ADVMAQIDLR VTTLGPKGVD LVEPDGTTIH 

       250        260        270        280        290        300 
VGVVPETSQT DPTGVGDAFR AGFLTGRSAG LGLERSAQLG SLVAVLVLES TGTQEWQWDY 

       310        320 
EAAASRLAGA YGEHAAAEIV AVLA

« Hide

References

[1]"Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence."
Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E., Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K. expand/collapse author list , Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J., Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S., Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S., Barrell B.G.
Nature 393:537-544(1998) [PubMed: 9634230] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 25618 / H37Rv.
[2]"Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains."
Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O., Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K., Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L., Delcher A., Utterback T.R. expand/collapse author list , Weidman J.F., Khouri H.M., Gill J., Mikula A., Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.
J. Bacteriol. 184:5479-5490(2002) [PubMed: 12218036] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CDC 1551 / Oshkosh.
[3]"targetTB: a target identification pipeline for Mycobacterium tuberculosis through an interactome, reactome and genome-scale structural analysis."
Raman K., Yeturu K., Chandra N.
BMC Syst. Biol. 2:109-109(2008) [PubMed: 19099550] [Abstract]
Cited for: IDENTIFICATION AS A DRUG TARGET [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BX842579 Genomic DNA. Translation: CAA94245.1.
AE000516 Genomic DNA. Translation: AAK46544.1.
PIRC70785.
RefSeqNP_216718.1. NC_000962.2.
NP_336730.1. NC_002755.2.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2PKFX-ray1.50A/B1-324[»]
2PKKX-ray1.93A1-324[»]
2PKMX-ray1.90A1-324[»]
2PKNX-ray1.90A1-324[»]
ProteinModelPortalP83734.
SMRP83734. Positions 1-324.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000001556; EBMYCP00000001556; EBMYCG00000001556.
EBMYCT00000070207; EBMYCP00000068266; EBMYCG00000070202.
GeneID888551.
924168.
GenomeReviewsGene locus MT2258 in contig AE000516_GR.
Gene locus Rv2202c in contig AL123456_GR.
KEGGmtc:MT2258.
mtu:Rv2202c.
PATRIC18126718. VBIMycTub22151_2471.
TIGRMT2258.

Organism-specific databases

TubercuListRv2202c.

Phylogenomic databases

GeneTreeEBGT00050000016732.
HOGENOMHBG296008.
OMAFTAQAFI.
PhylomeDBP83734.
ProtClustDBCLSK872029.

Enzyme and pathway databases

BRENDA2.7.1.20. 3445.

Family and domain databases

InterProIPR011611. Carb/pur_kinase.
IPR002173. Carboh/pur_kinase_PfkB_CS.
[Graphical view]
KOK00856.
PfamPF00294. PfkB. 1 hit.
[Graphical view]
PROSITEPS00583. PFKB_KINASES_1. 1 hit.
PS00584. PFKB_KINASES_2. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameADOK_MYCTU
AccessionPrimary (citable) accession number: P83734
Secondary accession number(s): Q10391
Entry history
Integrated into UniProtKB/Swiss-Prot: February 2, 2004
Last sequence update: January 23, 2007
Last modified: January 25, 2012
This is version 59 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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