P83127 (NAGAB_BOSIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Alpha-N-acetylgalactosaminidase
EC=3.2.1.49

Alternative name(s):
Alpha-galactosidase B

Gene names

Name:

NAGA

Organism

Bos indicus (Zebu)

Taxonomic identifier

9915 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	12 AA.
Sequence status	Fragment.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Removes terminal alpha-N-acetylgalactosamine residues from glycolipids and glycopeptides. Required for the breakdown of glycolipids By similarity.
Catalytic activity	Cleavage of non-reducing alpha-(1->3)-N-acetylgalactosamine residues from human blood group A and AB mucin glycoproteins, Forssman hapten and blood group A lacto series glycolipids.
Subunit structure	Homodimer By similarity.
Subcellular location	Lysosome By similarity.
Tissue specificity	Placenta. Ref.1
Post-translational modification	Glycosylated. Ref.1
Sequence similarities	Belongs to the glycosyl hydrolase 27 family.

Ontologies

Keywords
Cellular component	Lysosome
Molecular function	Glycosidase Hydrolase
PTM	Glycoprotein
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological_process	carbohydrate catabolic process Inferred from sequence or structural similarity. Source: UniProtKB glycolipid catabolic process Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	lysosome Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	alpha-N-acetylgalactosaminidase activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – ›12	›12	Alpha-N-acetylgalactosaminidase		PRO_0000134872
Experimental info
	Non-terminal residue	12	1

Sequences

	Sequence		Length	Mass (Da)
	P83127 [UniParc]. Last modified June 1, 2002. Version 1. Checksum: 53B124381F240727	FASTA	12	1,325
	10 LENGLLRKPP MG

References

[1]

"Characterization of pregnancy-associated glycoproteins extracted from zebu (Bos indicus) placentas removed at different gestational periods." Sousa N.M., Remy B., El Amiri B., De Figueiredo J.R., Banga-Mboko H., Dias Goncalves P.B., Beckers J.-F.M.P. Reprod. Nutr. Dev. 42:227-241(2002) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE, TISSUE SPECIFICITY, GLYCOSYLATION. Tissue: Fetal cotyledon.

Cross-references

3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
PROSITE	PS00512. ALPHA_GALACTOSIDASE. Partial match. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NAGAB_BOSIN

Accession

Primary (citable) accession number: P83127

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 4, 2005
Last sequence update:	June 1, 2002
Last modified:	October 19, 2011
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program