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Protein

Serine beta-lactamase-like protein LACTB, mitochondrial

Gene

LACTB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei164 – 1641Acyl-ester intermediateBy similarity

GO - Molecular functioni

  1. hydrolase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Protein family/group databases

MEROPSiS12.004.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine beta-lactamase-like protein LACTB, mitochondrial (EC:3.4.-.-)
Gene namesi
Name:LACTB
Synonyms:MRPL56
ORF Names:UNQ843/PRO1781
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:16468. LACTB.

Subcellular locationi

Mitochondrion 2 Publications

GO - Cellular componenti

  1. cytoplasm Source: HPA
  2. mitochondrion Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30262.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 115115MitochondrionSequence AnalysisAdd
BLAST
Chaini116 – 547432Serine beta-lactamase-like protein LACTB, mitochondrialPRO_0000195476Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei283 – 2831N6-succinyllysineBy similarity
Modified residuei284 – 2841N6-succinyllysineBy similarity
Modified residuei297 – 2971N6-acetyllysineBy similarity
Modified residuei342 – 3421N6-acetyllysine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP83111.
PaxDbiP83111.
PRIDEiP83111.

PTM databases

PhosphoSiteiP83111.

Expressioni

Tissue specificityi

Expressed predominantly in skeletal muscle.

Gene expression databases

BgeeiP83111.
CleanExiHS_LACTB.
ExpressionAtlasiP83111. baseline and differential.
GenevestigatoriP83111.

Organism-specific databases

HPAiHPA036361.
HPA036362.

Interactioni

Protein-protein interaction databases

BioGridi125311. 5 interactions.
IntActiP83111. 2 interactions.
MINTiMINT-2804983.
STRINGi9606.ENSP00000261893.

Structurei

3D structure databases

ProteinModelPortaliP83111.
SMRiP83111. Positions 118-502.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S12 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG1680.
GeneTreeiENSGT00390000001062.
HOGENOMiHOG000060285.
HOVERGENiHBG052296.
InParanoidiP83111.
KOiK17382.
OMAiQVGLFKN.
OrthoDBiEOG7353WG.
PhylomeDBiP83111.
TreeFamiTF315050.

Family and domain databases

Gene3Di3.40.710.10. 2 hits.
InterProiIPR001466. Beta-lactam-related.
IPR012338. Beta-lactam/transpept-like.
[Graphical view]
PfamiPF00144. Beta-lactamase. 2 hits.
[Graphical view]
SUPFAMiSSF56601. SSF56601. 2 hits.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P83111-1) [UniParc]FASTAAdd to basket

Also known as: a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MYRLMSAVTA RAAAPGGLAS SCGRRGVHQR AGLPPLGHGW VGGLGLGLGL
60 70 80 90 100
ALGVKLAGGL RGAAPAQSPA APDPEASPLA EPPQEQSLAP WSPQTPAPPC
110 120 130 140 150
SRCFARAIES SRDLLHRIKD EVGAPGIVVG VSVDGKEVWS EGLGYADVEN
160 170 180 190 200
RVPCKPETVM RIASISKSLT MVALAKLWEA GKLDLDIPVQ HYVPEFPEKE
210 220 230 240 250
YEGEKVSVTT RLLISHLSGI RHYEKDIKKV KEEKAYKALK MMKENVAFEQ
260 270 280 290 300
EKEGKSNEKN DFTKFKTEQE NEAKCRNSKP GKKKNDFEQG ELYLREKFEN
310 320 330 340 350
SIESLRLFKN DPLFFKPGSQ FLYSTFGYTL LAAIVERASG CKYLDYMQKI
360 370 380 390 400
FHDLDMLTTV QEENEPVIYN RARFYVYNKK KRLVNTPYVD NSYKWAGGGF
410 420 430 440 450
LSTVGDLLKF GNAMLYGYQV GLFKNSNENL LPGYLKPETM VMMWTPVPNT
460 470 480 490 500
EMSWDKEGKY AMAWGVVERK QTYGSCRKQR HYASHTGGAV GASSVLLVLP
510 520 530 540
EELDTETINN KVPPRGIIVS IICNMQSVGL NSTALKIALE FDKDRSD
Length:547
Mass (Da):60,694
Last modified:April 13, 2004 - v2
Checksum:i4CFAF56D2A390264
GO
Isoform 2 (identifier: P83111-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     374-547: Missing.

