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P83436

- COG7_HUMAN

UniProt

P83436 - COG7_HUMAN

Protein

Conserved oligomeric Golgi complex subunit 7

Gene

COG7

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 1 (30 Aug 2002)
      Previous versions | rss
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    Functioni

    Required for normal Golgi function.By similarity

    GO - Molecular functioni

    1. protein binding Source: UniProtKB

    GO - Biological processi

    1. intracellular protein transport Source: UniProtKB
    2. protein glycosylation Source: UniProtKB
    3. protein localization to Golgi apparatus Source: UniProtKB
    4. protein localization to organelle Source: UniProtKB
    5. protein stabilization Source: UniProtKB
    6. retrograde vesicle-mediated transport, Golgi to ER Source: UniProtKB

    Keywords - Biological processi

    Protein transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Conserved oligomeric Golgi complex subunit 7
    Short name:
    COG complex subunit 7
    Alternative name(s):
    Component of oligomeric Golgi complex 7
    Gene namesi
    Name:COG7
    ORF Names:UNQ3082/PRO10013
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:18622. COG7.

    Subcellular locationi

    Golgi apparatus membrane 1 Publication; Peripheral membrane protein 1 Publication

    GO - Cellular componenti

    1. Golgi apparatus Source: UniProtKB
    2. Golgi membrane Source: UniProtKB-SubCell
    3. Golgi transport complex Source: UniProtKB

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Congenital disorder of glycosylation 2E (CDG2E) [MIM:608779]: A multisystem disorder caused by a defect in glycoprotein biosynthesis and characterized by under-glycosylated serum glycoproteins. Congenital disorders of glycosylation result in a wide variety of clinical features, such as defects in the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.

    Keywords - Diseasei

    Congenital disorder of glycosylation

    Organism-specific databases

    MIMi608779. phenotype.
    Orphaneti79333. COG7-CDG.
    PharmGKBiPA38605.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 770770Conserved oligomeric Golgi complex subunit 7PRO_0000213518Add
    BLAST

    Proteomic databases

    MaxQBiP83436.
    PaxDbiP83436.
    PRIDEiP83436.

    PTM databases

    PhosphoSiteiP83436.

    Expressioni

    Gene expression databases

    BgeeiP83436.
    CleanExiHS_COG7.
    GenevestigatoriP83436.

    Organism-specific databases

    HPAiHPA040758.

    Interactioni

    Subunit structurei

    Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is required for normal Golgi morphology and localization.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    COG4Q9H9E34EBI-389534,EBI-368382
    COG5Q9UP832EBI-389534,EBI-389502
    Traf5P701912EBI-389534,EBI-523899From a different organism.

    Protein-protein interaction databases

    BioGridi124896. 16 interactions.
    IntActiP83436. 8 interactions.
    MINTiMINT-6773434.
    STRINGi9606.ENSP00000305442.

    Structurei

    3D structure databases

    ProteinModelPortaliP83436.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the COG7 family.Curated

    Phylogenomic databases

    eggNOGiNOG288194.
    HOGENOMiHOG000007766.
    HOVERGENiHBG020364.
    InParanoidiP83436.
    OMAiYKCHKAQ.
    OrthoDBiEOG78SQH8.
    PhylomeDBiP83436.
    TreeFamiTF324498.

    Family and domain databases

    InterProiIPR019335. COG7.
    [Graphical view]
    PANTHERiPTHR21443. PTHR21443. 1 hit.
    PfamiPF10191. COG7. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P83436-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDFSKFLADD FDVKEWINAA FRAGSKEAAS GKADGHAATL VMKLQLFIQE    50
    VNHAVEETSH QALQNMPKVL RDVEALKQEA SFLKEQMILV KEDIKKFEQD 100
    TSQSMQVLVE IDQVKSRMQL AAESLQEADK WSTLSADIEE TFKTQDIAVI 150
    SAKLTGMQNS LMMLVDTPDY SEKCVHLEAL KNRLEALASP QIVAAFTSQA 200
    VDQSKVFVKV FTEIDRMPQL LAYYYKCHKV QLLAAWQELC QSDLSLDRQL 250
    TGLYDALLGA WHTQIQWATQ VFQKPHEVVM VLLIQTLGAL MPSLPSCLSN 300
    GVERAGPEQE LTRLLEFYDA TAHFAKGLEM ALLPHLHEHN LVKVTELVDA 350
    VYDPYKPYQL KYGDMEESNL LIQMSAVPLE HGEVIDCVQE LSHSVNKLFG 400
    LASAAVDRCV RFTNGLGTCG LLSALKSLFA KYVSDFTSTL QSIRKKCKLD 450
    HIPPNSLFQE DWTAFQNSIR IIATCGELLR HCGDFEQQLA NRILSTAGKY 500
    LSDSCSPRSL AGFQESILTD KKNSAKNPWQ EYNYLQKDNP AEYASLMEIL 550
    YTLKEKGSSN HNLLAAPRAA LTRLNQQAHQ LAFDSVFLRI KQQLLLISKM 600
    DSWNTAGIGE TLTDELPAFS LTPLEYISNI GQYIMSLPLN LEPFVTQEDS 650
    ALELALHAGK LPFPPEQGDE LPELDNMADN WLGSIARATM QTYCDAILQI 700
    PELSPHSAKQ LATDIDYLIN VMDALGLQPS RTLQHIVTLL KTRPEDYRQV 750
    SKGLPRRLAT TVATMRSVNY 770
    Length:770
    Mass (Da):86,344
    Last modified:August 30, 2002 - v1
    Checksum:i14DAC431B291582C
    GO

