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P83325

- GSTP2_BUFBU

UniProt

P83325 - GSTP2_BUFBU

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Protein
Glutathione S-transferase P 2
Gene
N/A
Organism
Bufo bufo (European toad)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.1 Publication

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei7 – 71Glutathione By similarity
Binding sitei13 – 131Glutathione By similarity
Binding sitei38 – 381Glutathione By similarity
Binding sitei46 – 461Glutathione By similarity

GO - Molecular functioni

  1. glutathione transferase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Transferase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutathione S-transferase P 2 (EC:2.5.1.18)
    Alternative name(s):
    BBGSTP2-2
    GST class-pi
    OrganismiBufo bufo (European toad)
    Taxonomic identifieri8384 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraNeobatrachiaHyloideaBufonidaeBufo

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 210210Glutathione S-transferase P 2
    PRO_0000185909Add
    BLAST

    Expressioni

    Tissue specificityi

    Liver, kidney, muscle, skin, lung and ovary.1 Publication

    Interactioni

    Subunit structurei

    Homodimer.1 Publication

    Structurei

    3D structure databases

    ProteinModelPortaliP83325.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 8282GST N-terminal
    Add
    BLAST
    Domaini83 – 204122GST C-terminal
    Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni53 – 542Glutathione binding By similarity
    Regioni66 – 672Glutathione binding By similarity

    Sequence similaritiesi

    Belongs to the GST superfamily. Pi family.

    Phylogenomic databases

    HOVERGENiHBG108324.

    Family and domain databases

    Gene3Di1.20.1050.10. 1 hit.
    3.40.30.10. 1 hit.
    InterProiIPR010987. Glutathione-S-Trfase_C-like.
    IPR004045. Glutathione_S-Trfase_N.
    IPR004046. GST_C.
    IPR003082. GST_pi.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view]
    PfamiPF00043. GST_C. 1 hit.
    PF02798. GST_N. 1 hit.
    [Graphical view]
    PRINTSiPR01268. GSTRNSFRASEP.
    SUPFAMiSSF47616. SSF47616. 1 hit.
    SSF52833. SSF52833. 1 hit.
    PROSITEiPS50405. GST_CTER. 1 hit.
    PS50404. GST_NTER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P83325-1 [UniParc]FASTAAdd to Basket

    « Hide

    SGYTLTYFPL RGRAEAMRLL LGDQGVSWTD DEVQMQDWAA GIRDLKKNAV    50
    FGQIPRFQEG DFVLYQSQTI LRLLARYGLS GSNEREIAIN EMMNDGVEDL 100
    RLKYYKFIFW DNEANKEKFL EELATQLGYF ERILTNNAGK TFVLVGDKIS 150
    YADYNLLDTL FCVLDLSPTC LSGFPLLSDY VERLGKRPKL QQYLKSEGRK 200
    RRPINGNGKQ 210
    Length:210
    Mass (Da):24,179
    Last modified:May 27, 2002 - v1
    Checksum:i3D233F9AE53F3F8C
    GO

    Cross-referencesi

    3D structure databases

    ProteinModelPortali P83325.
    ModBasei Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG108324.

    Family and domain databases

    Gene3Di 1.20.1050.10. 1 hit.
    3.40.30.10. 1 hit.
    InterProi IPR010987. Glutathione-S-Trfase_C-like.
    IPR004045. Glutathione_S-Trfase_N.
    IPR004046. GST_C.
    IPR003082. GST_pi.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view ]
    Pfami PF00043. GST_C. 1 hit.
    PF02798. GST_N. 1 hit.
    [Graphical view ]
    PRINTSi PR01268. GSTRNSFRASEP.
    SUPFAMi SSF47616. SSF47616. 1 hit.
    SSF52833. SSF52833. 1 hit.
    PROSITEi PS50405. GST_CTER. 1 hit.
    PS50404. GST_NTER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: PROTEIN SEQUENCE, FUNCTION, CATALYTIC ACTIVITY, SUBUNIT, TISSUE SPECIFICITY.
      Tissue: Liver.

    Entry informationi

    Entry nameiGSTP2_BUFBU
    AccessioniPrimary (citable) accession number: P83325
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 27, 2002
    Last sequence update: May 27, 2002
    Last modified: October 16, 2013
    This is version 51 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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