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Protein

Conserved oligomeric Golgi complex subunit 7

Gene

COG7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for normal Golgi function.By similarity

GO - Biological processi

  • intracellular protein transport Source: UniProtKB
  • protein glycosylation Source: UniProtKB
  • protein localization to Golgi apparatus Source: UniProtKB
  • protein localization to organelle Source: UniProtKB
  • protein stabilization Source: UniProtKB
  • retrograde vesicle-mediated transport, Golgi to ER Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Conserved oligomeric Golgi complex subunit 7
Short name:
COG complex subunit 7
Alternative name(s):
Component of oligomeric Golgi complex 7
Gene namesi
Name:COG7
ORF Names:UNQ3082/PRO10013
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:18622. COG7.

Subcellular locationi

GO - Cellular componenti

  • Golgi apparatus Source: UniProtKB
  • Golgi membrane Source: UniProtKB-SubCell
  • Golgi transport complex Source: UniProtKB
  • intracellular membrane-bounded organelle Source: HPA
  • nucleolus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Involvement in diseasei

Congenital disorder of glycosylation 2E (CDG2E)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA multisystem disorder caused by a defect in glycoprotein biosynthesis and characterized by under-glycosylated serum glycoproteins. Congenital disorders of glycosylation result in a wide variety of clinical features, such as defects in the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions.

See also OMIM:608779

Keywords - Diseasei

Congenital disorder of glycosylation

Organism-specific databases

MIMi608779. phenotype.
Orphaneti79333. COG7-CDG.
PharmGKBiPA38605.

Polymorphism and mutation databases

BioMutaiCOG7.
DMDMi22653684.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 770770Conserved oligomeric Golgi complex subunit 7PRO_0000213518Add
BLAST

Proteomic databases

MaxQBiP83436.
PaxDbiP83436.
PRIDEiP83436.

PTM databases

PhosphoSiteiP83436.

Expressioni

Gene expression databases

BgeeiP83436.
CleanExiHS_COG7.
ExpressionAtlasiP83436. baseline and differential.
GenevisibleiP83436. HS.

Organism-specific databases

HPAiHPA040758.
HPA041824.

Interactioni

Subunit structurei

Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is required for normal Golgi morphology and localization.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
COG4Q9H9E34EBI-389534,EBI-368382
COG5Q9UP832EBI-389534,EBI-389502
TAX1BP1Q86VP13EBI-389534,EBI-529518
Traf5P701912EBI-389534,EBI-523899From a different organism.

Protein-protein interaction databases

BioGridi124896. 25 interactions.
IntActiP83436. 9 interactions.
MINTiMINT-6773434.
STRINGi9606.ENSP00000305442.

Structurei

3D structure databases

ProteinModelPortaliP83436.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the COG7 family.Curated

Phylogenomic databases

eggNOGiNOG288194.
GeneTreeiENSGT00390000001260.
HOGENOMiHOG000007766.
HOVERGENiHBG020364.
InParanoidiP83436.
OMAiRKKCKLE.
OrthoDBiEOG78SQH8.
PhylomeDBiP83436.
TreeFamiTF324498.

Family and domain databases

InterProiIPR019335. COG7.
[Graphical view]
PANTHERiPTHR21443. PTHR21443. 1 hit.
PfamiPF10191. COG7. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P83436-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDFSKFLADD FDVKEWINAA FRAGSKEAAS GKADGHAATL VMKLQLFIQE
60 70 80 90 100
VNHAVEETSH QALQNMPKVL RDVEALKQEA SFLKEQMILV KEDIKKFEQD
110 120 130 140 150
TSQSMQVLVE IDQVKSRMQL AAESLQEADK WSTLSADIEE TFKTQDIAVI
160 170 180 190 200
SAKLTGMQNS LMMLVDTPDY SEKCVHLEAL KNRLEALASP QIVAAFTSQA
210 220 230 240 250
VDQSKVFVKV FTEIDRMPQL LAYYYKCHKV QLLAAWQELC QSDLSLDRQL
260 270 280 290 300
TGLYDALLGA WHTQIQWATQ VFQKPHEVVM VLLIQTLGAL MPSLPSCLSN
310 320 330 340 350
GVERAGPEQE LTRLLEFYDA TAHFAKGLEM ALLPHLHEHN LVKVTELVDA
360 370 380 390 400
VYDPYKPYQL KYGDMEESNL LIQMSAVPLE HGEVIDCVQE LSHSVNKLFG
410 420 430 440 450
LASAAVDRCV RFTNGLGTCG LLSALKSLFA KYVSDFTSTL QSIRKKCKLD
460 470 480 490 500
HIPPNSLFQE DWTAFQNSIR IIATCGELLR HCGDFEQQLA NRILSTAGKY
510 520 530 540 550
LSDSCSPRSL AGFQESILTD KKNSAKNPWQ EYNYLQKDNP AEYASLMEIL
560 570 580 590 600
YTLKEKGSSN HNLLAAPRAA LTRLNQQAHQ LAFDSVFLRI KQQLLLISKM
610 620 630 640 650
DSWNTAGIGE TLTDELPAFS LTPLEYISNI GQYIMSLPLN LEPFVTQEDS
660 670 680 690 700
ALELALHAGK LPFPPEQGDE LPELDNMADN WLGSIARATM QTYCDAILQI
710 720 730 740 750
PELSPHSAKQ LATDIDYLIN VMDALGLQPS RTLQHIVTLL KTRPEDYRQV
760 770
SKGLPRRLAT TVATMRSVNY
Length:770
Mass (Da):86,344
Last modified:August 30, 2002 - v1
Checksum:i14DAC431B291582C
GO

