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P83119

- MTH12_DROME

UniProt

P83119 - MTH12_DROME

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Protein
Probable G-protein coupled receptor Mth-like 12
Gene
mthl12, Mth-like-12, CG32853
Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. determination of adult lifespan Source: UniProtKB
  2. response to starvation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor Mth-like 12
Alternative name(s):
Protein methuselah-like 12
Gene namesi
Name:mthl12
Synonyms:Mth-like-12
ORF Names:CG32853
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0045442. mthl12.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini18 – 215198Extracellular Reviewed prediction
Add
BLAST
Transmembranei216 – 23621Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini237 – 24711Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei248 – 26821Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini269 – 28315Extracellular Reviewed prediction
Add
BLAST
Transmembranei284 – 30421Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini305 – 31511Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei316 – 33621Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini337 – 37337Extracellular Reviewed prediction
Add
BLAST
Transmembranei374 – 39421Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini395 – 41622Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei417 – 43721Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini438 – 45417Extracellular Reviewed prediction
Add
BLAST
Transmembranei455 – 47521Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini476 – 48813Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717 Reviewed prediction
Add
BLAST
Chaini18 – 488471Probable G-protein coupled receptor Mth-like 12
PRO_0000013035Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi19 – 191N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi27 ↔ 81 By similarity
Glycosylationi34 – 341N-linked (GlcNAc...) Reviewed prediction
Glycosylationi55 – 551N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi83 ↔ 88 By similarity
Disulfide bondi92 ↔ 189 By similarity
Disulfide bondi93 ↔ 104 By similarity
Glycosylationi141 – 1411N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi155 ↔ 209 By similarity
Glycosylationi365 – 3651N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP83119.

Interactioni

Protein-protein interaction databases

STRINGi7227.FBpp0082214.

Structurei

3D structure databases

ProteinModelPortaliP83119.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4193.
GeneTreeiENSGT00530000064566.
InParanoidiP83119.
OrthoDBiEOG75QR3P.
PhylomeDBiP83119.

Family and domain databases

Gene3Di2.170.180.11. 1 hit.
InterProiIPR022343. GCR1-cAMP_receptor.
IPR017981. GPCR_2-like.
IPR023311. Methusela_ecto_dom_2.
IPR010596. Methuselah_N_dom.
[Graphical view]
PfamiPF06652. Methuselah_N. 1 hit.
[Graphical view]
PRINTSiPR02001. GCR1CAMPR.
PROSITEiPS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P83119-1 [UniParc]FASTAAdd to Basket

« Hide

MFLWLKCFCT LIIVTIAKNS SAKIPHCKYD ETINISHFKR LNDAYIYEHF    50
EIPANLTGEF DYKELMDGSK VPTEFPNLRG CICKVRPCIR ICCARKNILS 100
NGECSDGVKN EIKLTMLDLT MQDILLTDPT LAELNMIPQY NSTELLILRE 150
QFQPCDEIVS LKRDEYTILK DGSILLHTSA EILSNDQYCL YPEIYSDFPE 200
TIRIINRRCY RNVMPGIAQL SVISVVGFIL TLAVYLSVEK LRNLLGKCLI 250
CSLFSMFMEY FIWTMDYFRL LQSICSAAGY MKYFFSMSSY LWFSVVSFHL 300
WELFTSLNRH EPQYRFLIYN TFVWCTAAIP TVVIFSMNQM WENDPGKSEW 350
LPLVGYFGCS VKDWNSSSWF YSHIPIVILN SFNVIMFVLT AIYIWKVKKG 400
VKSFAQHDER NTTCLEFNVQ TYIQFVRLFL IMGASWLLDQ LTRLAEDSHL 450
LLDTIVLNLT VYLNAAFGIL IFVLLILKGS TFKMIMER 488
Length:488
Mass (Da):56,781
Last modified:July 11, 2003 - v2
Checksum:i3CE6B05F8D1DC103
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014297 Genomic DNA. Translation: AAN13556.2.
RefSeqiNP_731791.2. NM_169508.2.
UniGeneiDm.26413.

Genome annotation databases

EnsemblMetazoaiFBtr0082746; FBpp0082214; FBgn0045442.
GeneIDi261599.
KEGGidme:Dmel_CG32853.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014297 Genomic DNA. Translation: AAN13556.2 .
RefSeqi NP_731791.2. NM_169508.2.
UniGenei Dm.26413.

3D structure databases

ProteinModelPortali P83119.
ModBasei Search...

Protein-protein interaction databases

STRINGi 7227.FBpp0082214.

Protein family/group databases

GPCRDBi Search...

Proteomic databases

PaxDbi P83119.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0082746 ; FBpp0082214 ; FBgn0045442 .
GeneIDi 261599.
KEGGi dme:Dmel_CG32853.

Organism-specific databases

CTDi 261599.
FlyBasei FBgn0045442. mthl12.

Phylogenomic databases

eggNOGi KOG4193.
GeneTreei ENSGT00530000064566.
InParanoidi P83119.
OrthoDBi EOG75QR3P.
PhylomeDBi P83119.

Miscellaneous databases

GenomeRNAii 261599.
NextBioi 843695.

Family and domain databases

Gene3Di 2.170.180.11. 1 hit.
InterProi IPR022343. GCR1-cAMP_receptor.
IPR017981. GPCR_2-like.
IPR023311. Methusela_ecto_dom_2.
IPR010596. Methuselah_N_dom.
[Graphical view ]
Pfami PF06652. Methuselah_N. 1 hit.
[Graphical view ]
PRINTSi PR02001. GCR1CAMPR.
PROSITEi PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  2. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  3. "Crystal structure of the ectodomain of Methuselah, a Drosophila G protein-coupled receptor associated with extended lifespan."
    West A.P. Jr., Llamas L.L., Snow P.M., Benzer S., Bjorkman P.J.
    Proc. Natl. Acad. Sci. U.S.A. 98:3744-3749(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiMTH12_DROME
AccessioniPrimary (citable) accession number: P83119
Secondary accession number(s): Q8INH4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: July 11, 2003
Last modified: July 9, 2014
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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