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Reviewed, UniProtKB/Swiss-Prot P83270 (HBA1_ANAMI)

Last modified November 24, 2009. Version 42. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Hemoglobin subunit alpha-1
Alternative name(s):
    Hemoglobin alpha-1 chain
    Alpha-1-globin
Gene names
Name: hba1
OrganismAnarhichas minor (Arctic spotted wolffish)
Taxonomic identifier65739 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiEuteleosteiNeoteleosteiAcanthomorphaAcanthopterygiiPercomorphaPerciformesZoarcoideiAnarhichadidaeAnarhichas

Protein attributes

Sequence length143 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Involved in oxygen transport from gills to the various peripheral tissues. Ref.1

Subunit structure

Hb1 is a heterotetramer of two alpha-1 chains and two beta-1 chains.

Tissue specificity

Red blood cells. Ref.1

Miscellaneous

Hb1 displays a low, effector-enhanced Bohr effect and no root effect.

Sequence similarities

Belongs to the globin family.

Ontologies

Keywords
   Biological processOxygen transport
Transport
   LigandHeme
Iron
Metal-binding
   PTMAcetylation
   Technical termDirect protein sequencing
Gene Ontology (GO)
   Biological processoxygen transport

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componenthemoglobin complex

Inferred from electronic annotation. Source: InterPro

   Molecular functionheme binding

Inferred from electronic annotation. Source: InterPro

oxygen binding

Inferred from electronic annotation. Source: InterPro

oxygen transporter activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 143142Hemoglobin subunit alpha-1
PRO_0000052544

Sites

Metal binding601Iron (heme distal ligand) By similarity
Metal binding891Iron (heme proximal ligand) By similarity

Amino acid modifications

Modified residue21N-acetylserine Ref.1

Sequences

Sequence LengthMass (Da)Tools
P83270-1 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: 0F92508DA7BCC3BF

FASTA14315,763
        10         20         30         40         50         60 
MSLTAKDKDT VRAFWAKASG KAAEIGSDAL SRMLVVYPQT KTYFSHWKDL SPGSEPVKKH 

        70         80         90        100        110        120 
GKSVMGGVAD AVMKIEDLNA GLLNLSELHA FTLRVDPANF KILSHNILVV MAIMFPKDFT 

       130        140 
PEVHVAMDKF LAALSRALAE KYR 

« Hide

References

[1]"The functionally distinct hemoglobins of the Arctic spotted wolffish Anarhichas minor."
Verde C., Carratore V., Riccio A., Tamburrini M., Parisi E., Di Prisco G.
J. Biol. Chem. 277:36312-36320(2002) [PubMed: 12118003] [Abstract]
Cited for: PROTEIN SEQUENCE OF 2-143, FUNCTION, TISSUE SPECIFICITY, ACETYLATION AT SER-2.

Cross-references

3D structure databases

SMRP83270. Positions 2-143.
ModBaseSearch...

Phylogenomic databases

HOVERGENP83270.

Family and domain databases

InterProIPR012292. Globin.
IPR009050. Globin-like.
IPR000971. Globin_subset.
IPR002338. Haemoglobin_a.
[Graphical view]
Gene3DG3DSA:1.10.490.10. Globin_related. 1 hit.
PfamPF00042. Globin. 1 hit.
[Graphical view]
PRINTSPR00612. ALPHAHAEM.
PROSITEPS01033. GLOBIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHBA1_ANAMI
AccessionPrimary (citable) accession number: P83270
Entry history
Integrated into UniProtKB/Swiss-Prot: August 2, 2002
Last sequence update: January 23, 2007
Last modified: November 24, 2009
This is version 42 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents