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Protein

Isocitrate dehydrogenase [NADP]

Gene
N/A
Organism
Naegleria fowleri (Brain eating amoeba)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.By similarity

Cofactori

Mn2+By similarity, Mg2+By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

Magnesium, Manganese, NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP] (EC:1.1.1.42)
Short name:
IDH
Alternative name(s):
IDP
NADP(+)-specific ICDH
NF033
Oxalosuccinate decarboxylase
OrganismiNaegleria fowleri (Brain eating amoeba)Curated
Taxonomic identifieri5763 [NCBI]
Taxonomic lineageiEukaryotaHeteroloboseaSchizopyrenidaVahlkampfiidaeNaegleria

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – ›20›20Isocitrate dehydrogenase [NADP]PRO_0000083582Add
BLAST

Family & Domainsi

Sequence similaritiesi

Sequencei

Sequence statusi: Fragment.

P83726-1 [UniParc]FASTAAdd to basket

« Hide

        10         20
AXFQKIKVAN PVVELDGDEM
Length:20
Mass (Da):2,215
Last modified:January 16, 2004 - v1
Checksum:i4A8244E9BA01D677
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei20 – 201Curated

Cross-referencesi

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

ProtoNetiSearch...

Publicationsi

  1. "Comparative study of protein profiles on pathogenic and nonpathogenic Naegleria species by 2D-PAGE."
    Omura M., Furushima-Shimogawara R., Izumiyama S., Endo T.
    Submitted (DEC-2003) to UniProtKB
    Cited for: PROTEIN SEQUENCE.
    Strain: Nf 66.

Entry informationi

Entry nameiIDHC_NAEFO
AccessioniPrimary (citable) accession number: P83726
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: January 16, 2004
Last modified: January 7, 2015
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Miscellaneous

On the 2D-gel the determined pI of this protein is: 6.8, its MW is: 32.3 kDa.Curated

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.