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P83589 (HCDH_DEIRA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 40. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable 3-hydroxyacyl-CoA dehydrogenase

EC=1.1.1.35
Gene names
Ordered Locus Names:DR_2477
OrganismDeinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422) [Reference proteome] [HAMAP]
Taxonomic identifier243230 [NCBI]
Taxonomic lineageBacteriaDeinococcus-ThermusDeinococciDeinococcalesDeinococcaceaeDeinococcus

Protein attributes

Sequence length346 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

(S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH. UniProtKB Q8W1L6

Miscellaneous

On the 2D-gel the determined pI of this protein is: 6.00, its MW is: 83 kDa. Ref.2

Sequence similarities

Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.

Ontologies

Keywords
   Biological processFatty acid metabolism
Lipid metabolism
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processfatty acid metabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_function3-hydroxyacyl-CoA dehydrogenase activity

Inferred from electronic annotation. Source: UniProtKB-EC

NAD+ binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 346346Probable 3-hydroxyacyl-CoA dehydrogenase
PRO_0000308488

Sequences

Sequence LengthMass (Da)Tools
P83589 [UniParc].

Last modified October 23, 2007. Version 2.
Checksum: 16A529B759DBD82C

FASTA34637,540
        10         20         30         40         50         60 
MKIKKAAVIG AGVMGAAIAA QLANAGIPVL LLDIVLPDKP DRNFLAKAGV ERALKARPAA 

        70         80         90        100        110        120 
FMDNDRARLI EVGNLEDDLK KLKDVDWVLE AIIEKLDAKH DLWEKVEKVV KKTAIISSNS 

       130        140        150        160        170        180 
SGIPMHLQIE GRSEDFQRRF VGAHFFNPPR YLHLLEVIPT DKTDPQVVKD FSEFAEHTLG 

       190        200        210        220        230        240 
KGVVVANDVP GFVANRIGVY GIVRAMQHME KYGLTPAEVD QLTGPALGRA SSATFRTADL 

       250        260        270        280        290        300 
SGLDIISHVA TDIGGVTPDD EDFTLTESFK NMVAGGILGD KSGSGFYKKT KDEKARPRFS 

       310        320        330        340 
TTCKPANTKT RARCACPPWT PRANLSPSAT PCTPWKARKA TSCAPP 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE000513 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortalP83589.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243230.DR_2477.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

eggNOGCOG1250.
HOGENOMHOG000264370.

Family and domain databases

Gene3D1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProIPR022694. 3-OHacyl-CoA_DH.
IPR006176. 3-OHacyl-CoA_DH_NAD-bd.
IPR006108. 3HC_DH_C.
IPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamPF00725. 3HCDH. 1 hit.
PF02737. 3HCDH_N. 1 hit.
[Graphical view]
PIRSFPIRSF000105. HCDH. 1 hit.
SUPFAMSSF48179. SSF48179. 1 hit.
ProtoNetSearch...

Entry information

Entry nameHCDH_DEIRA
AccessionPrimary (citable) accession number: P83589
Entry history
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 23, 2007
Last modified: February 19, 2014
This is version 40 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families