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Protein

Delta-amaurobitoxin-Pl1d

Gene
N/A
Organism
Pireneitega luctuosa (Tangled nest spider) (Paracoelotes luctuosus)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Binds at site 4 of sodium channels (Nav) and inhibits the fast inactivation of cockroach channels. This toxin is active only on insects (By similarity) Has a potent activity against S.litura larvae.By similarity1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei8PharmacophoreBy similarity1
Sitei12PharmacophoreBy similarity1
Sitei22PharmacophoreBy similarity1
Sitei24PharmacophoreBy similarity1
Sitei26PharmacophoreBy similarity1
Sitei34PharmacophoreBy similarity1

GO - Molecular functioni

  • sodium channel inhibitor activity Source: UniProtKB
  • toxin activity Source: UniProtKB-KW

GO - Biological processi

  • pathogenesis Source: UniProtKB

Keywordsi

Molecular functionIon channel impairing toxin, Neurotoxin, Toxin, Voltage-gated sodium channel impairing toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Delta-amaurobitoxin-Pl1d
Short name:
Delta-AMATX-Pl1d
Alternative name(s):
Delta-palutoxin IT41 Publication
Short name:
Delta-paluIT41 Publication
OrganismiPireneitega luctuosa (Tangled nest spider) (Paracoelotes luctuosus)
Taxonomic identifieri185217 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAraneaeAraneomorphaeEntelegynaeAmaurobiidaePireneitega

Organism-specific databases

ArachnoServeriAS000304. delta-Amaurobitoxin-Pl1d.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PeptideiPRO_00000449641 – 37Delta-amaurobitoxin-Pl1dAdd BLAST37

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi2 ↔ 18By similarity
Disulfide bondi9 ↔ 23By similarity
Disulfide bondi17 ↔ 33By similarity
Disulfide bondi25 ↔ 31By similarity
Modified residuei37Serine amide1 Publication1

Keywords - PTMi

Amidation, Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.1 Publication

Structurei

3D structure databases

ProteinModelPortaliP83259.
SMRiP83259.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.By similarity

Sequence similaritiesi

Keywords - Domaini

Knottin

Family and domain databases

InterProiView protein in InterPro
IPR016328. Beta/delta-agatoxin_fam.
PIRSFiPIRSF001882. Curtatoxin. 1 hit.
PROSITEiView protein in PROSITE
PS60015. MU_AGATOXIN. 1 hit.

Sequencei

Sequence statusi: Complete.

P83259-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30 
ACATKNQRCA SWAGPYCCDG FYCSCRSYPG CMCRPNS
Length:37
Mass (Da):4,062
Last modified:March 1, 2002 - v1
Checksum:i7F9C5516D556E70C
GO

Mass spectrometryi

Molecular mass is 4052.3 Da from positions 1 - 37. Determined by MALDI. 1 Publication

Similar proteinsi

Entry informationi

Entry nameiT2DP4_PIRLC
AccessioniPrimary (citable) accession number: P83259
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2002
Last sequence update: March 1, 2002
Last modified: November 22, 2017
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families