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P83617

- GRP78_ASPKA

UniProt

P83617 - GRP78_ASPKA

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Protein
78 kDa glucose-regulated protein homolog
Gene
bipA
Organism
Aspergillus kawachii (White koji mold) (Aspergillus awamori var. kawachi)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER By similarity.By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW

GO - Biological processi

  1. response to unfolded protein Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Stress response

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
78 kDa glucose-regulated protein homolog
Short name:
GRP-78
Alternative name(s):
Immunoglobulin heavy chain-binding protein homolog
Short name:
BiP
Gene namesi
Name:bipA
OrganismiAspergillus kawachii (White koji mold) (Aspergillus awamori var. kawachi)
Taxonomic identifieri40384 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Subcellular locationi

Endoplasmic reticulum lumen By similarity By similarity

GO - Cellular componenti

  1. endoplasmic reticulum lumen Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3838 Reviewed prediction
Add
BLAST
Chaini39 – 67263478 kDa glucose-regulated protein homolog
PRO_0000013579Add
BLAST

Proteomic databases

PRIDEiP83617.

Structurei

3D structure databases

ProteinModelPortaliP83617.
SMRiP83617. Positions 49-589.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi669 – 6724Prevents secretion from ER By similarity

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
InterProiIPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
PS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P83617-1 [UniParc]FASTAAdd to Basket

« Hide

MARISHQGAA KPFTAWTTIF YLLLVFIAPL AFFGTAHAQD ETSPQESYGT    50
VIGIDLGTTY SCVGVMQNGK VEILVNDQGN RITPSYVAFT DEERLVGDAA 100
KNQYAANPRR TIFDIKRLIG RKFDDKDVQK DAKHFPYKVV NKDGKPHVKV 150
DVNQTPKTLT PEEVSAMVLG KMKEIAEGYL GKKVTHAVVT VPAYFNDAQR 200
QATKDAGTIA GLNVLRVVNE PTAAAIAYGL DKTGDERQVI VYDLGGGTFD 250
VSLLSIDNGV FEVLATAGDT HLGGEDFDQR VMDHFVKLYN KKNNVDVTKD 300
LKAMGKLKRE VEKAKRTLSS QMSTRIEIEA FHNGEDFSET LTRAKFEELN 350
MDLFKKTLKP VEQVLKDAKV KKSEVDDIVL VGGSTRIPKV QALLEEFFGG 400
KKASKGINPD EAVAFGAAVQ GGVLSGEEGT GDVVLMDVNP LTLGIETTGG 450
VMTKLIPRNT VIPTRKSQIF STAADNQPTV LIQVYEGERS LTKDNNLLGK 500
FELTGIPPAP RGVPQIEVSF DLDANGILKV HASDKGTGKA ESITITNDKG 550
RLSQEEIDRM VAEAEEFAEE DKAIKAKIEA RNTLENYAFS LKNQVNDENG 600
LGGQIDEDDK QTILDAVKEV TEWLEDNAAT ATTEDFEEQK EQLSNVAYPI 650
TSKLYGSAPA DEDDEPSGHD EL 672
Length:672
Mass (Da):73,459
Last modified:July 11, 2003 - v1
Checksum:iC701807FCE08C175
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF183893 Genomic DNA. Translation: AAG10649.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF183893 Genomic DNA. Translation: AAG10649.1 .

3D structure databases

ProteinModelPortali P83617.
SMRi P83617. Positions 49-589.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P83617.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
InterProi IPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view ]
Pfami PF00012. HSP70. 1 hit.
[Graphical view ]
PRINTSi PR00301. HEATSHOCK70.
SUPFAMi SSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
PROSITEi PS00014. ER_TARGET. 1 hit.
PS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning of the bipA gene of Aspergillus awamori var. kawachi."
    Goto M., Shinoda N., Furukawa K.
    Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ORI-1.

Entry informationi

Entry nameiGRP78_ASPKA
AccessioniPrimary (citable) accession number: P83617
Secondary accession number(s): O13280, O14453
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2003
Last sequence update: July 11, 2003
Last modified: June 11, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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