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P83617

- GRP78_ASPKA

UniProt

P83617 - GRP78_ASPKA

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Protein

78 kDa glucose-regulated protein homolog

Gene

bipA

Organism
Aspergillus kawachii (White koji mold) (Aspergillus awamori var. kawachi)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER.By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW

GO - Biological processi

  1. response to unfolded protein Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Stress response

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
78 kDa glucose-regulated protein homolog
Short name:
GRP-78
Alternative name(s):
Immunoglobulin heavy chain-binding protein homolog
Short name:
BiP
Gene namesi
Name:bipA
OrganismiAspergillus kawachii (White koji mold) (Aspergillus awamori var. kawachi)Curated
Taxonomic identifieri40384 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Subcellular locationi

Endoplasmic reticulum lumen By similarityPROSITE-ProRule annotation

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3838Sequence AnalysisAdd
BLAST
Chaini39 – 67263478 kDa glucose-regulated protein homologPRO_0000013579Add
BLAST

Proteomic databases

PRIDEiP83617.

Structurei

3D structure databases

ProteinModelPortaliP83617.
SMRiP83617. Positions 49-589.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi669 – 6724Prevents secretion from ERPROSITE-ProRule annotation

Sequence similaritiesi

Belongs to the heat shock protein 70 family.CuratedUniRule annotation

Keywords - Domaini

Signal

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
InterProiIPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
PS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P83617-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MARISHQGAA KPFTAWTTIF YLLLVFIAPL AFFGTAHAQD ETSPQESYGT
60 70 80 90 100
VIGIDLGTTY SCVGVMQNGK VEILVNDQGN RITPSYVAFT DEERLVGDAA
110 120 130 140 150
KNQYAANPRR TIFDIKRLIG RKFDDKDVQK DAKHFPYKVV NKDGKPHVKV
160 170 180 190 200
DVNQTPKTLT PEEVSAMVLG KMKEIAEGYL GKKVTHAVVT VPAYFNDAQR
210 220 230 240 250
QATKDAGTIA GLNVLRVVNE PTAAAIAYGL DKTGDERQVI VYDLGGGTFD
260 270 280 290 300
VSLLSIDNGV FEVLATAGDT HLGGEDFDQR VMDHFVKLYN KKNNVDVTKD
310 320 330 340 350
LKAMGKLKRE VEKAKRTLSS QMSTRIEIEA FHNGEDFSET LTRAKFEELN
360 370 380 390 400
MDLFKKTLKP VEQVLKDAKV KKSEVDDIVL VGGSTRIPKV QALLEEFFGG
410 420 430 440 450
KKASKGINPD EAVAFGAAVQ GGVLSGEEGT GDVVLMDVNP LTLGIETTGG
460 470 480 490 500
VMTKLIPRNT VIPTRKSQIF STAADNQPTV LIQVYEGERS LTKDNNLLGK
510 520 530 540 550
FELTGIPPAP RGVPQIEVSF DLDANGILKV HASDKGTGKA ESITITNDKG
560 570 580 590 600
RLSQEEIDRM VAEAEEFAEE DKAIKAKIEA RNTLENYAFS LKNQVNDENG
610 620 630 640 650
LGGQIDEDDK QTILDAVKEV TEWLEDNAAT ATTEDFEEQK EQLSNVAYPI
660 670
TSKLYGSAPA DEDDEPSGHD EL
Length:672
Mass (Da):73,459
Last modified:July 11, 2003 - v1
Checksum:iC701807FCE08C175
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF183893 Genomic DNA. Translation: AAG10649.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF183893 Genomic DNA. Translation: AAG10649.1 .

3D structure databases

ProteinModelPortali P83617.
SMRi P83617. Positions 49-589.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P83617.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
InterProi IPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view ]
Pfami PF00012. HSP70. 1 hit.
[Graphical view ]
PRINTSi PR00301. HEATSHOCK70.
SUPFAMi SSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
PROSITEi PS00014. ER_TARGET. 1 hit.
PS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning of the bipA gene of Aspergillus awamori var. kawachi."
    Goto M., Shinoda N., Furukawa K.
    Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ORI-1Imported.

Entry informationi

Entry nameiGRP78_ASPKA
AccessioniPrimary (citable) accession number: P83617
Secondary accession number(s): O13280, O14453
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2003
Last sequence update: July 11, 2003
Last modified: October 29, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3