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P83731

- RL24_HUMAN

UniProt

P83731 - RL24_HUMAN

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Protein

60S ribosomal protein L24

Gene

RPL24

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. poly(A) RNA binding Source: UniProtKB
  2. RNA binding Source: ProtInc
  3. structural constituent of ribosome Source: UniProtKB

GO - Biological processi

  1. cellular protein metabolic process Source: Reactome
  2. exit from mitosis Source: Ensembl
  3. gene expression Source: Reactome
  4. mitotic cell cycle checkpoint Source: Ensembl
  5. mRNA metabolic process Source: Reactome
  6. nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: Reactome
  7. optic nerve development Source: Ensembl
  8. retina development in camera-type eye Source: Ensembl
  9. retinal ganglion cell axon guidance Source: Ensembl
  10. ribosomal large subunit assembly Source: Ensembl
  11. RNA metabolic process Source: Reactome
  12. SRP-dependent cotranslational protein targeting to membrane Source: Reactome
  13. translation Source: UniProtKB
  14. translational elongation Source: Reactome
  15. translational initiation Source: Reactome
  16. translational termination Source: Reactome
  17. viral life cycle Source: Reactome
  18. viral process Source: Reactome
  19. viral transcription Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiREACT_115902. SRP-dependent cotranslational protein targeting to membrane.
REACT_1404. Peptide chain elongation.
REACT_1797. Formation of a pool of free 40S subunits.
REACT_1986. Eukaryotic Translation Termination.
REACT_2085. GTP hydrolysis and joining of the 60S ribosomal subunit.
REACT_75768. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
REACT_75822. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
REACT_79. L13a-mediated translational silencing of Ceruloplasmin expression.
REACT_9491. Viral mRNA Translation.

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L24
Alternative name(s):
60S ribosomal protein L30
Gene namesi
Name:RPL24
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:10325. RPL24.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: Reactome
  2. cytosolic large ribosomal subunit Source: UniProtKB
  3. extracellular vesicular exosome Source: UniProt
  4. membrane Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34701.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 15715760S ribosomal protein L24PRO_0000136867Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei27 – 271N6-acetyllysine1 Publication
Modified residuei77 – 771N6-acetyllysine1 Publication
Modified residuei83 – 831Phosphothreonine2 Publications
Modified residuei86 – 861Phosphoserine2 Publications
Modified residuei93 – 931N6-acetyllysine1 Publication
Modified residuei131 – 1311N6-succinyllysineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiP83731.
PaxDbiP83731.
PRIDEiP83731.

PTM databases

PhosphoSiteiP83731.

Expressioni

Gene expression databases

BgeeiP83731.
CleanExiHS_RPL24.
ExpressionAtlasiP83731. baseline and differential.
GenevestigatoriP83731.

Organism-specific databases

HPAiHPA051653.

Interactioni

Protein-protein interaction databases

BioGridi112071. 123 interactions.
IntActiP83731. 25 interactions.
MINTiMINT-5000278.
STRINGi9606.ENSP00000377640.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3J3Belectron microscopy5.00W1-157[»]
ProteinModelPortaliP83731.
SMRiP83731. Positions 1-107.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L24e family.Curated

Phylogenomic databases

eggNOGiCOG2075.
HOGENOMiHOG000184343.
HOVERGENiHBG001066.
InParanoidiP83731.
KOiK02896.
OMAiNQTEDFR.
OrthoDBiEOG77HDH1.
PhylomeDBiP83731.
TreeFamiTF312933.

Family and domain databases

Gene3Di2.30.170.20. 1 hit.
InterProiIPR023442. Ribosomal_L24e_CS.
IPR023441. Ribosomal_L24e_dom.
IPR000988. Ribosomal_L24e_rel.
IPR011017. TRASH_dom.
[Graphical view]
PANTHERiPTHR10792. PTHR10792. 1 hit.
PfamiPF01246. Ribosomal_L24e. 1 hit.
[Graphical view]
SMARTiSM00746. TRASH. 1 hit.
[Graphical view]
PROSITEiPS01073. RIBOSOMAL_L24E. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P83731-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKVELCSFSG YKIYPGHGRR YARTDGKVFQ FLNAKCESAF LSKRNPRQIN
60 70 80 90 100
WTVLYRRKHK KGQSEEIQKK RTRRAVKFQR AITGASLADI MAKRNQKPEV
110 120 130 140 150
RKAQREQAIR AAKEAKKAKQ ASKKTAMAAA KAPTKAAPKQ KIVKPVKVSA

PRVGGKR
Length:157
Mass (Da):17,779
Last modified:January 16, 2004 - v1
Checksum:i1D48EEB7C0652574
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M94314 mRNA. Translation: AAC28251.1.
AB061828 Genomic DNA. Translation: BAB79466.1.
CR456729 mRNA. Translation: CAG33010.1.
AK311992 mRNA. Translation: BAG34930.1.
CH471052 Genomic DNA. Translation: EAW79780.1.
BC000690 mRNA. Translation: AAH00690.1.
BC070193 mRNA. Translation: AAH70193.1.
AB007177 Genomic DNA. Translation: BAA25836.1.
CCDSiCCDS33809.1.
PIRiJN0549.
RefSeqiNP_000977.1. NM_000986.3.
UniGeneiHs.477028.
Hs.649475.

