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Protein

Antimicrobial peptide Alo-3

Gene
N/A
Organism
Acrocinus longimanus (Giant harlequin beetle)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Has antifungal activity against C.glabrata.Curated1 Publication

GO - Biological processi

Keywordsi

Molecular functionAntimicrobial, Fungicide

Names & Taxonomyi

Protein namesi
Recommended name:
Antimicrobial peptide Alo-3
OrganismiAcrocinus longimanus (Giant harlequin beetle)Curated
Taxonomic identifieri227548 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaColeopteraPolyphagaCucujiformiaChrysomeloideaCerambycidaeLamiinaeAcrocininiAcrocinus

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PeptideiPRO_00000450661 – 36Antimicrobial peptide Alo-3Add BLAST36

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi1 ↔ 18Curated
Disulfide bondi8 ↔ 22Curated
Disulfide bondi17 ↔ 33Curated

Keywords - PTMi

Disulfide bond

Structurei

Secondary structure

136
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 11Combined sources9
Beta strandi26 – 33Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Q3JNMR-A1-36[»]
ProteinModelPortaliP83653.
SMRiP83653.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP83653.

Family & Domainsi

Domaini

The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.

Sequence similaritiesi

Belongs to the AMP family.Curated

Keywords - Domaini

Knottin

Family and domain databases

InterProiView protein in InterPro
IPR013006. Antimicrobial_C6_CS.
IPR009101. Gurmarin/antifun_pep.
IPR024206. Gurmarin/antimicrobial_peptd.
PfamiView protein in Pfam
PF11410. Antifungal_pept. 1 hit.
SUPFAMiSSF57048. SSF57048. 1 hit.
PROSITEiView protein in PROSITE
PS60011. PLANT_C6_AMP. 1 hit.

Sequencei

Sequence statusi: Complete.

P83653-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30 
CIKNGNGCQP NGSQGNCCSG YCHKQPGWVA GYCRRK
Length:36
Mass (Da):3,875
Last modified:October 1, 2003 - v1
Checksum:i32685DDBF11ECC1A
GO

Mass spectrometryi

Molecular mass is 3869.4 Da from positions 1 - 36. Determined by MALDI. 1 Publication

Similar proteinsi

Entry informationi

Entry nameiALO3_ACRLO
AccessioniPrimary (citable) accession number: P83653
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: October 1, 2003
Last modified: April 12, 2017
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families