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Protein

Putative aldehyde dehydrogenase family 7 member A1 homolog

Gene

DDB_G0276821

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

An aldehyde + NAD+ + H2O = a carboxylate + NADH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei164 – 1641Transition state stabilizerBy similarity
Active sitei266 – 2661Proton acceptorPROSITE-ProRule annotation
Active sitei300 – 3001NucleophilePROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi244 – 2496NADBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

ReactomeiREACT_275963. Lysine catabolism.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative aldehyde dehydrogenase family 7 member A1 homolog (EC:1.2.1.3)
Alternative name(s):
Antiquitin-1
Gene namesi
ORF Names:DDB_G0276821
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195 Componentsi: Chromosome 2, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0276821.

Subcellular locationi

GO - Cellular componenti

  • phagocytic vesicle Source: dictyBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 509509Putative aldehyde dehydrogenase family 7 member A1 homologPRO_0000056500Add
BLAST

Proteomic databases

PRIDEiP83401.

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi44689.DDB0231504.

Structurei

3D structure databases

ProteinModelPortaliP83401.
SMRiP83401. Positions 6-496.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Phylogenomic databases

eggNOGiCOG1012.
InParanoidiP83401.
KOiK14085.
OMAiNAIIVFE.
PhylomeDBiP83401.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P83401-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTFNEYPFL AELGIKAENN DGVFNGKWGG AGEIIKCLNP TNNKVIATVR
60 70 80 90 100
GAAPEEYETC IQAMLAAKVK WALTPAPRRG EIVRLIGQAM REKIEPLSKL
110 120 130 140 150
ISLEMGKIYI EAKGEVQEFI DVCDYATGLS RSINGQVMPS ERPNHILMET
160 170 180 190 200
WNPLGLVGII TAFNFPCAVL GWNAAISMIC GNVQLWKGAS TTSLITLAVS
210 220 230 240 250
KIIEKVLVEN DVDPAVCCVL IGPGRTVGEQ MIQDKRFGLI SFTGSTEVGR
260 270 280 290 300
RISSTVHGYF GKTILELGGN NAIVVAEDAD IELVLRAVLF ASVGTTGQRC
310 320 330 340 350
TTCRRLFVHE SLYDTILERL TKAYKTIKIG NPLEEGVLVG PLHTQSAVKE
360 370 380 390 400
FTEGLEEIKK QGGKVVIGGN KLDISGGNFV EPTVVAIEHD APIVKTELFV
410 420 430 440 450
PILYIMKFKN LDDAFAWNNE VPQGLSSSLF TNNQKNIFKW LGPTGSDCGI
460 470 480 490 500
VNVNVATNGA EIGGAFGGEK ETGGGRESGS DSWKQYCRRS TNTINYGNTM

PLSQGINFN
Length:509
Mass (Da):55,190
Last modified:November 15, 2002 - v2
Checksum:iDD104624407CFC41
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000019 Genomic DNA. Translation: EAL68912.1.
RefSeqiXP_642906.1. XM_637814.1.

Genome annotation databases

EnsemblProtistsiDDB0231504; DDB0231504; DDB_G0276821.
GeneIDi8620772.
KEGGiddi:DDB_G0276821.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000019 Genomic DNA. Translation: EAL68912.1.
RefSeqiXP_642906.1. XM_637814.1.

3D structure databases

ProteinModelPortaliP83401.
SMRiP83401. Positions 6-496.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0231504.

Proteomic databases

PRIDEiP83401.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiDDB0231504; DDB0231504; DDB_G0276821.
GeneIDi8620772.
KEGGiddi:DDB_G0276821.

Organism-specific databases

dictyBaseiDDB_G0276821.

Phylogenomic databases

eggNOGiCOG1012.
InParanoidiP83401.
KOiK14085.
OMAiNAIIVFE.
PhylomeDBiP83401.

Enzyme and pathway databases

ReactomeiREACT_275963. Lysine catabolism.

Miscellaneous databases

PROiP83401.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.
  2. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.

Entry informationi

Entry nameiAL7A1_DICDI
AccessioniPrimary (citable) accession number: P83401
Secondary accession number(s): Q550M6, Q8MYH7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: November 15, 2002
Last modified: June 24, 2015
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.