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P83119

- MTH12_DROME

UniProt

P83119 - MTH12_DROME

Protein

Probable G-protein coupled receptor Mth-like 12

Gene

mthl12

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 2 (11 Jul 2003)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW

    GO - Biological processi

    1. determination of adult lifespan Source: UniProtKB
    2. response to starvation Source: UniProtKB

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable G-protein coupled receptor Mth-like 12
    Alternative name(s):
    Protein methuselah-like 12
    Gene namesi
    Name:mthl12
    Synonyms:Mth-like-12
    ORF Names:CG32853
    OrganismiDrosophila melanogaster (Fruit fly)
    Taxonomic identifieri7227 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000000803: Chromosome 3R

    Organism-specific databases

    FlyBaseiFBgn0045442. mthl12.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1717Sequence AnalysisAdd
    BLAST
    Chaini18 – 488471Probable G-protein coupled receptor Mth-like 12PRO_0000013035Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi19 – 191N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi27 ↔ 81By similarity
    Glycosylationi34 – 341N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi55 – 551N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi83 ↔ 88By similarity
    Disulfide bondi92 ↔ 189By similarity
    Disulfide bondi93 ↔ 104By similarity
    Glycosylationi141 – 1411N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi155 ↔ 209By similarity
    Glycosylationi365 – 3651N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP83119.

    Interactioni

    Protein-protein interaction databases

    STRINGi7227.FBpp0082214.

    Structurei

    3D structure databases

    ProteinModelPortaliP83119.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini18 – 215198ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini237 – 24711CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini269 – 28315ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini305 – 31511CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini337 – 37337ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini395 – 41622CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini438 – 45417ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini476 – 48813CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei216 – 23621Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei248 – 26821Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei284 – 30421Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei316 – 33621Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei374 – 39421Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei417 – 43721Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei455 – 47521Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiKOG4193.
    GeneTreeiENSGT00530000064566.
    InParanoidiP83119.
    OrthoDBiEOG75QR3P.
    PhylomeDBiP83119.

    Family and domain databases

    Gene3Di2.170.180.11. 1 hit.
    InterProiIPR022343. GCR1-cAMP_receptor.
    IPR017981. GPCR_2-like.
    IPR023311. Methusela_ecto_dom_2.
    IPR010596. Methuselah_N_dom.
    [Graphical view]
    PfamiPF06652. Methuselah_N. 1 hit.
    [Graphical view]
    PRINTSiPR02001. GCR1CAMPR.
    PROSITEiPS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P83119-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFLWLKCFCT LIIVTIAKNS SAKIPHCKYD ETINISHFKR LNDAYIYEHF    50
    EIPANLTGEF DYKELMDGSK VPTEFPNLRG CICKVRPCIR ICCARKNILS 100
    NGECSDGVKN EIKLTMLDLT MQDILLTDPT LAELNMIPQY NSTELLILRE 150
    QFQPCDEIVS LKRDEYTILK DGSILLHTSA EILSNDQYCL YPEIYSDFPE 200
    TIRIINRRCY RNVMPGIAQL SVISVVGFIL TLAVYLSVEK LRNLLGKCLI 250
    CSLFSMFMEY FIWTMDYFRL LQSICSAAGY MKYFFSMSSY LWFSVVSFHL 300
    WELFTSLNRH EPQYRFLIYN TFVWCTAAIP TVVIFSMNQM WENDPGKSEW 350
    LPLVGYFGCS VKDWNSSSWF YSHIPIVILN SFNVIMFVLT AIYIWKVKKG 400
    VKSFAQHDER NTTCLEFNVQ TYIQFVRLFL IMGASWLLDQ LTRLAEDSHL 450
    LLDTIVLNLT VYLNAAFGIL IFVLLILKGS TFKMIMER 488
    Length:488
    Mass (Da):56,781
    Last modified:July 11, 2003 - v2
    Checksum:i3CE6B05F8D1DC103
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014297 Genomic DNA. Translation: AAN13556.2.
    RefSeqiNP_731791.2. NM_169508.2.
    UniGeneiDm.26413.

    Genome annotation databases

    EnsemblMetazoaiFBtr0082746; FBpp0082214; FBgn0045442.
    GeneIDi261599.
    KEGGidme:Dmel_CG32853.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014297 Genomic DNA. Translation: AAN13556.2 .
    RefSeqi NP_731791.2. NM_169508.2.
    UniGenei Dm.26413.

    3D structure databases

    ProteinModelPortali P83119.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7227.FBpp0082214.

    Protein family/group databases

    GPCRDBi Search...

    Proteomic databases

    PaxDbi P83119.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0082746 ; FBpp0082214 ; FBgn0045442 .
    GeneIDi 261599.
    KEGGi dme:Dmel_CG32853.

    Organism-specific databases

    CTDi 261599.
    FlyBasei FBgn0045442. mthl12.

    Phylogenomic databases

    eggNOGi KOG4193.
    GeneTreei ENSGT00530000064566.
    InParanoidi P83119.
    OrthoDBi EOG75QR3P.
    PhylomeDBi P83119.

    Miscellaneous databases

    GenomeRNAii 261599.
    NextBioi 843695.

    Family and domain databases

    Gene3Di 2.170.180.11. 1 hit.
    InterProi IPR022343. GCR1-cAMP_receptor.
    IPR017981. GPCR_2-like.
    IPR023311. Methusela_ecto_dom_2.
    IPR010596. Methuselah_N_dom.
    [Graphical view ]
    Pfami PF06652. Methuselah_N. 1 hit.
    [Graphical view ]
    PRINTSi PR02001. GCR1CAMPR.
    PROSITEi PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Drosophila melanogaster."
      Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
      , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
      Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Berkeley.
    2. Cited for: GENOME REANNOTATION.
      Strain: Berkeley.
    3. "Crystal structure of the ectodomain of Methuselah, a Drosophila G protein-coupled receptor associated with extended lifespan."
      West A.P. Jr., Llamas L.L., Snow P.M., Benzer S., Bjorkman P.J.
      Proc. Natl. Acad. Sci. U.S.A. 98:3744-3749(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiMTH12_DROME
    AccessioniPrimary (citable) accession number: P83119
    Secondary accession number(s): Q8INH4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 2, 2001
    Last sequence update: July 11, 2003
    Last modified: October 1, 2014
    This is version 93 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3