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Protein

Isocitrate dehydrogenase [NADP]

Gene
N/A
Organism
Naegleria fowleri (Brain eating amoeba)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.By similarity

Cofactori

Mn2+By similarity, Mg2+By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

Magnesium, Manganese, NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP] (EC:1.1.1.42)
Short name:
IDH
Alternative name(s):
IDP
NADP(+)-specific ICDH
NF033
Oxalosuccinate decarboxylase
OrganismiNaegleria fowleri (Brain eating amoeba)Curated
Taxonomic identifieri5763 [NCBI]
Taxonomic lineageiEukaryotaHeteroloboseaSchizopyrenidaVahlkampfiidaeNaegleria

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – ›20›20Isocitrate dehydrogenase [NADP]PRO_0000083582Add
BLAST

Family & Domainsi

Sequence similaritiesi

Sequencei

Sequence statusi: Fragment.

P83726-1 [UniParc]FASTAAdd to basket

« Hide

        10         20
AXFQKIKVAN PVVELDGDEM
Length:20
Mass (Da):2,215
Last modified:January 16, 2004 - v1
Checksum:i4A8244E9BA01D677
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei20 – 201Curated

Cross-referencesi

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiIDHC_NAEFO
AccessioniPrimary (citable) accession number: P83726
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: January 16, 2004
Last modified: September 7, 2016
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Miscellaneous

On the 2D-gel the determined pI of this protein is: 6.8, its MW is: 32.3 kDa.Curated

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.