Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P83436

- COG7_HUMAN

UniProt

P83436 - COG7_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Conserved oligomeric Golgi complex subunit 7

Gene

COG7

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Required for normal Golgi function.By similarity

GO - Biological processi

  1. intracellular protein transport Source: UniProtKB
  2. protein glycosylation Source: UniProtKB
  3. protein localization to Golgi apparatus Source: UniProtKB
  4. protein localization to organelle Source: UniProtKB
  5. protein stabilization Source: UniProtKB
  6. retrograde vesicle-mediated transport, Golgi to ER Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Conserved oligomeric Golgi complex subunit 7
Short name:
COG complex subunit 7
Alternative name(s):
Component of oligomeric Golgi complex 7
Gene namesi
Name:COG7
ORF Names:UNQ3082/PRO10013
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:18622. COG7.

Subcellular locationi

Golgi apparatus membrane 1 Publication; Peripheral membrane protein 1 Publication

GO - Cellular componenti

  1. Golgi apparatus Source: UniProtKB
  2. Golgi transport complex Source: UniProtKB
  3. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Involvement in diseasei

Congenital disorder of glycosylation 2E (CDG2E) [MIM:608779]: A multisystem disorder caused by a defect in glycoprotein biosynthesis and characterized by under-glycosylated serum glycoproteins. Congenital disorders of glycosylation result in a wide variety of clinical features, such as defects in the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions.1 Publication
Note: The disease is caused by mutations affecting the gene represented in this entry.

Keywords - Diseasei

Congenital disorder of glycosylation

Organism-specific databases

MIMi608779. phenotype.
Orphaneti79333. COG7-CDG.
PharmGKBiPA38605.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 770770Conserved oligomeric Golgi complex subunit 7PRO_0000213518Add
BLAST

Proteomic databases

MaxQBiP83436.
PaxDbiP83436.
PRIDEiP83436.

PTM databases

PhosphoSiteiP83436.

Expressioni

Gene expression databases

BgeeiP83436.
CleanExiHS_COG7.
GenevestigatoriP83436.

Organism-specific databases

HPAiHPA040758.

Interactioni

Subunit structurei

Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is required for normal Golgi morphology and localization.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
COG4Q9H9E34EBI-389534,EBI-368382
COG5Q9UP832EBI-389534,EBI-389502
Traf5P701912EBI-389534,EBI-523899From a different organism.

Protein-protein interaction databases

BioGridi124896. 22 interactions.
IntActiP83436. 8 interactions.
MINTiMINT-6773434.
STRINGi9606.ENSP00000305442.

Structurei

3D structure databases

ProteinModelPortaliP83436.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the COG7 family.Curated

Phylogenomic databases

eggNOGiNOG288194.
GeneTreeiENSGT00390000001260.
HOGENOMiHOG000007766.
HOVERGENiHBG020364.
InParanoidiP83436.
OMAiYKCHKAQ.
OrthoDBiEOG78SQH8.
PhylomeDBiP83436.
TreeFamiTF324498.

Family and domain databases

InterProiIPR019335. COG7.
[Graphical view]
PANTHERiPTHR21443. PTHR21443. 1 hit.
PfamiPF10191. COG7. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P83436-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDFSKFLADD FDVKEWINAA FRAGSKEAAS GKADGHAATL VMKLQLFIQE
60 70 80 90 100
VNHAVEETSH QALQNMPKVL RDVEALKQEA SFLKEQMILV KEDIKKFEQD
110 120 130 140 150
TSQSMQVLVE IDQVKSRMQL AAESLQEADK WSTLSADIEE TFKTQDIAVI
160 170 180 190 200
SAKLTGMQNS LMMLVDTPDY SEKCVHLEAL KNRLEALASP QIVAAFTSQA
210 220 230 240 250
VDQSKVFVKV FTEIDRMPQL LAYYYKCHKV QLLAAWQELC QSDLSLDRQL
260 270 280 290 300
TGLYDALLGA WHTQIQWATQ VFQKPHEVVM VLLIQTLGAL MPSLPSCLSN
310 320 330 340 350
GVERAGPEQE LTRLLEFYDA TAHFAKGLEM ALLPHLHEHN LVKVTELVDA
360 370 380 390 400
VYDPYKPYQL KYGDMEESNL LIQMSAVPLE HGEVIDCVQE LSHSVNKLFG
410 420 430 440 450
LASAAVDRCV RFTNGLGTCG LLSALKSLFA KYVSDFTSTL QSIRKKCKLD
460 470 480 490 500
HIPPNSLFQE DWTAFQNSIR IIATCGELLR HCGDFEQQLA NRILSTAGKY
510 520 530 540 550
LSDSCSPRSL AGFQESILTD KKNSAKNPWQ EYNYLQKDNP AEYASLMEIL
560 570 580 590 600
YTLKEKGSSN HNLLAAPRAA LTRLNQQAHQ LAFDSVFLRI KQQLLLISKM
610 620 630 640 650
DSWNTAGIGE TLTDELPAFS LTPLEYISNI GQYIMSLPLN LEPFVTQEDS
660 670 680 690 700
ALELALHAGK LPFPPEQGDE LPELDNMADN WLGSIARATM QTYCDAILQI
710 720 730 740 750
PELSPHSAKQ LATDIDYLIN VMDALGLQPS RTLQHIVTLL KTRPEDYRQV
760 770
SKGLPRRLAT TVATMRSVNY
Length:770
Mass (Da):86,344
Last modified:August 30, 2002 - v1
Checksum:i14DAC431B291582C
GO

