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P83111

- LACTB_HUMAN

UniProt

P83111 - LACTB_HUMAN

Protein

Serine beta-lactamase-like protein LACTB, mitochondrial

Gene

LACTB

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 2 (13 Apr 2004)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei164 – 1641Acyl-ester intermediateBy similarity

    GO - Molecular functioni

    1. hydrolase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Protein family/group databases

    MEROPSiS12.004.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine beta-lactamase-like protein LACTB, mitochondrial (EC:3.4.-.-)
    Gene namesi
    Name:LACTB
    Synonyms:MRPL56
    ORF Names:UNQ843/PRO1781
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 15

    Organism-specific databases

    HGNCiHGNC:16468. LACTB.

    Subcellular locationi

    Mitochondrion 2 Publications

    GO - Cellular componenti

    1. cytoplasm Source: HPA
    2. mitochondrion Source: UniProt

    Keywords - Cellular componenti

    Mitochondrion

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30262.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 115115MitochondrionSequence AnalysisAdd
    BLAST
    Chaini116 – 547432Serine beta-lactamase-like protein LACTB, mitochondrialPRO_0000195476Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei283 – 2831N6-succinyllysineBy similarity
    Modified residuei284 – 2841N6-succinyllysineBy similarity
    Modified residuei297 – 2971N6-acetyllysineBy similarity
    Modified residuei342 – 3421N6-acetyllysine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiP83111.
    PaxDbiP83111.
    PRIDEiP83111.

    PTM databases

    PhosphoSiteiP83111.

    Expressioni

    Tissue specificityi

    Expressed predominantly in skeletal muscle.

    Gene expression databases

    ArrayExpressiP83111.
    BgeeiP83111.
    CleanExiHS_LACTB.
    GenevestigatoriP83111.

    Organism-specific databases

    HPAiHPA036361.
    HPA036362.

    Interactioni

    Protein-protein interaction databases

    BioGridi125311. 5 interactions.
    IntActiP83111. 2 interactions.
    MINTiMINT-2804983.
    STRINGi9606.ENSP00000261893.

    Structurei

    3D structure databases

    ProteinModelPortaliP83111.
    SMRiP83111. Positions 108-542.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase S12 family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG1680.
    HOGENOMiHOG000060285.
    HOVERGENiHBG052296.
    InParanoidiP83111.
    KOiK17382.
    OMAiQVGLFKN.
    OrthoDBiEOG7353WG.
    PhylomeDBiP83111.
    TreeFamiTF315050.

    Family and domain databases

    Gene3Di3.40.710.10. 2 hits.
    InterProiIPR001466. Beta-lactam-related.
    IPR012338. Beta-lactam/transpept-like.
    [Graphical view]
    PfamiPF00144. Beta-lactamase. 2 hits.
    [Graphical view]
    SUPFAMiSSF56601. SSF56601. 2 hits.

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P83111-1) [UniParc]FASTAAdd to Basket

    Also known as: a

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MYRLMSAVTA RAAAPGGLAS SCGRRGVHQR AGLPPLGHGW VGGLGLGLGL    50
    ALGVKLAGGL RGAAPAQSPA APDPEASPLA EPPQEQSLAP WSPQTPAPPC 100
    SRCFARAIES SRDLLHRIKD EVGAPGIVVG VSVDGKEVWS EGLGYADVEN 150
    RVPCKPETVM RIASISKSLT MVALAKLWEA GKLDLDIPVQ HYVPEFPEKE 200
    YEGEKVSVTT RLLISHLSGI RHYEKDIKKV KEEKAYKALK MMKENVAFEQ 250
    EKEGKSNEKN DFTKFKTEQE NEAKCRNSKP GKKKNDFEQG ELYLREKFEN 300
    SIESLRLFKN DPLFFKPGSQ FLYSTFGYTL LAAIVERASG CKYLDYMQKI 350
    FHDLDMLTTV QEENEPVIYN RARFYVYNKK KRLVNTPYVD NSYKWAGGGF 400
    LSTVGDLLKF GNAMLYGYQV GLFKNSNENL LPGYLKPETM VMMWTPVPNT 450
    EMSWDKEGKY AMAWGVVERK QTYGSCRKQR HYASHTGGAV GASSVLLVLP 500
    EELDTETINN KVPPRGIIVS IICNMQSVGL NSTALKIALE FDKDRSD 547
    Length:547
    Mass (Da):60,694
    Last modified:April 13, 2004 - v2
    Checksum:i4CFAF56D2A390264
    GO
    Isoform 2 (identifier: P83111-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         374-547: Missing.

