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Protein

60S ribosomal protein L24

Gene

RPL24

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • cadherin binding involved in cell-cell adhesion Source: BHF-UCL
  • poly(A) RNA binding Source: UniProtKB
  • RNA binding Source: ProtInc
  • structural constituent of ribosome Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-HSA-156902. Peptide chain elongation.
R-HSA-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-HSA-192823. Viral mRNA Translation.
R-HSA-2408557. Selenocysteine synthesis.
R-HSA-6791226. Major pathway of rRNA processing in the nucleolus.
R-HSA-72689. Formation of a pool of free 40S subunits.
R-HSA-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-HSA-72764. Eukaryotic Translation Termination.
R-HSA-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-HSA-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L24
Alternative name(s):
60S ribosomal protein L30
Gene namesi
Name:RPL24
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:10325. RPL24.

Subcellular locationi

GO - Cellular componenti

  • cell-cell adherens junction Source: BHF-UCL
  • cytoplasm Source: BHF-UCL
  • cytosol Source: Reactome
  • cytosolic large ribosomal subunit Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • membrane Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34701.

Polymorphism and mutation databases

BioMutaiRPL24.
DMDMi41393532.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 15715760S ribosomal protein L24PRO_0000136867Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei27 – 271N6-acetyllysineCombined sources
Modified residuei77 – 771N6-acetyllysineCombined sources
Modified residuei83 – 831PhosphothreonineCombined sources
Modified residuei86 – 861PhosphoserineCombined sources
Modified residuei93 – 931N6-acetyllysineCombined sources
Modified residuei131 – 1311N6-succinyllysineBy similarity
Modified residuei149 – 1491PhosphoserineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP83731.
PaxDbiP83731.
PeptideAtlasiP83731.
PRIDEiP83731.
TopDownProteomicsiP83731.

PTM databases

iPTMnetiP83731.
PhosphoSiteiP83731.
SwissPalmiP83731.

Expressioni

Gene expression databases

BgeeiENSG00000114391.
CleanExiHS_RPL24.
ExpressionAtlasiP83731. baseline and differential.
GenevisibleiP83731. HS.

Organism-specific databases

HPAiHPA051653.

Interactioni

GO - Molecular functioni

  • cadherin binding involved in cell-cell adhesion Source: BHF-UCL

Protein-protein interaction databases

BioGridi112071. 158 interactions.
IntActiP83731. 38 interactions.
MINTiMINT-5000278.
STRINGi9606.ENSP00000377640.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4UG0electron microscopy-LW1-157[»]
4V6Xelectron microscopy5.00CW1-157[»]
5A2Qelectron microscopy3.90w79-126[»]
5AJ0electron microscopy3.50AW1-157[»]
ProteinModelPortaliP83731.
SMRiP83731. Positions 1-56.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L24e family.Curated

Phylogenomic databases

eggNOGiKOG1722. Eukaryota.
COG2075. LUCA.
GeneTreeiENSGT00550000074809.
HOGENOMiHOG000184343.
HOVERGENiHBG001066.
InParanoidiP83731.
KOiK02896.
OMAiFRVELCS.
OrthoDBiEOG091G0ZDB.
PhylomeDBiP83731.
TreeFamiTF312933.

Family and domain databases

CDDicd00472. Ribosomal_L24e_L24. 1 hit.
Gene3Di2.30.170.20. 1 hit.
InterProiIPR000988. Ribosomal_L24e-rel.
IPR023442. Ribosomal_L24e_CS.
IPR011017. TRASH_dom.
[Graphical view]
PfamiPF01246. Ribosomal_L24e. 1 hit.
[Graphical view]
SMARTiSM00746. TRASH. 1 hit.
[Graphical view]
PROSITEiPS01073. RIBOSOMAL_L24E. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P83731-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVELCSFSG YKIYPGHGRR YARTDGKVFQ FLNAKCESAF LSKRNPRQIN
60 70 80 90 100
WTVLYRRKHK KGQSEEIQKK RTRRAVKFQR AITGASLADI MAKRNQKPEV
110 120 130 140 150
RKAQREQAIR AAKEAKKAKQ ASKKTAMAAA KAPTKAAPKQ KIVKPVKVSA

PRVGGKR
Length:157
Mass (Da):17,779
Last modified:January 16, 2004 - v1
Checksum:i1D48EEB7C0652574
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M94314 mRNA. Translation: AAC28251.1.
AB061828 Genomic DNA. Translation: BAB79466.1.
CR456729 mRNA. Translation: CAG33010.1.
AK311992 mRNA. Translation: BAG34930.1.
CH471052 Genomic DNA. Translation: EAW79780.1.
BC000690 mRNA. Translation: AAH00690.1.
BC070193 mRNA. Translation: AAH70193.1.
AB007177 Genomic DNA. Translation: BAA25836.1.
CCDSiCCDS33809.1.
PIRiJN0549.
RefSeqiNP_000977.1. NM_000986.3.
UniGeneiHs.477028.
Hs.649475.

