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Reviewed, UniProtKB/Swiss-Prot P83402 (AL7A1_ACASC)

Last modified November 25, 2008. Version 31. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Alpha-aminoadipic semialdehyde dehydrogenase
      Short name=Alpha-AASA dehydrogenase
    EC=1.2.1.31
Alternative name(s):
    Delta1-piperideine-6-carboxylate dehydrogenease
      Short name=P6c dehydrogenase
    Aldehyde dehydrogenase family 7 member A1
    Antiquitin-1
Gene names
Name: aldh7a1
OrganismAcanthopagrus schlegeli (Black porgy)
Taxonomic identifier72011 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiEuteleosteiNeoteleosteiAcanthomorphaAcanthopterygiiPercomorphaPerciformesPercoideiSparidaeAcanthopagrus

Protein attributes

Sequence length18 AA.
Sequence statusFragment.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Catalytic activity

L-2-aminoadipate 6-semialdehyde + NAD(P)(+) + H(2)O = L-2-aminoadipate + NAD(P)H.

Subunit structure

Homotetramer.

Sequence similarities

Belongs to the aldehyde dehydrogenase family.

Biophysicochemical properties

Kinetic parameters:

KM=2.0 mM for acetaldehyde

Vmax=1.3 µmol/min/mg enzyme

pH dependence:

Optimum pH is 9-10.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – ›18›18Alpha-aminoadipic semialdehyde dehydrogenase
PRO_0000056493

Experimental info

Non-terminal residue181

Sequences

Sequence LengthMass (Da)Tools
P83402-1 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: BFF8C3EF1A9B4047

FASTA182,059
        10 
SGLLINQPKY SWLKELGL 

« Hide

References

[1]"First purification of the antiquitin protein and demonstration of its enzymatic activity."
Tang W.-K., Cheng C.H.K., Fong W.-P.
FEBS Lett. 516:183-186(2002) [PubMed: 11959129] [Abstract]
Cited for: PROTEIN SEQUENCE, CATALYTIC ACTIVITY, COFACTOR, SUBUNIT.
Tissue: Liver.

Cross-references

3D structure databases

ModBaseSearch...

Phylogenomic databases

HOVERGENP83402.

Family and domain databases

InterProIPR016160. Ald_DHase_CS.
[Graphical view]
PROSITEPS00070. ALDEHYDE_DEHYDR_CYS. Partial match.
PS00687. ALDEHYDE_DEHYDR_GLU. Partial match.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameAL7A1_ACASC
AccessionPrimary (citable) accession number: P83402
Entry history
Integrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: October 1, 2002
Last modified: November 25, 2008
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents