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Protein

Osteocalcin

Gene

BGLAP

Organism
Bison priscus (Steppe wisent) (Steppe bison)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi17 – 171Calcium 3By similarity
Metal bindingi21 – 211Calcium 2By similarity
Metal bindingi24 – 241Calcium 1By similarity
Metal bindingi24 – 241Calcium 2By similarity
Metal bindingi30 – 301Calcium 1By similarity

GO - Molecular functioni

  1. calcium ion binding Source: InterPro

GO - Biological processi

  1. biomineral tissue development Source: UniProtKB-KW
  2. regulation of bone mineralization Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Biomineralization

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Osteocalcin
Alternative name(s):
Bone Gla protein
Short name:
BGP
Gamma-carboxyglutamic acid-containing protein
Gene namesi
Name:BGLAP
OrganismiBison priscus (Steppe wisent) (Steppe bison)
Taxonomic identifieri268291 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBison

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 4949OsteocalcinPRO_0000148895Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei9 – 91Hydroxyproline1 Publication
Modified residuei17 – 1714-carboxyglutamate1 PublicationPROSITE-ProRule annotation
Modified residuei21 – 2114-carboxyglutamate1 PublicationPROSITE-ProRule annotation
Disulfide bondi23 ↔ 29
Modified residuei24 – 2414-carboxyglutamate1 PublicationPROSITE-ProRule annotation

Post-translational modificationi

Gamma-carboxyglutamic acid residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Gamma-carboxyglutamic acid, Hydroxylation

Structurei

3D structure databases

ProteinModelPortaliP83489.
SMRiP83489. Positions 18-49.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 4747GlaPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 Gla (gamma-carboxy-glutamate) domain.PROSITE-ProRule annotation

Family and domain databases

InterProiIPR000294. GLA_domain.
IPR002384. Osteocalcin/MGP.
[Graphical view]
PfamiPF00594. Gla. 1 hit.
[Graphical view]
PRINTSiPR00002. GLABONE.
SMARTiSM00069. GLA. 1 hit.
[Graphical view]
SUPFAMiSSF57630. SSF57630. 1 hit.
PROSITEiPS00011. GLA_1. 1 hit.
PS50998. GLA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P83489-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40 
YLDHGLGAPA PYPDPLEPKR EVCELNPDCD ELADHIGFQE AYRRFYGPV
Length:49
Mass (Da):5,575
Last modified:March 1, 2003 - v1
Checksum:i718826015806CCBE
GO

Mass spectrometryi

Molecular mass is 5590 Da from positions 1 - 49. Determined by MALDI. 1 Publication

Cross-referencesi

Web resourcesi

Protein Spotlight

A small blast from the past - Issue 46 of May 2004

3D structure databases

ProteinModelPortaliP83489.
SMRiP83489. Positions 18-49.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiIPR000294. GLA_domain.
IPR002384. Osteocalcin/MGP.
[Graphical view]
PfamiPF00594. Gla. 1 hit.
[Graphical view]
PRINTSiPR00002. GLABONE.
SMARTiSM00069. GLA. 1 hit.
[Graphical view]
SUPFAMiSSF57630. SSF57630. 1 hit.
PROSITEiPS00011. GLA_1. 1 hit.
PS50998. GLA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Sequence preservation of osteocalcin protein and mitochondrial DNA in bison bones older than 55 ka."
    Nielsen-Marsh C.M., Ostrom P.H., Gandhi H., Shapiro B., Cooper A., Hauschka P.V., Collins M.J.
    Geology 30:1099-1102(2002)
    Cited for: PROTEIN SEQUENCE, HYDROXYLATION AT PRO-9, GAMMA-CARBOXYGLUTAMATION AT GLU-17; GLU-21 AND GLU-24, MASS SPECTROMETRY.
    Tissue: Bone.

Entry informationi

Entry nameiOSTCN_BISPR
AccessioniPrimary (citable) accession number: P83489
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: March 1, 2003
Last modified: January 7, 2015
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Sequence data obtained by MS from permafrost fossilized bones about 55.6 thousand years old.

Keywords - Technical termi

Direct protein sequencing, Extinct organism protein

Documents

  1. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.