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P83372

- CISY_FRAAN

UniProt

P83372 - CISY_FRAAN

Protein

Citrate synthase, mitochondrial

Gene

MCSI

Organism
Fragaria ananassa (Strawberry)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.PROSITE-ProRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei304 – 3041PROSITE-ProRule annotation
    Active sitei350 – 3501PROSITE-ProRule annotation
    Active sitei405 – 4051PROSITE-ProRule annotation

    GO - Molecular functioni

    1. citrate (Si)-synthase activity Source: InterPro

    GO - Biological processi

    1. cellular carbohydrate metabolic process Source: InterPro
    2. tricarboxylic acid cycle Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Tricarboxylic acid cycle

    Enzyme and pathway databases

    UniPathwayiUPA00223; UER00717.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Citrate synthase, mitochondrial (EC:2.3.3.16)
    Gene namesi
    Name:MCSI
    OrganismiFragaria ananassa (Strawberry)Curated
    Taxonomic identifieri3747 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsRosalesRosaceaeRosoideaePotentilleaeFragariinaeFragaria

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrial matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 2828Mitochondrion1 PublicationAdd
    BLAST
    Chaini29 – 469441Citrate synthase, mitochondrialPRO_0000005488Add
    BLAST

    Proteomic databases

    PRIDEiP83372.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP83372.
    SMRiP83372. Positions 35-465.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the citrate synthase family.Curated

    Keywords - Domaini

    Transit peptide

    Family and domain databases

    Gene3Di1.10.580.10. 1 hit.
    InterProiIPR016142. Citrate_synth-like_lrg_a-sub.
    IPR002020. Citrate_synthase-like.
    IPR016141. Citrate_synthase-like_core.
    IPR019810. Citrate_synthase_AS.
    IPR010109. Citrate_synthase_euk.
    [Graphical view]
    PANTHERiPTHR11739. PTHR11739. 1 hit.
    PfamiPF00285. Citrate_synt. 1 hit.
    [Graphical view]
    PRINTSiPR00143. CITRTSNTHASE.
    SUPFAMiSSF48256. SSF48256. 1 hit.
    TIGRFAMsiTIGR01793. cit_synth_euk. 1 hit.
    PROSITEiPS00480. CITRATE_SYNTHASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P83372-1 [UniParc]FASTAAdd to Basket

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    MAFFRTVTKL RSRLGQPPSL RDSVRCLQTQ ASSDLDLHSQ LKELIPEQQE    50
    RLKKLKKEHG KVQLGTITVD MVIGGMRGMT GLLWETSLLD PDEGIRFRGL 100
    SIPECQKVLP GATPGGEPLP EGLLWLLLTG KVPSRSKNMH YPVNNGVVPK 150
    FQIMCSRPLM LCLLEHIPMT QFTTGVMALQ VQSEFQKAYD KGIPKSRYWE 200
    PTYEDSLSLI AQLPVVASYV YRRIYKGGRM IPVDDSLDYG GNFSHLLGFD 250
    DHKMQELMRL YVTIHSDHEG GNVSAHTGHL VASALSDPFL SFAAALNGLA 300
    GPLHGLANQE VLLWIKSVVD ECGENITKDQ LKDYVWKTLN SGKVVPGFGH 350
    GVLRKTDPRY TCQREFALKH LPDDPLFRLV SKLYDVVPPI LTELGKVKNP 400
    WPNVDAHSGV LLNHFGLTEA RYFTVLFGVS RSIGIGSQLI WDRALGLPLE 450
    RPKSVTMESL ESFCKKAAS 469
    Length:469
    Mass (Da):52,283
    Last modified:October 1, 2002 - v1
    Checksum:iCD80AAED06246F65
    GO

    Cross-referencesi

    3D structure databases

    ProteinModelPortali P83372.
    SMRi P83372. Positions 35-465.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P83372.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00223 ; UER00717 .

    Family and domain databases

    Gene3Di 1.10.580.10. 1 hit.
    InterProi IPR016142. Citrate_synth-like_lrg_a-sub.
    IPR002020. Citrate_synthase-like.
    IPR016141. Citrate_synthase-like_core.
    IPR019810. Citrate_synthase_AS.
    IPR010109. Citrate_synthase_euk.
    [Graphical view ]
    PANTHERi PTHR11739. PTHR11739. 1 hit.
    Pfami PF00285. Citrate_synt. 1 hit.
    [Graphical view ]
    PRINTSi PR00143. CITRTSNTHASE.
    SUPFAMi SSF48256. SSF48256. 1 hit.
    TIGRFAMsi TIGR01793. cit_synth_euk. 1 hit.
    PROSITEi PS00480. CITRATE_SYNTHASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification, cloning and expression analysis of strawberry (Fragaria x ananassa) mitochondrial citrate synthase and mitochondrial malate dehydrogenase."
      Iannetta P.P.M., Escobar N.M., Ross H.A., Souleyre E.J., Hancock R.D., Witte C.P., Davies H.V.
      Physiol. Plantarum 121:15-26(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE, PROTEIN SEQUENCE OF 29-46.
      Strain: cv. Elsanta.
      Tissue: Fruit.

    Entry informationi

    Entry nameiCISY_FRAAN
    AccessioniPrimary (citable) accession number: P83372
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 2002
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Citrate synthase is found in nearly all cells capable of oxidative metabolism.By similarity

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3