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Protein

Killer cell immunoglobulin-like receptor 3DL1

Gene

Kir3dl1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor on natural killer (NK) cells. Inhibits the activity of NK cells thus preventing cell lysis.By similarity1 Publication

Keywordsi

Molecular functionReceptor

Enzyme and pathway databases

ReactomeiR-RNO-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Names & Taxonomyi

Protein namesi
Recommended name:
Killer cell immunoglobulin-like receptor 3DL1
Alternative name(s):
CD_antigen: CD158e
Gene namesi
Name:Kir3dl1
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi727836. Kir3dl1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 329ExtracellularSequence analysisAdd BLAST308
Transmembranei330 – 350HelicalSequence analysisAdd BLAST21
Topological domaini351 – 422CytoplasmicSequence analysisAdd BLAST72

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21By similarityAdd BLAST21
ChainiPRO_000001508922 – 422Killer cell immunoglobulin-like receptor 3DL1Add BLAST401

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi44N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi49 ↔ 95PROSITE-ProRule annotation
Glycosylationi137N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi142 ↔ 195PROSITE-ProRule annotation
Glycosylationi200N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi239N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi244 ↔ 293PROSITE-ProRule annotation
Glycosylationi299N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP83556.
PRIDEiP83556.

Expressioni

Gene expression databases

BgeeiENSRNOG00000027843.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000031521.

Structurei

3D structure databases

ProteinModelPortaliP83556.
SMRiP83556.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini42 – 100Ig-like C2-type 1Add BLAST59
Domaini135 – 202Ig-like C2-type 2Add BLAST68
Domaini237 – 300Ig-like C2-type 3Add BLAST64

Sequence similaritiesi

Belongs to the immunoglobulin superfamily.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410JAMM. Eukaryota.
ENOG410ZT7K. LUCA.
GeneTreeiENSGT00760000119033.
HOGENOMiHOG000234396.
HOVERGENiHBG074353.
InParanoidiP83556.
KOiK07980.
OMAiNSSHVWS.
OrthoDBiEOG091G09UV.
PhylomeDBiP83556.
TreeFamiTF352669.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiView protein in InterPro
IPR007110. Ig-like_dom.
IPR036179. Ig-like_dom_sf.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013151. Immunoglobulin.
PfamiView protein in Pfam
PF00047. ig. 2 hits.
SMARTiView protein in SMART
SM00409. IG. 2 hits.
SM00408. IGc2. 2 hits.
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiView protein in PROSITE
PS50835. IG_LIKE. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P83556-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMFEFLSLLC SGFFLVQRMS AHMGSYDKPF LCASPSYIVP QGQNVTLICD
60 70 80 90 100
SHSKPNIFKV YKEDGFPILQ LHEKTFTKSL DIGPVTPEYA GTYRCFHHQY
110 120 130 140 150
PNEISAHSEP LKIIISGIYM KPFLIAPQTP LANSGENVTL ECHSEIMFDT
160 170 180 190 200
YILTSHRMEI LKETLQHFQE SHFSGSYASF TIGPMTPDHS GTYTCYGAYN
210 220 230 240 250
HSLYEWSDSS DPVDIKITGE YKKPSLSSVM SPVLVSEQNM TLSCISNHQF
260 270 280 290 300
EMFHLSREGV PQGKGIPAMQ SHSGKFEAKF LLSPVIQKGN YRCYGSFKNS
310 320 330 340 350
SHVWSSPSDP LYLPAKDNLK NLHIQIGLLV TMVLVIVVII IIIIIIIIII
360 370 380 390 400
YYYYFSKKSS ILEQESEVKA TINRQDPERQ EEHKVTYIEF EQRIFNKNLM
410 420
PPISQSPKEF SIDTVVYTEV MI
Length:422
Mass (Da):48,074
Last modified:June 1, 2003 - v1
Checksum:i91E5CE3EFA2DDE70
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF527797 mRNA. Translation: AAO47865.1.
RefSeqiNP_852144.1. NM_181479.2.
UniGeneiRn.92529.

Genome annotation databases

EnsembliENSRNOT00000039823; ENSRNOP00000031521; ENSRNOG00000027843.
GeneIDi353253.
KEGGirno:353253.
UCSCiRGD:727836. rat.

Similar proteinsi

Entry informationi

Entry nameiKI3L1_RAT
AccessioniPrimary (citable) accession number: P83556
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: June 1, 2003
Last modified: October 25, 2017
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families