Sequence cautioni

The sequence AAQ88995.1 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti605 – 6051T → M.
Corresponds to variant rs16940094 [ dbSNP | Ensembl ].
VAR_048762

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC000549 mRNA. Translation: AAH00549.1.
BC037563 mRNA. Translation: AAH37563.1.
AY358632 mRNA. Translation: AAQ88995.1. Different initiation.
CCDSiCCDS10610.1.
RefSeqiNP_705831.1. NM_153603.3.
UniGeneiHs.185807.

Genome annotation databases

EnsembliENST00000307149; ENSP00000305442; ENSG00000168434.
GeneIDi91949.
KEGGihsa:91949.
UCSCiuc002dlo.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC000549 mRNA. Translation: AAH00549.1.
BC037563 mRNA. Translation: AAH37563.1.
AY358632 mRNA. Translation: AAQ88995.1. Different initiation.
CCDSiCCDS10610.1.
RefSeqiNP_705831.1. NM_153603.3.
UniGeneiHs.185807.

3D structure databases

ProteinModelPortaliP83436.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124896. 25 interactions.
IntActiP83436. 9 interactions.
MINTiMINT-6773434.
STRINGi9606.ENSP00000305442.

PTM databases

PhosphoSiteiP83436.

Polymorphism and mutation databases

BioMutaiCOG7.
DMDMi22653684.

Proteomic databases

MaxQBiP83436.
PaxDbiP83436.
PRIDEiP83436.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000307149; ENSP00000305442; ENSG00000168434.
GeneIDi91949.
KEGGihsa:91949.
UCSCiuc002dlo.3. human.

Organism-specific databases

CTDi91949.
GeneCardsiGC16M023307.
GeneReviewsiCOG7.
H-InvDBHIX0173261.
HGNCiHGNC:18622. COG7.
HPAiHPA040758.
HPA041824.
MIMi606978. gene.
608779. phenotype.
neXtProtiNX_P83436.
Orphaneti79333. COG7-CDG.
PharmGKBiPA38605.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG288194.
GeneTreeiENSGT00390000001260.
HOGENOMiHOG000007766.
HOVERGENiHBG020364.
InParanoidiP83436.
OMAiRKKCKLE.
OrthoDBiEOG78SQH8.
PhylomeDBiP83436.
TreeFamiTF324498.

Miscellaneous databases

ChiTaRSiCOG7. human.
GeneWikiiCOG7.
GenomeRNAii91949.
NextBioi77534.
PROiP83436.
SOURCEiSearch...

Gene expression databases

BgeeiP83436.
CleanExiHS_COG7.
ExpressionAtlasiP83436. baseline and differential.
GenevisibleiP83436. HS.

Family and domain databases

InterProiIPR019335. COG7.
[Graphical view]
PANTHERiPTHR21443. PTHR21443. 1 hit.
PfamiPF10191. COG7. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Mammary gland.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 257-770.
  3. "Characterization of a mammalian Golgi-localized protein complex, COG, that is required for normal Golgi morphology and function."
    Ungar D., Oka T., Brittle E.E., Vasile E., Lupashin V.V., Chatterton J.E., Heuser J.E., Krieger M., Waters M.G.
    J. Cell Biol. 157:405-415(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION, SUBUNIT, SUBCELLULAR LOCATION.
  4. "Mutation of the COG complex subunit gene COG7 causes a lethal congenital disorder."
    Wu X., Steet R.A., Bohorov O., Bakker J., Newell J., Krieger M., Spaapen L., Kornfeld S., Freeze H.H.
    Nat. Med. 10:518-523(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN CDG2E.
  5. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCOG7_HUMAN
AccessioniPrimary (citable) accession number: P83436
Secondary accession number(s): Q6UWU7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2002
Last sequence update: August 30, 2002
Last modified: July 22, 2015
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.