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P83402 (AL7A1_ACASC) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Alpha-aminoadipic semialdehyde dehydrogenase

Short name=Alpha-AASA dehydrogenase
EC=1.2.1.31
Alternative name(s):
Aldehyde dehydrogenase family 7 member A1
Antiquitin-1
Delta1-piperideine-6-carboxylate dehydrogenase
Short name=P6c dehydrogenase
Gene names
Name:aldh7a1
OrganismAcanthopagrus schlegelii (Black porgy)
Taxonomic identifier72011 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiEuteleosteiNeoteleosteiAcanthomorphaAcanthopterygiiPercomorphaPerciformesPercoideiSparidaeAcanthopagrus

Protein attributes

Sequence length18 AA.
Sequence statusFragment.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

(S)-2-amino-6-oxohexanoate + NAD(P)+ + H2O = L-2-aminoadipate + NAD(P)H. Ref.1

Subunit structure

Homotetramer. Ref.1

Sequence similarities

Belongs to the aldehyde dehydrogenase family.

Biophysicochemical properties

Kinetic parameters:

KM=2.0 mM for acetaldehyde

Vmax=1.3 µmol/min/mg enzyme

pH dependence:

Optimum pH is 9-10.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – ›18›18Alpha-aminoadipic semialdehyde dehydrogenase
PRO_0000056493

Experimental info

Non-terminal residue181

Sequences

Sequence LengthMass (Da)Tools
P83402 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: BFF8C3EF1A9B4047

FASTA182,059
        10 
SGLLINQPKY SWLKELGL 

« Hide

References

[1]"First purification of the antiquitin protein and demonstration of its enzymatic activity."
Tang W.-K., Cheng C.H.K., Fong W.-P.
FEBS Lett. 516:183-186(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE, CATALYTIC ACTIVITY, COFACTOR, SUBUNIT.
Tissue: Liver.

Cross-references

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

PROSITEPS00070. ALDEHYDE_DEHYDR_CYS. Partial match.
PS00687. ALDEHYDE_DEHYDR_GLU. Partial match.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameAL7A1_ACASC
AccessionPrimary (citable) accession number: P83402
Entry history
Integrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: October 1, 2002
Last modified: April 3, 2013
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families