Genome annotation databases

EnsembliENST00000394077; ENSP00000377640; ENSG00000114391.
GeneIDi6152.
KEGGihsa:6152.
UCSCiuc003dvh.1. human.

Polymorphism databases

DMDMi41393532.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M94314 mRNA. Translation: AAC28251.1 .
AB061828 Genomic DNA. Translation: BAB79466.1 .
CR456729 mRNA. Translation: CAG33010.1 .
AK311992 mRNA. Translation: BAG34930.1 .
CH471052 Genomic DNA. Translation: EAW79780.1 .
BC000690 mRNA. Translation: AAH00690.1 .
BC070193 mRNA. Translation: AAH70193.1 .
AB007177 Genomic DNA. Translation: BAA25836.1 .
CCDSi CCDS33809.1.
PIRi JN0549.
RefSeqi NP_000977.1. NM_000986.3.
UniGenei Hs.477028.
Hs.649475.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3J3B electron microscopy 5.00 W 1-157 [» ]
ProteinModelPortali P83731.
SMRi P83731. Positions 1-107.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 112071. 123 interactions.
IntActi P83731. 25 interactions.
MINTi MINT-5000278.
STRINGi 9606.ENSP00000377640.

PTM databases

PhosphoSitei P83731.

Polymorphism databases

DMDMi 41393532.

Proteomic databases

MaxQBi P83731.
PaxDbi P83731.
PRIDEi P83731.

Protocols and materials databases

DNASUi 6152.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000394077 ; ENSP00000377640 ; ENSG00000114391 .
GeneIDi 6152.
KEGGi hsa:6152.
UCSCi uc003dvh.1. human.

Organism-specific databases

CTDi 6152.
GeneCardsi GC03M101399.
HGNCi HGNC:10325. RPL24.
HPAi HPA051653.
MIMi 604180. gene.
neXtProti NX_P83731.
PharmGKBi PA34701.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG2075.
HOGENOMi HOG000184343.
HOVERGENi HBG001066.
InParanoidi P83731.
KOi K02896.
OMAi NQTEDFR.
OrthoDBi EOG77HDH1.
PhylomeDBi P83731.
TreeFami TF312933.

Enzyme and pathway databases

Reactomei REACT_115902. SRP-dependent cotranslational protein targeting to membrane.
REACT_1404. Peptide chain elongation.
REACT_1797. Formation of a pool of free 40S subunits.
REACT_1986. Eukaryotic Translation Termination.
REACT_2085. GTP hydrolysis and joining of the 60S ribosomal subunit.
REACT_75768. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
REACT_75822. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
REACT_79. L13a-mediated translational silencing of Ceruloplasmin expression.
REACT_9491. Viral mRNA Translation.

Miscellaneous databases

ChiTaRSi RPL24. human.
GeneWikii RPL24.
GenomeRNAii 6152.
NextBioi 23893.
PROi P83731.
SOURCEi Search...

Gene expression databases

Bgeei P83731.
CleanExi HS_RPL24.
ExpressionAtlasi P83731. baseline and differential.
Genevestigatori P83731.

Family and domain databases

Gene3Di 2.30.170.20. 1 hit.
InterProi IPR023442. Ribosomal_L24e_CS.
IPR023441. Ribosomal_L24e_dom.
IPR000988. Ribosomal_L24e_rel.
IPR011017. TRASH_dom.
[Graphical view ]
PANTHERi PTHR10792. PTHR10792. 1 hit.
Pfami PF01246. Ribosomal_L24e. 1 hit.
[Graphical view ]
SMARTi SM00746. TRASH. 1 hit.
[Graphical view ]
PROSITEi PS01073. RIBOSOMAL_L24E. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of cDNA clones encoding the human homologue of Saccharomyces cerevisiae ribosomal protein L30."
    Johnson K.R.
    Gene 123:283-285(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The human ribosomal protein genes: sequencing and comparative analysis of 73 genes."
    Yoshihama M., Uechi T., Asakawa S., Kawasaki K., Kato S., Higa S., Maeda N., Minoshima S., Tanaka T., Shimizu N., Kenmochi N.
    Genome Res. 12:379-390(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Thymus.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon.
  7. Bienvenut W.V., Bilsland A.E., Keith W.N.
    Submitted (JAN-2010) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 1-12; 28-44; 48-56 AND 81-93, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Colon carcinoma.
  8. "A map of 75 human ribosomal protein genes."
    Kenmochi N., Kawaguchi T., Rozen S., Davis E., Goodman N., Hudson T.J., Tanaka T., Page D.C.
    Genome Res. 8:509-523(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 132-157.
  9. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-83, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-83 AND SER-86, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-86, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  12. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-27; LYS-77 AND LYS-93, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  14. Cited for: STRUCTURE BY ELECTRON MICROSCOPY (5.0 ANGSTROMS).

Entry informationi

Entry nameiRL24_HUMAN
AccessioniPrimary (citable) accession number: P83731
Secondary accession number(s): B2R4Y3, P38663, Q6IBS3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: January 16, 2004
Last modified: October 29, 2014
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Ribosomal proteins
    Ribosomal proteins families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3