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Protein

60S ribosomal protein L24

Gene

RPL24

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902 Peptide chain elongation
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823 Viral mRNA Translation
R-HSA-2408557 Selenocysteine synthesis
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72689 Formation of a pool of free 40S subunits
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764 Eukaryotic Translation Termination
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L24
Alternative name(s):
60S ribosomal protein L30
Large ribosomal subunit protein eL241 Publication
Gene namesi
Name:RPL24
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000114391.12
HGNCiHGNC:10325 RPL24
MIMi604180 gene
neXtProtiNX_P83731

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi6152
OpenTargetsiENSG00000114391
PharmGKBiPA34701

Polymorphism and mutation databases

BioMutaiRPL24
DMDMi41393532

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001368671 – 15760S ribosomal protein L24Add BLAST157

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki2Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei27N6-acetyllysine; alternateCombined sources1
Cross-linki27Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Cross-linki35Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei77N6-acetyllysineCombined sources1
Modified residuei83PhosphothreonineCombined sources1
Modified residuei86PhosphoserineCombined sources1
Modified residuei93N6-acetyllysineCombined sources1
Modified residuei131N6-succinyllysineBy similarity1
Cross-linki147Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei149PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP83731
PaxDbiP83731
PeptideAtlasiP83731
PRIDEiP83731
TopDownProteomicsiP83731

PTM databases

iPTMnetiP83731
PhosphoSitePlusiP83731
SwissPalmiP83731

Expressioni

Gene expression databases

BgeeiENSG00000114391
CleanExiHS_RPL24
ExpressionAtlasiP83731 baseline and differential
GenevisibleiP83731 HS

Organism-specific databases

HPAiHPA051653

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi112071, 165 interactors
CORUMiP83731
IntActiP83731, 42 interactors
MINTiP83731
STRINGi9606.ENSP00000377640

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4UG0electron microscopy-LW1-157[»]
4V6Xelectron microscopy5.00CW1-157[»]
5A2Qelectron microscopy3.90w79-126[»]
5AJ0electron microscopy3.50AW1-157[»]
5LKSelectron microscopy3.60LW1-157[»]
5T2Celectron microscopy3.60Q1-157[»]
6EK0electron microscopy2.90LW1-157[»]
ProteinModelPortaliP83731
SMRiP83731
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1722 Eukaryota
COG2075 LUCA
GeneTreeiENSGT00550000074809
HOGENOMiHOG000184343
HOVERGENiHBG001066
InParanoidiP83731
KOiK02896
OMAiFHQRKNP
OrthoDBiEOG091G0ZDB
PhylomeDBiP83731
TreeFamiTF312933

Family and domain databases

CDDicd00472 Ribosomal_L24e_L24, 1 hit
Gene3Di2.30.170.20, 1 hit
InterProiView protein in InterPro
IPR038630 L24e/L24_sf
IPR000988 Ribosomal_L24e-rel
IPR023442 Ribosomal_L24e_CS
IPR011017 TRASH_dom
PANTHERiPTHR10792 PTHR10792, 1 hit
PfamiView protein in Pfam
PF01246 Ribosomal_L24e, 1 hit
SMARTiView protein in SMART
SM00746 TRASH, 1 hit
PROSITEiView protein in PROSITE
PS01073 RIBOSOMAL_L24E, 1 hit

Sequencei

Sequence statusi: Complete.

P83731-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVELCSFSG YKIYPGHGRR YARTDGKVFQ FLNAKCESAF LSKRNPRQIN
60 70 80 90 100
WTVLYRRKHK KGQSEEIQKK RTRRAVKFQR AITGASLADI MAKRNQKPEV
110 120 130 140 150
RKAQREQAIR AAKEAKKAKQ ASKKTAMAAA KAPTKAAPKQ KIVKPVKVSA

PRVGGKR
Length:157
Mass (Da):17,779
Last modified:January 16, 2004 - v1
Checksum:i1D48EEB7C0652574
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M94314 mRNA Translation: AAC28251.1
AB061828 Genomic DNA Translation: BAB79466.1
CR456729 mRNA Translation: CAG33010.1
AK311992 mRNA Translation: BAG34930.1
CH471052 Genomic DNA Translation: EAW79780.1
BC000690 mRNA Translation: AAH00690.1
BC070193 mRNA Translation: AAH70193.1
AB007177 Genomic DNA Translation: BAA25836.1
CCDSiCCDS33809.1
PIRiJN0549
RefSeqiNP_000977.1, NM_000986.3
UniGeneiHs.477028
Hs.649475

Genome annotation databases

EnsembliENST00000394077; ENSP00000377640; ENSG00000114391
GeneIDi6152
KEGGihsa:6152

Similar proteinsi

Entry informationi

Entry nameiRL24_HUMAN
AccessioniPrimary (citable) accession number: P83731
Secondary accession number(s): B2R4Y3, P38663, Q6IBS3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: January 16, 2004
Last modified: May 23, 2018
This is version 152 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health