Reviewed, UniProtKB/Swiss-Prot P83205 (CATB_SHEEP)

Names and origin

Protein names

Recommended name:
    Cathepsin B
    EC=3.4.22.1
Alternative name(s):
    Cathepsin B1

Gene names

Name:

CTSB

Organism

Ovis aries (Sheep)

Taxonomic identifier

9940 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Caprinae › Ovis

Protein attributes

Sequence length	10 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis. UniProtKB P00787
Catalytic activity	Hydrolysis of proteins with broad specificity for peptide bonds. Preferentially cleaves -Arg-Arg-|-Xaa bonds in small molecule substrates (thus differing from cathepsin L). In addition to being an endopeptidase, shows peptidyl-dipeptidase activity, liberating C-terminal dipeptides.
Subunit structure	Dimer of a heavy chain and a light chain cross-linked by a disulfide bond By similarity. UniProtKB P00787
Subcellular location	Lysosome By similarity. Melanosome By similarity. UniProtKB P00787
Sequence similarities	Belongs to the peptidase C1 family.

Ontologies

Keywords
Cellular component	Lysosome
Molecular function	Hydrolase Protease Thiol protease
PTM	Disulfide bond
Technical term	Direct protein sequencing
Gene Ontology (GO)
Cellular component	lysosome Inferred from electronic annotation. Source: UniProtKB-SubCell melanosome Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	cysteine-type peptidase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – ›10	›10	Cathepsin B		PRO_0000050534
Experimental info
	Non-terminal residue	10	1

Sequences

	Sequence		Length	Mass (Da)
	P83205-1 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 8795780DDAA9D5BA	FASTA	10	1,177
	10 LPDSFDAREQ

References

[1]

"Isolation and partial characterization of three pregnancy-associated glycoproteins from the ewe placenta." El Amiri B., Remy B., Sousa N.M., Joris B., Ottiers N.G., Perenyi Z., Mboko H.B., Beckers J.-F.M.P. Mol. Reprod. Dev. 64:199-206(2003) [PubMed: 12506352] [Abstract] Cited for: PROTEIN SEQUENCE. Tissue: Placenta.

Cross-references

3D structure databases
ModBase	Search...
Phylogenomic databases
HOVERGEN	P83205.
Enzyme and pathway databases
BRENDA	3.4.22.1. 271.
Family and domain databases
InterPro	IPR000169. Pept_cys_AS. [Graphical view]
PROSITE	PS00640. THIOL_PROTEASE_ASN. Partial match. PS00139. THIOL_PROTEASE_CYS. Partial match. PS00639. THIOL_PROTEASE_HIS. Partial match. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CATB_SHEEP

Accession

Primary (citable) accession number: P83205

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 11, 2003
Last sequence update:	October 1, 2002
Last modified:	June 16, 2009
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)