    Show »
    Length:373
    Mass (Da):41,239
    Checksum:iCD28AA12A2F1C74A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti5 – 51M → L(PubMed:12975309)Curated
    Sequence conflicti5 – 51M → L(PubMed:14702039)Curated
    Sequence conflicti61 – 611R → S in BAB55384. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti469 – 4691R → K.
    Corresponds to variant rs2729835 [ dbSNP | Ensembl ].
    VAR_018299

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei374 – 547174Missing in isoform 2. 2 PublicationsVSP_010011Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK027808 mRNA. Translation: BAB55384.1.
    AY358709 mRNA. Translation: AAQ89072.1.
    BC067288 mRNA. Translation: AAH67288.1.
    CCDSiCCDS10182.1. [P83111-1]
    CCDS45275.1. [P83111-2]
    RefSeqiNP_001275514.1. NM_001288585.1.
    NP_116246.2. NM_032857.4. [P83111-1]
    NP_741982.1. NM_171846.3. [P83111-2]
    UniGeneiHs.410388.

    Genome annotation databases

    EnsembliENST00000261893; ENSP00000261893; ENSG00000103642. [P83111-1]
    ENST00000413507; ENSP00000392956; ENSG00000103642. [P83111-2]
    GeneIDi114294.
    KEGGihsa:114294.
    UCSCiuc002alv.3. human. [P83111-1]

    Polymorphism databases

    DMDMi46397478.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK027808 mRNA. Translation: BAB55384.1 .
    AY358709 mRNA. Translation: AAQ89072.1 .
    BC067288 mRNA. Translation: AAH67288.1 .
    CCDSi CCDS10182.1. [P83111-1 ]
    CCDS45275.1. [P83111-2 ]
    RefSeqi NP_001275514.1. NM_001288585.1.
    NP_116246.2. NM_032857.4. [P83111-1 ]
    NP_741982.1. NM_171846.3. [P83111-2 ]
    UniGenei Hs.410388.

    3D structure databases

    ProteinModelPortali P83111.
    SMRi P83111. Positions 108-542.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 125311. 5 interactions.
    IntActi P83111. 2 interactions.
    MINTi MINT-2804983.
    STRINGi 9606.ENSP00000261893.

    Chemistry

    BindingDBi P83111.

    Protein family/group databases

    MEROPSi S12.004.

    PTM databases

    PhosphoSitei P83111.

    Polymorphism databases

    DMDMi 46397478.

    Proteomic databases

    MaxQBi P83111.
    PaxDbi P83111.
    PRIDEi P83111.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000261893 ; ENSP00000261893 ; ENSG00000103642 . [P83111-1 ]
    ENST00000413507 ; ENSP00000392956 ; ENSG00000103642 . [P83111-2 ]
    GeneIDi 114294.
    KEGGi hsa:114294.
    UCSCi uc002alv.3. human. [P83111-1 ]

    Organism-specific databases

    CTDi 114294.
    GeneCardsi GC15P063413.
    HGNCi HGNC:16468. LACTB.
    HPAi HPA036361.
    HPA036362.
    MIMi 608440. gene.
    neXtProti NX_P83111.
    PharmGKBi PA30262.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1680.
    HOGENOMi HOG000060285.
    HOVERGENi HBG052296.
    InParanoidi P83111.
    KOi K17382.
    OMAi QVGLFKN.
    OrthoDBi EOG7353WG.
    PhylomeDBi P83111.
    TreeFami TF315050.

    Miscellaneous databases

    GeneWikii LACTB.
    GenomeRNAii 114294.
    NextBioi 79053.
    PROi P83111.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P83111.
    Bgeei P83111.
    CleanExi HS_LACTB.
    Genevestigatori P83111.

    Family and domain databases

    Gene3Di 3.40.710.10. 2 hits.
    InterProi IPR001466. Beta-lactam-related.
    IPR012338. Beta-lactam/transpept-like.
    [Graphical view ]
    Pfami PF00144. Beta-lactamase. 2 hits.
    [Graphical view ]
    SUPFAMi SSF56601. SSF56601. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Placenta.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Pituitary.
    4. "The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present."
      Koc E.C., Burkhart W., Blackburn K., Moyer M.B., Schlatzer D.M., Moseley A., Spremulli L.L.
      J. Biol. Chem. 276:43958-43969(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION, SUBCELLULAR LOCATION, CONCEPTUAL TRANSLATION.
    5. "Identification, genomic organization, and mRNA expression of LACTB, encoding a serine beta-lactamase-like protein with an amino-terminal transmembrane domain."
      Smith T.S., Southan C., Ellington K., Campbell D., Tew D.G., Debouck C.
      Genomics 78:12-14(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION, CONCEPTUAL TRANSLATION.
    6. Cited for: SUBCELLULAR LOCATION.
    7. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
      Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-342, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiLACTB_HUMAN
    AccessioniPrimary (citable) accession number: P83111
    Secondary accession number(s): P83096
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 26, 2001
    Last sequence update: April 13, 2004
    Last modified: October 1, 2014
    This is version 109 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    Was originally identified as 39S ribosomal protein L56 (MRP-L56).1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 15
      Human chromosome 15: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Peptidase families
      Classification of peptidase families and list of entries
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3