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Protein

Nyctalopin

Gene

Nyx

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Sensory transduction, Vision

Names & Taxonomyi

Protein namesi
Recommended name:
Nyctalopin
Gene namesi
Name:Nyx
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:2448607. Nyx.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Involvement in diseasei

Defects in Nyx are the cause of the nob (no b-wave) phenotype which is characterized by a decreased sensitivity to light and an absence of the rod b-wave in electroretinograms. An 85-bp deletion in exon 3 results in the loss of 288 residues from the C-terminus of the protein.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000003277719 – 476NyctalopinAdd BLAST458

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi92N-linked (GlcNAc...)Sequence analysis1
Glycosylationi178N-linked (GlcNAc...)Sequence analysis1
Glycosylationi295N-linked (GlcNAc...)Sequence analysis1
Glycosylationi388N-linked (GlcNAc...)Sequence analysis1
Glycosylationi427N-linked (GlcNAc...)Sequence analysis1
Glycosylationi434N-linked (GlcNAc...)Sequence analysis1
Glycosylationi438N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein, Proteoglycan

Proteomic databases

PaxDbiP83503.
PRIDEiP83503.

PTM databases

PhosphoSitePlusiP83503.

Expressioni

Tissue specificityi

Expressed abundantly in retina with lower levels in brain, lung, spleen and testis. Not detected in kidney, heart or liver. In the retina, highest expression found in the inner nuclear layer and ganglion cell layer.2 Publications

Developmental stagei

Expressed during all stages of postnatal retinal development.1 Publication

Gene expression databases

BgeeiENSMUSG00000051228.
CleanExiMM_NYX.
GenevisibleiP83503. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000056313.

Structurei

3D structure databases

ProteinModelPortaliP83503.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini19 – 57LRRNTAdd BLAST39
Repeati58 – 79LRR 1Add BLAST22
Repeati82 – 103LRR 2Add BLAST22
Repeati106 – 128LRR 3Add BLAST23
Repeati131 – 154LRR 4Add BLAST24
Repeati155 – 177LRR 5Add BLAST23
Repeati178 – 199LRR 6Add BLAST22
Repeati202 – 223LRR 7Add BLAST22
Repeati226 – 247LRR 8Add BLAST22
Repeati250 – 271LRR 9Add BLAST22
Repeati274 – 295LRR 10Add BLAST22
Repeati298 – 319LRR 11Add BLAST22
Domaini331 – 383LRRCTAdd BLAST53

Sequence similaritiesi

Contains 11 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated
Contains 1 LRRNT domain.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiKOG4237. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000118777.
HOGENOMiHOG000230477.
HOVERGENiHBG031762.
InParanoidiP83503.
KOiK08129.
OMAiEACTRTC.
OrthoDBiEOG091G05RT.
PhylomeDBiP83503.
TreeFamiTF337463.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRRNT.
[Graphical view]
PfamiPF13855. LRR_8. 3 hits.
PF01462. LRRNT. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 9 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P83503-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLILLLHAVV FSLPYTRATE ACLRACPAAC TCSHVERGCS VRCDRAGLQR
60 70 80 90 100
VPQEFPCEAA SIDLDRNGLR ILGERAFGTL PSLRRLSLRH NNLSFITPGA
110 120 130 140 150
FKGLPRLAEL RLAHNGELRY LHVRTFAALG RLRRLDLAAC RLFSVPERLL
160 170 180 190 200
AELPALRELT AFDNLFRRVP GALRGLANLT HAHFERSRIE AVASGSLLGM
210 220 230 240 250
RRLRSLSLQA NRVRAVHAGA FGDCGALEDL LLNDNLLATL PAAAFRGLRR
260 270 280 290 300
LRTLNLGGNA LGSVARAWFS DLAELELLYL DRNSITFVEE GAFQNLSGLL
310 320 330 340 350
ALHLNGNRLT VLSWAAFQPG FFLGRLFLFR NPWRCDCQLE WLRDWMEGSG
360 370 380 390 400
RVADVACASP GSVAGQDLSQ VVFERSSDGL CVDPDELNFT TSSPGPSPEP
410 420 430 440 450
VATTVSRFSS LLSKLLAPRA PVEEVANTTW ELVNVSLNDS FRSHAVMVFC
460 470
YKATFLFTSC VLLSLAQYVV VGLQRE
Length:476
Mass (Da):52,431
Last modified:March 1, 2003 - v1
Checksum:iAF575C25638BC410
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY114303 mRNA. Translation: AAM47034.1.
BC035244 mRNA. Translation: AAH35244.1.
BC048381 mRNA. Translation: AAH48381.1.
AK038912 mRNA. Translation: BAC30165.1.
CCDSiCCDS40877.1.
RefSeqiNP_775591.1. NM_173415.4.
XP_006527675.1. XM_006527612.3.
XP_006527676.1. XM_006527613.3.
XP_006527677.1. XM_006527614.3.
UniGeneiMm.90233.

Genome annotation databases

EnsembliENSMUST00000050434; ENSMUSP00000056313; ENSMUSG00000051228.
GeneIDi236690.
KEGGimmu:236690.
UCSCiuc009srn.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY114303 mRNA. Translation: AAM47034.1.
BC035244 mRNA. Translation: AAH35244.1.
BC048381 mRNA. Translation: AAH48381.1.
AK038912 mRNA. Translation: BAC30165.1.
CCDSiCCDS40877.1.
RefSeqiNP_775591.1. NM_173415.4.
XP_006527675.1. XM_006527612.3.
XP_006527676.1. XM_006527613.3.
XP_006527677.1. XM_006527614.3.
UniGeneiMm.90233.

3D structure databases

ProteinModelPortaliP83503.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000056313.

PTM databases

PhosphoSitePlusiP83503.

Proteomic databases

PaxDbiP83503.
PRIDEiP83503.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000050434; ENSMUSP00000056313; ENSMUSG00000051228.
GeneIDi236690.
KEGGimmu:236690.
UCSCiuc009srn.1. mouse.

Organism-specific databases

CTDi60506.
MGIiMGI:2448607. Nyx.

Phylogenomic databases

eggNOGiKOG4237. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000118777.
HOGENOMiHOG000230477.
HOVERGENiHBG031762.
InParanoidiP83503.
KOiK08129.
OMAiEACTRTC.
OrthoDBiEOG091G05RT.
PhylomeDBiP83503.
TreeFamiTF337463.

Miscellaneous databases

PROiP83503.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000051228.
CleanExiMM_NYX.
GenevisibleiP83503. MM.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRRNT.
[Graphical view]
PfamiPF13855. LRR_8. 3 hits.
PF01462. LRRNT. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 9 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNYX_MOUSE
AccessioniPrimary (citable) accession number: P83503
Secondary accession number(s): Q8BYN4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.