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Protein

Killer cell immunoglobulin-like receptor 3DL1

Gene

Kir3dl1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor on natural killer (NK) cells. Inhibits the activity of NK cells thus preventing cell lysis.By similarity1 Publication

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Killer cell immunoglobulin-like receptor 3DL1
Alternative name(s):
CD_antigen: CD158e
Gene namesi
Name:Kir3dl1
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi727836. Kir3dl1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 329308ExtracellularSequence analysisAdd
BLAST
Transmembranei330 – 35021HelicalSequence analysisAdd
BLAST
Topological domaini351 – 42272CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121By similarityAdd
BLAST
Chaini22 – 422401Killer cell immunoglobulin-like receptor 3DL1PRO_0000015089Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi44 – 441N-linked (GlcNAc...)Sequence analysis
Disulfide bondi49 ↔ 95PROSITE-ProRule annotation
Glycosylationi137 – 1371N-linked (GlcNAc...)Sequence analysis
Disulfide bondi142 ↔ 195PROSITE-ProRule annotation
Glycosylationi200 – 2001N-linked (GlcNAc...)Sequence analysis
Glycosylationi239 – 2391N-linked (GlcNAc...)Sequence analysis
Disulfide bondi244 ↔ 293PROSITE-ProRule annotation
Glycosylationi299 – 2991N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP83556.
PRIDEiP83556.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000031521.

Structurei

3D structure databases

ProteinModelPortaliP83556.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini42 – 10059Ig-like C2-type 1Add
BLAST
Domaini135 – 20268Ig-like C2-type 2Add
BLAST
Domaini237 – 30064Ig-like C2-type 3Add
BLAST

Sequence similaritiesi

Belongs to the immunoglobulin superfamily.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410JAMM. Eukaryota.
ENOG410ZT7K. LUCA.
GeneTreeiENSGT00760000119033.
HOGENOMiHOG000234396.
HOVERGENiHBG074353.
InParanoidiP83556.
KOiK07980.
OMAiECHSEIM.
OrthoDBiEOG7H792J.
PhylomeDBiP83556.
TreeFamiTF352669.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013151. Immunoglobulin.
[Graphical view]
PfamiPF00047. ig. 2 hits.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
SM00408. IGc2. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P83556-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMFEFLSLLC SGFFLVQRMS AHMGSYDKPF LCASPSYIVP QGQNVTLICD
60 70 80 90 100
SHSKPNIFKV YKEDGFPILQ LHEKTFTKSL DIGPVTPEYA GTYRCFHHQY
110 120 130 140 150
PNEISAHSEP LKIIISGIYM KPFLIAPQTP LANSGENVTL ECHSEIMFDT
160 170 180 190 200
YILTSHRMEI LKETLQHFQE SHFSGSYASF TIGPMTPDHS GTYTCYGAYN
210 220 230 240 250
HSLYEWSDSS DPVDIKITGE YKKPSLSSVM SPVLVSEQNM TLSCISNHQF
260 270 280 290 300
EMFHLSREGV PQGKGIPAMQ SHSGKFEAKF LLSPVIQKGN YRCYGSFKNS
310 320 330 340 350
SHVWSSPSDP LYLPAKDNLK NLHIQIGLLV TMVLVIVVII IIIIIIIIII
360 370 380 390 400
YYYYFSKKSS ILEQESEVKA TINRQDPERQ EEHKVTYIEF EQRIFNKNLM
410 420
PPISQSPKEF SIDTVVYTEV MI
Length:422
Mass (Da):48,074
Last modified:June 1, 2003 - v1
Checksum:i91E5CE3EFA2DDE70
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF527797 mRNA. Translation: AAO47865.1.
RefSeqiNP_852144.1. NM_181479.2.
UniGeneiRn.92529.

Genome annotation databases

EnsembliENSRNOT00000039823; ENSRNOP00000031521; ENSRNOG00000027843.
GeneIDi353253.
KEGGirno:353253.
UCSCiRGD:727836. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF527797 mRNA. Translation: AAO47865.1.
RefSeqiNP_852144.1. NM_181479.2.
UniGeneiRn.92529.

3D structure databases

ProteinModelPortaliP83556.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000031521.

Proteomic databases

PaxDbiP83556.
PRIDEiP83556.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000039823; ENSRNOP00000031521; ENSRNOG00000027843.
GeneIDi353253.
KEGGirno:353253.
UCSCiRGD:727836. rat.

Organism-specific databases

CTDi3811.
RGDi727836. Kir3dl1.

Phylogenomic databases

eggNOGiENOG410JAMM. Eukaryota.
ENOG410ZT7K. LUCA.
GeneTreeiENSGT00760000119033.
HOGENOMiHOG000234396.
HOVERGENiHBG074353.
InParanoidiP83556.
KOiK07980.
OMAiECHSEIM.
OrthoDBiEOG7H792J.
PhylomeDBiP83556.
TreeFamiTF352669.

Miscellaneous databases

NextBioi672639.
PROiP83556.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013151. Immunoglobulin.
[Graphical view]
PfamiPF00047. ig. 2 hits.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
SM00408. IGc2. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning of a killer cell Ig-like receptor in the mouse and rat."
    Hoelsbrekken S.E., Nylenna O., Saether P.C., Slettedal I.O., Ryan J.C., Fossum S., Dissen E.
    J. Immunol. 170:2259-2263(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: PVG.
    Tissue: Natural killer cell.

Entry informationi

Entry nameiKI3L1_RAT
AccessioniPrimary (citable) accession number: P83556
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: June 1, 2003
Last modified: May 11, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.