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P83489

- OSTCN_BISPR

UniProt

P83489 - OSTCN_BISPR

Protein

Osteocalcin

Gene

BGLAP

Organism
Bison priscus (Steppe wisent) (Steppe bison)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi17 – 171Calcium 3By similarity
    Metal bindingi21 – 211Calcium 2By similarity
    Metal bindingi24 – 241Calcium 1By similarity
    Metal bindingi24 – 241Calcium 2By similarity
    Metal bindingi30 – 301Calcium 1By similarity

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro

    GO - Biological processi

    1. biomineral tissue development Source: UniProtKB-KW
    2. regulation of bone mineralization Source: InterPro

    Keywords - Biological processi

    Biomineralization

    Keywords - Ligandi

    Calcium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Osteocalcin
    Alternative name(s):
    Bone Gla protein
    Short name:
    BGP
    Gamma-carboxyglutamic acid-containing protein
    Gene namesi
    Name:BGLAP
    OrganismiBison priscus (Steppe wisent) (Steppe bison)
    Taxonomic identifieri268291 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBison

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 4949OsteocalcinPRO_0000148895Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei9 – 91Hydroxyproline1 Publication
    Modified residuei17 – 1714-carboxyglutamate1 PublicationPROSITE-ProRule annotation
    Modified residuei21 – 2114-carboxyglutamate1 PublicationPROSITE-ProRule annotation
    Disulfide bondi23 ↔ 29
    Modified residuei24 – 2414-carboxyglutamate1 PublicationPROSITE-ProRule annotation

    Post-translational modificationi

    Gamma-carboxyglutamic acid residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium By similarity.By similarity

    Keywords - PTMi

    Disulfide bond, Gamma-carboxyglutamic acid, Hydroxylation

    Structurei

    3D structure databases

    ProteinModelPortaliP83489.
    SMRiP83489. Positions 18-49.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 4747GlaPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 Gla (gamma-carboxy-glutamate) domain.PROSITE-ProRule annotation

    Family and domain databases

    InterProiIPR000294. GLA_domain.
    IPR002384. Osteocalcin/MGP.
    [Graphical view]
    PfamiPF00594. Gla. 1 hit.
    [Graphical view]
    PRINTSiPR00002. GLABONE.
    SMARTiSM00069. GLA. 1 hit.
    [Graphical view]
    SUPFAMiSSF57630. SSF57630. 1 hit.
    PROSITEiPS00011. GLA_1. 1 hit.
    PS50998. GLA_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P83489-1 [UniParc]FASTAAdd to Basket

    « Hide

    YLDHGLGAPA PYPDPLEPKR EVCELNPDCD ELADHIGFQE AYRRFYGPV    49
    Length:49
    Mass (Da):5,575
    Last modified:March 1, 2003 - v1
    Checksum:i718826015806CCBE
    GO

    Mass spectrometryi

    Molecular mass is 5590 Da from positions 1 - 49. Determined by MALDI. 1 Publication

    Cross-referencesi

    Web resourcesi

    Protein Spotlight

    A small blast from the past - Issue 46 of May 2004

    3D structure databases

    ProteinModelPortali P83489.
    SMRi P83489. Positions 18-49.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR000294. GLA_domain.
    IPR002384. Osteocalcin/MGP.
    [Graphical view ]
    Pfami PF00594. Gla. 1 hit.
    [Graphical view ]
    PRINTSi PR00002. GLABONE.
    SMARTi SM00069. GLA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57630. SSF57630. 1 hit.
    PROSITEi PS00011. GLA_1. 1 hit.
    PS50998. GLA_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence preservation of osteocalcin protein and mitochondrial DNA in bison bones older than 55 ka."
      Nielsen-Marsh C.M., Ostrom P.H., Gandhi H., Shapiro B., Cooper A., Hauschka P.V., Collins M.J.
      Geology 30:1099-1102(2002)
      Cited for: PROTEIN SEQUENCE, HYDROXYLATION AT PRO-9, GAMMA-CARBOXYGLUTAMATION AT GLU-17; GLU-21 AND GLU-24, MASS SPECTROMETRY.
      Tissue: Bone.

    Entry informationi

    Entry nameiOSTCN_BISPR
    AccessioniPrimary (citable) accession number: P83489
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 13, 2004
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Sequence data obtained by MS from permafrost fossilized bones about 55.6 thousand years old.

    Keywords - Technical termi

    Direct protein sequencing, Extinct organism protein

    Documents

    1. Protein Spotlight
      Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3