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Protein

Kunitz-type serine protease inhibitor DrTI

Gene
N/A
Organism
Delonix regia (Royal poinciana) (Poinciana regia)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Inhibits bovine trypsin and human plasma kallikrein.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei68 – 692Reactive bondSequence analysis

GO - Molecular functioni

  • serine-type endopeptidase inhibitor activity Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Kunitz-type serine protease inhibitor DrTI
OrganismiDelonix regia (Royal poinciana) (Poinciana regia)Curated
Taxonomic identifieri72433 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaeCaesalpinioideaeCaesalpinieaeDelonix

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 185185Kunitz-type serine protease inhibitor DrTIPRO_0000083324Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi44 ↔ 89By similarity
Disulfide bondi139 ↔ 147By similarity

Keywords - PTMi

Disulfide bond

Structurei

Secondary structure

1
185
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi18 – 247Combined sources
Beta strandi28 – 303Combined sources
Beta strandi33 – 375Combined sources
Beta strandi47 – 504Combined sources
Beta strandi61 – 644Combined sources
Beta strandi69 – 724Combined sources
Beta strandi79 – 857Combined sources
Beta strandi94 – 985Combined sources
Beta strandi100 – 1034Combined sources
Beta strandi105 – 1084Combined sources
Turni111 – 1133Combined sources
Helixi116 – 1183Combined sources
Beta strandi122 – 1287Combined sources
Beta strandi130 – 1323Combined sources
Beta strandi134 – 14310Combined sources
Beta strandi148 – 1536Combined sources
Beta strandi155 – 1573Combined sources
Beta strandi159 – 1624Combined sources
Beta strandi164 – 1674Combined sources
Beta strandi172 – 1754Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1R8NX-ray1.75A1-185[»]
ProteinModelPortaliP83667.
SMRiP83667. Positions 1-185.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP83667.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiIPR011065. Kunitz_inhibitor_ST1-like.
IPR002160. Prot_inh_Kunz-lg.
[Graphical view]
PfamiPF00197. Kunitz_legume. 1 hit.
[Graphical view]
PRINTSiPR00291. KUNITZINHBTR.
SMARTiSM00452. STI. 1 hit.
[Graphical view]
SUPFAMiSSF50386. SSF50386. 1 hit.

Sequencei

Sequence statusi: Complete.

P83667-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
SDAEKVYDIE GYPVFLGSEY YIVSAIIGAG GGGVRPGRTR GSMCPMSIIQ
60 70 80 90 100
EQSDLQMGLP VRFSSPEESQ GKIYTDTELE IEFVEKPDCA ESSKWVIVKD
110 120 130 140 150
SGEARVAIGG SEDHPQGELV RGFFKIEKLG SLAYKLVFCP KSSSGSCSDI
160 170 180
GINYEGRRSL VLKSSDDSPF RVVFVKPRSG SETES
Length:185
Mass (Da):20,094
Last modified:December 15, 2003 - v1
Checksum:i55CFF042CC50C7CC
GO

Cross-referencesi

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1R8NX-ray1.75A1-185[»]
ProteinModelPortaliP83667.
SMRiP83667. Positions 1-185.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP83667.

Family and domain databases

InterProiIPR011065. Kunitz_inhibitor_ST1-like.
IPR002160. Prot_inh_Kunz-lg.
[Graphical view]
PfamiPF00197. Kunitz_legume. 1 hit.
[Graphical view]
PRINTSiPR00291. KUNITZINHBTR.
SMARTiSM00452. STI. 1 hit.
[Graphical view]
SUPFAMiSSF50386. SSF50386. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Primary sequence determination of a Kunitz inhibitor isolated from Delonix regia seeds."
    Pando S.C., Oliva M.L.V., Sampaio C.A.M., Di Ciero L., Novello J.C., Marangoni S.
    Phytochemistry 57:625-631(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE, FUNCTION.
    Tissue: Seed1 Publication.

Entry informationi

Entry nameiDRTI_DELRE
AccessioniPrimary (citable) accession number: P83667
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: December 15, 2003
Last modified: July 6, 2016
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Caution

The reactive bond has a Glu in position P1 instead of an expected Arg or Lys.Curated

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.