Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P83325 (GSTP2_BUFBU) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glutathione S-transferase P 2

EC=2.5.1.18
Alternative name(s):
BBGSTP2-2
GST class-pi
OrganismBufo bufo (European toad)
Taxonomic identifier8384 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraNeobatrachiaHyloideaBufonidaeBufo

Protein attributes

Sequence length210 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Ref.1

Catalytic activity

RX + glutathione = HX + R-S-glutathione. Ref.1

Subunit structure

Homodimer. Ref.1

Tissue specificity

Liver, kidney, muscle, skin, lung and ovary. Ref.1

Sequence similarities

Belongs to the GST superfamily. Pi family.

Contains 1 GST C-terminal domain.

Contains 1 GST N-terminal domain.

Ontologies

Keywords
   Molecular functionTransferase
   Technical termDirect protein sequencing
Gene Ontology (GO)
   Molecular_functionglutathione transferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 210210Glutathione S-transferase P 2
PRO_0000185909

Regions

Domain1 – 8282GST N-terminal
Domain83 – 204122GST C-terminal
Region53 – 542Glutathione binding By similarity
Region66 – 672Glutathione binding By similarity

Sites

Binding site71Glutathione By similarity
Binding site131Glutathione By similarity
Binding site381Glutathione By similarity
Binding site461Glutathione By similarity

Sequences

Sequence LengthMass (Da)Tools
P83325 [UniParc].

Last modified May 27, 2002. Version 1.
Checksum: 3D233F9AE53F3F8C

FASTA21024,179
        10         20         30         40         50         60 
SGYTLTYFPL RGRAEAMRLL LGDQGVSWTD DEVQMQDWAA GIRDLKKNAV FGQIPRFQEG 

        70         80         90        100        110        120 
DFVLYQSQTI LRLLARYGLS GSNEREIAIN EMMNDGVEDL RLKYYKFIFW DNEANKEKFL 

       130        140        150        160        170        180 
EELATQLGYF ERILTNNAGK TFVLVGDKIS YADYNLLDTL FCVLDLSPTC LSGFPLLSDY 

       190        200        210 
VERLGKRPKL QQYLKSEGRK RRPINGNGKQ 

« Hide

References

[1]"Amino acid sequence of the major form of toad liver glutathione transferase."
Bucciarelli T., Sacchetta P., Amicarelli F., Petruzzelli R., Melino S., Rotilio D., Celli N., Di Ilio C.
Int. J. Biochem. Cell Biol. 34:1286-1290(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE, FUNCTION, CATALYTIC ACTIVITY, SUBUNIT, TISSUE SPECIFICITY.
Tissue: Liver.

Cross-references

3D structure databases

ProteinModelPortalP83325.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG108324.

Family and domain databases

Gene3D1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR003082. GST_pi.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
PRINTSPR01268. GSTRNSFRASEP.
SUPFAMSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGSTP2_BUFBU
AccessionPrimary (citable) accession number: P83325
Entry history
Integrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: May 27, 2002
Last modified: October 16, 2013
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families