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P83703

- P83703_THETH

UniProt

P83703 - P83703_THETH

Protein

3-dehydroquinate synthase

Gene

aroB

Organism
Thermus thermophilus
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 45 (01 Oct 2014)
      Sequence version 1 (15 Dec 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate = 3-dehydroquinate + phosphate.UniRule annotationSAAS annotation

    Cofactori

    Divalent metal cations.UniRule annotationSAAS annotation
    NAD.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei109 – 1091Important for catalytic activityImported
    Active sitei131 – 1311Proton donor/acceptorImported
    Sitei210 – 2101Important for catalytic activityImported
    Active sitei220 – 2201Proton donor/acceptorImported
    Sitei224 – 2241Important for catalytic activityImported
    Sitei228 – 2281Important for catalytic activityImported
    Active sitei235 – 2351Proton donor/acceptorImported

    GO - Molecular functioni

    1. 3-dehydroquinate synthase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. aromatic amino acid family biosynthetic process Source: UniProtKB-HAMAP
    2. chorismate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    LyaseUniRule annotation

    Keywords - Biological processi

    Amino-acid biosynthesis, Aromatic amino acid biosynthesisUniRule annotationSAAS annotation

    Keywords - Ligandi

    NADUniRule annotationSAAS annotation

    Enzyme and pathway databases

    UniPathwayiUPA00053; UER00085.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    3-dehydroquinate synthaseUniRule annotation (EC:4.2.3.4UniRule annotation)
    Gene namesi
    Name:aroBUniRule annotation
    OrganismiThermus thermophilusImported
    Taxonomic identifieri274 [NCBI]
    Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus

    Subcellular locationi

    Cytoplasm UniRule annotationSAAS annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotationSAAS annotation

    Interactioni

    Subunit structurei

    Monomer.UniRule annotationSAAS annotation

    Protein-protein interaction databases

    STRINGi262724.TTC1020.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1UJNX-ray1.80A/B1-348[»]
    ProteinModelPortaliP83703.
    SMRiP83703. Positions 1-347.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP83703.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the dehydroquinate synthase family.UniRule annotation

    Family and domain databases

    HAMAPiMF_00110. DHQ_synthase.
    InterProiIPR016037. DHQ_synth_AroB.
    [Graphical view]
    PIRSFiPIRSF001455. DHQ_synth. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P83703-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQRLEVREPV PYPILVGEGV LKEVPPLAGP AALLFDRRVE GFAQEVAKAL    50
    GVRHLLGLPG GEAAKSLEVY GKVLSWLAEK GLPRNATLLV VGGGTLTDLG 100
    GFVAATYLRG VAYLAFPTTT LAIVDASVGG KTGINLPEGK NLVGAFHFPQ 150
    GVYAELRALK TLPLPTFKEG LVEAFKHGLI AGDEALLKVE DLTPQSPRLE 200
    AFLARAVAVK VRVTEEDPLE KGKRRLLNLG HTLGHALEAQ TRHALPHGMA 250
    VAYGLLYAAL LGRALGGEDL LPPVRRLLLW LSPPPLPPLA FEDLLPYLLR 300
    DKKKVSESLH WVVPLAPGRL VVRPLPEGLL REAFAAWREE LKGLGLLR 348
    Length:348
    Mass (Da):37,510
    Last modified:December 15, 2003 - v1
    Checksum:i642813E920F4880F
    GO

    Cross-referencesi

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1UJN X-ray 1.80 A/B 1-348 [» ]
    ProteinModelPortali P83703.
    SMRi P83703. Positions 1-347.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 262724.TTC1020.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00053 ; UER00085 .

    Miscellaneous databases

    EvolutionaryTracei P83703.

    Family and domain databases

    HAMAPi MF_00110. DHQ_synthase.
    InterProi IPR016037. DHQ_synth_AroB.
    [Graphical view ]
    PIRSFi PIRSF001455. DHQ_synth. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Crystal structure of dehydroquinate synthase from Thermus thermophilus HB8 showing functional importance of the dimeric state."
      Sugahara M., Nodake Y., Sugahara M., Kunishima N.
      Proteins 58:249-252(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS), ACTIVE SITE.

    Entry informationi

    Entry nameiP83703_THETH
    AccessioniPrimary (citable) accession number: P83703
    Entry historyi
    Integrated into UniProtKB/TrEMBL: December 15, 2003
    Last sequence update: December 15, 2003
    Last modified: October 1, 2014
    This is version 45 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported

    External Data

    Dasty 3