P83726 (IDHC_NAEFO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Isocitrate dehydrogenase [NADP] Short name=IDH EC=1.1.1.42 Alternative name(s): IDP NADP(+)-specific ICDH NF033 Oxalosuccinate decarboxylase
Organism	Naegleria fowleri (Brain eating amoeba)
Taxonomic identifier	5763 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Heterolobosea › Schizopyrenida › Vahlkampfiidae › Naegleria

Protein attributes

Sequence length	20 AA.
Sequence status	Fragment.
Protein existence	Evidence at protein level

General annotation (Comments)

Catalytic activity	Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH. UniProtKB Q06197
Cofactor	Manganese or magnesium By similarity.
Subcellular location	Cytoplasm By similarity UniProtKB Q06197.
Miscellaneous	On the 2D-gel the determined pI of this protein is: 6.8, its MW is: 32.3 kDa.
Sequence similarities	Belongs to the isocitrate and isopropylmalate dehydrogenases family.

Ontologies

Keywords
Biological process	Tricarboxylic acid cycle
Cellular component	Cytoplasm
Ligand	Magnesium Manganese NADP
Molecular function	Oxidoreductase
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological_process	tricarboxylic acid cycle Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	isocitrate dehydrogenase (NADP+) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – ›20	›20	Isocitrate dehydrogenase [NADP]		PRO_0000083582
Experimental info
	Non-terminal residue	20	1

Sequences

	Sequence		Length	Mass (Da)
	P83726 [UniParc]. Last modified January 16, 2004. Version 1. Checksum: 4A8244E9BA01D677	FASTA	20	2,215
	10 20 AXFQKIKVAN PVVELDGDEM

References

[1]	"Comparative study of protein profiles on pathogenic and nonpathogenic Naegleria species by 2D-PAGE." Omura M., Furushima-Shimogawara R., Izumiyama S., Endo T. Submitted (DEC-2003) to UniProtKB Cited for: PROTEIN SEQUENCE. Strain: Nf 66.

Cross-references

3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
PROSITE	PS00470. IDH_IMDH. Partial match. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

IDHC_NAEFO

Accession

Primary (citable) accession number: P83726

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 16, 2004
Last sequence update:	January 16, 2004
Last modified:	June 28, 2011
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)