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Protein

Conserved oligomeric Golgi complex subunit 7

Gene

COG7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for normal Golgi function.By similarity

GO - Biological processi

  • ER to Golgi vesicle-mediated transport Source: Reactome
  • Golgi organization Source: GO_Central
  • intracellular protein transport Source: UniProtKB
  • protein glycosylation Source: UniProtKB
  • protein localization to Golgi apparatus Source: UniProtKB
  • protein localization to organelle Source: UniProtKB
  • protein stabilization Source: UniProtKB
  • retrograde vesicle-mediated transport, Golgi to ER Source: UniProtKB

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-6807878. COPI-mediated anterograde transport.
R-HSA-6811438. Intra-Golgi traffic.
R-HSA-6811440. Retrograde transport at the Trans-Golgi-Network.

Names & Taxonomyi

Protein namesi
Recommended name:
Conserved oligomeric Golgi complex subunit 7
Short name:
COG complex subunit 7
Alternative name(s):
Component of oligomeric Golgi complex 7
Gene namesi
Name:COG7
ORF Names:UNQ3082/PRO10013
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000168434.12.
HGNCiHGNC:18622. COG7.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Involvement in diseasei

Congenital disorder of glycosylation 2E (CDG2E)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA multisystem disorder caused by a defect in glycoprotein biosynthesis and characterized by under-glycosylated serum glycoproteins. Congenital disorders of glycosylation result in a wide variety of clinical features, such as defects in the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions.
See also OMIM:608779

Keywords - Diseasei

Congenital disorder of glycosylation

Organism-specific databases

DisGeNETi91949.
GeneReviewsiCOG7.
MalaCardsiCOG7.
MIMi608779. phenotype.
OpenTargetsiENSG00000168434.
Orphaneti79333. COG7-CDG.
PharmGKBiPA38605.

Polymorphism and mutation databases

BioMutaiCOG7.
DMDMi22653684.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002135181 – 770Conserved oligomeric Golgi complex subunit 7Add BLAST770

Proteomic databases

EPDiP83436.
MaxQBiP83436.
PaxDbiP83436.
PeptideAtlasiP83436.
PRIDEiP83436.

PTM databases

iPTMnetiP83436.
PhosphoSitePlusiP83436.

Expressioni

Gene expression databases

BgeeiENSG00000168434.
CleanExiHS_COG7.
ExpressionAtlasiP83436. baseline and differential.
GenevisibleiP83436. HS.

Organism-specific databases

HPAiHPA040758.
HPA064645.

Interactioni

Subunit structurei

Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is required for normal Golgi morphology and localization.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi124896. 46 interactors.
CORUMiP83436.
IntActiP83436. 11 interactors.
MINTiMINT-6773434.
STRINGi9606.ENSP00000305442.

Structurei

3D structure databases

ProteinModelPortaliP83436.
SMRiP83436.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the COG7 family.Curated

Phylogenomic databases

eggNOGiKOG4182. Eukaryota.
ENOG410XT6U. LUCA.
GeneTreeiENSGT00390000001260.
HOGENOMiHOG000007766.
HOVERGENiHBG020364.
InParanoidiP83436.
KOiK20294.
OMAiQWATQVF.
OrthoDBiEOG091G05X1.
PhylomeDBiP83436.
TreeFamiTF324498.

Family and domain databases

InterProiView protein in InterPro
IPR019335. COG7.
PANTHERiPTHR21443. PTHR21443. 1 hit.
PfamiView protein in Pfam
PF10191. COG7. 1 hit.

Sequencei

Sequence statusi: Complete.

P83436-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDFSKFLADD FDVKEWINAA FRAGSKEAAS GKADGHAATL VMKLQLFIQE
60 70 80 90 100
VNHAVEETSH QALQNMPKVL RDVEALKQEA SFLKEQMILV KEDIKKFEQD
110 120 130 140 150
TSQSMQVLVE IDQVKSRMQL AAESLQEADK WSTLSADIEE TFKTQDIAVI
160 170 180 190 200
SAKLTGMQNS LMMLVDTPDY SEKCVHLEAL KNRLEALASP QIVAAFTSQA
210 220 230 240 250
VDQSKVFVKV FTEIDRMPQL LAYYYKCHKV QLLAAWQELC QSDLSLDRQL
260 270 280 290 300
TGLYDALLGA WHTQIQWATQ VFQKPHEVVM VLLIQTLGAL MPSLPSCLSN
310 320 330 340 350
GVERAGPEQE LTRLLEFYDA TAHFAKGLEM ALLPHLHEHN LVKVTELVDA
360 370 380 390 400
VYDPYKPYQL KYGDMEESNL LIQMSAVPLE HGEVIDCVQE LSHSVNKLFG
410 420 430 440 450
LASAAVDRCV RFTNGLGTCG LLSALKSLFA KYVSDFTSTL QSIRKKCKLD
460 470 480 490 500
HIPPNSLFQE DWTAFQNSIR IIATCGELLR HCGDFEQQLA NRILSTAGKY
510 520 530 540 550
LSDSCSPRSL AGFQESILTD KKNSAKNPWQ EYNYLQKDNP AEYASLMEIL
560 570 580 590 600
YTLKEKGSSN HNLLAAPRAA LTRLNQQAHQ LAFDSVFLRI KQQLLLISKM
610 620 630 640 650
DSWNTAGIGE TLTDELPAFS LTPLEYISNI GQYIMSLPLN LEPFVTQEDS
660 670 680 690 700
ALELALHAGK LPFPPEQGDE LPELDNMADN WLGSIARATM QTYCDAILQI
710 720 730 740 750
PELSPHSAKQ LATDIDYLIN VMDALGLQPS RTLQHIVTLL KTRPEDYRQV
760 770
SKGLPRRLAT TVATMRSVNY
Length:770
Mass (Da):86,344
Last modified:August 30, 2002 - v1
Checksum:i14DAC431B291582C
GO

Sequence cautioni

The sequence AAQ88995 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_048762605T → M. Corresponds to variant dbSNP:rs16940094Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC000549 mRNA. Translation: AAH00549.1.
BC037563 mRNA. Translation: AAH37563.1.
AY358632 mRNA. Translation: AAQ88995.1. Different initiation.
CCDSiCCDS10610.1.
RefSeqiNP_705831.1. NM_153603.3.
UniGeneiHs.185807.

Genome annotation databases

EnsembliENST00000307149; ENSP00000305442; ENSG00000168434.
GeneIDi91949.
KEGGihsa:91949.
UCSCiuc002dlo.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCOG7_HUMAN
AccessioniPrimary (citable) accession number: P83436
Secondary accession number(s): Q6UWU7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2002
Last sequence update: August 30, 2002
Last modified: September 27, 2017
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families