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Glutathione S-transferase

Asaphis dichotoma
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli


Has a strong specific activity toward 1-chloro-2,4-dinitrobenzene and ethacrynic acid.1 Publication


In A.dichotoma there are at least two isozymes of glutathione S-transferase.1 Publication

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.1 Publication


  1. KM=0.68 mM for 1-chloro-2,4-dinitrobenzene1 Publication
  2. KM=0.106 mM for glutathione1 Publication
  1. Vmax=0.1446 mmol/min/mg enzyme toward CDNB1 Publication
  2. Vmax=0.033 mmol/min/mg enzyme toward GSH1 Publication

pH dependencei

Optimum pH is 8.5 with 1-chloro-2,4-dinitrobenzene as substrate.1 Publication


Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei7GlutathioneBy similarity1

GO - Molecular functioni

  • glutathione transferase activity Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB

GO - Biological processi

  • glutathione metabolic process Source: UniProtKB


Molecular functionTransferase

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase (EC:
Alternative name(s):
GST class-sigma
OrganismiAsaphis dichotomaCurated
Taxonomic identifieri184428 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaBivalviaHeteroconchiaEuheterodontaVeneroidaTellinoideaPsammobiidaeAsaphis

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001859231 – ›15Glutathione S-transferaseAdd BLAST›15


Subunit structurei

Homodimer.1 Publication

GO - Molecular functioni

  • protein homodimerization activity Source: UniProtKB

Family & Domainsi

Sequence similaritiesi

Belongs to the GST superfamily. Sigma family.By similarity


Sequence statusi: Fragment.

Mass (Da):1,767
Last modified:March 1, 2002 - v1

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei151 Publication1

Mass spectrometryi

Molecular mass is 23138 Da from positions 1 - ?. Determined by MALDI. 1 Publication

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiGST_ASADI
AccessioniPrimary (citable) accession number: P83246
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: March 1, 2002
Last modified: January 20, 2016
This is version 37 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)


Keywords - Technical termi

Direct protein sequencing


  1. SIMILARITY comments
    Index of protein domains and families