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P83542

- PA1_POLGA

UniProt

P83542 - PA1_POLGA

Protein

Phospholipase A1

Gene
N/A
Organism
Polistes gallicus (Paper wasp)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Hydrolysis of phosphatidylcholine with phospholipase A1 (EC 3.1.1.32) activity. Has weak hemolytic activity By similarity.By similarity

    Catalytic activityi

    Phosphatidylcholine + H2O = 2-acylglycerophosphocholine + a carboxylate.1 Publication

    GO - Molecular functioni

    1. 1-acyl-2-lysophosphatidylserine acylhydrolase activity Source: UniProtKB-EC
    2. phosphatidylcholine 1-acylhydrolase activity Source: UniProtKB-EC
    3. phosphatidylserine 1-acylhydrolase activity Source: UniProtKB-EC

    GO - Biological processi

    1. hemolysis in other organism Source: UniProtKB-KW
    2. lipid catabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Cytolysis, Hemolysis, Lipid degradation, Lipid metabolism

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phospholipase A1 (EC:3.1.1.32)
    Alternative name(s):
    Allergen: Pol g 1
    OrganismiPolistes gallicus (Paper wasp)Curated
    Taxonomic identifieri34730 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaHymenopteraApocritaAculeataVespoideaVespidaePolistinaePolistiniPolistes

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Allergenic propertiesi

    Causes an allergic reaction in human.

    Keywords - Diseasei

    Allergen

    Protein family/group databases

    Allergomei1208. Pol g 1.
    3443. Pol g 1.0101.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – ›42›42Phospholipase A1PRO_0000090377Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi6 ↔ ?By similarity

    Post-translational modificationi

    Contains six disulfide bonds.By similarity

    Keywords - PTMi

    Disulfide bond

    Expressioni

    Tissue specificityi

    Expressed by the venom gland.

    Interactioni

    Subunit structurei

    Monomer.1 PublicationCurated

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the AB hydrolase superfamily. Lipase family.Curated

    Sequencei

    Sequence statusi: Fragment.

    P83542-1 [UniParc]FASTAAdd to Basket

    « Hide

    GITPDCTFNE KDIELHVYSR DKRNGIILKK EILKNYDLFK ES           42
    Length:42
    Mass (Da):4,985
    Last modified:June 1, 2003 - v1
    Checksum:i524589208F2113C3
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei42 – 421Curated

    Mass spectrometryi

    Molecular mass is 33475 Da from positions 1 - ?. Determined by ESI. 1 Publication

    Cross-referencesi

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    Allergomei 1208. Pol g 1.
    3443. Pol g 1.0101.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "Characterization of the major allergens purified from the venom of the paper wasp Polistes gallicus."
      Pantera B., Hoffman D.R., Carresi L., Cappugi G., Turillazzi S., Manao G., Severino M., Spadolini I., Orsomando G., Moneti G., Pazzagli L.
      Biochim. Biophys. Acta 1623:72-81(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE, CATALYTIC ACTIVITY, SUBUNIT, MASS SPECTROMETRY.
      Tissue: Venom.

    Entry informationi

    Entry nameiPA1_POLGA
    AccessioniPrimary (citable) accession number: P83542
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 16, 2004
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 36 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. Allergens
      Nomenclature of allergens and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3