Potassium channel toxin alpha-KTx 19.1

Functionⁱ

Selective inhibitor of high conductance calcium-activated potassium channels KCa1.1/KCNMA1. May be insect specific.2 Publications

Miscellaneous

Has no effect on voltage-gated potassium channels Kv1.1/KCNA1, Kv1.2/KCNA2, Kv1.3/KCNA3, Kv11.1/KCNH2, Kv11.2/KCNH6, Kv11.3/KCNH7, Kv7.1/KCNQ1 and on Kir2.1/KCNJ2.1 Publication

Sites

Feature key	Position(s)	DescriptionActions	Length
Siteⁱ	9	Crucial for toxin bindingCurated	1
Siteⁱ	11	Crucial for toxin bindingCurated	1
Siteⁱ	21	Basic residue of the functional dyadBy similarity	1
Siteⁱ	30	Aromatic residue of the functional dyadBy similarity	1

GO - Molecular functionⁱ

ion channel inhibitor activity Source: InterPro

Complete GO annotation...

GO - Biological processⁱ

defense response Source: InterPro
pathogenesis Source: InterPro

Complete GO annotation...

Keywordsⁱ

Molecular function	Calcium-activated potassium channel impairing toxin, Ion channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin

Molecular function

Calcium-activated potassium channel impairing toxin, Ion channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Potassium channel toxin alpha-KTx 19.1 Alternative name(s): BmK37 Neurotoxin BmBKTx1
Organismⁱ	Mesobuthus martensii (Manchurian scorpion) (Buthus martensii)Curated
Taxonomic identifierⁱ	34649 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Chelicerata › Arachnida › Scorpiones › Buthida › Buthoidea › Buthidae › Mesobuthus

Subcellular locationⁱ

Secreted Curated
1 Publication
Manual assertion based on experiment inⁱ
- Ref.1
  Xu C.-Q., Chi C.-W.
  Submitted (JUL-2002) to UniProtKB
  Cited for: PROTEIN SEQUENCE, FUNCTION, SUBUNIT, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, MASS SPECTROMETRY, DISULFIDE BONDS.

GO - Cellular componentⁱ

extracellular region Source: UniProtKB-SubCell

Complete GO annotation...

Keywords - Cellular componentⁱ

Secreted

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
PeptideⁱPRO_0000044898	1 – 31	Potassium channel toxin alpha-KTx 19.1Add BLAST		31

Amino acid modifications

Feature key	Position(s)	DescriptionActions
Disulfide bondⁱ	3 ↔ 22	Curated
Disulfide bondⁱ	8 ↔ 27	Curated
Disulfide bondⁱ	12 ↔ 29	Curated

Keywords - PTMⁱ

Disulfide bond

Expressionⁱ

Tissue specificityⁱ

Expressed by the venom gland.1 Publication

Interactionⁱ

Subunit structureⁱ

Monomer.Curated1 Publication

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Show more details

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	5 – 14	Combined sources	10
Beta strandⁱ	18 – 23	Combined sources	6
Beta strandⁱ	26 – 30	Combined sources	5

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1Q2K	NMR	-	A	1-31	[»]
	1R1G	X-ray	1.72	A/B	1-31	[»]
	3E8Y	X-ray	1.10	X	1-31	[»]
ProteinModelPortalⁱ	P83407.
SMRⁱ	P83407.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P83407.

EvolutionaryTraceⁱ

P83407.

Family & Domainsⁱ

Domainⁱ

Has the structural arrangement of an alpha-helix connected to a beta-sheet by disulfide bonds (CSalpha/beta).

Sequence similaritiesⁱ

Belongs to the short scorpion toxin superfamily. Potassium channel inhibitor family. Alpha-KTx 19 subfamily.Curated

Family and domain databases

Gene3Dⁱ	3.30.30.10. 1 hit.
InterProⁱ	View protein in InterPro IPR003614. Scorpion_toxin-like. IPR001947. Scorpion_toxinS_K_inh.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00451. Toxin_2. 1 hit.
SUPFAMⁱ	SSF57095. SSF57095. 1 hit.
PROSITEⁱ	View protein in PROSITE PS01138. SCORP_SHORT_TOXIN. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

P83407-1 [UniParc]FASTA Add to basket

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        10         20         30 
AACYSSDCRV KCVAMGFSSG KCINSKCKCY K

Length:31

Mass (Da):3,342

Last modified:October 1, 2002 - v1

Checksum:ⁱFD13B6FDB90746F1

GO

Mass spectrometryⁱ

Molecular mass is 3335.14 Da from positions 1 - 31. Determined by MALDI. 1 Publication

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1Q2K	NMR	-	A	1-31	[»]
	1R1G	X-ray	1.72	A/B	1-31	[»]
	3E8Y	X-ray	1.10	X	1-31	[»]
ProteinModelPortalⁱ	P83407.
SMRⁱ	P83407.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P83407.

EvolutionaryTraceⁱ

P83407.

Family and domain databases

Gene3Dⁱ	3.30.30.10. 1 hit.
InterProⁱ	View protein in InterPro IPR003614. Scorpion_toxin-like. IPR001947. Scorpion_toxinS_K_inh.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00451. Toxin_2. 1 hit.
SUPFAMⁱ	SSF57095. SSF57095. 1 hit.
PROSITEⁱ	View protein in PROSITE PS01138. SCORP_SHORT_TOXIN. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	KA191_MESMA
Accessionⁱ	P83407Primary (citable) accession number: P83407
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 2002
	Last sequence update:	October 1, 2002
	Last modified:	November 2, 2016
	This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Animal Toxin Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Direct protein sequencing

Documents

PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Scorpion potassium channel toxins
Nomenclature of scorpion potassium channel toxins and list of entries
SIMILARITY comments
Index of protein domains and families

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P83407 (KA191_MESMA)

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

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<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

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Documents

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Mass spectrometryⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