P83324 (RIP_FLAVE) Reviewed, UniProtKB/Swiss-Prot
Last modified
May 31, 2011.
Version 25.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Ribosome-inactivating protein velutin EC=3.2.2.22 Alternative name(s): rRNA N-glycosidase |
| Organism | Flammulina velutipes |
| Taxonomic identifier | 38945 [NCBI] |
| Taxonomic lineage | Eukaryota › Fungi › Dikarya › Basidiomycota › Agaricomycotina › Homobasidiomycetes › Agaricomycetidae › Agaricales › Physalacriaceae › Flammulina |
Protein attributes
| Sequence length | 25 AA. |
| Sequence status | Fragment. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | Inhibits protein synthesis but does not possess ribonuclease activity. Also inhibits HIV-1 reverse transcriptase, beta-glucosidase and beta-glucuronidase. Ref.1 |
| Catalytic activity | Endohydrolysis of the N-glycosidic bond at one specific adenosine on the 28S rRNA. |
| Sequence similarities | Belongs to the ribosome-inactivating protein family. |
Ontologies
| Keywords | |
|---|---|
| Molecular function | Hydrolase Protein synthesis inhibitor Toxin |
| Technical term | Direct protein sequencing |
| Gene Ontology (GO) | |
| Biological process | negative regulation of translation Inferred from direct assay Ref.1. Source: UniProtKB |
| Molecular function | rRNA N-glycosylase activity Inferred from direct assay Ref.1. Source: UniProtKB |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
References
| [1] | "Isolation and characterization of velutin, a novel low-molecular-weight ribosome-inactivating protein from winter mushroom (Flammulina velutipes) fruiting bodies." Wang H., Ng T.B. Life Sci. 68:2151-2158(2001) [PubMed: 11324720] [Abstract] Cited for: PROTEIN SEQUENCE, FUNCTION. |
Cross-references
Entry information
| Entry name | RIP_FLAVE | ||||||||
| Accession | Primary (citable) accession number: P83324 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Fungal Protein Annotation Program | ||||||||
Relevant documents
| SIMILARITY comments Index of protein domains and families |

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