P83662 (ACMSD_PIG) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
2-amino-3-carboxymuconate-6-semialdehyde decarboxylase
EC=4.1.1.45

Alternative name(s):
Picolinate carboxylase

Gene names

Name:

ACMSD

Organism

Sus scrofa (Pig) [Complete proteome]

Taxonomic identifier

9823 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Suina › Suidae › Sus

Protein attributes

Sequence length	138 AA.
Sequence status	Fragments.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Converts alpha-amino-beta-carboxymuconate-epsilon-semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway. Ref.1 UniProtKB Q8TDX5
Catalytic activity	2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate = 2-aminomuconate semialdehyde + CO2.
Pathway	Secondary metabolite metabolism; quinolate metabolism.
Subunit structure	Monomer By similarity.
Sequence similarities	Belongs to the ACMSD family.

Ontologies

Keywords
Ligand	Metal-binding Zinc
Molecular function	Decarboxylase Lyase
PTM	Phosphoprotein
Technical term	Complete proteome Direct protein sequencing
Gene Ontology (GO)
Biological process	quinolinate metabolic process Inferred from sequence or structural similarity. Source: UniProtKB
Cellular component	cytosol Inferred from sequence or structural similarity. Source: UniProtKB
Molecular function	aminocarboxymuconate-semialdehyde decarboxylase activity Inferred from sequence or structural similarity. Source: UniProtKB metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – ›138	›138	2-amino-3-carboxymuconate-6-semialdehyde decarboxylase		PRO_0000190981
Sites
	Metal binding	6	1	Zinc By similarity
	Metal binding	8	1	Zinc By similarity
	Metal binding	70	1	Zinc By similarity
	Metal binding	126	1	Zinc By similarity
	Binding site	47	1	Substrate By similarity
Amino acid modifications
	Modified residue	58	1	Phosphothreonine By similarity
Experimental info
	Sequence uncertainty	23	1	Y or G Ref.1
	Sequence uncertainty	43	1	G or D Ref.1
	Sequence uncertainty	48	1	V or R Ref.1
	Non-adjacent residues	51 – 52	2
	Non-adjacent residues	64 – 65	2
	Non-adjacent residues	75 – 76	2
	Non-adjacent residues	103 – 104	2
	Non-adjacent residues	120 – 121	2
	Non-terminal residue	138	1

Sequences

	Sequence		Length	Mass (Da)
	P83662 [UniParc]. Last modified November 7, 2003. Version 1. Checksum: C2A558B31AB57120	FASTA	138	15,679
	10 20 30 40 50 60 MKIDIHSHIL PKEWPDLKKR FGYXGWVELQ HHSEGEAKML KDGKVFRVVQ ERFVGLGTLP 70 80 90 100 110 120 MQAPXSLFVH PWDMQYWFPW LIGMPAETTT AXESMMMGGV FEKVXFAHGG GSFPFTVGRI 130 VILGTDYPFP LGELEPGK

References

[1]

"Identification and expression of a cDNA encoding human alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase (ACMSD). A key enzyme for the tryptophan-niacine pathway and 'quinolinate hypothesis'." Fukuoka S., Ishiguro K., Yanagihara K., Tanabe A., Egashira Y., Sanada H., Shibata K. J. Biol. Chem. 277:35162-35167(2002) [PubMed: 12140278] [Abstract] Cited for: PROTEIN SEQUENCE. Tissue: Brain.

Cross-references

3D structure databases
ProteinModelPortal	P83662.
ModBase	Search...
Protein-protein interaction databases
STRING	P83662.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
ProtoNet	Search...

Entry information

Entry name

ACMSD_PIG

Accession

Primary (citable) accession number: P83662

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 7, 2003
Last sequence update:	November 7, 2003
Last modified:	July 27, 2011
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program