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Protein

Probable G-protein coupled receptor Mth-like 12

Gene

mthl12

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: FlyBase

GO - Biological processi

  1. determination of adult lifespan Source: UniProtKB
  2. G-protein coupled receptor signaling pathway Source: FlyBase
  3. response to starvation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor Mth-like 12
Alternative name(s):
Protein methuselah-like 12
Gene namesi
Name:mthl12
Synonyms:Mth-like-12
ORF Names:CG32853
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0045442. mthl12.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini18 – 215198ExtracellularSequence AnalysisAdd
BLAST
Transmembranei216 – 23621Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini237 – 24711CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei248 – 26821Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini269 – 28315ExtracellularSequence AnalysisAdd
BLAST
Transmembranei284 – 30421Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini305 – 31511CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei316 – 33621Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini337 – 37337ExtracellularSequence AnalysisAdd
BLAST
Transmembranei374 – 39421Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini395 – 41622CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei417 – 43721Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini438 – 45417ExtracellularSequence AnalysisAdd
BLAST
Transmembranei455 – 47521Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini476 – 48813CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: FlyBase
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence AnalysisAdd
BLAST
Chaini18 – 488471Probable G-protein coupled receptor Mth-like 12PRO_0000013035Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi19 – 191N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi27 ↔ 81By similarity
Glycosylationi34 – 341N-linked (GlcNAc...)Sequence Analysis
Glycosylationi55 – 551N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi83 ↔ 88By similarity
Disulfide bondi92 ↔ 189By similarity
Disulfide bondi93 ↔ 104By similarity
Glycosylationi141 – 1411N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi155 ↔ 209By similarity
Glycosylationi365 – 3651N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP83119.

Interactioni

Protein-protein interaction databases

STRINGi7227.FBpp0082214.

Structurei

3D structure databases

ProteinModelPortaliP83119.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4193.
GeneTreeiENSGT00530000064566.
InParanoidiP83119.
OMAiCIRICCA.
OrthoDBiEOG75QR3P.
PhylomeDBiP83119.

Family and domain databases

Gene3Di2.170.180.11. 1 hit.
InterProiIPR022343. GCR1-cAMP_receptor.
IPR017981. GPCR_2-like.
IPR023311. Methusela_ecto_dom_2.
IPR010596. Methuselah_N_dom.
[Graphical view]
PfamiPF06652. Methuselah_N. 1 hit.
[Graphical view]
PRINTSiPR02001. GCR1CAMPR.
PROSITEiPS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P83119-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFLWLKCFCT LIIVTIAKNS SAKIPHCKYD ETINISHFKR LNDAYIYEHF
60 70 80 90 100
EIPANLTGEF DYKELMDGSK VPTEFPNLRG CICKVRPCIR ICCARKNILS
110 120 130 140 150
NGECSDGVKN EIKLTMLDLT MQDILLTDPT LAELNMIPQY NSTELLILRE
160 170 180 190 200
QFQPCDEIVS LKRDEYTILK DGSILLHTSA EILSNDQYCL YPEIYSDFPE
210 220 230 240 250
TIRIINRRCY RNVMPGIAQL SVISVVGFIL TLAVYLSVEK LRNLLGKCLI
260 270 280 290 300
CSLFSMFMEY FIWTMDYFRL LQSICSAAGY MKYFFSMSSY LWFSVVSFHL
310 320 330 340 350
WELFTSLNRH EPQYRFLIYN TFVWCTAAIP TVVIFSMNQM WENDPGKSEW
360 370 380 390 400
LPLVGYFGCS VKDWNSSSWF YSHIPIVILN SFNVIMFVLT AIYIWKVKKG
410 420 430 440 450
VKSFAQHDER NTTCLEFNVQ TYIQFVRLFL IMGASWLLDQ LTRLAEDSHL
460 470 480
LLDTIVLNLT VYLNAAFGIL IFVLLILKGS TFKMIMER
Length:488
Mass (Da):56,781
Last modified:July 11, 2003 - v2
Checksum:i3CE6B05F8D1DC103
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA. Translation: AAN13556.2.
RefSeqiNP_731791.2. NM_169508.2.
UniGeneiDm.26413.

Genome annotation databases

EnsemblMetazoaiFBtr0082746; FBpp0082214; FBgn0045442.
GeneIDi261599.
KEGGidme:Dmel_CG32853.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA. Translation: AAN13556.2.
RefSeqiNP_731791.2. NM_169508.2.
UniGeneiDm.26413.

3D structure databases

ProteinModelPortaliP83119.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7227.FBpp0082214.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiP83119.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0082746; FBpp0082214; FBgn0045442.
GeneIDi261599.
KEGGidme:Dmel_CG32853.

Organism-specific databases

CTDi261599.
FlyBaseiFBgn0045442. mthl12.

Phylogenomic databases

eggNOGiKOG4193.
GeneTreeiENSGT00530000064566.
InParanoidiP83119.
OMAiCIRICCA.
OrthoDBiEOG75QR3P.
PhylomeDBiP83119.

Miscellaneous databases

GenomeRNAii261599.
NextBioi843695.

Family and domain databases

Gene3Di2.170.180.11. 1 hit.
InterProiIPR022343. GCR1-cAMP_receptor.
IPR017981. GPCR_2-like.
IPR023311. Methusela_ecto_dom_2.
IPR010596. Methuselah_N_dom.
[Graphical view]
PfamiPF06652. Methuselah_N. 1 hit.
[Graphical view]
PRINTSiPR02001. GCR1CAMPR.
PROSITEiPS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  2. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  3. "Crystal structure of the ectodomain of Methuselah, a Drosophila G protein-coupled receptor associated with extended lifespan."
    West A.P. Jr., Llamas L.L., Snow P.M., Benzer S., Bjorkman P.J.
    Proc. Natl. Acad. Sci. U.S.A. 98:3744-3749(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiMTH12_DROME
AccessioniPrimary (citable) accession number: P83119
Secondary accession number(s): Q8INH4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: July 11, 2003
Last modified: February 4, 2015
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.