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P83589

- HCDH_DEIRA

UniProt

P83589 - HCDH_DEIRA

Protein

Probable 3-hydroxyacyl-CoA dehydrogenase

Gene

DR_2477

Organism
Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 41 (01 Oct 2014)
      Sequence version 2 (23 Oct 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    (S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH.By similarity

    GO - Molecular functioni

    1. 3-hydroxyacyl-CoA dehydrogenase activity Source: UniProtKB-EC
    2. NAD+ binding Source: InterPro

    GO - Biological processi

    1. fatty acid metabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Fatty acid metabolism, Lipid metabolism

    Keywords - Ligandi

    NAD

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable 3-hydroxyacyl-CoA dehydrogenase (EC:1.1.1.35)
    Gene namesi
    Ordered Locus Names:DR_2477
    OrganismiDeinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
    Taxonomic identifieri243230 [NCBI]
    Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciDeinococcalesDeinococcaceaeDeinococcus
    ProteomesiUP000002524: Chromosome I

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 346346Probable 3-hydroxyacyl-CoA dehydrogenasePRO_0000308488Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi243230.DR_2477.

    Structurei

    3D structure databases

    ProteinModelPortaliP83589.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.Sequence Analysis

    Phylogenomic databases

    eggNOGiCOG1250.
    HOGENOMiHOG000264370.

    Family and domain databases

    Gene3Di1.10.1040.10. 1 hit.
    3.40.50.720. 1 hit.
    InterProiIPR022694. 3-OHacyl-CoA_DH.
    IPR006176. 3-OHacyl-CoA_DH_NAD-bd.
    IPR006108. 3HC_DH_C.
    IPR008927. 6-PGluconate_DH_C-like.
    IPR013328. DH_multihelical.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PfamiPF00725. 3HCDH. 1 hit.
    PF02737. 3HCDH_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000105. HCDH. 1 hit.
    SUPFAMiSSF48179. SSF48179. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P83589-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKIKKAAVIG AGVMGAAIAA QLANAGIPVL LLDIVLPDKP DRNFLAKAGV    50
    ERALKARPAA FMDNDRARLI EVGNLEDDLK KLKDVDWVLE AIIEKLDAKH 100
    DLWEKVEKVV KKTAIISSNS SGIPMHLQIE GRSEDFQRRF VGAHFFNPPR 150
    YLHLLEVIPT DKTDPQVVKD FSEFAEHTLG KGVVVANDVP GFVANRIGVY 200
    GIVRAMQHME KYGLTPAEVD QLTGPALGRA SSATFRTADL SGLDIISHVA 250
    TDIGGVTPDD EDFTLTESFK NMVAGGILGD KSGSGFYKKT KDEKARPRFS 300
    TTCKPANTKT RARCACPPWT PRANLSPSAT PCTPWKARKA TSCAPP 346
    Length:346
    Mass (Da):37,540
    Last modified:October 23, 2007 - v2
    Checksum:i16A529B759DBD82C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000513 Genomic DNA. No translation available.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000513 Genomic DNA. No translation available.

    3D structure databases

    ProteinModelPortali P83589.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243230.DR_2477.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    eggNOGi COG1250.
    HOGENOMi HOG000264370.

    Family and domain databases

    Gene3Di 1.10.1040.10. 1 hit.
    3.40.50.720. 1 hit.
    InterProi IPR022694. 3-OHacyl-CoA_DH.
    IPR006176. 3-OHacyl-CoA_DH_NAD-bd.
    IPR006108. 3HC_DH_C.
    IPR008927. 6-PGluconate_DH_C-like.
    IPR013328. DH_multihelical.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    Pfami PF00725. 3HCDH. 1 hit.
    PF02737. 3HCDH_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000105. HCDH. 1 hit.
    SUPFAMi SSF48179. SSF48179. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422.
    2. Joshi B.S., Apte S.K., Schmid R., Altendorf K.
      Submitted (MAY-2003) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 1-16.
      Strain: ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422.

    Entry informationi

    Entry nameiHCDH_DEIRA
    AccessioniPrimary (citable) accession number: P83589
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 23, 2007
    Last sequence update: October 23, 2007
    Last modified: October 1, 2014
    This is version 41 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    On the 2D-gel the determined pI of this protein is: 6.00, its MW is: 83 kDa.

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3