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Protein

Glutathione peroxidase 1, mitochondrial

Gene

GPX

Organism
Chlamydomonas reinhardtii (Chlamydomonas smithii)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May constitute a glutathione peroxidase-like protective system against oxidative stresses. Hydrogen peroxide, tert-butyl hydroperoxide and cumene, but not phosphatidylcholine hydroperoxide, can act as acceptors.1 Publication

Catalytic activityi

2 glutathione + H2O2 = glutathione disulfide + 2 H2O.1 Publication

GO - Molecular functioni

  • glutathione peroxidase activity Source: UniProtKB

GO - Biological processi

  • response to oxidative stress Source: UniProtKB

Keywordsi

Molecular functionOxidoreductase, Peroxidase
LigandSelenium

Protein family/group databases

PeroxiBasei2590 CreGPx02

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione peroxidase 1, mitochondrial1 Publication (EC:1.11.1.9)
Short name:
CrGPx11 Publication
Gene namesi
Name:GPXImported
Synonyms:PHGPX11 Publication
ORF Names:CHLREDRAFT_206090
OrganismiChlamydomonas reinhardtii (Chlamydomonas smithii)
Taxonomic identifieri3055 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeChlorophytaChlorophyceaeChlamydomonadalesChlamydomonadaceaeChlamydomonas

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 27MitochondrionAdd BLAST27
ChainiPRO_000001308928 – 201Glutathione peroxidase 1, mitochondrialSequence analysisAdd BLAST174

Proteomic databases

PaxDbiP83564

Expressioni

Inductioni

By selenium, particularly under autotrophic conditions.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi3055.EDP06633

Structurei

3D structure databases

ProteinModelPortaliP83564
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glutathione peroxidase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1651 Eukaryota
COG0386 LUCA
InParanoidiP83564
KOiK00432

Family and domain databases

CDDicd00340 GSH_Peroxidase, 1 hit
InterProiView protein in InterPro
IPR000889 Glutathione_peroxidase
IPR029759 GPX_AS
IPR029760 GPX_CS
IPR036249 Thioredoxin-like_sf
PANTHERiPTHR11592 PTHR11592, 1 hit
PfamiView protein in Pfam
PF00255 GSHPx, 1 hit
PIRSFiPIRSF000303 Glutathion_perox, 1 hit
PRINTSiPR01011 GLUTPROXDASE
SUPFAMiSSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS00460 GLUTATHIONE_PEROXID_1, 1 hit
PS00763 GLUTATHIONE_PEROXID_2, 1 hit
PS51355 GLUTATHIONE_PEROXID_3, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P83564-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLTRKNVAV RPARAARRDV RAMSLLGNLF GGGSKPTSST SNFHQLSALD
60 70 80 90 100
IDKKNVDFKS LNNRVVLVVN VASKUGLTAA NYKEFATLLG KYPATDLTIV
110 120 130 140 150
AFPCNQFGGQ EPGTNAEIKA FASARGFSGA GALLMDKVDV NGANASPVYN
160 170 180 190 200
FLKVAAGDTS DIGWNFGKFL VRPDGTVFGR YAPTTGPLSL EKYIVELINS

R
Length:201
Mass (Da):21,499
Last modified:February 26, 2008 - v2
Checksum:i1030F45EBA62C219
GO

Mass spectrometryi

Molecular mass is 18496 Da from positions 28 - 201. Determined by MALDI. 1 Publication
Molecular mass is 18571 Da from positions 28 - 201. Determined by ESI. 1 Publication

Non-standard residue

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-standard residuei75Selenocysteine2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY051144 mRNA Translation: AAL14348.1
DS496114 Genomic DNA Translation: EDP06633.1
RefSeqiXP_001701658.1, XM_001701606.1
UniGeneiCre.4579

Genome annotation databases

EnsemblPlantsiEDP06633; EDP06633; CHLREDRAFT_206090
GeneIDi5727250
GrameneiEDP06633; EDP06633; CHLREDRAFT_206090
KEGGicre:CHLREDRAFT_206090

Keywords - Coding sequence diversityi

Selenocysteine

Similar proteinsi

Entry informationi

Entry nameiGPX1_CHLRE
AccessioniPrimary (citable) accession number: P83564
Secondary accession number(s): A8IAD7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: February 26, 2008
Last modified: April 25, 2018
This is version 77 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health