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Protein

Hemoglobin D subunit alpha

Gene
N/A
Organism
Aldabrachelys gigantea (Aldabra giant tortoise) (Geochelone gigantea)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Involved in oxygen transport from the lung to the various peripheral tissues.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi58 – 581Iron (heme distal ligand)PROSITE-ProRule annotation
Metal bindingi87 – 871Iron (heme proximal ligand)PROSITE-ProRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Oxygen transport, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Hemoglobin D subunit alpha
Alternative name(s):
Hemoglobin D alpha chain
OrganismiAldabrachelys gigantea (Aldabra giant tortoise) (Geochelone gigantea)Curated
Taxonomic identifieri167804 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaTestudinesCryptodiraDurocryptodiraTestudinoideaTestudinidaeAldabrachelys

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 141141Hemoglobin D subunit alphaPRO_0000052541Add
BLAST

Expressioni

Tissue specificityi

Red blood cells.Curated

Interactioni

Subunit structurei

Tetramer of two alpha chains and two beta chains.Curated

Structurei

Secondary structure

1
141
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi4 – 1714Combined sources
Helixi18 – 203Combined sources
Helixi21 – 3515Combined sources
Helixi37 – 426Combined sources
Helixi53 – 7119Combined sources
Turni72 – 743Combined sources
Helixi76 – 794Combined sources
Helixi81 – 899Combined sources
Helixi95 – 11319Combined sources
Helixi114 – 1163Combined sources
Helixi119 – 13618Combined sources
Helixi138 – 1403Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1V75X-ray2.02A1-141[»]
1WMUX-ray1.65A1-141[»]
2Z6NX-ray1.86A1-141[»]
ProteinModelPortaliP83134.
SMRiP83134. Positions 1-141.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP83134.

Family & Domainsi

Sequence similaritiesi

Belongs to the globin family.PROSITE-ProRule annotation

Phylogenomic databases

HOVERGENiHBG009709.

Family and domain databases

Gene3Di1.10.490.10. 1 hit.
InterProiIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin/Proto.
IPR002338. Haemoglobin_a.
[Graphical view]
PfamiPF00042. Globin. 1 hit.
[Graphical view]
PRINTSiPR00612. ALPHAHAEM.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiPS01033. GLOBIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P83134-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLTEDDKQLI QHVWEKVLEH QEDFGAEALE RMFIVYPSTK TYFPHFDLHH
60 70 80 90 100
DSEQIRHHGK KVVGALGDAV KHIDNLSATL SELSNLHAYN LRVDPVNFKL
110 120 130 140
LSHCFQVVLG AHLGREYTPQ VQVAYDKFLA AVSAVLAEKY R
Length:141
Mass (Da):16,165
Last modified:December 1, 2001 - v1
Checksum:i2931C3E22597D9D3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB072353 Genomic DNA. Translation: BAB68554.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB072353 Genomic DNA. Translation: BAB68554.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1V75X-ray2.02A1-141[»]
1WMUX-ray1.65A1-141[»]
2Z6NX-ray1.86A1-141[»]
ProteinModelPortaliP83134.
SMRiP83134. Positions 1-141.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG009709.

Miscellaneous databases

EvolutionaryTraceiP83134.

Family and domain databases

Gene3Di1.10.490.10. 1 hit.
InterProiIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin/Proto.
IPR002338. Haemoglobin_a.
[Graphical view]
PfamiPF00042. Globin. 1 hit.
[Graphical view]
PRINTSiPR00612. ALPHAHAEM.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiPS01033. GLOBIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Alpha D-globin gene of hemoglobin D from the Aldabra giant tortoises, Geochelone gigantea."
    Shishikura F.
    Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The amino acid sequences of the alpha- and beta-globin chains of hemoglobin from the Aldabra giant tortoises, Geochelone gigantea."
    Shishikura F., Takami K.
    Zool. Sci. 18:515-526(2001)
    Cited for: PROTEIN SEQUENCE OF 1-20.
    Tissue: Erythrocyte.

Entry informationi

Entry nameiHBAD_ALDGI
AccessioniPrimary (citable) accession number: P83134
Secondary accession number(s): Q90Y76
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: December 1, 2001
Last modified: October 14, 2015
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Hemoglobin A is the major, and hemoglobin D the minor hemoglobin of this species.Curated

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.