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P83658

- DIDS_ECHCA

UniProt

P83658 - DIDS_ECHCA

Protein

Disintegrin schistatin

Gene
N/A
Organism
Echis carinatus (Saw-scaled viper)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    May bind to both alpha-IIb/beta-3 (ITGA2B/ITGB3) and alpha-V/beta-3 (ITGAV/ITGB3) integrins, and may inhibit platelet aggregation.

    Keywords - Molecular functioni

    Cell adhesion impairing toxin, Hemostasis impairing toxin, Platelet aggregation inhibiting toxin, Toxin

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Disintegrin schistatin
    OrganismiEchis carinatus (Saw-scaled viper)Curated
    Taxonomic identifieri40353 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaSerpentesColubroideaViperidaeViperinaeEchis

    Subcellular locationi

    Secreted 1 PublicationCurated

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 6464Disintegrin schistatinPRO_0000101800Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi6 ↔ 29Curated
    Disulfide bondi7 – 7Interchain (with C-12)
    Disulfide bondi12 – 12Interchain (with C-7)
    Disulfide bondi20 ↔ 26Curated
    Disulfide bondi25 ↔ 50Curated
    Disulfide bondi38 ↔ 57Curated

    Keywords - PTMi

    Disulfide bond

    Expressioni

    Tissue specificityi

    Expressed by the venom gland.1 PublicationCurated

    Interactioni

    Subunit structurei

    Homodimer; disulfide-linked.2 Publications

    Structurei

    Secondary structure

    1
    64
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Turni9 – 113
    Beta strandi12 – 143
    Beta strandi37 – 393
    Beta strandi42 – 454

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1RMRX-ray2.50A1-64[»]
    ProteinModelPortaliP83658.
    SMRiP83658. Positions 1-64.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP83658.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 6464DisintegrinPROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi42 – 443Cell attachment site

    Sequence similaritiesi

    Contains 1 disintegrin domain.PROSITE-ProRule annotation

    Phylogenomic databases

    HOVERGENiHBG005487.

    Family and domain databases

    Gene3Di4.10.70.10. 1 hit.
    InterProiIPR001762. Blood-coag_inhib_Disintegrin.
    IPR018358. Disintegrin_CS.
    [Graphical view]
    PfamiPF00200. Disintegrin. 1 hit.
    [Graphical view]
    PRINTSiPR00289. DISINTEGRIN.
    SMARTiSM00050. DISIN. 1 hit.
    [Graphical view]
    SUPFAMiSSF57552. SSF57552. 1 hit.
    PROSITEiPS00427. DISINTEGRIN_1. 1 hit.
    PS50214. DISINTEGRIN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P83658-1 [UniParc]FASTAAdd to Basket

    « Hide

    NSVHPCCDPV ICEPREGEHC ISGPCCENCY FLNSGTICKR ARGDGNQDYC   50
    TGITPDCPRN RYNV 64
    Length:64
    Mass (Da):7,083
    Last modified:October 1, 2003 - v1
    Checksum:iFD0CA30A2048EE51
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti8 – 81D → P AA sequence (PubMed:11679739)Curated

    Cross-referencesi

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1RMR X-ray 2.50 A 1-64 [» ]
    ProteinModelPortali P83658.
    SMRi P83658. Positions 1-64.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG005487.

    Miscellaneous databases

    EvolutionaryTracei P83658.

    Family and domain databases

    Gene3Di 4.10.70.10. 1 hit.
    InterProi IPR001762. Blood-coag_inhib_Disintegrin.
    IPR018358. Disintegrin_CS.
    [Graphical view ]
    Pfami PF00200. Disintegrin. 1 hit.
    [Graphical view ]
    PRINTSi PR00289. DISINTEGRIN.
    SMARTi SM00050. DISIN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57552. SSF57552. 1 hit.
    PROSITEi PS00427. DISINTEGRIN_1. 1 hit.
    PS50214. DISINTEGRIN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Bilgrami S., Jabeen T., Kumar J., Yadav S., Sharma S., Kaur P., Singh T.P.
      Submitted (SEP-2003) to UniProtKB
      Cited for: PROTEIN SEQUENCE, SUBUNIT, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DISULFIDE BONDS.
      Tissue: VenomCurated.
    2. "Purification, crystallization and preliminary X-ray diffraction studies of disintegrin (schistatin) from saw-scaled viper (Echis carinatus)."
      Tomar S., Yadav S., Chandra V., Kumar P., Singh T.P.
      Acta Crystallogr. D 57:1669-1670(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 1-19, X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS).
      Tissue: Venom1 Publication.
    3. "Crystal structure of schistatin, a disintegrin homodimer from saw-scaled viper (Echis carinatus) at 2.5 A resolution."
      Bilgrami S., Tomar S., Yadav S., Kaur P., Kumar J., Jabeen T., Sharma S., Singh T.P.
      J. Mol. Biol. 341:829-837(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS), DISULFIDE BONDS.

    Entry informationi

    Entry nameiDIDS_ECHCA
    AccessioniPrimary (citable) accession number: P83658
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 16, 2004
    Last sequence update: October 1, 2003
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programAnimal Toxin Annotation Program
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Direct protein sequencing

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3