Genome annotation databases

EnsembliENST00000394077; ENSP00000377640; ENSG00000114391.
GeneIDi6152.
KEGGihsa:6152.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M94314 mRNA. Translation: AAC28251.1.
AB061828 Genomic DNA. Translation: BAB79466.1.
CR456729 mRNA. Translation: CAG33010.1.
AK311992 mRNA. Translation: BAG34930.1.
CH471052 Genomic DNA. Translation: EAW79780.1.
BC000690 mRNA. Translation: AAH00690.1.
BC070193 mRNA. Translation: AAH70193.1.
AB007177 Genomic DNA. Translation: BAA25836.1.
CCDSiCCDS33809.1.
PIRiJN0549.
RefSeqiNP_000977.1. NM_000986.3.
UniGeneiHs.477028.
Hs.649475.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4UG0electron microscopy-LW1-157[»]
4V6Xelectron microscopy5.00CW1-157[»]
5A2Qelectron microscopy3.90w79-126[»]
5AJ0electron microscopy3.50AW1-157[»]
ProteinModelPortaliP83731.
SMRiP83731. Positions 1-56.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112071. 158 interactions.
IntActiP83731. 38 interactions.
MINTiMINT-5000278.
STRINGi9606.ENSP00000377640.

PTM databases

iPTMnetiP83731.
PhosphoSiteiP83731.
SwissPalmiP83731.

Polymorphism and mutation databases

BioMutaiRPL24.
DMDMi41393532.

Proteomic databases

EPDiP83731.
PaxDbiP83731.
PeptideAtlasiP83731.
PRIDEiP83731.
TopDownProteomicsiP83731.

Protocols and materials databases

DNASUi6152.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000394077; ENSP00000377640; ENSG00000114391.
GeneIDi6152.
KEGGihsa:6152.

Organism-specific databases

CTDi6152.
GeneCardsiRPL24.
HGNCiHGNC:10325. RPL24.
HPAiHPA051653.
MIMi604180. gene.
neXtProtiNX_P83731.
PharmGKBiPA34701.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1722. Eukaryota.
COG2075. LUCA.
GeneTreeiENSGT00550000074809.
HOGENOMiHOG000184343.
HOVERGENiHBG001066.
InParanoidiP83731.
KOiK02896.
OMAiFRVELCS.
OrthoDBiEOG091G0ZDB.
PhylomeDBiP83731.
TreeFamiTF312933.

Enzyme and pathway databases

ReactomeiR-HSA-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-HSA-156902. Peptide chain elongation.
R-HSA-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-HSA-192823. Viral mRNA Translation.
R-HSA-2408557. Selenocysteine synthesis.
R-HSA-6791226. Major pathway of rRNA processing in the nucleolus.
R-HSA-72689. Formation of a pool of free 40S subunits.
R-HSA-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-HSA-72764. Eukaryotic Translation Termination.
R-HSA-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-HSA-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Miscellaneous databases

ChiTaRSiRPL24. human.
GeneWikiiRPL24.
GenomeRNAii6152.
PROiP83731.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000114391.
CleanExiHS_RPL24.
ExpressionAtlasiP83731. baseline and differential.
GenevisibleiP83731. HS.

Family and domain databases

CDDicd00472. Ribosomal_L24e_L24. 1 hit.
Gene3Di2.30.170.20. 1 hit.
InterProiIPR000988. Ribosomal_L24e-rel.
IPR023442. Ribosomal_L24e_CS.
IPR011017. TRASH_dom.
[Graphical view]
PfamiPF01246. Ribosomal_L24e. 1 hit.
[Graphical view]
SMARTiSM00746. TRASH. 1 hit.
[Graphical view]
PROSITEiPS01073. RIBOSOMAL_L24E. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRL24_HUMAN
AccessioniPrimary (citable) accession number: P83731
Secondary accession number(s): B2R4Y3, P38663, Q6IBS3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: January 16, 2004
Last modified: September 7, 2016
This is version 134 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Ribosomal proteins
    Ribosomal proteins families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.