    Sequence cautioni

    The sequence AAQ88995.1 differs from that shown. Reason: Erroneous initiation.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti605 – 6051T → M.
    Corresponds to variant rs16940094 [ dbSNP | Ensembl ].
    VAR_048762

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC000549 mRNA. Translation: AAH00549.1.
    BC037563 mRNA. Translation: AAH37563.1.
    AY358632 mRNA. Translation: AAQ88995.1. Different initiation.
    CCDSiCCDS10610.1.
    RefSeqiNP_705831.1. NM_153603.3.
    UniGeneiHs.185807.

    Genome annotation databases

    EnsembliENST00000307149; ENSP00000305442; ENSG00000168434.
    GeneIDi91949.
    KEGGihsa:91949.
    UCSCiuc002dlo.3. human.

    Polymorphism databases

    DMDMi22653684.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC000549 mRNA. Translation: AAH00549.1 .
    BC037563 mRNA. Translation: AAH37563.1 .
    AY358632 mRNA. Translation: AAQ88995.1 . Different initiation.
    CCDSi CCDS10610.1.
    RefSeqi NP_705831.1. NM_153603.3.
    UniGenei Hs.185807.

    3D structure databases

    ProteinModelPortali P83436.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 124896. 16 interactions.
    IntActi P83436. 8 interactions.
    MINTi MINT-6773434.
    STRINGi 9606.ENSP00000305442.

    PTM databases

    PhosphoSitei P83436.

    Polymorphism databases

    DMDMi 22653684.

    Proteomic databases

    MaxQBi P83436.
    PaxDbi P83436.
    PRIDEi P83436.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000307149 ; ENSP00000305442 ; ENSG00000168434 .
    GeneIDi 91949.
    KEGGi hsa:91949.
    UCSCi uc002dlo.3. human.

    Organism-specific databases

    CTDi 91949.
    GeneCardsi GC16M023307.
    GeneReviewsi COG7.
    H-InvDB HIX0173261.
    HGNCi HGNC:18622. COG7.
    HPAi HPA040758.
    MIMi 606978. gene.
    608779. phenotype.
    neXtProti NX_P83436.
    Orphaneti 79333. COG7-CDG.
    PharmGKBi PA38605.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG288194.
    HOGENOMi HOG000007766.
    HOVERGENi HBG020364.
    InParanoidi P83436.
    OMAi YKCHKAQ.
    OrthoDBi EOG78SQH8.
    PhylomeDBi P83436.
    TreeFami TF324498.

    Miscellaneous databases

    ChiTaRSi COG7. human.
    GeneWikii COG7.
    GenomeRNAii 91949.
    NextBioi 77534.
    PROi P83436.
    SOURCEi Search...

    Gene expression databases

    Bgeei P83436.
    CleanExi HS_COG7.
    Genevestigatori P83436.

    Family and domain databases

    InterProi IPR019335. COG7.
    [Graphical view ]
    PANTHERi PTHR21443. PTHR21443. 1 hit.
    Pfami PF10191. COG7. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain and Mammary gland.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 257-770.
    3. "Characterization of a mammalian Golgi-localized protein complex, COG, that is required for normal Golgi morphology and function."
      Ungar D., Oka T., Brittle E.E., Vasile E., Lupashin V.V., Chatterton J.E., Heuser J.E., Krieger M., Waters M.G.
      J. Cell Biol. 157:405-415(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION, SUBUNIT, SUBCELLULAR LOCATION.
    4. "Mutation of the COG complex subunit gene COG7 causes a lethal congenital disorder."
      Wu X., Steet R.A., Bohorov O., Bakker J., Newell J., Krieger M., Spaapen L., Kornfeld S., Freeze H.H.
      Nat. Med. 10:518-523(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INVOLVEMENT IN CDG2E.
    5. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiCOG7_HUMAN
    AccessioniPrimary (citable) accession number: P83436
    Secondary accession number(s): Q6UWU7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 30, 2002
    Last sequence update: August 30, 2002
    Last modified: October 1, 2014
    This is version 104 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3