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P83726 (IDHC_NAEFO) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 41. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Isocitrate dehydrogenase [NADP]

Short name=IDH
EC=1.1.1.42
Alternative name(s):
IDP
NADP(+)-specific ICDH
NF033
Oxalosuccinate decarboxylase
OrganismNaegleria fowleri (Brain eating amoeba)
Taxonomic identifier5763 [NCBI]
Taxonomic lineageEukaryotaHeteroloboseaSchizopyrenidaVahlkampfiidaeNaegleria

Protein attributes

Sequence length20 AA.
Sequence statusFragment.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH. UniProtKB Q06197

Cofactor

Manganese or magnesium By similarity.

Subcellular location

Cytoplasm By similarity UniProtKB Q06197.

Miscellaneous

On the 2D-gel the determined pI of this protein is: 6.8, its MW is: 32.3 kDa.

Sequence similarities

Belongs to the isocitrate and isopropylmalate dehydrogenases family.

Ontologies

Keywords
   Biological processTricarboxylic acid cycle
   Cellular componentCytoplasm
   LigandMagnesium
Manganese
NADP
   Molecular functionOxidoreductase
   Technical termDirect protein sequencing
Gene Ontology (GO)
   Biological_processtricarboxylic acid cycle

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionisocitrate dehydrogenase (NADP+) activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – ›20›20Isocitrate dehydrogenase [NADP]
PRO_0000083582

Experimental info

Non-terminal residue201

Sequences

Sequence LengthMass (Da)Tools
P83726 [UniParc].

Last modified January 16, 2004. Version 1.
Checksum: 4A8244E9BA01D677

FASTA202,215
        10         20 
AXFQKIKVAN PVVELDGDEM 

« Hide

References

[1]"Comparative study of protein profiles on pathogenic and nonpathogenic Naegleria species by 2D-PAGE."
Omura M., Furushima-Shimogawara R., Izumiyama S., Endo T.
Submitted (DEC-2003) to UniProtKB
Cited for: PROTEIN SEQUENCE.
Strain: Nf 66.

Cross-references

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

ProtoNetSearch...

Entry information

Entry nameIDHC_NAEFO
AccessionPrimary (citable) accession number: P83726
Entry history
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: January 16, 2004
Last modified: February 19, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families