P83169 (PLMN_STRCA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Plasminogen
EC=3.4.21.7

Gene names

Name:

PLG

Organism

Struthio camelus (Ostrich)

Taxonomic identifier

8801 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Palaeognathae › Struthioniformes › Struthionidae › Struthio

Protein attributes

Sequence length	33 AA.
Sequence status	Fragments.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation; in ovulation it weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. It cleaves fibrin, fibronectin, thrombospondin, laminin and von Willebrand factor By similarity. UniProtKB P00747
Catalytic activity	Preferential cleavage: Lys-|-Xaa > Arg-|-Xaa; higher selectivity than trypsin. Converts fibrin into soluble products. UniProtKB P00747
Subcellular location	Secreted.
Miscellaneous	Plasmin is inactivated by alpha-2-antiplasmin immediately after dissociation from the clot By similarity. UniProtKB P00747
Sequence similarities	Belongs to the peptidase S1 family. Plasminogen subfamily.
Biophysicochemical properties	pH dependence: Optimum pH is 8. Temperature dependence: Optimum temperature is 40 degrees Celsius.

Ontologies

Keywords
Biological process	Blood coagulation Fibrinolysis
Cellular component	Secreted
Molecular function	Hydrolase Protease Serine protease
PTM	Zymogen
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	blood coagulation Inferred from electronic annotation. Source: UniProtKB-KW fibrinolysis Inferred from electronic annotation. Source: UniProtKB-KW proteolysis Non-traceable author statement Ref.1. Source: UniProtKB
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	serine-type peptidase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – ›33	›33	Plasminogen		PRO_0000088705
Experimental info
	Non-adjacent residues	16 – 17	2
	Non-terminal residue	33	1

Sequences

	Sequence		Length	Mass (Da)
	P83169 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 22BE697EA379E7C2	FASTA	33	3,946
	10 20 30 NILDGYVRXE GAWLLSRIYL DEVEGRDVVY YRT

References

[1]

"Purification and partial characterisation of alpha(2)-antiplasmin and plasmin(ogen) from ostrich plasma." Thomas A.R., Naude R.J., Oelofsen W., Naganuma T., Muramoto K. Comp. Biochem. Physiol. 129B:809-820(2001) [PubMed: 11435135] [Abstract] Cited for: PROTEIN SEQUENCE, CHARACTERIZATION. Tissue: Plasma.

Cross-references

3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
ProtoNet	Search...

Entry information

Entry name

PLMN_STRCA

Accession

Primary (citable) accession number: P83169

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 31, 2004
Last sequence update:	December 1, 2001
Last modified:	May 31, 2011
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program