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P83658 (DIDS_ECHCA) Reviewed, UniProtKB/Swiss-Prot

Last modified December 11, 2013. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Disintegrin schistatin
OrganismEchis carinatus (Saw-scaled viper)
Taxonomic identifier40353 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaSerpentesColubroideaViperidaeViperinaeEchis

Protein attributes

Sequence length64 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May bind to both alpha-2b/beta-3 (ITGA2B/ITGB3) and alpha-V/beta-3 (ITGAV/ITGB3) integrins, and may inhibit platelet aggregation.

Subunit structure

Homodimer; disulfide-linked. Ref.1 Ref.3

Subcellular location

Secreted Ref.1.

Tissue specificity

Expressed by the venom gland. Ref.1

Sequence similarities

Belongs to the disintegrin family. Dimeric disintegrin subfamily.

Contains 1 disintegrin domain.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 6464Disintegrin schistatin
PRO_0000101800

Regions

Domain1 – 6464Disintegrin
Motif42 – 443Cell attachment site

Amino acid modifications

Disulfide bond6 ↔ 29 Ref.1 Ref.3
Disulfide bond7Interchain (with C-12) Ref.1 Ref.3
Disulfide bond12Interchain (with C-7) Ref.1 Ref.3
Disulfide bond20 ↔ 26 Ref.1 Ref.3
Disulfide bond25 ↔ 50 Ref.1 Ref.3
Disulfide bond38 ↔ 57 Ref.1 Ref.3

Experimental info

Sequence conflict81D → P AA sequence Ref.2

Secondary structure

........ 64
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P83658 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: FD0CA30A2048EE51

FASTA647,083
        10         20         30         40         50         60 
NSVHPCCDPV ICEPREGEHC ISGPCCENCY FLNSGTICKR ARGDGNQDYC TGITPDCPRN 


RYNV 

« Hide

References

[1]Bilgrami S., Jabeen T., Kumar J., Yadav S., Sharma S., Kaur P., Singh T.P.
Submitted (SEP-2003) to UniProtKB
Cited for: PROTEIN SEQUENCE, SUBUNIT, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DISULFIDE BONDS.
Tissue: Venom.
[2]"Purification, crystallization and preliminary X-ray diffraction studies of disintegrin (schistatin) from saw-scaled viper (Echis carinatus)."
Tomar S., Yadav S., Chandra V., Kumar P., Singh T.P.
Acta Crystallogr. D 57:1669-1670(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 1-19, X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS).
Tissue: Venom.
[3]"Crystal structure of schistatin, a disintegrin homodimer from saw-scaled viper (Echis carinatus) at 2.5 A resolution."
Bilgrami S., Tomar S., Yadav S., Kaur P., Kumar J., Jabeen T., Sharma S., Singh T.P.
J. Mol. Biol. 341:829-837(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS), DISULFIDE BONDS.

Cross-references

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1RMRX-ray2.50A1-64[»]
ProteinModelPortalP83658.
SMRP83658. Positions 1-64.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG005487.

Family and domain databases

Gene3D4.10.70.10. 1 hit.
InterProIPR001762. Blood-coag_inhib_Disintegrin.
IPR018358. Disintegrin_CS.
[Graphical view]
PfamPF00200. Disintegrin. 1 hit.
[Graphical view]
PRINTSPR00289. DISINTEGRIN.
SMARTSM00050. DISIN. 1 hit.
[Graphical view]
SUPFAMSSF57552. SSF57552. 1 hit.
PROSITEPS00427. DISINTEGRIN_1. 1 hit.
PS50214. DISINTEGRIN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP83658.

Entry information

Entry nameDIDS_ECHCA
AccessionPrimary (citable) accession number: P83658
Entry history
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: October 1, 2003
Last modified: December 11, 2013
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references