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P83436 (COG7_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Conserved oligomeric Golgi complex subunit 7

Short name=COG complex subunit 7
Alternative name(s):
Component of oligomeric Golgi complex 7
Gene names
Name:COG7
ORF Names:UNQ3082/PRO10013
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length770 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Required for normal Golgi function By similarity.

Subunit structure

Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is required for normal Golgi morphology and localization. Ref.3

Subcellular location

Golgi apparatus membrane; Peripheral membrane protein Ref.3.

Involvement in disease

Congenital disorder of glycosylation 2E (CDG2E) [MIM:608779]: A multisystem disorder caused by a defect in glycoprotein biosynthesis and characterized by under-glycosylated serum glycoproteins. Congenital disorders of glycosylation result in a wide variety of clinical features, such as defects in the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions.
Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.4

Sequence similarities

Belongs to the COG7 family.

Sequence caution

The sequence AAQ88995.1 differs from that shown. Reason: Erroneous initiation.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

COG4Q9H9E34EBI-389534,EBI-368382
COG5Q9UP832EBI-389534,EBI-389502
Traf5P701912EBI-389534,EBI-523899From a different organism.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 770770Conserved oligomeric Golgi complex subunit 7
PRO_0000213518

Natural variations

Natural variant6051T → M.
Corresponds to variant rs16940094 [ dbSNP | Ensembl ].
VAR_048762

Sequences

Sequence LengthMass (Da)Tools
P83436 [UniParc].

Last modified August 30, 2002. Version 1.
Checksum: 14DAC431B291582C

FASTA77086,344
        10         20         30         40         50         60 
MDFSKFLADD FDVKEWINAA FRAGSKEAAS GKADGHAATL VMKLQLFIQE VNHAVEETSH 

        70         80         90        100        110        120 
QALQNMPKVL RDVEALKQEA SFLKEQMILV KEDIKKFEQD TSQSMQVLVE IDQVKSRMQL 

       130        140        150        160        170        180 
AAESLQEADK WSTLSADIEE TFKTQDIAVI SAKLTGMQNS LMMLVDTPDY SEKCVHLEAL 

       190        200        210        220        230        240 
KNRLEALASP QIVAAFTSQA VDQSKVFVKV FTEIDRMPQL LAYYYKCHKV QLLAAWQELC 

       250        260        270        280        290        300 
QSDLSLDRQL TGLYDALLGA WHTQIQWATQ VFQKPHEVVM VLLIQTLGAL MPSLPSCLSN 

       310        320        330        340        350        360 
GVERAGPEQE LTRLLEFYDA TAHFAKGLEM ALLPHLHEHN LVKVTELVDA VYDPYKPYQL 

       370        380        390        400        410        420 
KYGDMEESNL LIQMSAVPLE HGEVIDCVQE LSHSVNKLFG LASAAVDRCV RFTNGLGTCG 

       430        440        450        460        470        480 
LLSALKSLFA KYVSDFTSTL QSIRKKCKLD HIPPNSLFQE DWTAFQNSIR IIATCGELLR 

       490        500        510        520        530        540 
HCGDFEQQLA NRILSTAGKY LSDSCSPRSL AGFQESILTD KKNSAKNPWQ EYNYLQKDNP 

       550        560        570        580        590        600 
AEYASLMEIL YTLKEKGSSN HNLLAAPRAA LTRLNQQAHQ LAFDSVFLRI KQQLLLISKM 

       610        620        630        640        650        660 
DSWNTAGIGE TLTDELPAFS LTPLEYISNI GQYIMSLPLN LEPFVTQEDS ALELALHAGK 

       670        680        690        700        710        720 
LPFPPEQGDE LPELDNMADN WLGSIARATM QTYCDAILQI PELSPHSAKQ LATDIDYLIN 

       730        740        750        760        770 
VMDALGLQPS RTLQHIVTLL KTRPEDYRQV SKGLPRRLAT TVATMRSVNY 

« Hide

References

« Hide 'large scale' references
[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain and Mammary gland.
[2]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 257-770.
[3]"Characterization of a mammalian Golgi-localized protein complex, COG, that is required for normal Golgi morphology and function."
Ungar D., Oka T., Brittle E.E., Vasile E., Lupashin V.V., Chatterton J.E., Heuser J.E., Krieger M., Waters M.G.
J. Cell Biol. 157:405-415(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION, SUBUNIT, SUBCELLULAR LOCATION.
[4]"Mutation of the COG complex subunit gene COG7 causes a lethal congenital disorder."
Wu X., Steet R.A., Bohorov O., Bakker J., Newell J., Krieger M., Spaapen L., Kornfeld S., Freeze H.H.
Nat. Med. 10:518-523(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: INVOLVEMENT IN CDG2E.
[5]"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[6]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[7]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC000549 mRNA. Translation: AAH00549.1.
BC037563 mRNA. Translation: AAH37563.1.
AY358632 mRNA. Translation: AAQ88995.1. Different initiation.
RefSeqNP_705831.1. NM_153603.3.
UniGeneHs.185807.

3D structure databases

ProteinModelPortalP83436.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid124896. 16 interactions.
IntActP83436. 8 interactions.
MINTMINT-6773434.
STRING9606.ENSP00000305442.

PTM databases

PhosphoSiteP83436.

Polymorphism databases

DMDM22653684.

Proteomic databases

PaxDbP83436.
PRIDEP83436.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000307149; ENSP00000305442; ENSG00000168434.
GeneID91949.
KEGGhsa:91949.
UCSCuc002dlo.3. human.

Organism-specific databases

CTD91949.
GeneCardsGC16M023307.
H-InvDBHIX0173261.
HGNCHGNC:18622. COG7.
HPAHPA040758.
MIM606978. gene.
608779. phenotype.
neXtProtNX_P83436.
Orphanet79333. COG7-CDG.
PharmGKBPA38605.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG288194.
HOGENOMHOG000007766.
HOVERGENHBG020364.
InParanoidP83436.
OMAYKCHKAQ.
OrthoDBEOG78SQH8.
PhylomeDBP83436.
TreeFamTF324498.

Gene expression databases

BgeeP83436.
CleanExHS_COG7.
GenevestigatorP83436.

Family and domain databases

InterProIPR019335. COG7.
[Graphical view]
PANTHERPTHR21443. PTHR21443. 1 hit.
PfamPF10191. COG7. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSCOG7. human.
GeneWikiCOG7.
GenomeRNAi91949.
NextBio77534.
PROP83436.
SOURCESearch...

Entry information

Entry nameCOG7_HUMAN
AccessionPrimary (citable) accession number: P83436
Secondary accession number(s): Q6UWU7
Entry history
Integrated into UniProtKB/Swiss-Prot: August 30, 2002
Last sequence update: August 30, 2002
Last modified: April 16, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 16

Human chromosome 16: entries, gene names and cross-references to MIM