Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P83244 (KA132_ORTSC) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Potassium channel toxin alpha-KTx 13.2

Short name=OsK-2
Short name=OsK2
OrganismOrthochirus scrobiculosus (Central Asian scorpion)
Taxonomic identifier6892 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesButhidaButhoideaButhidaeOrthochirus

Protein attributes

Sequence length28 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Potent and selective inhibitor of Kv1.2/KCNA2 potassium channels. Ref.1

Subcellular location

Secreted.

Tissue specificity

Expressed by the venom gland.

Miscellaneous

Does not block Kv1.1/KCNA1 and Kv1.3/KCNA3 potassium channels (Ref.1).

Sequence similarities

Belongs to the short scorpion toxin superfamily. Potassium channel inhibitor family. Alpha-KTx 13 subfamily.

Mass spectrometry

Molecular mass is 2892.14 Da from positions 1 - 28. Determined by MALDI. Ref.1

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Peptide1 – 2828Potassium channel toxin alpha-KTx 13.2
PRO_0000044910

Regions

Region17 – 248Interaction with Ca(2+)-activated K(+) channels Potential

Sites

Site181Basic residue of the functional dyad By similarity
Site271Aromatic residue of the functional dyad By similarity

Amino acid modifications

Disulfide bond2 ↔ 19 By similarity UniProtKB P40755
Disulfide bond6 ↔ 24 By similarity UniProtKB P40755
Disulfide bond10 ↔ 26 By similarity

Sequences

Sequence LengthMass (Da)Tools
P83244 [UniParc].

Last modified October 31, 2003. Version 2.
Checksum: A9BD3332061F99E5

FASTA282,901
        10         20 
ACGPGCSGSC RQKGDRIKCI NGSCHCYP 

« Hide

References

[1]"OsK2, a new selective inhibitor of Kv1.2 potassium channels purified from the venom of the scorpion Orthochirus scrobiculosus."
Dudina E.E., Korolkova Y.V., Bocharova N.E., Koshelev S.G., Egorov T.A., Huys I., Tytgat J., Grishin E.V.
Biochem. Biophys. Res. Commun. 286:841-847(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE, FUNCTION, MASS SPECTROMETRY.
Tissue: Venom.

Cross-references

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

ProtoNetSearch...

Entry information

Entry nameKA132_ORTSC
AccessionPrimary (citable) accession number: P83244
Entry history
Integrated into UniProtKB/Swiss-Prot: November 28, 2002
Last sequence update: October 31, 2003
Last modified: March 19, 2014
This is version 46 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Scorpion potassium channel toxins

Nomenclature of scorpion potassium channel toxins and list of entries