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Protein

Hemoglobin A/D subunit beta

Gene
N/A
Organism
Aldabrachelys gigantea (Aldabra giant tortoise) (Geochelone gigantea)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Involved in oxygen transport from the lung to the various peripheral tissues.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi63Iron (heme distal ligand)PROSITE-ProRule annotation1
Metal bindingi92Iron (heme proximal ligand)PROSITE-ProRule annotation1

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Oxygen transport, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Hemoglobin A/D subunit beta
Alternative name(s):
Hemoglobin A/D beta chain
OrganismiAldabrachelys gigantea (Aldabra giant tortoise) (Geochelone gigantea)Curated
Taxonomic identifieri167804 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaTestudinesCryptodiraDurocryptodiraTestudinoideaTestudinidaeAldabrachelys

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000528611 – 146Hemoglobin A/D subunit betaAdd BLAST146

Proteomic databases

PRIDEiP83133.

Expressioni

Tissue specificityi

Red blood cells.Curated

Interactioni

Subunit structurei

Hemoglobins A and D are heterotetramers of alpha-1, alpha-2 and two identical beta chains.Curated

Structurei

Secondary structure

1146
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi5 – 15Combined sources11
Helixi20 – 34Combined sources15
Helixi36 – 45Combined sources10
Helixi51 – 55Combined sources5
Helixi58 – 75Combined sources18
Helixi76 – 80Combined sources5
Helixi81 – 84Combined sources4
Helixi86 – 94Combined sources9
Helixi101 – 117Combined sources17
Turni119 – 121Combined sources3
Helixi124 – 142Combined sources19
Turni143 – 145Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1V75X-ray2.02B1-146[»]
1WMUX-ray1.65B1-146[»]
2Z6NX-ray1.86B1-146[»]
ProteinModelPortaliP83133.
SMRiP83133.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP83133.

Family & Domainsi

Sequence similaritiesi

Belongs to the globin family.PROSITE-ProRule annotation

Phylogenomic databases

HOVERGENiHBG009709.

Family and domain databases

CDDicd08925. Hb-beta_like. 1 hit.
Gene3Di1.10.490.10. 1 hit.
InterProiIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin/Proto.
IPR002337. Haemoglobin_b.
[Graphical view]
PfamiPF00042. Globin. 1 hit.
[Graphical view]
PRINTSiPR00814. BETAHAEM.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiPS01033. GLOBIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P83133-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
VHWTSEEKQY ITSLWAKVNV GEVGGEALAR LLIVYPWTQR FFASFGNLSS
60 70 80 90 100
ANAILHNAKV LAHGQKVLTS FGEAVKNLDN IKKTFAQLSE LHCEKLHVDP
110 120 130 140
ENFKLLGNIL IIVLATHFPK EFTPASQAAW TKLVNAVAHA LALGYH
Length:146
Mass (Da):16,174
Last modified:December 1, 2001 - v1
Checksum:iA66CB0866946902F
GO

Cross-referencesi

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1V75X-ray2.02B1-146[»]
1WMUX-ray1.65B1-146[»]
2Z6NX-ray1.86B1-146[»]
ProteinModelPortaliP83133.
SMRiP83133.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP83133.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG009709.

Miscellaneous databases

EvolutionaryTraceiP83133.

Family and domain databases

CDDicd08925. Hb-beta_like. 1 hit.
Gene3Di1.10.490.10. 1 hit.
InterProiIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin/Proto.
IPR002337. Haemoglobin_b.
[Graphical view]
PfamiPF00042. Globin. 1 hit.
[Graphical view]
PRINTSiPR00814. BETAHAEM.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiPS01033. GLOBIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHBB_ALDGI
AccessioniPrimary (citable) accession number: P83133
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: December 1, 2001
Last modified: November 2, 2016
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Hemoglobin A is the major, and hemoglobin D the minor hemoglobin of this species.Curated

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.