Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P83244

- KA132_ORTSC

UniProt

P83244 - KA132_ORTSC

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Potassium channel toxin alpha-KTx 13.2

Gene
N/A
Organism
Orthochirus scrobiculosus (Central Asian scorpion)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Potent and selective inhibitor of Kv1.2/KCNA2 potassium channels.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei18 – 181Basic residue of the functional dyadBy similarity
Sitei27 – 271Aromatic residue of the functional dyadBy similarity

GO - Molecular functioni

  1. potassium channel inhibitor activity Source: UniProtKB

GO - Biological processi

  1. cytolysis Source: UniProtKB
  2. pathogenesis Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Ion channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin, Voltage-gated potassium channel impairing toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium channel toxin alpha-KTx 13.2
Short name:
OsK-2
Short name:
OsK2
OrganismiOrthochirus scrobiculosus (Central Asian scorpion)Curated
Taxonomic identifieri6892 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesButhidaButhoideaButhidaeOrthochirus

Subcellular locationi

Secreted Curated

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Peptidei1 – 2828Potassium channel toxin alpha-KTx 13.2PRO_0000044910Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi2 ↔ 19By similarity
Disulfide bondi6 ↔ 24By similarity
Disulfide bondi10 ↔ 26By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni17 – 248Interaction with Ca(2+)-activated K(+) channelsSequence Analysis

Sequence similaritiesi

Sequencei

Sequence statusi: Complete.

P83244-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20 
ACGPGCSGSC RQKGDRIKCI NGSCHCYP
Length:28
Mass (Da):2,901
Last modified:October 31, 2003 - v2
Checksum:iA9BD3332061F99E5
GO

Mass spectrometryi

Molecular mass is 2892.14 Da from positions 1 - 28. Determined by MALDI. 1 Publication

Cross-referencesi

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

ProtoNeti Search...

Publicationsi

  1. "OsK2, a new selective inhibitor of Kv1.2 potassium channels purified from the venom of the scorpion Orthochirus scrobiculosus."
    Dudina E.E., Korolkova Y.V., Bocharova N.E., Koshelev S.G., Egorov T.A., Huys I., Tytgat J., Grishin E.V.
    Biochem. Biophys. Res. Commun. 286:841-847(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE, FUNCTION, MASS SPECTROMETRY.
    Tissue: Venom.

Entry informationi

Entry nameiKA132_ORTSC
AccessioniPrimary (citable) accession number: P83244
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2002
Last sequence update: October 31, 2003
Last modified: October 29, 2014
This is version 48 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Miscellaneous

Does not block Kv1.1/KCNA1 and Kv1.3/KCNA3 potassium channels.1 Publication

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Scorpion potassium channel toxins
    Nomenclature of scorpion potassium channel toxins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3