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P83589

- HCDH_DEIRA

UniProt

P83589 - HCDH_DEIRA

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Protein

Probable 3-hydroxyacyl-CoA dehydrogenase

Gene

DR_2477

Organism
Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

(S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH.By similarity

GO - Molecular functioni

  1. 3-hydroxyacyl-CoA dehydrogenase activity Source: UniProtKB-EC
  2. NAD+ binding Source: InterPro

GO - Biological processi

  1. fatty acid metabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Fatty acid metabolism, Lipid metabolism

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Probable 3-hydroxyacyl-CoA dehydrogenase (EC:1.1.1.35)
Gene namesi
Ordered Locus Names:DR_2477
OrganismiDeinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Taxonomic identifieri243230 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciDeinococcalesDeinococcaceaeDeinococcus
ProteomesiUP000002524: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 346346Probable 3-hydroxyacyl-CoA dehydrogenasePRO_0000308488Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243230.DR_2477.

Structurei

3D structure databases

ProteinModelPortaliP83589.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.Sequence Analysis

Phylogenomic databases

eggNOGiCOG1250.
HOGENOMiHOG000264370.
InParanoidiP83589.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR022694. 3-OHacyl-CoA_DH.
IPR006176. 3-OHacyl-CoA_DH_NAD-bd.
IPR006108. 3HC_DH_C.
IPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00725. 3HCDH. 1 hit.
PF02737. 3HCDH_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000105. HCDH. 1 hit.
SUPFAMiSSF48179. SSF48179. 1 hit.

Sequencei

Sequence statusi: Complete.

P83589-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKIKKAAVIG AGVMGAAIAA QLANAGIPVL LLDIVLPDKP DRNFLAKAGV
60 70 80 90 100
ERALKARPAA FMDNDRARLI EVGNLEDDLK KLKDVDWVLE AIIEKLDAKH
110 120 130 140 150
DLWEKVEKVV KKTAIISSNS SGIPMHLQIE GRSEDFQRRF VGAHFFNPPR
160 170 180 190 200
YLHLLEVIPT DKTDPQVVKD FSEFAEHTLG KGVVVANDVP GFVANRIGVY
210 220 230 240 250
GIVRAMQHME KYGLTPAEVD QLTGPALGRA SSATFRTADL SGLDIISHVA
260 270 280 290 300
TDIGGVTPDD EDFTLTESFK NMVAGGILGD KSGSGFYKKT KDEKARPRFS
310 320 330 340
TTCKPANTKT RARCACPPWT PRANLSPSAT PCTPWKARKA TSCAPP
Length:346
Mass (Da):37,540
Last modified:October 23, 2007 - v2
Checksum:i16A529B759DBD82C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000513 Genomic DNA. No translation available.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000513 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortali P83589.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243230.DR_2477.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

eggNOGi COG1250.
HOGENOMi HOG000264370.
InParanoidi P83589.

Family and domain databases

Gene3Di 1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProi IPR022694. 3-OHacyl-CoA_DH.
IPR006176. 3-OHacyl-CoA_DH_NAD-bd.
IPR006108. 3HC_DH_C.
IPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
Pfami PF00725. 3HCDH. 1 hit.
PF02737. 3HCDH_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000105. HCDH. 1 hit.
SUPFAMi SSF48179. SSF48179. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422.
  2. Joshi B.S., Apte S.K., Schmid R., Altendorf K.
    Submitted (MAY-2003) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 1-16.
    Strain: ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422.

Entry informationi

Entry nameiHCDH_DEIRA
AccessioniPrimary (citable) accession number: P83589
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 23, 2007
Last modified: October 29, 2014
This is version 42 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

On the 2D-gel the determined pI of this protein is: 6.00, its MW is: 83 kDa.

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3