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Protein

Delta-hexatoxin-Mg1a

Gene
N/A
Organism
Macrothele gigas (Spider)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Selectively slows channel inactivation of mammalian Nav1.1/SCN1A, Nav1.3/SCN3A, and Nav1.6/SCN8A and shows higher affinity for insect Nav1/para channels (site 3). Induces tonic repetitive firing of nerve impulses in insect neurons accompanied by plateau potentials.2 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel impairing toxin, Neurotoxin, Toxin, Voltage-gated sodium channel impairing toxin

Protein family/group databases

TCDBi8.B.6.2.2. the ca(2+) channel-targeting spider toxin (cst) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Delta-hexatoxin-Mg1a
Short name:
Delta-HXTX-Mg1a
Alternative name(s):
Neurotoxin magi-4
OrganismiMacrothele gigas (Spider)Curated
Taxonomic identifieri223896 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAraneaeMygalomorphaeHexathelidaeMacrothele

Organism-specific databases

ArachnoServeriAS000382. delta-hexatoxin-Mg1a.

Subcellular locationi

  • Secreted Curated1 Publication

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Toxic dosei

LD50 is 1.2 nmol/kg to lepidopteran larvae, and 0.15 pmol/g to mice by intracranial injection.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
PropeptideiPRO_000003552919 – 60Add BLAST42
PeptideiPRO_000003553063 – 105Delta-hexatoxin-Mg1aAdd BLAST43

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi63 ↔ 77
Disulfide bondi70 ↔ 82
Disulfide bondi76 ↔ 93
Disulfide bondi78 ↔ 105

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.Curated1 Publication

Structurei

Secondary structure

1105
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi66 – 69Combined sources4
Helixi73 – 75Combined sources3
Beta strandi81 – 84Combined sources4
Helixi86 – 88Combined sources3
Beta strandi89 – 94Combined sources6
Beta strandi100 – 102Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2ROONMR-A63-105[»]
ProteinModelPortaliP83560.
SMRiP83560.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP83560.

Family & Domainsi

Domaini

The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.By similarity

Sequence similaritiesi

Belongs to the delta-atracotoxin family.Curated

Keywords - Domaini

Knottin, Signal

Family and domain databases

InterProiView protein in InterPro
IPR008017. Atracotoxin_delta.
PfamiView protein in Pfam
PF05353. Atracotoxin. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD026455. Atracotoxin. 1 hit.
PROSITEiView protein in PROSITE
PS60018. DELTA_ACTX. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P83560-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTLVIACVA LVLVVVHGEV IEEVNEKQLQ ESVEEKYSLL QRLEKLDEAI
60 70 80 90 100
TAEENRNSRV RRCGSKRAWC KEKKDCCCGY NCVYAWYNQQ SSCERKWKYL

FTGEC
Length:105
Mass (Da):12,289
Last modified:August 22, 2003 - v2
Checksum:i0DDBC59A6102C9A1
GO

Mass spectrometryi

Molecular mass is 5150.0 Da from positions 63 - 105. Determined by MALDI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB105149 mRNA. Translation: BAC80149.1.

Entry informationi

Entry nameiTXMG4_MACGS
AccessioniPrimary (citable) accession number: P83560
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2003
Last sequence update: August 22, 2003
Last modified: November 2, 2016
This is version 70 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families