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P83489 (OSTCN_BISPR) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Osteocalcin
Alternative name(s):
Bone Gla protein
Short name=BGP
Gamma-carboxyglutamic acid-containing protein
Gene names
Name:BGLAP
OrganismBison priscus (Steppe wisent) (Steppe bison)
Taxonomic identifier268291 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBison

Protein attributes

Sequence length49 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium By similarity. UniProtKB P02820

Subcellular location

Secreted UniProtKB P02820.

Post-translational modification

Gamma-carboxyglutamic acid residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium By similarity. UniProtKB P02820

Miscellaneous

Sequence data obtained by MS from permafrost fossilized bones about 55.6 thousand years old.

Sequence similarities

Belongs to the osteocalcin/matrix Gla protein family.

Contains 1 Gla (gamma-carboxy-glutamate) domain.

Mass spectrometry

Molecular mass is 5590 Da from positions 1 - 49. Determined by MALDI. Ref.1

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 4949Osteocalcin
PRO_0000148895

Regions

Domain1 – 4747Gla

Sites

Metal binding171Calcium 3 By similarity
Metal binding211Calcium 2 By similarity
Metal binding241Calcium 1 By similarity
Metal binding241Calcium 2 By similarity
Metal binding301Calcium 1 By similarity

Amino acid modifications

Modified residue91Hydroxyproline UniProtKB P02820
Modified residue1714-carboxyglutamate Ref.1 UniProtKB P02820
Modified residue2114-carboxyglutamate Ref.1 UniProtKB P02820
Modified residue2414-carboxyglutamate Ref.1 UniProtKB P02820
Disulfide bond23 ↔ 29 UniProtKB P02820

Sequences

Sequence LengthMass (Da)Tools
P83489 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 718826015806CCBE

FASTA495,575
        10         20         30         40 
YLDHGLGAPA PYPDPLEPKR EVCELNPDCD ELADHIGFQE AYRRFYGPV 

« Hide

References

[1]"Sequence preservation of osteocalcin protein and mitochondrial DNA in bison bones older than 55 ka."
Nielsen-Marsh C.M., Ostrom P.H., Gandhi H., Shapiro B., Cooper A., Hauschka P.V., Collins M.J.
Geology 30:1099-1102(2002)
Cited for: PROTEIN SEQUENCE, HYDROXYLATION AT PRO-9, GAMMA-CARBOXYGLUTAMATION AT GLU-17; GLU-21 AND GLU-24, MASS SPECTROMETRY.
Tissue: Bone.

Web resources

Protein Spotlight

A small blast from the past - Issue 46 of May 2004

Cross-references

3D structure databases

ProteinModelPortalP83489.
SMRP83489. Positions 18-49.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR000294. GLA_domain.
IPR002384. Osteocalcin/MGP.
[Graphical view]
PfamPF00594. Gla. 1 hit.
[Graphical view]
PRINTSPR00002. GLABONE.
SMARTSM00069. GLA. 1 hit.
[Graphical view]
SUPFAMSSF57630. SSF57630. 1 hit.
PROSITEPS00011. GLA_1. 1 hit.
PS50998. GLA_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameOSTCN_BISPR
AccessionPrimary (citable) accession number: P83489
Entry history
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: March 1, 2003
Last modified: February 19, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Protein Spotlight

Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries