Reviewed, UniProtKB/Swiss-Prot P83200 (PRDX5_VULVU)

Names and origin

Protein names

Recommended name:
    Peroxiredoxin-5
    EC=1.11.1.15
Alternative name(s):
    Prx-V
    Thioredoxin reductase
    Autoantigenic sperm protein 5
    fSP5

Gene names

Name:

PRDX5

Organism

Vulpes vulpes (Red fox)

Taxonomic identifier

9627 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Carnivora › Caniformia › Canidae › Vulpes

Protein attributes

Sequence length	16 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Reduces hydrogen peroxide and alkyl hydroperoxides with reducing equivalents provided through the thioredoxin system. Involved in intracellular redox signaling By similarity.
Catalytic activity	2 R'-SH + ROOH = R'-S-S-R' + H(2)O + ROH.
Subunit structure	Monomer By similarity.
Subcellular location	MitochondrionBy similarity. CytoplasmBy similarity. PeroxisomeBy similarity.
Sequence similarities	Belongs to the peroxiredoxin 2 family.

Ontologies

Keywords
Cellular component	Cytoplasm Mitochondrion Peroxisome
Domain	Redox-active center
Molecular function	Antioxidant Oxidoreductase Peroxidase
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	mitochondrion Inferred from electronic annotation. Source: UniProtKB-KW peroxisome Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	peroxiredoxin activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – ›16	›16	Peroxiredoxin-5		PRO_0000312688
Experimental info
	Non-terminal residue	16	1

Sequences

	Sequence		Length	Mass (Da)
	P83200-1 [UniParc]. Last modified December 4, 2007. Version 1. Checksum: 1138D10324279F20	FASTA	16	1,677
	10 APIKVGDAIP XVXVFE

References

[1]	"Partial characterisation of antigenic sperm proteins in foxes (Vulpes vulpes)." Verdier Y., Rouet N., Artois M., Boue F. Submitted (DEC-2001) to UniProtKB Cited for: PROTEIN SEQUENCE. Tissue: Sperm.

Cross-references

3D structure databases
ModBase	Search...
Family and domain databases
ProtoNet	Search...

Entry information

Entry name

PRDX5_VULVU

Accession

Primary (citable) accession number: P83200

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 4, 2007
Last sequence update:	December 4, 2007
Last modified:	November 4, 2008
This is version 5 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)