Potassium channel toxin kappa-KTx 1.3

Functionⁱ

Has no effect on potassium channels.

Miscellaneous

Has no effect on Kv1.1/KCNA1, Kv1.2/KCNA2 and Kv1.3/KCNA3 potassium channels, suggesting that the presence of an additional charged residue in a position adjacent to the dyad lysine impedes the functional block of Kv1 channels produced by this toxin.1 Publication

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Siteⁱ	5	Aromatic residue of the functional dyadBy similarity		1
Siteⁱ	19	Basic residue of the functional dyadBy similarity		1

GO - Biological processⁱ

pathogenesis Source: InterPro

Complete GO annotation...

Keywordsⁱ

Molecular function	Toxin

Molecular function

Toxin

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Potassium channel toxin kappa-KTx 1.31 Publication
Organismⁱ	Heterometrus spinifer (Asia giant forest scorpion) (Malaysian black scorpion)
Taxonomic identifierⁱ	118530 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Chelicerata › Arachnida › Scorpiones › Iurida › Scorpionoidea › Scorpionidae › Scorpioninae › Heterometrus

Subcellular locationⁱ

Secreted
1 Publication
Manual assertion based on experiment inⁱ
- Ref.1
  "Assignment of voltage-gated potassium channel blocking activity to kappa-KTx1.3, a non-toxic homologue of kappa-hefutoxin-1, from Heterometrus spinifer venom."
  Nirthanan S., Pil J., Abdel-Mottaleb Y., Sugahara Y., Gopalakrishnakone P., Joseph J.S., Sato K., Tytgat J.
  Biochem. Pharmacol. 69:669-678(2005) [PubMed] [Europe PMC] [Abstract]
  Cited for: PROTEIN SEQUENCE, SUBUNIT, SUBCELLULAR LOCATION, DISULFIDE BOND, MUTAGENESIS OF LYS-20, MASS SPECTROMETRY.

GO - Cellular componentⁱ

extracellular region Source: UniProtKB-SubCell

Complete GO annotation...

Keywords - Cellular componentⁱ

Secreted

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	20	K → A: Blocks both Kv1.2/KCNA2 (IC(50)=36.9 uM) and Kv1.3/KCNA3 (IC(50)=115.7 uM) but also Kv1.1/KCNA1 (IC(50)=110.7 uM). 1 Publication	1
Mutagenesisⁱ	20	K → E: Blocks Kv1.2/KCNA2 (IC(50)=36.8 uM) and Kv1.3/KCNA3 (IC(50)=53.7 uM), but not Kv1.1/KCNA1. 1 Publication	1
Mutagenesisⁱ	20	K → R: Does not block any channel subtype tested. 1 Publication	1

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
PeptideⁱPRO_0000044546	1 – 23	Potassium channel toxin kappa-KTx 1.31 PublicationAdd BLAST		23

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Disulfide bondⁱ	4 ↔ 22	1 Publication
Disulfide bondⁱ	8 ↔ 18	1 Publication

Keywords - PTMⁱ

Disulfide bond

Expressionⁱ

Tissue specificityⁱ

Expressed by the venom gland.1 Publication

Interactionⁱ

Subunit structureⁱ

Monomer.1 Publication

Family & Domainsⁱ

Domainⁱ

Has the structural arrangement of two alpha-helices stabilized by two disulfide bonds (CSalpha/alpha 2(S-S)).By similarity

Sequence similaritiesⁱ

Belongs to the short scorpion toxin superfamily. Potassium channel inhibitor kappa-KTx family. Kappa-KTx 1 subfamily.Curated

Family and domain databases

InterProⁱ	View protein in InterPro IPR012630. Toxin_25.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF08095. Toxin_25. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

P83655-1 [UniParc]FASTA Add to basket

« Hide

        10         20 
GFGCYRSCWK AGHDEETCKK ECS

Length:23

Mass (Da):2,625

Last modified:December 7, 2004 - v1

Checksum:ⁱAE059DD3CA5D61CE

GO

Mass spectrometryⁱ

Molecular mass is 2620.7 Da from positions 1 - 23. Determined by MALDI. 1 Publication

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Family and domain databases

InterProⁱ	View protein in InterPro IPR012630. Toxin_25.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF08095. Toxin_25. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	KKX13_HETSP
Accessionⁱ	P83655Primary (citable) accession number: P83655
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 7, 2004
	Last sequence update:	December 7, 2004
	Last modified:	July 5, 2017
	This is version 33 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Animal Toxin Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Direct protein sequencing

Documents

Scorpion potassium channel toxins
Nomenclature of scorpion potassium channel toxins and list of entries
SIMILARITY comments
Index of protein domains and families

UniProtKB - P83655 (KKX13_HETSP)

Your basket is currently empty.

Select a section on the left to see content.

Functionⁱ

Miscellaneous

Sites

GO - Biological processⁱ

Keywordsⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Mutagenesis

PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Expressionⁱ

Tissue specificityⁱ

Interactionⁱ

Subunit structureⁱ

Family & Domainsⁱ

Domainⁱ

Sequence similaritiesⁱ

Family and domain databases

Sequenceⁱ

Mass spectrometryⁱ

Similar proteinsⁱ

Cross-referencesⁱ

3D structure databases

Protocols and materials databases

Family and domain databases

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P83655 (KKX13_HETSP)

Your basket is currently empty.

Potassium channel toxin kappa-KTx 1.3

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the ‘Sequence’ section reports information derived from mass spectrometry experiments done on the entire protein or on biologically active derived peptide(s).<p><a href='/help/mass_spectrometry' target='_top'>More...</a></p>Mass spectrometryi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Protocols and materials databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Mass spectrometryⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