P83134 (HBAD_ALDEL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Hemoglobin D subunit alpha Alternative name(s): Hemoglobin D alpha chain
Organism	Aldabrachelys elephantina (Aldabra giant tortoise) (Geochelone gigantea)
Taxonomic identifier	167804 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Testudines › Cryptodira › Testudinoidea › Testudinidae › Dipsochelys

Protein attributes

Sequence length	141 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Involved in oxygen transport from the lung to the various peripheral tissues. UniProtKB P07417
Subunit structure	Tetramer of two alpha chains and two beta chains.
Tissue specificity	Red blood cells.
Miscellaneous	Hemoglobin A is the major, and hemoglobin D the minor hemoglobin of this species.
Sequence similarities	Belongs to the globin family. UniProtKB P07417

Ontologies

Keywords
Biological process	Oxygen transport Transport
Ligand	Heme Iron Metal-binding
Technical term	3D-structure Direct protein sequencing
Gene Ontology (GO)
Cellular component	hemoglobin complex Inferred from electronic annotation. Source: InterPro
Molecular function	heme binding Inferred from electronic annotation. Source: InterPro oxygen binding Inferred from electronic annotation. Source: InterPro oxygen transporter activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 141

141

Hemoglobin D subunit alpha

PRO_0000052541

Sites

Metal binding

58

1

Iron (heme distal ligand) By similarity UniProtKB P07417

Metal binding

87

1

Iron (heme proximal ligand) By similarity UniProtKB P07417

Secondary structure

1

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.

.

141

Helix Strand Turn

Details...

Helix

4 – 17

14

Helix

18 – 20

3

Helix

21 – 35

15

Helix

37 – 42

6

Helix

53 – 71

19

Helix

73 – 75

3

Helix

76 – 89

14

Helix

95 – 113

19

Helix

114 – 116

3

Helix

119 – 137

19

Helix

138 – 140

3

Sequences

	Sequence		Length	Mass (Da)
	P83134 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 2931C3E22597D9D3	FASTA	141	16,165
	10 20 30 40 50 60 MLTEDDKQLI QHVWEKVLEH QEDFGAEALE RMFIVYPSTK TYFPHFDLHH DSEQIRHHGK 70 80 90 100 110 120 KVVGALGDAV KHIDNLSATL SELSNLHAYN LRVDPVNFKL LSHCFQVVLG AHLGREYTPQ 130 140 VQVAYDKFLA AVSAVLAEKY R

References

[1]	"Alpha D-globin gene of hemoglobin D from the Aldabra giant tortoises, Geochelone gigantea." Shishikura F. Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The amino acid sequences of the alpha- and beta-globin chains of hemoglobin from the Aldabra giant tortoises, Geochelone gigantea." Shishikura F., Takami K. Zool. Sci. 18:515-526(2001) Cited for: PROTEIN SEQUENCE OF 1-20. Tissue: Erythrocyte.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AB072353 Genomic DNA. Translation: BAB68554.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1V75	X-ray	2.02	A	1-141	[»]
1WMU	X-ray	1.65	A	1-141	[»]
2Z6N	X-ray	1.86	A	1-141	[»]

ProteinModelPortal

P83134.

SMR

P83134. Positions 1-141.

ModBase

Search...

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Phylogenomic databases

HOVERGEN

HBG009709.

Family and domain databases

InterPro

IPR009050. Globin-like.
IPR012292. Globin_dom.
IPR000971. Globin_subset.
IPR002338. Haemoglobin_a.
[Graphical view]

Gene3D

G3DSA:1.10.490.10. Globin_related. 1 hit.

Pfam

PF00042. Globin. 1 hit.
[Graphical view]

PRINTS

PR00612. ALPHAHAEM.

SUPFAM

SSF46458. Globin_like. 1 hit.

PROSITE

PS01033. GLOBIN. 1 hit.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

HBAD_ALDEL

Accession

Primary (citable) accession number: P83134
Secondary accession number(s): Q90Y76

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 2002
Last sequence update:	December 1, 2001
Last modified:	October 19, 2011
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program