P83270 (HBA1_ANAMI) Reviewed, UniProtKB/Swiss-Prot
Last modified
October 19, 2011.
Version 46.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Hemoglobin subunit alpha-1 Alternative name(s): Alpha-1-globin Hemoglobin alpha-1 chain | ||
| Gene names |
| ||
| Organism | Anarhichas minor (Arctic spotted wolffish) | ||
| Taxonomic identifier | 65739 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Euteleostei › Neoteleostei › Acanthomorpha › Acanthopterygii › Percomorpha › Perciformes › Zoarcoidei › Anarhichadidae › Anarhichas |
Protein attributes
| Sequence length | 143 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | Involved in oxygen transport from gills to the various peripheral tissues. Ref.1 |
| Subunit structure | Hb1 is a heterotetramer of two alpha-1 chains and two beta-1 chains. |
| Tissue specificity | Red blood cells. Ref.1 |
| Miscellaneous | Hb1 displays a low, effector-enhanced Bohr effect and no root effect. |
| Sequence similarities | Belongs to the globin family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Oxygen transport Transport |
| Ligand | Heme Iron Metal-binding |
| PTM | Acetylation |
| Technical term | Direct protein sequencing |
| Gene Ontology (GO) | |
| Cellular component | hemoglobin complex Inferred from electronic annotation. Source: InterPro |
| Molecular function | heme binding Inferred from electronic annotation. Source: InterPro oxygen bindingInferred from electronic annotation. Source: InterPro oxygen transporter activityInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Initiator methionine | 1 | 1 | Removed By similarity | ||||||
| Chain | 2 – 143 | 142 | Hemoglobin subunit alpha-1 | PRO_0000052544 | |||||
Sites | |||||||||
| Metal binding | 60 | 1 | Iron (heme distal ligand) By similarity | ||||||
| Metal binding | 89 | 1 | Iron (heme proximal ligand) By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 2 | 1 | N-acetylserine Ref.1 | ||||||
Sequences
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References
| [1] | "The functionally distinct hemoglobins of the Arctic spotted wolffish Anarhichas minor." Verde C., Carratore V., Riccio A., Tamburrini M., Parisi E., Di Prisco G. J. Biol. Chem. 277:36312-36320(2002) [PubMed: 12118003] [Abstract] Cited for: PROTEIN SEQUENCE OF 2-143, FUNCTION, TISSUE SPECIFICITY, ACETYLATION AT SER-2. |
| + | Additional computationally mapped references. |
Cross-references
3D structure databases | |
|---|---|
| ProteinModelPortal | P83270. |
| SMR | P83270. Positions 2-143. |
| ModBase | Search... |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Phylogenomic databases | |
| HOVERGEN | HBG009709. |
Family and domain databases | |
| InterPro | IPR009050. Globin-like. IPR012292. Globin_dom. IPR000971. Globin_subset. IPR002338. Haemoglobin_a. [Graphical view] |
| Gene3D | G3DSA:1.10.490.10. Globin_related. 1 hit. |
| Pfam | PF00042. Globin. 1 hit. [Graphical view] |
| PRINTS | PR00612. ALPHAHAEM. |
| SUPFAM | SSF46458. Globin_like. 1 hit. |
| PROSITE | PS01033. GLOBIN. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | HBA1_ANAMI | ||||||||
| Accession | Primary (citable) accession number: P83270 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
Relevant documents
| SIMILARITY comments Index of protein domains and families |

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