Show »
Length:373
Mass (Da):41,239
Checksum:iCD28AA12A2F1C74A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti5 – 51M → L (PubMed:12975309).Curated
Sequence conflicti5 – 51M → L (PubMed:14702039).Curated
Sequence conflicti61 – 611R → S in BAB55384 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti469 – 4691R → K.
Corresponds to variant rs2729835 [ dbSNP | Ensembl ].
VAR_018299

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei374 – 547174Missing in isoform 2. 2 PublicationsVSP_010011Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027808 mRNA. Translation: BAB55384.1.
AY358709 mRNA. Translation: AAQ89072.1.
BC067288 mRNA. Translation: AAH67288.1.
CCDSiCCDS10182.1. [P83111-1]
CCDS45275.1. [P83111-2]
RefSeqiNP_001275514.1. NM_001288585.1.
NP_116246.2. NM_032857.4. [P83111-1]
NP_741982.1. NM_171846.3. [P83111-2]
UniGeneiHs.410388.

Genome annotation databases

EnsembliENST00000261893; ENSP00000261893; ENSG00000103642. [P83111-1]
ENST00000413507; ENSP00000392956; ENSG00000103642. [P83111-2]
GeneIDi114294.
KEGGihsa:114294.
UCSCiuc002alv.3. human. [P83111-1]

Polymorphism databases

DMDMi46397478.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027808 mRNA. Translation: BAB55384.1.
AY358709 mRNA. Translation: AAQ89072.1.
BC067288 mRNA. Translation: AAH67288.1.
CCDSiCCDS10182.1. [P83111-1]
CCDS45275.1. [P83111-2]
RefSeqiNP_001275514.1. NM_001288585.1.
NP_116246.2. NM_032857.4. [P83111-1]
NP_741982.1. NM_171846.3. [P83111-2]
UniGeneiHs.410388.

3D structure databases

ProteinModelPortaliP83111.
SMRiP83111. Positions 118-502.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125311. 5 interactions.
IntActiP83111. 2 interactions.
MINTiMINT-2804983.
STRINGi9606.ENSP00000261893.

Chemistry

BindingDBiP83111.

Protein family/group databases

MEROPSiS12.004.

PTM databases

PhosphoSiteiP83111.

Polymorphism databases

DMDMi46397478.

Proteomic databases

MaxQBiP83111.
PaxDbiP83111.
PRIDEiP83111.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000261893; ENSP00000261893; ENSG00000103642. [P83111-1]
ENST00000413507; ENSP00000392956; ENSG00000103642. [P83111-2]
GeneIDi114294.
KEGGihsa:114294.
UCSCiuc002alv.3. human. [P83111-1]

Organism-specific databases

CTDi114294.
GeneCardsiGC15P063413.
HGNCiHGNC:16468. LACTB.
HPAiHPA036361.
HPA036362.
MIMi608440. gene.
neXtProtiNX_P83111.
PharmGKBiPA30262.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG1680.
GeneTreeiENSGT00390000001062.
HOGENOMiHOG000060285.
HOVERGENiHBG052296.
InParanoidiP83111.
KOiK17382.
OMAiQVGLFKN.
OrthoDBiEOG7353WG.
PhylomeDBiP83111.
TreeFamiTF315050.

Miscellaneous databases

ChiTaRSiLACTB. human.
GeneWikiiLACTB.
GenomeRNAii114294.
NextBioi79053.
PROiP83111.
SOURCEiSearch...

Gene expression databases

BgeeiP83111.
CleanExiHS_LACTB.
ExpressionAtlasiP83111. baseline and differential.
GenevestigatoriP83111.

Family and domain databases

Gene3Di3.40.710.10. 2 hits.
InterProiIPR001466. Beta-lactam-related.
IPR012338. Beta-lactam/transpept-like.
[Graphical view]
PfamiPF00144. Beta-lactamase. 2 hits.
[Graphical view]
SUPFAMiSSF56601. SSF56601. 2 hits.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Placenta.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Pituitary.
  4. "The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present."
    Koc E.C., Burkhart W., Blackburn K., Moyer M.B., Schlatzer D.M., Moseley A., Spremulli L.L.
    J. Biol. Chem. 276:43958-43969(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION, SUBCELLULAR LOCATION, CONCEPTUAL TRANSLATION.
  5. "Identification, genomic organization, and mRNA expression of LACTB, encoding a serine beta-lactamase-like protein with an amino-terminal transmembrane domain."
    Smith T.S., Southan C., Ellington K., Campbell D., Tew D.G., Debouck C.
    Genomics 78:12-14(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION, CONCEPTUAL TRANSLATION.
  6. Cited for: SUBCELLULAR LOCATION.
  7. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-342, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiLACTB_HUMAN
AccessioniPrimary (citable) accession number: P83111
Secondary accession number(s): P83096
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: April 13, 2004
Last modified: March 4, 2015
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Was originally identified as 39S ribosomal protein L56 (MRP-L56).1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Peptidase families
    Classification of peptidase families and list of entries
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.