Reviewed, UniProtKB/Swiss-Prot P83273 (HBB2_ANAMI)

Names and origin

Protein names

Recommended name:
    Hemoglobin subunit beta-2
Alternative name(s):
    Hemoglobin beta-2 chain
    Beta-2-globin

Gene names

Name:

hbb2

Organism

Anarhichas minor (Arctic spotted wolffish)

Taxonomic identifier

65739 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Euteleostei › Neoteleostei › Acanthomorpha › Acanthopterygii › Percomorpha › Perciformes › Zoarcoidei › Anarhichadidae › Anarhichas

Protein attributes

Sequence length	146 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Involved in oxygen transport from gills to the various peripheral tissues. Ref.1
Subunit structure	Hb3 is a heterotetramer of two alpha-2 chains and two beta-2 chains.
Tissue specificity	Red blood cells. Ref.1
Miscellaneous	Hb3 displays pronounced Bohr and root effects, accompanied by strong organophosphate regulation.
Sequence similarities	Belongs to the globin family.

Ontologies

Keywords
Biological process	Oxygen transport Transport
Ligand	Heme Iron Metal-binding
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	oxygen transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	hemoglobin complex Inferred from electronic annotation. Source: InterPro
Molecular function	heme binding Inferred from electronic annotation. Source: InterPro oxygen binding Inferred from electronic annotation. Source: InterPro oxygen transporter activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 146	146	Hemoglobin subunit beta-2		PRO_0000052867
Sites
	Metal binding	63	1	Iron (heme distal ligand) By similarity
	Metal binding	92	1	Iron (heme proximal ligand) By similarity

Sequences

	Sequence		Length	Mass (Da)
	P83273-1 [UniParc]. Last modified August 2, 2002. Version 1. Checksum: 139B6730B659B800	FASTA	146	16,289
	10 20 30 40 50 60 VEWTDFERAT IQDIFSKMDY EVVGPAALSR CLIVYPWTQR YFGSFGNLYN AAAIMGNPNV 70 80 90 100 110 120 AKHGTIILHG LDRGVKNMDN IKETYAELSV LHSEKLHVDP DNFKLISDCL TVVVAAQFGK 130 140 AFTGEVQAAF QKFMAVVVSA LGRQYH

References

[1]	"The functionally distinct hemoglobins of the Arctic spotted wolffish Anarhichas minor." Verde C., Carratore V., Riccio A., Tamburrini M., Parisi E., Di Prisco G. J. Biol. Chem. 277:36312-36320(2002) [PubMed: 12118003] [Abstract] Cited for: PROTEIN SEQUENCE, FUNCTION, TISSUE SPECIFICITY.

Cross-references

3D structure databases
SMR	P83273. Positions 1-146.
ModBase	Search...
Phylogenomic databases
HOVERGEN	P83273.
Family and domain databases
InterPro	IPR012292. Globin. IPR009050. Globin-like. IPR000971. Globin_subset. IPR002337. Haemoglobin_b. [Graphical view]
Gene3D	G3DSA:1.10.490.10. Globin_related. 1 hit.
PANTHER	PTHR11442:SF7. Beta_haem. 1 hit.
Pfam	PF00042. Globin. 1 hit. [Graphical view]
PRINTS	PR00814. BETAHAEM.
PROSITE	PS01033. GLOBIN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HBB2_ANAMI

Accession

Primary (citable) accession number: P83273

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 2, 2002
Last sequence update:	August 2, 2002
Last modified:	November 24, 2009
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)