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P83726

- IDHC_NAEFO

UniProt

P83726 - IDHC_NAEFO

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Protein

Isocitrate dehydrogenase [NADP]

Gene
N/A
Organism
Naegleria fowleri (Brain eating amoeba)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.By similarity

Cofactori

Manganese or magnesium.By similarity

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC

GO - Biological processi

  1. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

Magnesium, Manganese, NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP] (EC:1.1.1.42)
Short name:
IDH
Alternative name(s):
IDP
NADP(+)-specific ICDH
NF033
Oxalosuccinate decarboxylase
OrganismiNaegleria fowleri (Brain eating amoeba)Curated
Taxonomic identifieri5763 [NCBI]
Taxonomic lineageiEukaryotaHeteroloboseaSchizopyrenidaVahlkampfiidaeNaegleria

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – ›20›20Isocitrate dehydrogenase [NADP]PRO_0000083582Add
BLAST

Family & Domainsi

Sequence similaritiesi

Sequencei

Sequence statusi: Fragment.

P83726-1 [UniParc]FASTAAdd to Basket

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        10         20
AXFQKIKVAN PVVELDGDEM
Length:20
Mass (Da):2,215
Last modified:January 16, 2004 - v1
Checksum:i4A8244E9BA01D677
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei20 – 201Curated

Cross-referencesi

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

ProtoNeti Search...

Publicationsi

  1. "Comparative study of protein profiles on pathogenic and nonpathogenic Naegleria species by 2D-PAGE."
    Omura M., Furushima-Shimogawara R., Izumiyama S., Endo T.
    Submitted (DEC-2003) to UniProtKB
    Cited for: PROTEIN SEQUENCE.
    Strain: Nf 66.

Entry informationi

Entry nameiIDHC_NAEFO
AccessioniPrimary (citable) accession number: P83726
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: January 16, 2004
Last modified: October 29, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Miscellaneous

On the 2D-gel the determined pI of this protein is: 6.8, its MW is: 32.3 kDa.Curated

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3