Hemoglobin D subunit alpha - Aldabrachelys elephantina (Aldabra giant tortoise)

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Reviewed, UniProtKB/Swiss-Prot P83134 (HBAD_ALDEL)

Last modified November 24, 2009. Version 50. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein names	Recommended name: Hemoglobin D subunit alpha Alternative name(s): Hemoglobin D alpha chain
Organism	Aldabrachelys elephantina (Aldabra giant tortoise) (Geochelone gigantea)
Taxonomic identifier	167804 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Testudines › Cryptodira › Testudinoidea › Testudinidae › Dipsochelys

Protein attributes

Sequence length	141 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Involved in oxygen transport from the lung to the various peripheral tissues. UniProtKB P07417
Subunit structure	Tetramer of two alpha chains and two beta chains.
Tissue specificity	Red blood cells.
Miscellaneous	Hemoglobin A is the major, and hemoglobin D the minor hemoglobin of this species.
Sequence similarities	Belongs to the globin family.

Ontologies

Keywords
Biological process	Oxygen transport Transport
Ligand	Heme Iron Metal-binding
Technical term	3D-structure Direct protein sequencing
Gene Ontology (GO)
Biological process	oxygen transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	hemoglobin complex Inferred from electronic annotation. Source: InterPro
Molecular function	heme binding Inferred from electronic annotation. Source: InterPro oxygen binding Inferred from electronic annotation. Source: InterPro oxygen transporter activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

141

Hemoglobin D subunit alpha

PRO_0000052541

Sites

Metal binding

1

Iron (heme distal ligand) By similarity UniProtKB P07417

Metal binding

1

Iron (heme proximal ligand) By similarity UniProtKB P07417

Secondary structure

1

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141

Helix Strand Turn

Sequences

Sequence

Length

Mass (Da)

Tools

P83134-1 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 2931C3E22597D9D3
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141

16,165

        10         20         30         40         50         60 
MLTEDDKQLI QHVWEKVLEH QEDFGAEALE RMFIVYPSTK TYFPHFDLHH DSEQIRHHGK 

        70         80         90        100        110        120 
KVVGALGDAV KHIDNLSATL SELSNLHAYN LRVDPVNFKL LSHCFQVVLG AHLGREYTPQ 

       130        140 
VQVAYDKFLA AVSAVLAEKY R

References

[1]	"Alpha D-globin gene of hemoglobin D from the Aldabra giant tortoises, Geochelone gigantea." Shishikura F. Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The amino acid sequences of the alpha- and beta-globin chains of hemoglobin from the Aldabra giant tortoises, Geochelone gigantea." Shishikura F., Takami K. Zool. Sci. 18:515-526(2001) Cited for: PROTEIN SEQUENCE OF 1-20. Tissue: Erythrocyte.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AB072353 Genomic DNA. Translation: BAB68554.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1V75	X-ray	2.02	A	1-141	[»]
1WMU	X-ray	1.65	A	1-141	[»]
2Z6N	X-ray	1.86	A	1-141	[»]

ModBase

Phylogenomic databases

HOVERGEN

Family and domain databases

InterPro

IPR012292. Globin.
IPR009050. Globin-like.
IPR000971. Globin_subset.
IPR002338. Haemoglobin_a.
IPR018331. Haemoglobin_alpha_chain.
[Graphical view]

Gene3D

G3DSA:1.10.490.10. Globin_related. 1 hit.

PANTHER

PTHR11442:SF14. Pi_haem. 1 hit.

Pfam

PF00042. Globin. 1 hit.
[Graphical view]

PRINTS

PR00612. ALPHAHAEM.

PROSITE

PS01033. GLOBIN. 1 hit.
[Graphical view]

ProtoNet

Entry information

Entry name

HBAD_ALDEL

Accession

Primary (citable) accession number: P83134
Secondary accession number(s): Q90Y76

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 2002
Last sequence update:	December 1, 2001
Last modified:	November 24, 2009
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents