P83133 (HBB_ALDEL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Hemoglobin A/D subunit beta Alternative name(s): Hemoglobin A/D beta chain
Organism	Aldabrachelys elephantina (Aldabra giant tortoise) (Geochelone gigantea)
Taxonomic identifier	167804 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Testudines › Cryptodira › Testudinoidea › Testudinidae › Dipsochelys

Protein attributes

Sequence length	146 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Involved in oxygen transport from the lung to the various peripheral tissues. UniProtKB P13274
Subunit structure	Hemoglobins A and D are heterotetramers of alpha-1, alpha-2 and two identical beta chains.
Tissue specificity	Red blood cells.
Miscellaneous	Hemoglobin A is the major, and hemoglobin D the minor hemoglobin of this species.
Sequence similarities	Belongs to the globin family. UniProtKB P13274

Ontologies

Keywords
Biological process	Oxygen transport Transport
Ligand	Heme Iron Metal-binding
Technical term	3D-structure Direct protein sequencing
Gene Ontology (GO)
Cellular component	hemoglobin complex Inferred from electronic annotation. Source: InterPro
Molecular function	heme binding Inferred from electronic annotation. Source: InterPro oxygen binding Inferred from electronic annotation. Source: InterPro oxygen transporter activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 146

146

Hemoglobin A/D subunit beta

PRO_0000052861

Sites

Metal binding

63

1

Iron (heme distal ligand) By similarity UniProtKB P13274

Metal binding

92

1

Iron (heme proximal ligand) By similarity UniProtKB P13274

Secondary structure

1

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146

Helix Strand Turn

Details...

Helix

5 – 15

11

Helix

20 – 34

15

Helix

36 – 45

10

Helix

51 – 55

5

Helix

58 – 75

18

Turn

76 – 79

4

Helix

81 – 93

13

Turn

94 – 96

3

Helix

101 – 117

17

Turn

119 – 121

3

Helix

124 – 142

19

Sequences

	Sequence		Length	Mass (Da)
	P83133 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: A66CB0866946902F	FASTA	146	16,174
	10 20 30 40 50 60 VHWTSEEKQY ITSLWAKVNV GEVGGEALAR LLIVYPWTQR FFASFGNLSS ANAILHNAKV 70 80 90 100 110 120 LAHGQKVLTS FGEAVKNLDN IKKTFAQLSE LHCEKLHVDP ENFKLLGNIL IIVLATHFPK 130 140 EFTPASQAAW TKLVNAVAHA LALGYH

References

[1]	"The amino acid sequences of the alpha- and beta-globin chains of hemoglobin from the Aldabra giant tortoises, Geochelone gigantea." Shishikura F., Takami K. Zool. Sci. 18:515-526(2001) Cited for: PROTEIN SEQUENCE. Tissue: Erythrocyte.
+	Additional computationally mapped references.

Cross-references

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1V75	X-ray	2.02	B	1-146	[»]
1WMU	X-ray	1.65	B	1-146	[»]
2Z6N	X-ray	1.86	B	1-146	[»]

ProteinModelPortal

P83133.

SMR

P83133. Positions 1-146.

ModBase

Search...

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Phylogenomic databases

HOVERGEN

HBG009709.

Family and domain databases

InterPro

IPR009050. Globin-like.
IPR012292. Globin_dom.
IPR000971. Globin_subset.
IPR002337. Haemoglobin_b.
[Graphical view]

Gene3D

G3DSA:1.10.490.10. Globin_related. 1 hit.

PANTHER

PTHR11442:SF7. Beta_haem. 1 hit.

Pfam

PF00042. Globin. 1 hit.
[Graphical view]

PRINTS

PR00814. BETAHAEM.

SUPFAM

SSF46458. Globin_like. 1 hit.

PROSITE

PS01033. GLOBIN. 1 hit.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

HBB_ALDEL

Accession

Primary (citable) accession number: P83133

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 2002
Last sequence update:	December 1, 2001
Last modified:	October 19, 2011
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program