P83402 (AL7A1_ACASC) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Alpha-aminoadipic semialdehyde dehydrogenase
Short name=Alpha-AASA dehydrogenase
EC=1.2.1.31

Alternative name(s):
Aldehyde dehydrogenase family 7 member A1
Antiquitin-1
Delta1-piperideine-6-carboxylate dehydrogenase
Short name=P6c dehydrogenase

Gene names

Name:

aldh7a1

Organism

Acanthopagrus schlegelii (Black porgy)

Taxonomic identifier

72011 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Actinopterygii › Actinopteri › Neopterygii › Teleostei › Elopocephala › Clupeocephala › Euteleostei › Neognathi › Neoteleostei › Eurypterygii › Ctenosquamata › Acanthomorpha › Euacanthomorpha › Holacanthopterygii › Acanthopterygii › Euacanthopterygii › Percomorpha › Perciformes › Percoidei › Sparidae › Acanthopagrus

Protein attributes

Sequence length	18 AA.
Sequence status	Fragment.
Protein existence	Evidence at protein level

General annotation (Comments)

Catalytic activity	(S)-2-amino-6-oxohexanoate + NAD(P)+ + H2O = L-2-aminoadipate + NAD(P)H. Ref.1
Subunit structure	Homotetramer. Ref.1
Sequence similarities	Belongs to the aldehyde dehydrogenase family.
Biophysicochemical properties	Kinetic parameters: KM=2.0 mM for acetaldehyde Vmax=1.3 µmol/min/mg enzyme pH dependence: Optimum pH is 9-10.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological_process	cellular aldehyde metabolic process Inferred from direct assay Ref.1. Source: UniProtKB
Molecular_function	L-aminoadipate-semialdehyde dehydrogenase activity Inferred from electronic annotation. Source: EC aldehyde dehydrogenase (NAD) activity Inferred from direct assay Ref.1. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – ›18	›18	Alpha-aminoadipic semialdehyde dehydrogenase		PRO_0000056493
Experimental info
	Non-terminal residue	18	1

Sequences

	Sequence		Length	Mass (Da)
	P83402 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: BFF8C3EF1A9B4047	FASTA	18	2,059
	10 SGLLINQPKY SWLKELGL

References

[1]	"First purification of the antiquitin protein and demonstration of its enzymatic activity." Tang W.-K., Cheng C.H.K., Fong W.-P. FEBS Lett. 516:183-186(2002) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE, CATALYTIC ACTIVITY, COFACTOR, SUBUNIT. Tissue: Liver.

Cross-references

3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. Partial match. PS00687. ALDEHYDE_DEHYDR_GLU. Partial match. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AL7A1_ACASC

Accession

Primary (citable) accession number: P83402

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 15, 2002
Last sequence update:	October 1, 2002
Last modified:	April 3, 2013
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program