Sequence cautioni

The sequence AAQ88995.1 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti605 – 6051T → M.
Corresponds to variant rs16940094 [ dbSNP | Ensembl ].
VAR_048762

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC000549 mRNA. Translation: AAH00549.1.
BC037563 mRNA. Translation: AAH37563.1.
AY358632 mRNA. Translation: AAQ88995.1. Different initiation.
CCDSiCCDS10610.1.
RefSeqiNP_705831.1. NM_153603.3.
UniGeneiHs.185807.

Genome annotation databases

EnsembliENST00000307149; ENSP00000305442; ENSG00000168434.
GeneIDi91949.
KEGGihsa:91949.
UCSCiuc002dlo.3. human.

Polymorphism databases

DMDMi22653684.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC000549 mRNA. Translation: AAH00549.1 .
BC037563 mRNA. Translation: AAH37563.1 .
AY358632 mRNA. Translation: AAQ88995.1 . Different initiation.
CCDSi CCDS10610.1.
RefSeqi NP_705831.1. NM_153603.3.
UniGenei Hs.185807.

3D structure databases

ProteinModelPortali P83436.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 124896. 22 interactions.
IntActi P83436. 8 interactions.
MINTi MINT-6773434.
STRINGi 9606.ENSP00000305442.

PTM databases

PhosphoSitei P83436.

Polymorphism databases

DMDMi 22653684.

Proteomic databases

MaxQBi P83436.
PaxDbi P83436.
PRIDEi P83436.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000307149 ; ENSP00000305442 ; ENSG00000168434 .
GeneIDi 91949.
KEGGi hsa:91949.
UCSCi uc002dlo.3. human.

Organism-specific databases

CTDi 91949.
GeneCardsi GC16M023307.
GeneReviewsi COG7.
H-InvDB HIX0173261.
HGNCi HGNC:18622. COG7.
HPAi HPA040758.
MIMi 606978. gene.
608779. phenotype.
neXtProti NX_P83436.
Orphaneti 79333. COG7-CDG.
PharmGKBi PA38605.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG288194.
GeneTreei ENSGT00390000001260.
HOGENOMi HOG000007766.
HOVERGENi HBG020364.
InParanoidi P83436.
OMAi YKCHKAQ.
OrthoDBi EOG78SQH8.
PhylomeDBi P83436.
TreeFami TF324498.

Miscellaneous databases

ChiTaRSi COG7. human.
GeneWikii COG7.
GenomeRNAii 91949.
NextBioi 77534.
PROi P83436.
SOURCEi Search...

Gene expression databases

Bgeei P83436.
CleanExi HS_COG7.
Genevestigatori P83436.

Family and domain databases

InterProi IPR019335. COG7.
[Graphical view ]
PANTHERi PTHR21443. PTHR21443. 1 hit.
Pfami PF10191. COG7. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Mammary gland.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 257-770.
  3. "Characterization of a mammalian Golgi-localized protein complex, COG, that is required for normal Golgi morphology and function."
    Ungar D., Oka T., Brittle E.E., Vasile E., Lupashin V.V., Chatterton J.E., Heuser J.E., Krieger M., Waters M.G.
    J. Cell Biol. 157:405-415(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION, SUBUNIT, SUBCELLULAR LOCATION.
  4. "Mutation of the COG complex subunit gene COG7 causes a lethal congenital disorder."
    Wu X., Steet R.A., Bohorov O., Bakker J., Newell J., Krieger M., Spaapen L., Kornfeld S., Freeze H.H.
    Nat. Med. 10:518-523(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN CDG2E.
  5. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCOG7_HUMAN
AccessioniPrimary (citable) accession number: P83436
Secondary accession number(s): Q6UWU7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2002
Last sequence update: August 30, 2002
Last modified: October 29, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3