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Protein

Hemoglobin subunit alpha-1

Gene

hba1

Organism
Anarhichas minor (Arctic spotted wolffish)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in oxygen transport from gills to the various peripheral tissues.1 Publication

Miscellaneous

Hb1 displays a low, effector-enhanced Bohr effect and no Root effect.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi60Iron (heme distal ligand)PROSITE-ProRule annotation1
Metal bindingi89Iron (heme proximal ligand)PROSITE-ProRule annotation1

GO - Molecular functioni

Keywordsi

Biological processOxygen transport, Transport
LigandHeme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Hemoglobin subunit alpha-1
Alternative name(s):
Alpha-1-globin
Hemoglobin alpha-1 chain
Gene namesi
Name:hba1
OrganismiAnarhichas minor (Arctic spotted wolffish)
Taxonomic identifieri65739 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataEupercariaPerciformesCottioideiZoarcalesAnarhichadidaeAnarhichas

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000525442 – 143Hemoglobin subunit alpha-1Add BLAST142

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserine1 Publication1

Keywords - PTMi

Acetylation

PTM databases

iPTMnetiP83270

Expressioni

Tissue specificityi

Red blood cells.1 Publication

Interactioni

Subunit structurei

Hb1 is a heterotetramer of two alpha-1 chains and two beta-1 chains.

Structurei

3D structure databases

ProteinModelPortaliP83270
SMRiP83270
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the globin family.PROSITE-ProRule annotation

Phylogenomic databases

HOVERGENiHBG009709

Family and domain databases

CDDicd08927 Hb-alpha_like, 1 hit
Gene3Di1.10.490.10, 1 hit
InterProiView protein in InterPro
IPR000971 Globin
IPR009050 Globin-like_sf
IPR012292 Globin/Proto
IPR002338 Haemoglobin_a-typ
PfamiView protein in Pfam
PF00042 Globin, 1 hit
PRINTSiPR00612 ALPHAHAEM
SUPFAMiSSF46458 SSF46458, 1 hit
PROSITEiView protein in PROSITE
PS01033 GLOBIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P83270-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLTAKDKDT VRAFWAKASG KAAEIGSDAL SRMLVVYPQT KTYFSHWKDL
60 70 80 90 100
SPGSEPVKKH GKSVMGGVAD AVMKIEDLNA GLLNLSELHA FTLRVDPANF
110 120 130 140
KILSHNILVV MAIMFPKDFT PEVHVAMDKF LAALSRALAE KYR
Length:143
Mass (Da):15,763
Last modified:January 23, 2007 - v2
Checksum:i0F92508DA7BCC3BF
GO

Similar proteinsi

Entry informationi

Entry nameiHBA1_ANAMI
AccessioniPrimary (citable) accession number: P83270
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 2, 2002
Last sequence update: January 23, 2007
Last modified: April 25, 2018
This is version 66 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing
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Main funding by: National Institutes of Health