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P83703

- P83703_THETH

UniProt

P83703 - P83703_THETH

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Protein

3-dehydroquinate synthase

Gene
aroB
Organism
Thermus thermophilus
Status
Unreviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate = 3-dehydroquinate + phosphate.UniRule annotation

Cofactori

Divalent metal cations By similarity.UniRule annotationSAAS annotations
NAD By similarity.UniRule annotationSAAS annotations

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei109 – 1091Important for catalytic activityImported
Active sitei131 – 1311Proton donor/acceptorImported
Sitei210 – 2101Important for catalytic activityImported
Active sitei220 – 2201Proton donor/acceptorImported
Sitei224 – 2241Important for catalytic activityImported
Sitei228 – 2281Important for catalytic activityImported
Active sitei235 – 2351Proton donor/acceptorImported

GO - Molecular functioni

  1. 3-dehydroquinate synthase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. aromatic amino acid family biosynthetic process Source: UniProtKB-HAMAP
  2. chorismate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotation

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesisUniRule annotationSAAS annotations

Keywords - Ligandi

NADUniRule annotationSAAS annotations

Enzyme and pathway databases

UniPathwayiUPA00053; UER00085.

Names & Taxonomyi

Protein namesi
Recommended name:
3-dehydroquinate synthaseUniRule annotation (EC:4.2.3.4UniRule annotation)
Gene namesi
Name:aroBUniRule annotation
OrganismiThermus thermophilusImported
Taxonomic identifieri274 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus

Subcellular locationi

Cytoplasm By similarity UniRule annotationSAAS annotations

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotations

Interactioni

Subunit structurei

Monomer By similarity.UniRule annotationSAAS annotations

Protein-protein interaction databases

STRINGi262724.TTC1020.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1UJNX-ray1.80A/B1-348[»]
ProteinModelPortaliP83703.
SMRiP83703. Positions 1-347.

Miscellaneous databases

EvolutionaryTraceiP83703.

Family & Domainsi

Sequence similaritiesi

Belongs to the dehydroquinate synthase family.UniRule annotation

Family and domain databases

HAMAPiMF_00110. DHQ_synthase.
InterProiIPR016037. DHQ_synth_AroB.
[Graphical view]
PIRSFiPIRSF001455. DHQ_synth. 1 hit.

Sequencei

Sequence statusi: Complete.

P83703-1 [UniParc]FASTAAdd to Basket

« Hide

MQRLEVREPV PYPILVGEGV LKEVPPLAGP AALLFDRRVE GFAQEVAKAL    50
GVRHLLGLPG GEAAKSLEVY GKVLSWLAEK GLPRNATLLV VGGGTLTDLG 100
GFVAATYLRG VAYLAFPTTT LAIVDASVGG KTGINLPEGK NLVGAFHFPQ 150
GVYAELRALK TLPLPTFKEG LVEAFKHGLI AGDEALLKVE DLTPQSPRLE 200
AFLARAVAVK VRVTEEDPLE KGKRRLLNLG HTLGHALEAQ TRHALPHGMA 250
VAYGLLYAAL LGRALGGEDL LPPVRRLLLW LSPPPLPPLA FEDLLPYLLR 300
DKKKVSESLH WVVPLAPGRL VVRPLPEGLL REAFAAWREE LKGLGLLR 348
Length:348
Mass (Da):37,510
Last modified:December 15, 2003 - v1
Checksum:i642813E920F4880F
GO

Cross-referencesi

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1UJN X-ray 1.80 A/B 1-348 [» ]
ProteinModelPortali P83703.
SMRi P83703. Positions 1-347.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 262724.TTC1020.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00053 ; UER00085 .

Miscellaneous databases

EvolutionaryTracei P83703.

Family and domain databases

HAMAPi MF_00110. DHQ_synthase.
InterProi IPR016037. DHQ_synth_AroB.
[Graphical view ]
PIRSFi PIRSF001455. DHQ_synth. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Crystal structure of dehydroquinate synthase from Thermus thermophilus HB8 showing functional importance of the dimeric state."
    Sugahara M., Nodake Y., Sugahara M., Kunishima N.
    Proteins 58:249-252(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS), ACTIVE SITE.

Entry informationi

Entry nameiP83703_THETH
AccessioniPrimary (citable) accession number: P83703
Entry historyi
Integrated into UniProtKB/TrEMBL: December 15, 2003
Last sequence update: December 15, 2003
Last modified: June 11, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported

External Data

Dasty 3

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