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P83401

- AL7A1_DICDI

UniProt

P83401 - AL7A1_DICDI

Protein

Putative aldehyde dehydrogenase family 7 member A1 homolog

Gene

DDB_G0276821

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 2 (15 Nov 2002)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    An aldehyde + NAD+ + H2O = a carboxylate + NADH.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei164 – 1641Transition state stabilizerBy similarity
    Active sitei266 – 2661Proton acceptorPROSITE-ProRule annotation
    Active sitei300 – 3001NucleophilePROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi244 – 2496NADBy similarity

    GO - Molecular functioni

    1. aldehyde dehydrogenase (NAD) activity Source: UniProtKB

    GO - Biological processi

    1. cellular aldehyde metabolic process Source: UniProtKB

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NAD

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative aldehyde dehydrogenase family 7 member A1 homolog (EC:1.2.1.3)
    Alternative name(s):
    Antiquitin-1
    Gene namesi
    ORF Names:DDB_G0276821
    OrganismiDictyostelium discoideum (Slime mold)
    Taxonomic identifieri44689 [NCBI]
    Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
    ProteomesiUP000002195: Chromosome 2, UP000002195: Unassembled WGS sequence

    Organism-specific databases

    dictyBaseiDDB_G0276821.

    Subcellular locationi

    GO - Cellular componenti

    1. phagocytic vesicle Source: dictyBase

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 509509Putative aldehyde dehydrogenase family 7 member A1 homologPRO_0000056500Add
    BLAST

    Proteomic databases

    PRIDEiP83401.

    Interactioni

    Subunit structurei

    Homotetramer.By similarity

    Protein-protein interaction databases

    STRINGi44689.DDB_0231504.

    Structurei

    3D structure databases

    ProteinModelPortaliP83401.
    SMRiP83401. Positions 6-496.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the aldehyde dehydrogenase family.Curated

    Phylogenomic databases

    eggNOGiCOG1012.
    KOiK14085.
    OMAiPGHRMAE.
    PhylomeDBiP83401.

    Family and domain databases

    Gene3Di3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    [Graphical view]
    PfamiPF00171. Aldedh. 1 hit.
    [Graphical view]
    SUPFAMiSSF53720. SSF53720. 1 hit.
    PROSITEiPS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P83401-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTTFNEYPFL AELGIKAENN DGVFNGKWGG AGEIIKCLNP TNNKVIATVR    50
    GAAPEEYETC IQAMLAAKVK WALTPAPRRG EIVRLIGQAM REKIEPLSKL 100
    ISLEMGKIYI EAKGEVQEFI DVCDYATGLS RSINGQVMPS ERPNHILMET 150
    WNPLGLVGII TAFNFPCAVL GWNAAISMIC GNVQLWKGAS TTSLITLAVS 200
    KIIEKVLVEN DVDPAVCCVL IGPGRTVGEQ MIQDKRFGLI SFTGSTEVGR 250
    RISSTVHGYF GKTILELGGN NAIVVAEDAD IELVLRAVLF ASVGTTGQRC 300
    TTCRRLFVHE SLYDTILERL TKAYKTIKIG NPLEEGVLVG PLHTQSAVKE 350
    FTEGLEEIKK QGGKVVIGGN KLDISGGNFV EPTVVAIEHD APIVKTELFV 400
    PILYIMKFKN LDDAFAWNNE VPQGLSSSLF TNNQKNIFKW LGPTGSDCGI 450
    VNVNVATNGA EIGGAFGGEK ETGGGRESGS DSWKQYCRRS TNTINYGNTM 500
    PLSQGINFN 509
    Length:509
    Mass (Da):55,190
    Last modified:November 15, 2002 - v2
    Checksum:iDD104624407CFC41
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFI02000019 Genomic DNA. Translation: EAL68912.1.
    RefSeqiXP_642906.1. XM_637814.1.

    Genome annotation databases

    EnsemblProtistsiDDB0231504; DDB0231504; DDB_G0276821.
    GeneIDi8620772.
    KEGGiddi:DDB_G0276821.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFI02000019 Genomic DNA. Translation: EAL68912.1 .
    RefSeqi XP_642906.1. XM_637814.1.

    3D structure databases

    ProteinModelPortali P83401.
    SMRi P83401. Positions 6-496.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 44689.DDB_0231504.

    Proteomic databases

    PRIDEi P83401.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblProtistsi DDB0231504 ; DDB0231504 ; DDB_G0276821 .
    GeneIDi 8620772.
    KEGGi ddi:DDB_G0276821.

    Organism-specific databases

    dictyBasei DDB_G0276821.

    Phylogenomic databases

    eggNOGi COG1012.
    KOi K14085.
    OMAi PGHRMAE.
    PhylomeDBi P83401.

    Miscellaneous databases

    PROi P83401.

    Family and domain databases

    Gene3Di 3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    [Graphical view ]
    Pfami PF00171. Aldedh. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53720. SSF53720. 1 hit.
    PROSITEi PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AX4.
    2. "The genome of the social amoeba Dictyostelium discoideum."
      Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
      , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
      Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AX4.

    Entry informationi

    Entry nameiAL7A1_DICDI
    AccessioniPrimary (citable) accession number: P83401
    Secondary accession number(s): Q550M6, Q8MYH7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 15, 2002
    Last sequence update: November 15, 2002
    Last modified: October 1, 2014
    This is version 81 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Dictyostelium discoideum
      Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3