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Protein

Potassium channel toxin alpha-KTx 13.2

Gene
N/A
Organism
Orthochirus scrobiculosus (Central Asian scorpion)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Potent and selective inhibitor of Kv1.2/KCNA2 potassium channels.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei18 – 181Basic residue of the functional dyadBy similarity
Sitei27 – 271Aromatic residue of the functional dyadBy similarity

GO - Molecular functioni

  1. potassium channel inhibitor activity Source: UniProtKB

GO - Biological processi

  1. cytolysis Source: UniProtKB
  2. pathogenesis Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Ion channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin, Voltage-gated potassium channel impairing toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium channel toxin alpha-KTx 13.2
Short name:
OsK-2
Short name:
OsK2
OrganismiOrthochirus scrobiculosus (Central Asian scorpion)Curated
Taxonomic identifieri6892 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesButhidaButhoideaButhidaeOrthochirus

Subcellular locationi

Secreted Curated

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Peptidei1 – 2828Potassium channel toxin alpha-KTx 13.2PRO_0000044910Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi2 ↔ 19By similarity
Disulfide bondi6 ↔ 24By similarity
Disulfide bondi10 ↔ 26By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni17 – 248Interaction with Ca(2+)-activated K(+) channelsSequence Analysis

Sequence similaritiesi

Sequencei

Sequence statusi: Complete.

P83244-1 [UniParc]FASTAAdd to basket

« Hide

        10         20 
ACGPGCSGSC RQKGDRIKCI NGSCHCYP
Length:28
Mass (Da):2,901
Last modified:October 30, 2003 - v2
Checksum:iA9BD3332061F99E5
GO

Mass spectrometryi

Molecular mass is 2892.14 Da from positions 1 - 28. Determined by MALDI. 1 Publication

Cross-referencesi

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

ProtoNetiSearch...

Publicationsi

  1. "OsK2, a new selective inhibitor of Kv1.2 potassium channels purified from the venom of the scorpion Orthochirus scrobiculosus."
    Dudina E.E., Korolkova Y.V., Bocharova N.E., Koshelev S.G., Egorov T.A., Huys I., Tytgat J., Grishin E.V.
    Biochem. Biophys. Res. Commun. 286:841-847(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE, FUNCTION, MASS SPECTROMETRY.
    Tissue: Venom.

Entry informationi

Entry nameiKA132_ORTSC
AccessioniPrimary (citable) accession number: P83244
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 27, 2002
Last sequence update: October 30, 2003
Last modified: January 6, 2015
This is version 49 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Miscellaneous

Does not block Kv1.1/KCNA1 and Kv1.3/KCNA3 potassium channels.1 Publication

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Scorpion potassium channel toxins
    Nomenclature of scorpion potassium channel toxins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.