Reviewed, UniProtKB/Swiss-Prot P83402 (AL7A1_ACASC)

Names and origin

Protein names

Recommended name:
    Alpha-aminoadipic semialdehyde dehydrogenase
      Short name=Alpha-AASA dehydrogenase
    EC=1.2.1.31
Alternative name(s):
    Delta1-piperideine-6-carboxylate dehydrogenease
      Short name=P6c dehydrogenase
    Aldehyde dehydrogenase family 7 member A1
    Antiquitin-1

Gene names

Name:

aldh7a1

Organism

Acanthopagrus schlegeli (Black porgy)

Taxonomic identifier

72011 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Euteleostei › Neoteleostei › Acanthomorpha › Acanthopterygii › Percomorpha › Perciformes › Percoidei › Sparidae › Acanthopagrus

Protein attributes

Sequence length	18 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Catalytic activity	L-2-aminoadipate 6-semialdehyde + NAD(P)(+) + H(2)O = L-2-aminoadipate + NAD(P)H.
Subunit structure	Homotetramer.
Sequence similarities	Belongs to the aldehyde dehydrogenase family.
Biophysicochemical properties	Kinetic parameters: KM=2.0 mM for acetaldehyde Vmax=1.3 µmol/min/mg enzyme pH dependence: Optimum pH is 9-10.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	cellular aldehyde metabolic process Ref.1 Inferred from direct assay. Source: UniProtKB oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	L-aminoadipate-semialdehyde dehydrogenase activity Inferred from electronic annotation. Source: EC aldehyde dehydrogenase (NAD) activity Ref.1 Inferred from direct assay. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – ›18	›18	Alpha-aminoadipic semialdehyde dehydrogenase		PRO_0000056493
Experimental info
	Non-terminal residue	18	1

Sequences

	Sequence		Length	Mass (Da)
	P83402-1 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: BFF8C3EF1A9B4047	FASTA	18	2,059
	10 SGLLINQPKY SWLKELGL

References

[1]	"First purification of the antiquitin protein and demonstration of its enzymatic activity." Tang W.-K., Cheng C.H.K., Fong W.-P. FEBS Lett. 516:183-186(2002) [PubMed: 11959129] [Abstract] Cited for: PROTEIN SEQUENCE, CATALYTIC ACTIVITY, COFACTOR, SUBUNIT. Tissue: Liver.

Cross-references

3D structure databases
ModBase	Search...
Phylogenomic databases
HOVERGEN	P83402.
Family and domain databases
InterPro	IPR016160. Ald_DHase_CS. [Graphical view]
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. Partial match. PS00687. ALDEHYDE_DEHYDR_GLU. Partial match. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AL7A1_ACASC

Accession

Primary (citable) accession number: P83402

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 15, 2002
Last sequence update:	October 1, 2002
Last modified:	November 25, 2008
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)