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Protein

Hemoglobin A/D subunit beta

Gene
N/A
Organism
Aldabrachelys gigantea (Aldabra giant tortoise) (Geochelone gigantea)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Involved in oxygen transport from the lung to the various peripheral tissues.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi63 – 631Iron (heme distal ligand)PROSITE-ProRule annotation
Metal bindingi92 – 921Iron (heme proximal ligand)PROSITE-ProRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Oxygen transport, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Hemoglobin A/D subunit beta
Alternative name(s):
Hemoglobin A/D beta chain
OrganismiAldabrachelys gigantea (Aldabra giant tortoise) (Geochelone gigantea)Curated
Taxonomic identifieri167804 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaTestudinesCryptodiraDurocryptodiraTestudinoideaTestudinidaeAldabrachelys

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 146146Hemoglobin A/D subunit betaPRO_0000052861Add
BLAST

Expressioni

Tissue specificityi

Red blood cells.Curated

Interactioni

Subunit structurei

Hemoglobins A and D are heterotetramers of alpha-1, alpha-2 and two identical beta chains.Curated

Structurei

Secondary structure

1
146
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi5 – 1511Combined sources
Helixi20 – 3415Combined sources
Helixi36 – 4510Combined sources
Helixi51 – 555Combined sources
Helixi58 – 7518Combined sources
Helixi76 – 805Combined sources
Helixi81 – 844Combined sources
Helixi86 – 949Combined sources
Helixi101 – 11717Combined sources
Turni119 – 1213Combined sources
Helixi124 – 14219Combined sources
Turni143 – 1453Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1V75X-ray2.02B1-146[»]
1WMUX-ray1.65B1-146[»]
2Z6NX-ray1.86B1-146[»]
ProteinModelPortaliP83133.
SMRiP83133. Positions 1-146.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP83133.

Family & Domainsi

Sequence similaritiesi

Belongs to the globin family.PROSITE-ProRule annotation

Phylogenomic databases

HOVERGENiHBG009709.

Family and domain databases

Gene3Di1.10.490.10. 1 hit.
InterProiIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin/Proto.
IPR002337. Haemoglobin_b.
[Graphical view]
PfamiPF00042. Globin. 1 hit.
[Graphical view]
PRINTSiPR00814. BETAHAEM.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiPS01033. GLOBIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P83133-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
VHWTSEEKQY ITSLWAKVNV GEVGGEALAR LLIVYPWTQR FFASFGNLSS
60 70 80 90 100
ANAILHNAKV LAHGQKVLTS FGEAVKNLDN IKKTFAQLSE LHCEKLHVDP
110 120 130 140
ENFKLLGNIL IIVLATHFPK EFTPASQAAW TKLVNAVAHA LALGYH
Length:146
Mass (Da):16,174
Last modified:December 1, 2001 - v1
Checksum:iA66CB0866946902F
GO

Cross-referencesi

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1V75X-ray2.02B1-146[»]
1WMUX-ray1.65B1-146[»]
2Z6NX-ray1.86B1-146[»]
ProteinModelPortaliP83133.
SMRiP83133. Positions 1-146.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG009709.

Miscellaneous databases

EvolutionaryTraceiP83133.

Family and domain databases

Gene3Di1.10.490.10. 1 hit.
InterProiIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin/Proto.
IPR002337. Haemoglobin_b.
[Graphical view]
PfamiPF00042. Globin. 1 hit.
[Graphical view]
PRINTSiPR00814. BETAHAEM.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiPS01033. GLOBIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The amino acid sequences of the alpha- and beta-globin chains of hemoglobin from the Aldabra giant tortoises, Geochelone gigantea."
    Shishikura F., Takami K.
    Zool. Sci. 18:515-526(2001)
    Cited for: PROTEIN SEQUENCE.
    Tissue: Erythrocyte.

Entry informationi

Entry nameiHBB_ALDGI
AccessioniPrimary (citable) accession number: P83133
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: December 1, 2001
Last modified: November 11, 2015
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Hemoglobin A is the major, and hemoglobin D the minor hemoglobin of this species.Curated

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.