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P83402

- AL7A1_ACASC

UniProt

P83402 - AL7A1_ACASC

Protein

Alpha-aminoadipic semialdehyde dehydrogenase

Gene

aldh7a1

Organism
Acanthopagrus schlegelii (Black porgy)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Catalytic activityi

    (S)-2-amino-6-oxohexanoate + NAD(P)+ + H2O = L-2-aminoadipate + NAD(P)H.1 Publication

    Kineticsi

    1. KM=2.0 mM for acetaldehyde

    Vmax=1.3 µmol/min/mg enzyme

    pH dependencei

    Optimum pH is 9-10.

    GO - Molecular functioni

    1. aldehyde dehydrogenase (NAD) activity Source: UniProtKB
    2. L-aminoadipate-semialdehyde dehydrogenase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cellular aldehyde metabolic process Source: UniProtKB

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NAD

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alpha-aminoadipic semialdehyde dehydrogenase (EC:1.2.1.31)
    Short name:
    Alpha-AASA dehydrogenase
    Alternative name(s):
    Aldehyde dehydrogenase family 7 member A1
    Antiquitin-1
    Delta1-piperideine-6-carboxylate dehydrogenase
    Short name:
    P6c dehydrogenase
    Gene namesi
    Name:aldh7a1
    OrganismiAcanthopagrus schlegelii (Black porgy)Curated
    Taxonomic identifieri72011 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataPercomorphariaSpariformesSparidaeAcanthopagrus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – ›18›18Alpha-aminoadipic semialdehyde dehydrogenasePRO_0000056493Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.1 Publication

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the aldehyde dehydrogenase family.Curated

    Sequencei

    Sequence statusi: Fragment.

    P83402-1 [UniParc]FASTAAdd to Basket

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    SGLLINQPKY SWLKELGL                                      18
    Length:18
    Mass (Da):2,059
    Last modified:October 1, 2002 - v1
    Checksum:iBFF8C3EF1A9B4047
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei18 – 1811 Publication

    Cross-referencesi

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "First purification of the antiquitin protein and demonstration of its enzymatic activity."
      Tang W.-K., Cheng C.H.K., Fong W.-P.
      FEBS Lett. 516:183-186(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE, CATALYTIC ACTIVITY, COFACTOR, SUBUNIT.
      Tissue: Liver.

    Entry informationi

    Entry nameiAL7A1_ACASC
    AccessioniPrimary (citable) accession number: P83402
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 15, 2002
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3