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P83244

- KA132_ORTSC

UniProt

P83244 - KA132_ORTSC

Protein

Potassium channel toxin alpha-KTx 13.2

Gene
N/A
Organism
Orthochirus scrobiculosus (Central Asian scorpion)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Potent and selective inhibitor of Kv1.2/KCNA2 potassium channels.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei18 – 181Basic residue of the functional dyadBy similarity
    Sitei27 – 271Aromatic residue of the functional dyadBy similarity

    GO - Molecular functioni

    1. potassium channel inhibitor activity Source: UniProtKB

    GO - Biological processi

    1. cytolysis Source: UniProtKB
    2. pathogenesis Source: UniProtKB

    Keywords - Molecular functioni

    Ion channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin, Voltage-gated potassium channel impairing toxin

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Potassium channel toxin alpha-KTx 13.2
    Short name:
    OsK-2
    Short name:
    OsK2
    OrganismiOrthochirus scrobiculosus (Central Asian scorpion)Curated
    Taxonomic identifieri6892 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesButhidaButhoideaButhidaeOrthochirus

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Peptidei1 – 2828Potassium channel toxin alpha-KTx 13.2PRO_0000044910Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi2 ↔ 19By similarity
    Disulfide bondi6 ↔ 24By similarity
    Disulfide bondi10 ↔ 26By similarity

    Keywords - PTMi

    Disulfide bond

    Expressioni

    Tissue specificityi

    Expressed by the venom gland.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni17 – 248Interaction with Ca(2+)-activated K(+) channelsSequence Analysis

    Sequence similaritiesi

    Sequencei

    Sequence statusi: Complete.

    P83244-1 [UniParc]FASTAAdd to Basket

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    ACGPGCSGSC RQKGDRIKCI NGSCHCYP                           28
    Length:28
    Mass (Da):2,901
    Last modified:October 31, 2003 - v2
    Checksum:iA9BD3332061F99E5
    GO

    Mass spectrometryi

    Molecular mass is 2892.14 Da from positions 1 - 28. Determined by MALDI. 1 Publication

    Cross-referencesi

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "OsK2, a new selective inhibitor of Kv1.2 potassium channels purified from the venom of the scorpion Orthochirus scrobiculosus."
      Dudina E.E., Korolkova Y.V., Bocharova N.E., Koshelev S.G., Egorov T.A., Huys I., Tytgat J., Grishin E.V.
      Biochem. Biophys. Res. Commun. 286:841-847(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE, FUNCTION, MASS SPECTROMETRY.
      Tissue: Venom.

    Entry informationi

    Entry nameiKA132_ORTSC
    AccessioniPrimary (citable) accession number: P83244
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 28, 2002
    Last sequence update: October 31, 2003
    Last modified: October 1, 2014
    This is version 47 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programAnimal Toxin Annotation Program

    Miscellaneousi

    Miscellaneous

    Does not block Kv1.1/KCNA1 and Kv1.3/KCNA3 potassium channels.1 Publication

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. Scorpion potassium channel toxins
      Nomenclature of scorpion potassium channel toxins and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3