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P83402

- AL7A1_ACASC

UniProt

P83402 - AL7A1_ACASC

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Protein

Alpha-aminoadipic semialdehyde dehydrogenase

Gene

aldh7a1

Organism
Acanthopagrus schlegelii (Black porgy)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

(S)-2-amino-6-oxohexanoate + NAD(P)+ + H2O = L-2-aminoadipate + NAD(P)H.1 Publication

Kineticsi

  1. KM=2.0 mM for acetaldehyde

Vmax=1.3 µmol/min/mg enzyme

pH dependencei

Optimum pH is 9-10.

GO - Molecular functioni

  1. aldehyde dehydrogenase (NAD) activity Source: UniProtKB
  2. L-aminoadipate-semialdehyde dehydrogenase activity Source: UniProtKB-EC

GO - Biological processi

  1. cellular aldehyde metabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-aminoadipic semialdehyde dehydrogenase (EC:1.2.1.31)
Short name:
Alpha-AASA dehydrogenase
Alternative name(s):
Aldehyde dehydrogenase family 7 member A1
Antiquitin-1
Delta1-piperideine-6-carboxylate dehydrogenase
Short name:
P6c dehydrogenase
Gene namesi
Name:aldh7a1
OrganismiAcanthopagrus schlegelii (Black porgy)Curated
Taxonomic identifieri72011 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataEupercariaSpariformesSparidaeAcanthopagrus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – ›18›18Alpha-aminoadipic semialdehyde dehydrogenasePRO_0000056493Add
BLAST

Interactioni

Subunit structurei

Homotetramer.1 Publication

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Sequencei

Sequence statusi: Fragment.

P83402-1 [UniParc]FASTAAdd to Basket

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        10 
SGLLINQPKY SWLKELGL
Length:18
Mass (Da):2,059
Last modified:October 1, 2002 - v1
Checksum:iBFF8C3EF1A9B4047
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei18 – 1811 Publication

Cross-referencesi

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

ProtoNeti Search...

Publicationsi

  1. "First purification of the antiquitin protein and demonstration of its enzymatic activity."
    Tang W.-K., Cheng C.H.K., Fong W.-P.
    FEBS Lett. 516:183-186(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE, CATALYTIC ACTIVITY, COFACTOR, SUBUNIT.
    Tissue: Liver.

Entry informationi

Entry nameiAL7A1_ACASC
AccessioniPrimary (citable) accession number: P83402
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: October 1, 2002
Last modified: October 29, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3