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P83401 (AL7A1_DICDI) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative aldehyde dehydrogenase family 7 member A1 homolog

EC=1.2.1.3
Alternative name(s):
Antiquitin-1
Gene names
ORF Names:DDB_G0276821
OrganismDictyostelium discoideum (Slime mold) [Reference proteome]
Taxonomic identifier44689 [NCBI]
Taxonomic lineageEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium

Protein attributes

Sequence length509 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

An aldehyde + NAD+ + H2O = a carboxylate + NADH.

Subunit structure

Homotetramer By similarity. UniProtKB P83402

Sequence similarities

Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcellular aldehyde metabolic process

Inferred from sequence or structural similarity. Source: UniProtKB

   Cellular_componentphagocytic vesicle

Inferred from direct assay PubMed 19482547. Source: dictyBase

   Molecular_functionaldehyde dehydrogenase (NAD) activity

Inferred from sequence or structural similarity. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 509509Putative aldehyde dehydrogenase family 7 member A1 homolog
PRO_0000056500

Regions

Nucleotide binding244 – 2496NAD By similarity

Sites

Active site2661Proton acceptor By similarity
Active site3001Nucleophile By similarity
Site1641Transition state stabilizer By similarity

Sequences

Sequence LengthMass (Da)Tools
P83401 [UniParc].

Last modified November 15, 2002. Version 2.
Checksum: DD104624407CFC41

FASTA50955,190
        10         20         30         40         50         60 
MTTFNEYPFL AELGIKAENN DGVFNGKWGG AGEIIKCLNP TNNKVIATVR GAAPEEYETC 

        70         80         90        100        110        120 
IQAMLAAKVK WALTPAPRRG EIVRLIGQAM REKIEPLSKL ISLEMGKIYI EAKGEVQEFI 

       130        140        150        160        170        180 
DVCDYATGLS RSINGQVMPS ERPNHILMET WNPLGLVGII TAFNFPCAVL GWNAAISMIC 

       190        200        210        220        230        240 
GNVQLWKGAS TTSLITLAVS KIIEKVLVEN DVDPAVCCVL IGPGRTVGEQ MIQDKRFGLI 

       250        260        270        280        290        300 
SFTGSTEVGR RISSTVHGYF GKTILELGGN NAIVVAEDAD IELVLRAVLF ASVGTTGQRC 

       310        320        330        340        350        360 
TTCRRLFVHE SLYDTILERL TKAYKTIKIG NPLEEGVLVG PLHTQSAVKE FTEGLEEIKK 

       370        380        390        400        410        420 
QGGKVVIGGN KLDISGGNFV EPTVVAIEHD APIVKTELFV PILYIMKFKN LDDAFAWNNE 

       430        440        450        460        470        480 
VPQGLSSSLF TNNQKNIFKW LGPTGSDCGI VNVNVATNGA EIGGAFGGEK ETGGGRESGS 

       490        500 
DSWKQYCRRS TNTINYGNTM PLSQGINFN 

« Hide

References

[1]"Sequence and analysis of chromosome 2 of Dictyostelium discoideum."
Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T., Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R., Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A., Noegel A.A.
Nature 418:79-85(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: AX4.
[2]"The genome of the social amoeba Dictyostelium discoideum."
Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. expand/collapse author list , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: AX4.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AAFI02000019 Genomic DNA. Translation: EAL68912.1.
RefSeqXP_642906.1. XM_637814.1.

3D structure databases

ProteinModelPortalP83401.
SMRP83401. Positions 6-496.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING44689.DDB_0231504.

Proteomic databases

PRIDEP83401.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsDDB0231504; DDB0231504; DDB_G0276821.
GeneID8620772.
KEGGddi:DDB_G0276821.

Organism-specific databases

dictyBaseDDB_G0276821.

Phylogenomic databases

eggNOGCOG1012.
OMAPGHRMAE.
PhylomeDBP83401.

Family and domain databases

Gene3D3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMSSF53720. SSF53720. 1 hit.
PROSITEPS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROP83401.

Entry information

Entry nameAL7A1_DICDI
AccessionPrimary (citable) accession number: P83401
Secondary accession number(s): Q550M6, Q8MYH7
Entry history
Integrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: November 15, 2002
Last modified: July 9, 2014
This is version 79 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Dictyostelium discoideum

Dictyostelium discoideum: entries, gene names and cross-references to dictyBase