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P83703 (P83703_THETH) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-dehydroquinate synthase HAMAP-Rule MF_00110

EC=4.2.3.4 HAMAP-Rule MF_00110
Gene names
Name:aroB HAMAP-Rule MF_00110
OrganismThermus thermophilus PDB 1UJN
Taxonomic identifier274 [NCBI]
Taxonomic lineageBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus

Protein attributes

Sequence length348 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate = 3-dehydroquinate + phosphate. HAMAP-Rule MF_00110

Cofactor

Divalent metal cations By similarity. HAMAP-Rule MF_00110 SAAS SAAS016037

NAD By similarity. HAMAP-Rule MF_00110 SAAS SAAS016037

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7. HAMAP-Rule MF_00110 SAAS SAAS016037

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00110 SAAS SAAS016037

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00110 SAAS SAAS016037.

Sequence similarities

Belongs to the dehydroquinate synthase family. HAMAP-Rule MF_00110

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site1311Proton donor/acceptor PDB 1UJN
Active site2201Proton donor/acceptor PDB 1UJN
Active site2351Proton donor/acceptor PDB 1UJN
Site1091Important for catalytic activity PDB 1UJN
Site2101Important for catalytic activity PDB 1UJN
Site2241Important for catalytic activity PDB 1UJN
Site2281Important for catalytic activity PDB 1UJN

Sequences

Sequence LengthMass (Da)Tools
P83703 [UniParc].

Last modified December 15, 2003. Version 1.
Checksum: 642813E920F4880F

FASTA34837,510
        10         20         30         40         50         60 
MQRLEVREPV PYPILVGEGV LKEVPPLAGP AALLFDRRVE GFAQEVAKAL GVRHLLGLPG 

        70         80         90        100        110        120 
GEAAKSLEVY GKVLSWLAEK GLPRNATLLV VGGGTLTDLG GFVAATYLRG VAYLAFPTTT 

       130        140        150        160        170        180 
LAIVDASVGG KTGINLPEGK NLVGAFHFPQ GVYAELRALK TLPLPTFKEG LVEAFKHGLI 

       190        200        210        220        230        240 
AGDEALLKVE DLTPQSPRLE AFLARAVAVK VRVTEEDPLE KGKRRLLNLG HTLGHALEAQ 

       250        260        270        280        290        300 
TRHALPHGMA VAYGLLYAAL LGRALGGEDL LPPVRRLLLW LSPPPLPPLA FEDLLPYLLR 

       310        320        330        340 
DKKKVSESLH WVVPLAPGRL VVRPLPEGLL REAFAAWREE LKGLGLLR 

« Hide

References

[1]"Crystal structure of dehydroquinate synthase from Thermus thermophilus HB8 showing functional importance of the dimeric state."
Sugahara M., Nodake Y., Sugahara M., Kunishima N.
Proteins 58:249-252(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS), ACTIVE SITE.

Cross-references

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1UJNX-ray1.80A/B1-348[»]
ProteinModelPortalP83703.
SMRP83703. Positions 1-347.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING262724.TTC1020.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00053; UER00085.

Family and domain databases

HAMAPMF_00110. DHQ_synthase.
InterProIPR016037. DHQ_synth_AroB.
[Graphical view]
PIRSFPIRSF001455. DHQ_synth. 1 hit.
ProtoNetSearch...

Other

EvolutionaryTraceP83703.

Entry information

Entry nameP83703_THETH
AccessionPrimary (citable) accession number: P83703
Entry history
Integrated into UniProtKB/TrEMBL: December 15, 2003
Last sequence update: December 15, 2003
Last modified: June 11, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)