Reviewed, UniProtKB/Swiss-Prot P83270 (HBA1_ANAMI)

Names and origin

Protein names

Recommended name:
    Hemoglobin subunit alpha-1
Alternative name(s):
    Hemoglobin alpha-1 chain
    Alpha-1-globin

Gene names

Name:

hba1

Organism

Anarhichas minor (Arctic spotted wolffish)

Taxonomic identifier

65739 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Euteleostei › Neoteleostei › Acanthomorpha › Acanthopterygii › Percomorpha › Perciformes › Zoarcoidei › Anarhichadidae › Anarhichas

Protein attributes

Sequence length	143 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Involved in oxygen transport from gills to the various peripheral tissues. Ref.1
Subunit structure	Hb1 is a heterotetramer of two alpha-1 chains and two beta-1 chains.
Tissue specificity	Red blood cells. Ref.1
Miscellaneous	Hb1 displays a low, effector-enhanced Bohr effect and no root effect.
Sequence similarities	Belongs to the globin family.

Ontologies

Keywords
Biological process	Oxygen transport Transport
Ligand	Heme Iron Metal-binding
PTM	Acetylation
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	oxygen transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	hemoglobin complex Inferred from electronic annotation. Source: InterPro
Molecular function	heme binding Inferred from electronic annotation. Source: InterPro oxygen binding Inferred from electronic annotation. Source: InterPro oxygen transporter activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 143	142	Hemoglobin subunit alpha-1		PRO_0000052544
Sites
	Metal binding	60	1	Iron (heme distal ligand) By similarity
	Metal binding	89	1	Iron (heme proximal ligand) By similarity
Amino acid modifications
	Modified residue	2	1	N-acetylserine Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P83270-1 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: 0F92508DA7BCC3BF	FASTA	143	15,763
	10 20 30 40 50 60 MSLTAKDKDT VRAFWAKASG KAAEIGSDAL SRMLVVYPQT KTYFSHWKDL SPGSEPVKKH 70 80 90 100 110 120 GKSVMGGVAD AVMKIEDLNA GLLNLSELHA FTLRVDPANF KILSHNILVV MAIMFPKDFT 130 140 PEVHVAMDKF LAALSRALAE KYR

References

[1]

"The functionally distinct hemoglobins of the Arctic spotted wolffish Anarhichas minor." Verde C., Carratore V., Riccio A., Tamburrini M., Parisi E., Di Prisco G. J. Biol. Chem. 277:36312-36320(2002) [PubMed: 12118003] [Abstract] Cited for: PROTEIN SEQUENCE OF 2-143, FUNCTION, TISSUE SPECIFICITY, ACETYLATION AT SER-2.

Cross-references

3D structure databases
SMR	P83270. Positions 2-143.
ModBase	Search...
Phylogenomic databases
HOVERGEN	P83270.
Family and domain databases
InterPro	IPR012292. Globin. IPR009050. Globin-like. IPR000971. Globin_subset. IPR002338. Haemoglobin_a. [Graphical view]
Gene3D	G3DSA:1.10.490.10. Globin_related. 1 hit.
Pfam	PF00042. Globin. 1 hit. [Graphical view]
PRINTS	PR00612. ALPHAHAEM.
PROSITE	PS01033. GLOBIN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HBA1_ANAMI

Accession

Primary (citable) accession number: P83270

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 2, 2002
Last sequence update:	January 23, 2007
Last modified:	November 24, 2009
This is version 42 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)