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Reviewed, UniProtKB/Swiss-Prot P83726 (IDHC_NAEFO)

Last modified November 25, 2008. Version 30. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Isocitrate dehydrogenase [NADP]
      Short name=IDH
    EC=1.1.1.42
Alternative name(s):
    Oxalosuccinate decarboxylase
    NADP(+)-specific ICDH
    IDP
    NF033
OrganismNaegleria fowleri (Brain eating amoeba)
Taxonomic identifier5763 [NCBI]
Taxonomic lineageEukaryotaHeteroloboseaSchizopyrenidaVahlkampfiidaeNaegleria

Protein attributes

Sequence length20 AA.
Sequence statusFragment.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Catalytic activity

Isocitrate + NADP(+) = 2-oxoglutarate + CO(2) + NADPH.

Oxalosuccinate + NADP(+) = 2-oxoglutarate + CO(2) + NADPH.

Cofactor

Manganese or magnesium By similarity.

Subcellular location

CytoplasmBy similarity.

Miscellaneous

On the 2D-gel the determined pI of this protein is: 6.8, its MW is: 32.3 kDa.

Sequence similarities

Belongs to the isocitrate and isopropylmalate dehydrogenases family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – ›20›20Isocitrate dehydrogenase [NADP]
PRO_0000083582

Experimental info

Non-terminal residue201

Sequences

Sequence LengthMass (Da)Tools
P83726-1 [UniParc].

Last modified January 16, 2004. Version 1.
Checksum: 4A8244E9BA01D677

FASTA202,215
        10         20 
AXFQKIKVAN PVVELDGDEM 

« Hide

References

[1]"Comparative study of protein profiles on pathogenic and nonpathogenic Naegleria species by 2D-PAGE."
Omura M., Furushima-Shimogawara R., Izumiyama S., Endo T.
Submitted (DEC-2003) to UniProtKB
Cited for: PROTEIN SEQUENCE.
Strain: Nf 66.

Cross-references

3D structure databases

ModBaseSearch...

Family and domain databases

InterProIPR004790. IsoCit_DHase_NADP-dep_euk.
IPR001804. IsoCit_IM_DHase.
[Graphical view]
PANTHERPTHR11822. IDH_NADP_euk. 1 hit.
PROSITEPS00470. IDH_IMDH. Partial match.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameIDHC_NAEFO
AccessionPrimary (citable) accession number: P83726
Entry history
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: January 16, 2004
Last modified: November 25, 2008
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents