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Protein

Potassium channel toxin alpha-KTx 13.2

Gene
N/A
Organism
Orthochirus scrobiculosus (Central Asian scorpion)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Potent and selective inhibitor of Kv1.2/KCNA2 potassium channels.1 Publication

Miscellaneous

Does not block Kv1.1/KCNA1 and Kv1.3/KCNA3 potassium channels.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei18Basic residue of the functional dyadBy similarity1
Sitei27Aromatic residue of the functional dyadBy similarity1

GO - Molecular functioni

  • potassium channel inhibitor activity Source: UniProtKB

GO - Biological processi

  • cytolysis Source: UniProtKB
  • pathogenesis Source: UniProtKB

Keywordsi

Molecular functionIon channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin, Voltage-gated potassium channel impairing toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium channel toxin alpha-KTx 13.2
Short name:
OsK-2
Short name:
OsK2
OrganismiOrthochirus scrobiculosus (Central Asian scorpion)Curated
Taxonomic identifieri6892 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesButhidaButhoideaButhidaeOrthochirus

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PeptideiPRO_00000449101 – 28Potassium channel toxin alpha-KTx 13.2Add BLAST28

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi2 ↔ 19By similarity
Disulfide bondi6 ↔ 24By similarity
Disulfide bondi10 ↔ 26By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.

Structurei

3D structure databases

SMRiP83244.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni17 – 24Interaction with Ca(2+)-activated K(+) channelsSequence analysis8

Sequence similaritiesi

Sequencei

Sequence statusi: Complete.

P83244-1 [UniParc]FASTAAdd to basket

« Hide

        10         20 
ACGPGCSGSC RQKGDRIKCI NGSCHCYP
Length:28
Mass (Da):2,901
Last modified:October 31, 2003 - v2
Checksum:iA9BD3332061F99E5
GO

Mass spectrometryi

Molecular mass is 2892.14 Da from positions 1 - 28. Determined by MALDI. 1 Publication

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiKA132_ORTSC
AccessioniPrimary (citable) accession number: P83244
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2002
Last sequence update: October 31, 2003
Last modified: May 10, 2017
This is version 53 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Scorpion potassium channel toxins
    Nomenclature of scorpion potassium channel toxins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families