Reviewed, UniProtKB/Swiss-Prot P83401 (AL7A1_DICDI)

Names and origin

Protein names

Recommended name:
    Putative aldehyde dehydrogenase family 7 member A1 homolog
    EC=1.2.1.3
Alternative name(s):
    Antiquitin-1

Gene names

ORF Names:

DDB_G0276821

Organism

Dictyostelium discoideum (Slime mold) [Complete proteome]

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	509 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	An aldehyde + NAD(+) + H(2)O = an acid + NADH.
Subunit structure	Homotetramer By similarity.
Sequence similarities	Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cellular aldehyde metabolic process Inferred from sequence or structural similarity. Source: UniProtKB oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	aldehyde dehydrogenase (NAD) activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 509	509	Putative aldehyde dehydrogenase family 7 member A1 homolog		PRO_0000056500
Regions
	Nucleotide binding	244 – 249	6	NAD By similarity
Sites
	Active site	266	1	Proton acceptor By similarity
	Active site	300	1	Nucleophile By similarity
	Site	164	1	Transition state stabilizer By similarity

Sequences

	Sequence		Length	Mass (Da)
	P83401-1 [UniParc]. Last modified November 15, 2002. Version 2. Checksum: DD104624407CFC41	FASTA	509	55,190
	10 20 30 40 50 60 MTTFNEYPFL AELGIKAENN DGVFNGKWGG AGEIIKCLNP TNNKVIATVR GAAPEEYETC 70 80 90 100 110 120 IQAMLAAKVK WALTPAPRRG EIVRLIGQAM REKIEPLSKL ISLEMGKIYI EAKGEVQEFI 130 140 150 160 170 180 DVCDYATGLS RSINGQVMPS ERPNHILMET WNPLGLVGII TAFNFPCAVL GWNAAISMIC 190 200 210 220 230 240 GNVQLWKGAS TTSLITLAVS KIIEKVLVEN DVDPAVCCVL IGPGRTVGEQ MIQDKRFGLI 250 260 270 280 290 300 SFTGSTEVGR RISSTVHGYF GKTILELGGN NAIVVAEDAD IELVLRAVLF ASVGTTGQRC 310 320 330 340 350 360 TTCRRLFVHE SLYDTILERL TKAYKTIKIG NPLEEGVLVG PLHTQSAVKE FTEGLEEIKK 370 380 390 400 410 420 QGGKVVIGGN KLDISGGNFV EPTVVAIEHD APIVKTELFV PILYIMKFKN LDDAFAWNNE 430 440 450 460 470 480 VPQGLSSSLF TNNQKNIFKW LGPTGSDCGI VNVNVATNGA EIGGAFGGEK ETGGGRESGS 490 500 DSWKQYCRRS TNTINYGNTM PLSQGINFN

References

[1]

"Sequence and analysis of chromosome 2 of Dictyostelium discoideum." Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T., Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R., Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A., Noegel A.A. Nature 418:79-85(2002) [PubMed: 12097910] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.

[2]

"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed: 15875012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AC117076 Genomic DNA. Translation: AAM33716.3. AAFI02000019 Genomic DNA. Translation: EAL68912.1.
RefSeq	XP_642906.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3394123.
KEGG	ddi:DDB_0231504.
Organism-specific databases
dictyBase	DDB_G0276821.
Family and domain databases
InterPro	IPR016160. Ald_DHase_CS. IPR016162. Ald_DHase_N. IPR015590. Aldehyde_DHase. [Graphical view]
Gene3D	G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHER	PTHR11699. Aldehyde_dehyd. 1 hit.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. False negative. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AL7A1_DICDI

Accession

Primary (citable) accession number: P83401
Secondary accession number(s): Q550M6, Q8MYH7

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 15, 2002
Last sequence update:	November 15, 2002
Last modified:	November 25, 2008
This is version 44 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)