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Protein

Hemoglobin subunit alpha-1

Gene

hba1

Organism
Anarhichas minor (Arctic spotted wolffish)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in oxygen transport from gills to the various peripheral tissues.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi60 – 601Iron (heme distal ligand)PROSITE-ProRule annotation
Metal bindingi89 – 891Iron (heme proximal ligand)PROSITE-ProRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Oxygen transport, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Hemoglobin subunit alpha-1
Alternative name(s):
Alpha-1-globin
Hemoglobin alpha-1 chain
Gene namesi
Name:hba1
OrganismiAnarhichas minor (Arctic spotted wolffish)
Taxonomic identifieri65739 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataEupercariaPerciformesCottioideiZoarcalesAnarhichadidaeAnarhichas

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 143142Hemoglobin subunit alpha-1PRO_0000052544Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine1 Publication

Keywords - PTMi

Acetylation

Expressioni

Tissue specificityi

Red blood cells.1 Publication

Interactioni

Subunit structurei

Hb1 is a heterotetramer of two alpha-1 chains and two beta-1 chains.

Structurei

3D structure databases

ProteinModelPortaliP83270.
SMRiP83270. Positions 2-143.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the globin family.PROSITE-ProRule annotation

Phylogenomic databases

HOVERGENiHBG009709.

Family and domain databases

Gene3Di1.10.490.10. 1 hit.
InterProiIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin/Proto.
IPR002338. Haemoglobin_a.
[Graphical view]
PfamiPF00042. Globin. 1 hit.
[Graphical view]
PRINTSiPR00612. ALPHAHAEM.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiPS01033. GLOBIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P83270-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLTAKDKDT VRAFWAKASG KAAEIGSDAL SRMLVVYPQT KTYFSHWKDL
60 70 80 90 100
SPGSEPVKKH GKSVMGGVAD AVMKIEDLNA GLLNLSELHA FTLRVDPANF
110 120 130 140
KILSHNILVV MAIMFPKDFT PEVHVAMDKF LAALSRALAE KYR
Length:143
Mass (Da):15,763
Last modified:January 23, 2007 - v2
Checksum:i0F92508DA7BCC3BF
GO

Cross-referencesi

3D structure databases

ProteinModelPortaliP83270.
SMRiP83270. Positions 2-143.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG009709.

Family and domain databases

Gene3Di1.10.490.10. 1 hit.
InterProiIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin/Proto.
IPR002338. Haemoglobin_a.
[Graphical view]
PfamiPF00042. Globin. 1 hit.
[Graphical view]
PRINTSiPR00612. ALPHAHAEM.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiPS01033. GLOBIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The functionally distinct hemoglobins of the Arctic spotted wolffish Anarhichas minor."
    Verde C., Carratore V., Riccio A., Tamburrini M., Parisi E., Di Prisco G.
    J. Biol. Chem. 277:36312-36320(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-143, FUNCTION, TISSUE SPECIFICITY, ACETYLATION AT SER-2.

Entry informationi

Entry nameiHBA1_ANAMI
AccessioniPrimary (citable) accession number: P83270
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 2, 2002
Last sequence update: January 23, 2007
Last modified: December 9, 2015
This is version 59 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Hb1 displays a low, effector-enhanced Bohr effect and no Root effect.

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.