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P83373

- MDHM_FRAAN

UniProt

P83373 - MDHM_FRAAN

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Protein

Malate dehydrogenase, mitochondrial

Gene

MMDHI

Organism
Fragaria ananassa (Strawberry)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.CuratedPROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei59 – 591NADBy similarity
Binding sitei106 – 1061SubstratePROSITE-ProRule annotation
Binding sitei112 – 1121SubstratePROSITE-ProRule annotation
Binding sitei119 – 1191NADBy similarity
Binding sitei144 – 1441SubstratePROSITE-ProRule annotation
Binding sitei178 – 1781SubstratePROSITE-ProRule annotation
Active sitei202 – 2021Proton acceptorBy similarity
Binding sitei253 – 2531NADBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi33 – 397NADBy similarity
Nucleotide bindingi142 – 1443NADBy similarity

GO - Molecular functioni

  1. L-malate dehydrogenase activity Source: UniProtKB-EC

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. malate metabolic process Source: InterPro
  3. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenase, mitochondrial (EC:1.1.1.37)
Gene namesi
Name:MMDHI
OrganismiFragaria ananassa (Strawberry)Curated
Taxonomic identifieri3747 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsRosalesRosaceaeRosoideaePotentilleaeFragariinaeFragaria

Subcellular locationi

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 1919Mitochondrion1 PublicationAdd
BLAST
Chaini20 – 339320Malate dehydrogenase, mitochondrialPRO_0000018627Add
BLAST

Proteomic databases

PRIDEiP83373.

Interactioni

Subunit structurei

Homodimer.By similarityCurated

Structurei

3D structure databases

ProteinModelPortaliP83373.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 1 family.Curated

Keywords - Domaini

Transit peptide

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR001252. Malate_DH_AS.
IPR010097. Malate_DH_type1.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMiSSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01772. MDH_euk_gproteo. 1 hit.
PROSITEiPS00068. MDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P83373-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRPSMSLIRS VSRVARRGYS SESVPQRKVA VLGAAGGIGQ PLALLMKLNP
60 70 80 90 100
LVSQLSLYDI AGTPGVAADV SHINTRSEVK GYAGEEQLGE ALEGCDVVII
110 120 130 140 150
PAGVPRKPGM TRDDLFNINA GIVRSLTAAI AKYCPHAIIN MISNPVNSTV
160 170 180 190 200
PIASEVLKKA GVYDEKKLFG VTTLDVVRAK TFYAGKAGVP VAEVNVPVVG
210 220 230 240 250
GHAGITILPL FSQATPKANL SDDYIKALTK RTQDGGTEVV EAKAGKGSAT
260 270 280 290 300
LSMAYAGALF ADACLXGLNG VPDVVECSYV QSSITELPFF ASKVRLGKNG
310 320 330
VEEVLDLGPL SDFEKEGLKQ LKPELKSSIE KGIKFANQS
Length:339
Mass (Da):35,622
Last modified:October 1, 2002 - v1
Checksum:i22D4EF65E225A00C
GO

Cross-referencesi

3D structure databases

ProteinModelPortali P83373.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P83373.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
InterProi IPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR001252. Malate_DH_AS.
IPR010097. Malate_DH_type1.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR11540. PTHR11540. 1 hit.
Pfami PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMi SSF56327. SSF56327. 1 hit.
TIGRFAMsi TIGR01772. MDH_euk_gproteo. 1 hit.
PROSITEi PS00068. MDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Identification, cloning and expression analysis of strawberry (Fragaria x ananassa) mitochondrial citrate synthase and mitochondrial malate dehydrogenase."
    Iannetta P.P.M., Escobar N.M., Ross H.A., Souleyre E.J., Hancock R.D., Witte C.P., Davies H.V.
    Physiol. Plantarum 121:15-26(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE, PROTEIN SEQUENCE OF 20-37.
    Strain: cv. Elsanta.
    Tissue: Fruit.

Entry informationi

Entry nameiMDHM_FRAAN
AccessioniPrimary (citable) accession number: P83373
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: October 1, 2002
Last modified: October 29, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3