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Protein

Hemoglobin D subunit alpha

Gene
N/A
Organism
Aldabrachelys gigantea (Aldabra giant tortoise) (Geochelone gigantea)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in oxygen transport from the lung to the various peripheral tissues.By similarity

Miscellaneous

Hemoglobin A is the major, and hemoglobin D the minor hemoglobin of this species.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi58Iron (heme distal ligand)PROSITE-ProRule annotation1
Metal bindingi87Iron (heme proximal ligand)PROSITE-ProRule annotation1

GO - Molecular functioni

Keywordsi

Biological processOxygen transport, Transport
LigandHeme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Hemoglobin D subunit alpha
Alternative name(s):
Hemoglobin D alpha chain
OrganismiAldabrachelys gigantea (Aldabra giant tortoise) (Geochelone gigantea)Curated
Taxonomic identifieri167804 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaTestudinesCryptodiraDurocryptodiraTestudinoideaTestudinidaeAldabrachelys

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000525411 – 141Hemoglobin D subunit alphaAdd BLAST141

Expressioni

Tissue specificityi

Red blood cells.Curated

Interactioni

Subunit structurei

Tetramer of two alpha chains and two beta chains.Curated

Structurei

Secondary structure

1141
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi4 – 17Combined sources14
Helixi18 – 20Combined sources3
Helixi21 – 35Combined sources15
Helixi37 – 42Combined sources6
Helixi53 – 71Combined sources19
Turni72 – 74Combined sources3
Helixi76 – 79Combined sources4
Helixi81 – 89Combined sources9
Helixi95 – 113Combined sources19
Helixi114 – 116Combined sources3
Helixi119 – 136Combined sources18
Helixi138 – 140Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1V75X-ray2.02A1-141[»]
1WMUX-ray1.65A1-141[»]
2Z6NX-ray1.86A1-141[»]
ProteinModelPortaliP83134
SMRiP83134
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP83134

Family & Domainsi

Sequence similaritiesi

Belongs to the globin family.PROSITE-ProRule annotation

Phylogenomic databases

HOVERGENiHBG009709

Family and domain databases

CDDicd08927 Hb-alpha_like, 1 hit
Gene3Di1.10.490.10, 1 hit
InterProiView protein in InterPro
IPR000971 Globin
IPR009050 Globin-like_sf
IPR012292 Globin/Proto
IPR002338 Haemoglobin_a-typ
PfamiView protein in Pfam
PF00042 Globin, 1 hit
PRINTSiPR00612 ALPHAHAEM
SUPFAMiSSF46458 SSF46458, 1 hit
PROSITEiView protein in PROSITE
PS01033 GLOBIN, 1 hit

Sequencei

Sequence statusi: Complete.

P83134-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLTEDDKQLI QHVWEKVLEH QEDFGAEALE RMFIVYPSTK TYFPHFDLHH
60 70 80 90 100
DSEQIRHHGK KVVGALGDAV KHIDNLSATL SELSNLHAYN LRVDPVNFKL
110 120 130 140
LSHCFQVVLG AHLGREYTPQ VQVAYDKFLA AVSAVLAEKY R
Length:141
Mass (Da):16,165
Last modified:December 1, 2001 - v1
Checksum:i2931C3E22597D9D3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB072353 Genomic DNA Translation: BAB68554.1

Similar proteinsi

Entry informationi

Entry nameiHBAD_ALDGI
AccessioniPrimary (citable) accession number: P83134
Secondary accession number(s): Q90Y76
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: December 1, 2001
Last modified: May 23, 2018
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

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